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1. 发明授权

US08227017B2 System and method for enhancing the efficacy of antimicrobial contact lenses and other surfaces 失效
标题翻译：用于增强抗微生物隐形眼镜和其它表面的功效的系统和方法
公开(公告)号：US08227017B2
公开(公告)日：2012-07-24
申请号：US12742923
申请日：2008-11-13
申请人： Susan Leander , William Toreki , Gerald Olderman , Albina Mikhaylova
发明人： Susan Leander , William Toreki , Gerald Olderman , Albina Mikhaylova
IPC分类号： B05D3/10 , A61K9/08 , G02C7/04
CPC分类号： A61L12/08 , A61L12/145
摘要： A system and method of enhancing the antimicrobial and biofilm-resistant efficacy of surfaces that have cationic polyelectrolytes nonleachably bound thereto in order to impart antimicrobial activity to the surface. The system for enhancing antimicrobial efficacy involves brushing, dipping, wiping, spraying, or storing the surface in a solution containing citrate ion. The method involves treatment of the surface with a solution which enhances the antimicrobial and biofilm-resistant efficacy of the surface, and which prevents a loss of the antimicrobial properties of the surface which may occur over time. Preferably, the enhancement agent is citrate ion and the cationic polyelectrolyte is poly(diallyldimethylammonium chloride), also known as polyDADMAC. The system is particularly beneficial for surfaces of articles such as contact lenses.
摘要翻译：提高具有阳离子聚电解质与其无关的表面的抗微生物和抗生物膜抗性功效的系统和方法，以赋予表面抗微生物活性。用于增强抗微生物功效的系统涉及刷洗，浸渍，擦拭，喷雾或将表面储存在含有柠檬酸根离子的溶液中。该方法包括用提高表面的抗微生物和抗生物膜的功效的溶液处理表面，并且防止表面随时间发生的抗微生物性能的损失。优选地，增强剂是柠檬酸根离子，阳离子聚电解质是聚（二烯丙基二甲基氯化铵），也称为聚DADMAC。该系统特别有益于诸如隐形眼镜的物品的表面。

2. 发明申请

US20100255178A1 System and Method for Enhancing the Efficacy of Antimicrobial Contact Lenses and Other Surfaces 失效
标题翻译：提高抗微生物隐形眼镜及其他表面效能的系统和方法
公开(公告)号：US20100255178A1
公开(公告)日：2010-10-07
申请号：US12742923
申请日：2008-11-13
申请人： Susan Leander , William Toreki , Gerald Olderman , Albina Mikhaylova
发明人： Susan Leander , William Toreki , Gerald Olderman , Albina Mikhaylova
IPC分类号： B05D3/00
CPC分类号： A61L12/08 , A61L12/145
摘要： A system and method of enhancing the antimicrobial and biofilm-resistant efficacy of surfaces that have cationic polyelectrolytes nonleachably bound thereto in order to impart antimicrobial activity to the surface. The system for enhancing antimicrobial efficacy involves brushing, dipping, wiping, spraying, or storing the surface in a solution containing citrate ion. The method involves treatment of the surface with a solution which enhances the antimicrobial and biofilm-resistant efficacy of the surface, and which prevents a loss of the antimicrobial properties of the surface which may occur over time. Preferably, the enhancement agent is citrate ion and the cationic polyelectrolyte is poly(diallyldimethylammonium chloride), also known as poly-DADMAC. The system is particularly beneficial for surfaces of articles such as contact lenses.
摘要翻译：提高具有阳离子聚电解质与其无关的表面的抗微生物和抗生物膜抗性功效的系统和方法，以赋予表面抗微生物活性。用于增强抗微生物功效的系统涉及刷洗，浸渍，擦拭，喷雾或将表面储存在含有柠檬酸根离子的溶液中。该方法包括用提高表面的抗微生物和抗生物膜抗性功效的溶液处理表面，并且防止表面随时间发生的抗微生物性能的丧失。优选地，增强剂是柠檬酸根离子，阳离子聚电解质是聚（二烯丙基二甲基氯化铵），也称为多-DADMAC。该系统特别有益于诸如隐形眼镜的物品的表面。

3. 发明授权

US08277827B2 Antimicrobial textiles comprising peroxide 有权
标题翻译：含有过氧化物的抗菌纺织品
公开(公告)号：US08277827B2
公开(公告)日：2012-10-02
申请号：US12971659
申请日：2010-12-17
申请人： William Toreki , Albina Mikhaylova , Susan Leander , Bernd Liesenfeld , Gerald M. Olderman
发明人： William Toreki , Albina Mikhaylova , Susan Leander , Bernd Liesenfeld , Gerald M. Olderman
IPC分类号： A01N25/34 , A01N59/00 , A61L15/44 , A61L15/18 , A01P1/00 , C09K3/00 , B05D3/00
CPC分类号： D06M11/50 , A61L15/46 , A61L2300/11 , A61L2300/404 , C09D5/14 , C11D3/046 , C11D3/3947 , C11D17/048 , D06M11/155 , D06M11/57 , D06M11/65 , D06M16/00
摘要： This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared by adjusting the pH of a mixture of a metal salt in aqueous hydrogen peroxide to about 7.5. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.
摘要翻译：本发明涉及赋予基材，特别是纺织品持久的抗微生物活性的方法。通过将金属盐在过氧化氢水溶液中的混合物的pH调节至约7.5来制备不含乙酸盐的金属和过氧化物抗微生物处理制剂。用组合物处理底物并干燥以提供具有抗微生物活性的经处理的底物。锌盐，离子或络合物是优选的。

4. 发明申请

US20130011491A1 Antimicrobial Textiles Comprising Peroxide 有权
标题翻译：包含过氧化物的抗菌纺织品
公开(公告)号：US20130011491A1
公开(公告)日：2013-01-10
申请号：US13616209
申请日：2012-09-14
申请人： William Toreki , Albina Mikhaylova , Susan Leander , Bernd Liesenfeld , Gerald M. Olderman
发明人： William Toreki , Albina Mikhaylova , Susan Leander , Bernd Liesenfeld , Gerald M. Olderman
IPC分类号： A01N59/00 , B05D3/00 , A01P1/00 , D06M11/50 , C09K3/00
CPC分类号： D06M11/50 , A61L15/46 , A61L2300/11 , A61L2300/404 , C09D5/14 , C11D3/046 , C11D3/3947 , C11D17/048 , D06M11/155 , D06M11/57 , D06M11/65 , D06M16/00
摘要： This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared by adjusting the pH of a mixture of a metal salt in aqueous hydrogen peroxide to about 7.5. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.
摘要翻译：本发明涉及赋予基材，特别是纺织品持久的抗微生物活性的方法。通过将金属盐在过氧化氢水溶液中的混合物的pH调节至约7.5来制备不含乙酸盐的金属和过氧化物抗微生物处理制剂。用组合物处理底物并干燥以提供具有抗微生物活性的经处理的底物。锌盐，离子或络合物是优选的。

5. 发明申请

US20110171280A1 Antimicrobial Textiles Comprising Peroxide 有权
标题翻译：包含过氧化物的抗菌纺织品
公开(公告)号：US20110171280A1
公开(公告)日：2011-07-14
申请号：US12971659
申请日：2010-12-17
申请人： William Toreki , Albina Mikhaylova , Susan Leander , Bernd Liesenfeld , Gerald M. Olderman
发明人： William Toreki , Albina Mikhaylova , Susan Leander , Bernd Liesenfeld , Gerald M. Olderman
IPC分类号： A01N25/34 , A01N59/00 , A61L15/44 , A61L15/18 , A01P1/00 , C09K3/00 , B05D3/00
CPC分类号： D06M11/50 , A61L15/46 , A61L2300/11 , A61L2300/404 , C09D5/14 , C11D3/046 , C11D3/3947 , C11D17/048 , D06M11/155 , D06M11/57 , D06M11/65 , D06M16/00
摘要： This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared by adjusting the pH of a mixture of a metal salt in aqueous hydrogen peroxide to about 7.5. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.
摘要翻译：本发明涉及赋予基材，特别是纺织品持久的抗微生物活性的方法。通过将金属盐在过氧化氢水溶液中的混合物的pH调节至约7.5来制备不含乙酸盐的金属和过氧化物抗微生物处理制剂。用组合物处理底物并干燥以提供具有抗微生物活性的经处理的底物。锌盐，离子或络合物是优选的。

6. 发明授权

US08926999B2 Antimicrobial textiles comprising peroxide 有权
标题翻译：含有过氧化物的抗菌纺织品
公开(公告)号：US08926999B2
公开(公告)日：2015-01-06
申请号：US13616209
申请日：2012-09-14
申请人： William Toreki , Albina Mikhaylova , Susan Leander , Bernd Liesenfeld , Gerald M. Olderman
发明人： William Toreki , Albina Mikhaylova , Susan Leander , Bernd Liesenfeld , Gerald M. Olderman
IPC分类号： A01N59/00 , B05D3/00 , A01P1/00 , D06M11/50 , C09K3/00 , D06M11/155 , D06M11/65 , D06M16/00
CPC分类号： D06M11/50 , A61L15/46 , A61L2300/11 , A61L2300/404 , C09D5/14 , C11D3/046 , C11D3/3947 , C11D17/048 , D06M11/155 , D06M11/57 , D06M11/65 , D06M16/00
摘要： This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared from a metal derivative, hydrogen peroxide and a source of hydroxide ion. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.
摘要翻译：本发明涉及赋予基材，特别是纺织品持久的抗微生物活性的方法。从金属衍生物，过氧化氢和氢氧根离子源制备无乙酸盐的金属和过氧化物抗微生物处理制剂。用组合物处理底物并干燥以提供具有抗微生物活性的经处理的底物。锌盐，离子或络合物是优选的。

7. 发明授权

US08545862B2 Polyelectrolyte complex for imparting antimicrobial properties to a substrate 有权
标题翻译：用于赋予基质抗微生物性能的聚电解质络合物
公开(公告)号：US08545862B2
公开(公告)日：2013-10-01
申请号：US12830062
申请日：2010-07-02
申请人： William Toreki , David N. Moore , Bernd Liesenfeld , Albina Mikhaylova , Gerald M. Olderman
发明人： William Toreki , David N. Moore , Bernd Liesenfeld , Albina Mikhaylova , Gerald M. Olderman
IPC分类号： A01N25/00
CPC分类号： A61F13/00995 , A61F13/00063 , A61F2013/0091 , A61F2013/00931 , A61L2/18 , A61L2/232 , A61L15/44 , A61L15/46 , A61L2202/24 , A61L2202/26 , Y10T428/3154 , Y10T428/31565 , Y10T428/31663 , Y10T428/31736 , Y10T428/3179 , Y10T428/31797
摘要： Anionic polyelectrolytes are used as binding agents to reduce the solubility of cationic antimicrobial polyelectrolytes. Ionic attraction between the anionic stabilizing polyelectrolytes and the antimicrobial cationic polyelectrolytes results in formation of a polyelectrolyte complex (PEC). A treatment liquid comprising a stable colloid, suspension, dispersion, solution, coacervate, or emulsion of the PEC in an aqueous carrier is used to treat an article, thus coating, infiltrating, or infusing the PEC onto or into the article. Subsequent drying results in an antimicrobial article wherein the PEC is bound to the article and is significantly less prone, relative to either of the component polyelectrolytes, to being washed, leached, leaked, extracted, or migrated from the antimicrobial article during use, or when exposed to aqueous fluids or solvents. The antimicrobial article can be further treated with ethylene oxide which enhances its antimicrobial efficacy, its biocompatibility, and its utility in wound dressings, medical devices, clothing, etc.
摘要翻译：阴离子聚电解质用作粘合剂以降低阳离子抗菌聚电解质的溶解度。阴离子稳定聚电解质与抗微生物阳离子聚电解质之间的离子吸引导致聚电解质络合物（PEC）的形成。使用包含PEC在水性载体中的稳定的胶体，悬浮液，分散体，溶液，凝聚层或乳液的处理液来处理制品，从而将PEC涂覆，渗透或注入到物品上或进入该物品。随后的干燥导致抗微生物制品，其中PEC与制品结合，并且相对于组分聚电解质中的任何一种，在使用期间被洗涤，浸出，泄漏，提取或从抗微生物制品迁移，或者当暴露于含水流体或溶剂。抗菌制品可以进一步用环氧乙烷处理，提高其抗菌效能，其生物相容性及其在伤口敷料，医疗器械，衣服等中的应用。

8. 发明申请

US20100291169A1 Polyelectrolyte Complex for Imparting Antimicrobial Properties to a Substrate 有权
标题翻译：将抗微生物性质赋予基材的聚电解质复合物
公开(公告)号：US20100291169A1
公开(公告)日：2010-11-18
申请号：US12830062
申请日：2010-07-02
申请人： William Toreki , David N. Moore , Bernd Liesenfeld , Albina Mikhaylova , Gerald M. Olderman
发明人： William Toreki , David N. Moore , Bernd Liesenfeld , Albina Mikhaylova , Gerald M. Olderman
IPC分类号： A01N25/34 , A61K9/70 , A61K31/785 , A01N33/12 , A01P1/00 , A61P31/04 , B05D3/10 , C23C16/52 , B32B27/10 , B32B27/08 , B01J39/20
CPC分类号： A61F13/00995 , A61F13/00063 , A61F2013/0091 , A61F2013/00931 , A61L2/18 , A61L2/232 , A61L15/44 , A61L15/46 , A61L2202/24 , A61L2202/26 , Y10T428/3154 , Y10T428/31565 , Y10T428/31663 , Y10T428/31736 , Y10T428/3179 , Y10T428/31797
摘要： Anionic polyelectrolytes are used as binding agents to reduce the solubility of cationic antimicrobial polyelectrolytes. Ionic attraction between the anionic stabilizing polyelectrolytes and the antimicrobial cationic polyelectrolytes results in formation of a polyelectrolyte complex (PEC). A treatment liquid comprising a stable colloid, suspension, dispersion, solution, coacervate, or emulsion of the PEC in an aqueous carrier is used to treat an article, thus coating, infiltrating, or infusing the PEC onto or into the article. Subsequent drying results in an antimicrobial article wherein the PEC is bound to the article and is significantly less prone, relative to either of the component polyelectrolytes, to being washed, leached, leaked, extracted, or migrated from the antimicrobial article during use, or when exposed to aqueous fluids or solvents. The antimicrobial article can be further treated with ethylene oxide which enhances its antimicrobial efficacy, its biocompatibility, and its utility in wound dressings, medical devices, clothing, etc.
摘要翻译：阴离子聚电解质用作粘合剂以降低阳离子抗菌聚电解质的溶解度。阴离子稳定聚电解质与抗微生物阳离子聚电解质之间的离子吸引导致聚电解质络合物（PEC）的形成。使用包含PEC在水性载体中的稳定的胶体，悬浮液，分散体，溶液，凝聚层或乳液的处理液来处理制品，从而将PEC涂覆，渗透或注入到物品上或进入该物品。随后的干燥导致抗微生物制品，其中PEC与制品结合，并且相对于组分聚电解质中的任何一种，在使用期间被洗涤，浸出，泄漏，提取或从抗微生物制品迁移，或者当暴露于含水流体或溶剂。抗菌制品可以进一步用环氧乙烷处理，提高其抗菌效能，其生物相容性及其在伤口敷料，医疗器械，衣服等中的应用。

9. 发明申请

US20100311865A1 Gypsum Board Containing Antimicrobial And Antibacterial Compounds 失效
标题翻译：含有抗菌和抗菌化合物的石膏板
公开(公告)号：US20100311865A1
公开(公告)日：2010-12-09
申请号：US12845979
申请日：2010-07-29
申请人： William Toreki , Gerald Olderman , Gregory Staab
发明人： William Toreki , Gerald Olderman , Gregory Staab
IPC分类号： C09D5/00
CPC分类号： A01N25/34 , A01N33/12 , B32B13/08 , E04C2/043 , Y10T428/31986 , Y10T428/31993 , Y10T428/31996 , A01N43/40 , A01N37/12 , A01N55/02 , A01N2300/00
摘要： A novel gypsum board having improved antimicrobial and antibacterial properties is disclosed. The board comprises a gypsum core, front and back paper facings, and a polymeric antimicrobial or antibacterial compound effective at inhibiting fungal growth. Preferred polymeric antimicrobial and antibacterial compounds include polyDADMAC, polyTMMC, and quaternized polyvinyl pyridine derivatives. The novel gypsum board further comprises a non-polymeric antimicrobial or antibacterial compound. Preferred non-polymeric antimicrobial or antibacteral compounds include cetyl pyridinium chloride and sodium pyrithione. The polymeric antimicrobial or antibacterial compound can be present in the gypsum core and/or on one or both of the paper facings. The non-polymeric antimicrobial or antibacterial compound may be encapsulated in a material or ionically associated with the polymeric antimicrobial or antibacterial compound to allow releases of the non-polymeric antimicrobial or antibacterial compound over time and/or upon exposure to moisture. Methods for preparing the aforementioned novel gypsum board are also disclosed.
摘要翻译：公开了具有改进的抗菌和抗菌性能的新型石膏板。该板包括石膏芯，正面和背面纸面，以及有效抑制真菌生长的聚合抗微生物或抗菌化合物。优选的聚合抗微生物和抗菌化合物包括polyDADMAC，polyTMMC和季铵化的聚乙烯吡啶衍生物。新型石膏板还包含非聚合抗微生物或抗菌化合物。优选的非聚合抗微生物或抗菌化合物包括氯化十六烷基吡啶鎓和吡啶硫酮钠。聚合物抗微生物或抗菌化合物可以存在于石膏芯中和/或在一个或两个纸面上。非聚合物抗微生物剂或抗菌化合物可以被包封在与聚合物抗微生物或抗菌化合物的离子缔合物质中，以允许随着时间和/或暴露于水分而释放非聚合物抗微生物剂或抗菌化合物。还公开了制备上述新型石膏板的方法。

10. 发明申请

US20100211035A1 Antimicrobial Bandage Material Comprising Superabsorbent and Non-Superabsorbent Layers 失效
标题翻译：包含超吸收剂和非超吸收层的抗菌绷带材料
公开(公告)号：US20100211035A1
公开(公告)日：2010-08-19
申请号：US12772686
申请日：2010-05-03
申请人： William Toreki , Gerald Olderman
发明人： William Toreki , Gerald Olderman
IPC分类号： A61L15/46
CPC分类号： A01N25/34 , A61F13/8405 , A61L15/46 , A61L2300/206 , A61L2300/208 , A61L2300/404 , A61L2300/606 , A01N25/10 , A01N33/12 , A01N47/44
摘要： This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.
摘要翻译：本发明涉及具有抗菌性能的非浸出涂层的材料的方法和组合物。将涂层施加到诸如纱布式伤口敷料的基底上。在底物和形成涂层的聚合物分子之间形成共价，非浸出，不可水解的键。在多长度聚合物链上具有高浓度的抗微生物群和相当长的平均链长，有助于具有高水平抗微生物效果的吸收剂或超吸收剂表面。

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