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1. 发明授权

US4454232A Estriol assay 失效
标题翻译：雌三醇测定
公开(公告)号：US4454232A
公开(公告)日：1984-06-12
申请号：US385598
申请日：1982-06-07
申请人： Susan E. Breglio , Mark S. Hanamoto
发明人： Susan E. Breglio , Mark S. Hanamoto
IPC分类号： G01N33/74 , G01N33/54 , G01N33/58 , G01N33/60
CPC分类号： G01N33/743 , Y10S436/80 , Y10S436/804 , Y10S436/826
摘要： An improved immunoassay technique for determining the presence of estriol in human sera comprises adding preselected amounts of a non-ionic detergent and a surface active agent to the assay medium to lessen inaccuracies resulting from variable serum protein concentrations in the sample.
摘要翻译：用于测定人血清中雌三醇的存在的改进的免疫测定技术包括将预选量的非离子洗涤剂和表面活性剂加入到测定培养基中，以减少由样品中可变血清蛋白浓度导致的不准确性。

2. 发明授权

US5877216A Treatment of female sexual dysfunction 失效
标题翻译：治疗女性性功能障碍
公开(公告)号：US5877216A
公开(公告)日：1999-03-02
申请号：US959064
申请日：1997-10-28
申请人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
发明人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
IPC分类号： A61K9/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , A61K31/19
CPC分类号： B82Y5/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , A61K9/0034
摘要： Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasodilating agent is administered to the vagina or vulvar area of the individual undergoing treatment. Suitable vasodilating agents include naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, pharmaceutically acceptable salts, esters and inclusion complexes of any of the foregoing, and mixtures thereof. The novel formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.
摘要翻译：提供了治疗女性性功能障碍的方法和制剂。将配制成含有选择的血管舒张剂的药物组合物施用于经历治疗的个体的阴道或外阴区域。合适的血管舒张剂包括天然存在的前列腺素，合成前列腺素衍生物，内皮衍生的松弛因子，血管活性肠多肽激动剂，平滑肌松弛剂，白细胞三烯抑制剂，药学上可接受的盐，任何前述的药物和包合物，及其混合物。新型制剂也可用于预防酵母菌感染的发生，改善阴道肌张力和组织健康，增强阴道润滑，并使过量胶原蛋白沉积最小化。还提供阴蒂药物递送装置。

3. 发明授权

US06294550B1 Treatment of female sexual dysfunction 有权
公开(公告)号：US06294550B1
公开(公告)日：2001-09-25
申请号：US09501098
申请日：2000-02-09
申请人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
发明人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
IPC分类号： A61K3144
CPC分类号： B82Y5/00 , A61K9/0034 , A61K9/02 , A61K31/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.

4. 发明授权

US4389491A Method and kit for chromatographic separation of hemoglobin A.sub.1c 失效
标题翻译：血红蛋白A1c色谱分离方法和试剂盒
公开(公告)号：US4389491A
公开(公告)日：1983-06-21
申请号：US371844
申请日：1982-04-26
申请人： Mark S. Hanamoto , Steve K. Tanaka
发明人： Mark S. Hanamoto , Steve K. Tanaka
IPC分类号： G01N33/66 , G01N30/88 , G01N33/72
CPC分类号： G01N33/723
摘要： An ion exchange method and kit for the separation of hemoglobin A.sub.1c from other hemoglobin components in a sample of human blood. The sample is lysed, then used to impregnate a weak cation exchanger. Two buffer solutions are then passed through the column in succession, the first having an alkali metal ion concentration of from about 0.02M to about 0.05M and the second having an alkali metal ion concentration of from about 0.06M to about 0.11M. The second eluate contains substantially all of the hemoglobin A.sub.1c and substantially none of the other hemoglobin components in the original sample. Analysis of the second eluate thus provides a reliable indication of the long-term glucose level in the blood of a patient, and hence the patient's ability to regulate the quantity of glucose ingested. The hemolysate with the Schiff base precursor is introduced directly to the chromatographic column.
摘要翻译：用于将血红蛋白A1c与人血样品中的其他血红蛋白成分分离的离子交换方法和试剂盒。将样品裂解，然后用于浸渍弱阳离子交换剂。然后将两个缓冲溶液依次通过柱，第一个碱金属离子浓度为约0.02M至约0.05M，第二种碱金属离子浓度为约0.06M至约0.11M。第二洗脱液基本上含有原始样品中的所有血红蛋白A1c和基本上没有其他血红蛋白成分。因此，第二洗脱液的分析提供了患者血液中长期葡萄糖水平的可靠指示，因此提供了患者调节摄取的葡萄糖量的能力。将含有席夫碱前体的溶血液直接引入色谱柱。

5. 发明授权

US06306841B1 Treatment of female sexual dysfunction 有权
标题翻译：治疗女性性功能障碍
公开(公告)号：US06306841B1
公开(公告)日：2001-10-23
申请号：US09539484
申请日：2000-03-30
申请人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
发明人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
IPC分类号： A61K31655
CPC分类号： B82Y5/00 , A61K9/0034 , A61K9/02 , A61K31/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.
摘要翻译：提供了治疗女性性功能障碍的方法和制剂。将配制成含有选择的血管活性剂的药物组合物施用于经历治疗的个体的阴道，外阴区域或尿道。合适的血管活性剂是血管扩张剂，包括天然存在的前列腺素，合成的前列腺素衍生物，内皮衍生的松弛因子，血管活性肠多肽激动剂，平滑肌松弛剂，白细胞三烯抑制剂等。该制剂也可用于预防酵母菌感染的发生，改善阴道肌张力和组织健康，增强阴道润滑，并使过量的胶原蛋白沉积最小化。还提供阴蒂药物递送装置。

6. 发明授权

US5919474A Transurethral administration of vasoactive agents to treat peripheral vascular disease, related vascular diseases, and vascular impotence associated therewith 失效
标题翻译：经尿道给药血管活性剂以治疗外周血管疾病，相关血管疾病和与之相关的血管阳。
公开(公告)号：US5919474A
公开(公告)日：1999-07-06
申请号：US959063
申请日：1997-10-28
申请人： Virgil A. Place , Mark S. Hanamoto , Paul C. Doherty, Jr. , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
发明人： Virgil A. Place , Mark S. Hanamoto , Paul C. Doherty, Jr. , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
IPC分类号： A61F5/41 , A61F6/06 , A61F13/02
CPC分类号： A61M31/007 , A61F5/41 , A61K47/10 , A61K47/34 , A61K9/0034 , A61K9/02 , A61M2210/1096
摘要： A method for treating peripheral vascular disease (PVD), related vascular diseases, and vascular impotence associated with such diseases, is provided. The method involves transurethral administration of a pharmaceutical formulation containing a selected vasoactive agent within the context of an effective dosing regimen. Preferred vasoactive agents are vasodilating agents selected from the group consisting of naturally occurring prostaglandins, synthetic prostaglandin derivatives, and combinations thereof. The pharmaceutical formulations used in conjunction with the novel method may also contain enzyme inhibitors, transurethral permeation enhancers, carriers, preservatives, surfactants, and the like. Kits and pharmaceutical formulations are provided as well.
摘要翻译：提供了治疗与这些疾病相关的外周血管疾病（PVD），相关的血管疾病和血管阳。的方法。该方法涉及在有效给药方案的情况下经尿道给药含有选择的血管活性剂的药物制剂。优选的血管活性剂是选自天然存在的前列腺素，合成前列腺素衍生物及其组合的血管舒张剂。与新方法结合使用的药物制剂还可以含有酶抑制剂，经尿道渗透促进剂，载体，防腐剂，表面活性剂等。还提供了试剂盒和药物制剂。

7. 发明授权

US06472434B1 Method for minimizing excess collagen deposition 有权
标题翻译：减少多余胶原蛋白沉积的方法
公开(公告)号：US06472434B1
公开(公告)日：2002-10-29
申请号：US09539737
申请日：2000-03-30
申请人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
发明人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
IPC分类号： A61K3119
CPC分类号： B82Y5/00 , A61K9/0034 , A61K9/02 , A61K31/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： Methods and formulations for minimizing excess collagen are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others.
摘要翻译：提供了减少过量胶原蛋白的方法和制剂。将配制成含有选择的血管活性剂的药物组合物施用于经历治疗的个体的阴道，外阴区域或尿道。合适的血管活性剂是血管扩张剂，包括天然存在的前列腺素，合成的前列腺素衍生物，内皮衍生的松弛因子，血管活性肠多肽激动剂，平滑肌松弛剂，白细胞三烯抑制剂等。

8. 发明授权

US06290981B1 Use of nitric oxide-releasing agents to treat impotency 失效
标题翻译：使用一氧化氮释放剂来治疗阳。
公开(公告)号：US06290981B1
公开(公告)日：2001-09-18
申请号：US09289570
申请日：1999-04-09
申请人： Larry K. Keefer , Joseph E. Saavedra , Paul C. Doherty , Mark S. Hanamoto , Virgil A. Place
发明人： Larry K. Keefer , Joseph E. Saavedra , Paul C. Doherty , Mark S. Hanamoto , Virgil A. Place
IPC分类号： A61K3785
CPC分类号： A61K31/655 , A61K31/785 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/64 , C08F8/32 , Y10S514/963 , Y10S514/968 , C08F112/14
摘要： A method of treatment for impotency is provided. The method involves the administration of nitric oxide by a nitric oxide-releasing agent capable of providing a penile erection-inducing amount of nitric oxide to the corpus cavernosum of the penis of an impotent male animal. Also provided is a nitric oxide delivery means for use in the method.
摘要翻译：提供了一种治疗阳A的方法。该方法包括通过能够向无力雄性动物的阴茎的阴茎海绵体提供阴茎勃起诱导量的一氧化氮的一氧化一氮释放剂来施用一氧化氮。还提供了用于该方法的一氧化氮递送装置。

9. 发明授权

US4409335A Method for eliminating glucose dependent Schiff base effect from hemoglobin A.sub.1 assay 失效
标题翻译：从血红蛋白A1检测中消除葡萄糖依赖性席夫碱效应的方法
公开(公告)号：US4409335A
公开(公告)日：1983-10-11
申请号：US382899
申请日：1982-05-28
申请人： Mark S. Hanamoto , Steve K. Tanaka
发明人： Mark S. Hanamoto , Steve K. Tanaka
IPC分类号： A61K35/18 , A61K38/16 , G01N33/66 , G01N33/72
CPC分类号： G01N33/723 , Y10T436/144444
摘要： An ion exchange method for the separation of hemoglobin A.sub.1 from its Schiff base precursors and from nonglycosylated hemoglobin in a sample of human blood. The known method of lysing the sample, using it to impregnate a weak cation exchange resin, eluting out the glycosylated components with a buffer solution containing from about 0.6 M to about 0.11 M alkali metal ion dissolved therein, and recovering the eluate, is modified by the inclusion of a dihydroxyboryl compound in either the hemolysate, the elution buffer, or both.
摘要翻译：用于将血红蛋白A1与其席夫碱前体和人血液样品中的非糖基化血红蛋白分离的离子交换方法。利用已知的方法裂解样品以浸渍弱阳离子交换树脂，用含有约0.6M至约0.11M的碱金属离子溶解于其中的缓冲溶液洗脱糖基化组分并回收洗脱液，由在溶血液，洗脱缓冲液或二者中包含二羟基硼烷化合物。

10. 发明授权

US06593313B2 Co-administration of a prostaglandin and an androgenic agent in the treatment of female sexual dysfunction 有权
标题翻译：共同管理前列腺素和雄激素药物治疗女性性功能障碍
公开(公告)号：US06593313B2
公开(公告)日：2003-07-15
申请号：US09905458
申请日：2001-07-13
申请人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
发明人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
IPC分类号： A61K3119
CPC分类号： B82Y5/00 , A61K9/0034 , A61K9/02 , A61K31/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.
摘要翻译：提供了治疗女性性功能障碍的方法和制剂。将配制成含有选择的血管活性剂的药物组合物施用于经历治疗的个体的阴道，外阴区域或尿道。合适的血管活性剂是血管扩张剂，包括天然存在的前列腺素，合成的前列腺素衍生物，内皮衍生的松弛因子，血管活性肠多肽激动剂，平滑肌松弛剂，白细胞三烯抑制剂等。该制剂也可用于预防酵母菌感染的发生，改善阴道肌张力和组织健康，增强阴道润滑，并使过量的胶原蛋白沉积最小化。还提供阴蒂药物递送装置。

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