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1. 发明授权

US09839920B2 Apparatus for manipulating particles using at least one chamber having an inlet and an opposed outlet 有权
公开(公告)号：US09839920B2
公开(公告)日：2017-12-12
申请号：US13499807
申请日：2010-10-06
申请人： Sunil Mehta , Tod Herman , Joe McMahon , Stephen Wilson , Ian Fitzpatrick , Timothy Craig
发明人： Sunil Mehta , Tod Herman , Joe McMahon , Stephen Wilson , Ian Fitzpatrick , Timothy Craig
IPC分类号： B04B5/04
CPC分类号： B04B5/0442 , B04B2005/0471 , B04B2005/0492
摘要： An apparatus for manipulating particles includes: a rotor rotatable at a speed about an axis, the rotor having an outer periphery and front and rear opposite sides; at least one chamber (50) mounted on the rotor, each chamber having an inlet and an outlet; an umbilical assembly rotatable about the axis; and a drive mechanism configured to rotate the umbilical assembly at about one-half the speed of the rotor. The umbilical assembly includes: a curvilinear guide tube (125) connecting to a drum at the rear side of the rotor; a flexible conduit (130) residing in the guide tube; and first and second elongate passageways (135) for each chamber extending through the conduit, wherein the first passageway is in fluid communication with the inlet of a respective chamber and the second passageway is in fluid communication with the outlet of the respective chamber. The passageways are held in a spaced-apart relationship relative to one another.

2. 发明申请

US20120270717A1 Methods, Systems and Apparatus for Manipulating Particles 有权
标题翻译：用于操作颗粒的方法，系统和装置
公开(公告)号：US20120270717A1
公开(公告)日：2012-10-25
申请号：US13499807
申请日：2010-10-06
申请人： Sunil Mehta , Tod Herman , Joe McMahon , Stephen Wilson , Ian Fitzpatrick , Timothy Craig
发明人： Sunil Mehta , Tod Herman , Joe McMahon , Stephen Wilson , Ian Fitzpatrick , Timothy Craig
IPC分类号： B04B5/04 , B01D43/00 , B04B15/00
CPC分类号： B04B5/0442 , B04B2005/0471 , B04B2005/0492
摘要： An apparatus for manipulating particles includes: a rotor rotatable at a speed about an axis, the rotor having an outer periphery and front and rear opposite sides; at least one chamber (50) mounted on the rotor, each chamber having an inlet and an outlet; an umbilical assembly rotatable about the axis; and a drive mechanism configured to rotate the umbilical assembly at about one-half the speed of the rotor. The umbilical assembly includes: a curvilinear guide tube (125) connecting to a drum at the rear side of the rotor; a flexible conduit (130) residing in the guide tube; and first and second elongate passageways (135) for each chamber extending through the conduit, wherein the first passageway is in fluid communication with the inlet of a respective chamber and the second passageway is in fluid communication with the outlet of the respective chamber. The passageways are held in a spaced-apart relationship relative to one another.
摘要翻译：一种用于操纵颗粒的装置包括：以围绕轴线的速度旋转的转子，所述转子具有外周边和前后相对侧; 安装在转子上的至少一个室（50），每个室具有入口和出口; 围绕所述轴线旋转的脐带组件; 以及驱动机构，其构造成使所述脐带组件以所述转子的大约一半的速度旋转。脐带组件包括：连接到转子后侧的鼓的曲线导管（125）; 位于引导管中的柔性导管（130）; 以及用于每个室延伸穿过导管的第一和第二细长通道（135），其中第一通道与相应室的入口流体连通，并且第二通道与相应室的出口流体连通。通道相对于彼此保持间隔开的关系。

3. 发明申请

US20110207225A1 Methods and Systems for Manipulating Particles Using a Fluidized Bed 有权
标题翻译：使用流化床处理颗粒的方法和系统
公开(公告)号：US20110207225A1
公开(公告)日：2011-08-25
申请号：US13054276
申请日：2009-07-16
申请人： Sunil Mehta , Tod Herman , Harold Ross , Khurshid Iqbal , Joe McMahon
发明人： Sunil Mehta , Tod Herman , Harold Ross , Khurshid Iqbal , Joe McMahon
IPC分类号： C12N11/00 , C12N15/63 , C12N13/00 , C07K1/30 , C12M1/00
CPC分类号： C12N5/0603 , B01D21/262 , C07K1/30 , C12M25/20 , C12M27/10 , C12N13/00 , C12N15/63 , C12N15/87
摘要： The present invention comprises methods and systems for manipulation of media and particles, whether inert materials or biomaterials, such as cells in suspension cell culture. The methods and systems comprise use of an apparatus comprising a rotating chamber wherein the actions of the combined forces fluid flow force and centrifugal force form a fluidized bed within the rotating chamber.
摘要翻译：本发明包括用于操纵介质和颗粒的方法和系统，无论是惰性材料还是生物材料，例如悬浮细胞培养物中的细胞。所述方法和系统包括使用包括旋转室的装置，其中组合力流体流动力和离心力的作用在旋转室内形成流化床。

4. 发明授权

US09279133B2 Methods and systems for manipulating particles using a fluidized bed 有权
标题翻译：使用流化床操作颗粒的方法和系统
公开(公告)号：US09279133B2
公开(公告)日：2016-03-08
申请号：US13054292
申请日：2009-07-16
申请人： Sunil Mehta , Tod Herman , Harold Ross , Khurshid Iqbal , Joe McMahon
发明人： Sunil Mehta , Tod Herman , Harold Ross , Khurshid Iqbal , Joe McMahon
IPC分类号： C12M3/00 , C12N15/87 , C12M1/12 , C12M3/04
CPC分类号： C12N5/0603 , B01D21/262 , C07K1/30 , C12M25/20 , C12M27/10 , C12N13/00 , C12N15/63 , C12N15/87
摘要： The present invention comprises methods and systems for manipulation of media and particles, whether inert materials or biomaterials, such as cells in suspension cell culture. The methods and systems comprise use of an apparatus comprising a rotating chamber wherein the actions of the combined forces of gravity, fluid flow force and centrifugal force form a fluidized bed within the rotating chamber.
摘要翻译：本发明包括用于操纵介质和颗粒的方法和系统，无论是惰性材料还是生物材料，例如悬浮细胞培养物中的细胞。所述方法和系统包括使用包括旋转室的设备，其中重力，流体流动力和离心力的组合作用在旋转室内形成流化床。

5. 发明授权

US09090910B2 Methods and systems for manipulating particles using a fluidized bed 有权
标题翻译：使用流化床操作颗粒的方法和系统
公开(公告)号：US09090910B2
公开(公告)日：2015-07-28
申请号：US13054276
申请日：2009-07-16
申请人： Sunil Mehta , Tod Herman , Harold Ross , Khurshid Iqbal , Joe McMahon
发明人： Sunil Mehta , Tod Herman , Harold Ross , Khurshid Iqbal , Joe McMahon
IPC分类号： C12N5/00 , C12N5/02 , C12N1/00 , C12M1/00 , C12N15/87 , C12M1/12 , C12M3/04
CPC分类号： C12N5/0603 , B01D21/262 , C07K1/30 , C12M25/20 , C12M27/10 , C12N13/00 , C12N15/63 , C12N15/87
摘要： The present invention comprises methods and systems for manipulation of media and particles, whether inert materials or biomaterials, such as cells in suspension cell culture. The methods and systems comprise use of an apparatus comprising a rotating chamber wherein the actions of the combined forces fluid flow force and centrifugal force form a fluidized bed within the rotating chamber.
摘要翻译：本发明包括用于操纵介质和颗粒的方法和系统，无论是惰性材料还是生物材料，例如悬浮细胞培养物中的细胞。所述方法和系统包括使用包括旋转室的装置，其中组合力流体流动力和离心力的作用在旋转室内形成流化床。

6. 发明申请

US20110207222A1 Methods and Systems For Manipulating Particles Using a Fluidized Bed 有权
标题翻译：使用流化床操作颗粒的方法和系统
公开(公告)号：US20110207222A1
公开(公告)日：2011-08-25
申请号：US13054292
申请日：2009-07-16
申请人： Sunil Mehta , Tod Herman , Harold Ross , Khurshid Iqbal , Joe McMahon
发明人： Sunil Mehta , Tod Herman , Harold Ross , Khurshid Iqbal , Joe McMahon
IPC分类号： C12N15/63 , C12N13/00 , C07K1/36 , C12N5/07 , B01D33/06 , B01D24/38
CPC分类号： C12N5/0603 , B01D21/262 , C07K1/30 , C12M25/20 , C12M27/10 , C12N13/00 , C12N15/63 , C12N15/87
摘要： The present invention comprises methods and systems for manipulation of media and particles, whether inert materials or biomaterials, such as cells in suspension cell culture. The methods and systems comprise use of an apparatus comprising a rotating chamber wherein the actions of the combined forces of gravity, fluid flow force and centrifugal force form a fluidized bed within the rotating chamber.
摘要翻译：本发明包括用于操纵介质和颗粒的方法和系统，无论是惰性材料还是生物材料，例如悬浮细胞培养物中的细胞。所述方法和系统包括使用包括旋转室的设备，其中重力，流体流动力和离心力的组合作用在旋转室内形成流化床。

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