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1. 发明申请

US20110159070A1 BIOMATERIALS AND IMPLANTS FOR ENHANCED CARTILAGE FORMATION, AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：生物材料和植入物，用于增强纤维形成，以及制造和使用它们的方法
公开(公告)号：US20110159070A1
公开(公告)日：2011-06-30
申请号：US12997689
申请日：2009-07-02
申请人： Sungho JIN , Seunghan Oh , Karla Brammer
发明人： Sungho JIN , Seunghan Oh , Karla Brammer
IPC分类号： A61L27/54 , A61L27/38 , A61K9/00 , A61K9/70 , A61K35/12 , A61K9/127 , A61K31/7088 , A61K48/00 , A61K38/02 , A61K38/18 , A61K38/22 , C12N5/077 , A61P43/00 , A61P19/04 , A61P19/08 , C23F1/04 , B23K31/02 , H05B6/02 , B23K15/00 , B23K26/20 , B82Y5/00 , B82Y30/00 , B82Y40/00
CPC分类号： A61L27/54 , A61K9/127 , A61K31/7088 , A61K35/32 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , A61L27/025 , A61L27/06 , A61L27/3817 , A61L27/3834 , A61L27/3843 , A61L2300/414 , A61L2300/602 , A61L2300/626 , A61L2300/64 , A61L2400/12 , A61L2430/06 , B23K15/0046 , B23K26/20 , C12M25/00 , C12N5/0655 , H05B6/02
摘要： The invention provides products of manufacture, e.g., biomaterials and implants, for cartilage maintenance and/or formation in-vivo, in-vitro, and ex-vivo, using nanotechnology, e.g., using nanotube, nanowire, nanopillar and/or nanodepots configured on surface structures of the products of manufacture.
摘要翻译：本发明提供了使用纳米技术（例如使用配置在纳米技术，纳米线和/或纳米棒）上的纳米技术来生产例如生物材料和植入物的产品，用于体内，体外和离体的软骨维持和/或形成制造产品的表面结构。

2. 发明授权

US09149564B2 Articles comprising large-surface-area bio-compatible materials and methods for making and using them 有权
标题翻译：包含大面积生物相容性材料的物品及其制作和使用方法
公开(公告)号：US09149564B2
公开(公告)日：2015-10-06
申请号：US12305887
申请日：2007-06-22
申请人： Sungho Jin , Seunghan Oh
发明人： Sungho Jin , Seunghan Oh
IPC分类号： A61K49/00 , A01N63/00 , A61F2/00 , A61L27/54 , A61L27/30 , A61L27/38
CPC分类号： A61L27/306 , A61L27/10 , A61L27/14 , A61L27/16 , A61L27/18 , A61L27/30 , A61L27/3839 , A61L27/54 , A61L2300/252 , A61L2300/254 , A61L2300/256 , A61L2300/258 , A61L2300/406 , A61L2300/414 , A61L2300/43 , A61L2300/624 , A61L2400/12 , A61L2400/18 , C23C28/32 , C23C28/345 , C23C30/00 , C25D7/006 , C25D11/02
摘要： The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and/or cell growth, e.g., for bone, tooth, kidney or liver growth, and uses thereof, e.g., for in vitro testing of drugs, chemicals or toxins, or as in vivo implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as drug delivery devices. The present invention provides biocompatible nanostructures with significantly increased surface area, such as with nanotube and nanopore array on the surface of metallic, ceramic, or polymer materials for enhanced cell and bone growth, for in vitro and in vivo testing, cleansing reaction, implants and therapeutics. The present invention provides optically transparent or translucent cell-culturing substrates. The present invention provides biocompatible and cell-growth-enhancing culture substrates comprising elastically compliant protruding nanostructure substrates coated with Ti, TiO2 or related metal and metal oxide films.
摘要翻译：本发明提供包含生物相容性纳米结构的制品，其包括显着增加例如器官，组织和/或细胞生长的表面积，例如用于骨，牙齿，肾脏或肝脏生长，以及其用途，例如用于体外测试药物，化学物质或毒素，或作为体内植入物，包括其在制备和使用人造组织和器官中的用途，以及相关的，诊断，筛选，研究和开发以及治疗用途，例如作为药物递送装置。本发明提供具有显着增加的表面积的生物相容纳米结构，例如在用于增强细胞和骨生长的金属，陶瓷或聚合物材料的表面上的纳米管和纳米孔阵列，用于体外和体内测试，清洁反应，植入物和疗法。本发明提供光学透明或半透明的细胞培养基质。本发明提供生物相容性和细胞生长增强培养基质，其包含用Ti，TiO 2或相关金属和金属氧化物膜涂覆的弹性柔顺突出的纳米结构基材。

3. 发明申请

US20100303722A1 ARTICLES COMPRISING LARGE-SURFACE-AREA BIO-COMPATIBLE MATERIALS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：包含大面积生物兼容材料的文章及其制作和使用方法
公开(公告)号：US20100303722A1
公开(公告)日：2010-12-02
申请号：US12305887
申请日：2007-06-22
申请人： Sungho Jin , Seunghan Oh
发明人： Sungho Jin , Seunghan Oh
IPC分类号： A61K49/00 , A61F2/00 , A61K35/12 , A61C8/00 , C12N11/14 , C12N5/02 , C12M1/00 , C40B30/00 , C40B40/02 , A61B5/00 , A61F2/02
CPC分类号： A61L27/306 , A61L27/10 , A61L27/14 , A61L27/16 , A61L27/18 , A61L27/30 , A61L27/3839 , A61L27/54 , A61L2300/252 , A61L2300/254 , A61L2300/256 , A61L2300/258 , A61L2300/406 , A61L2300/414 , A61L2300/43 , A61L2300/624 , A61L2400/12 , A61L2400/18 , C23C28/32 , C23C28/345 , C23C30/00 , C25D7/006 , C25D11/02
摘要： The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and/or cell growth, e.g., for bone, tooth, kidney or liver growth, and uses thereof, e.g., for in vitro testing of drugs, chemicals or toxins, or as in vivo implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as drug delivery devices. The present invention provides biocompatible nanostructures with significantly increased surface area, such as with nanotube and nanopore array on the surface of metallic, ceramic, or polymer materials for enhanced cell and bone growth, for in vitro and in vivo testing, cleansing reaction, implants and therapeutics. The present invention provides optically transparent or translucent cell-culturing substrates. The present invention provides biocompatible and cell-growth-enhancing culture substrates comprising elastically compliant protruding nanostructure substrates coated with Ti, TiO2 or related metal and metal oxide films.
摘要翻译：本发明提供包含生物相容性纳米结构的制品，其包括显着增加例如器官，组织和/或细胞生长的表面积，例如用于骨，牙齿，肾脏或肝脏生长，以及其用途，例如用于体外测试药物，化学物质或毒素，或作为体内植入物，包括其在制备和使用人造组织和器官中的用途，以及相关的，诊断，筛选，研究和开发以及治疗用途，例如作为药物递送装置。本发明提供具有显着增加的表面积的生物相容纳米结构，例如在用于增强细胞和骨生长的金属，陶瓷或聚合物材料的表面上的纳米管和纳米孔阵列，用于体外和体内测试，清洁反应，植入物和疗法。本发明提供光学透明或半透明的细胞培养基质。本发明提供生物相容性和细胞生长增强培养基质，其包含用Ti，TiO 2或相关金属和金属氧化物膜涂覆的弹性柔顺突出的纳米结构基材。

4. 发明授权

US08968699B2 Switchable nano-vehicle delivery systems, and methods for making and using them 有权
标题翻译：可切换的纳米载体递送系统，以及制造和使用它们的方法
公开(公告)号：US08968699B2
公开(公告)日：2015-03-03
申请号：US12741590
申请日：2008-11-14
申请人： Sungho Jin , Seunghan Oh , Karla Brammer , Seong Kong
发明人： Sungho Jin , Seunghan Oh , Karla Brammer , Seong Kong
IPC分类号： A61K51/00 , A61K39/395 , A61K39/00 , A61K33/34 , A61K33/24 , A61K33/26 , A61K33/28 , A61N2/00 , A61M37/00 , A61N7/00
CPC分类号： A61N2/00 , A61M37/0092 , A61N7/00
摘要： The invention provides nanodevices or products of manufacture for use as drug delivery vehicles. In one aspect, the invention provides nanodevices or products of manufacture having on-off release mechanisms, e.g., that are “switchable”, or “actuatable” (for example magnetically or ultrasonically switchable), for compounds contained within, e.g., for use as drug delivery nano-vehicles having on-off drug release mechanisms, and their therapeutic applications.
摘要翻译：本发明提供用作药物递送载体的纳米装置或制造产品。在一个方面，本发明提供了具有开关释放机构的纳米器件或制品，例如“可切换”或“可激活”（例如磁性或超声可切换的），其包含在例如用于具有开关药物释放机制的药物递送纳米载体及其治疗应用。

5. 发明授权

US08414908B2 Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same 有权
标题翻译：包含用于细胞，组织和人造器官生长的纳米结构的组合物，以及制备和使用它们的方法
公开(公告)号：US08414908B2
公开(公告)日：2013-04-09
申请号：US11913062
申请日：2006-04-28
申请人： Sungho Jin , Seunghan Oh
发明人： Sungho Jin , Seunghan Oh
IPC分类号： A61F2/00
CPC分类号： A61M37/0092 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61L27/06 , A61L27/306 , A61L27/54 , A61L27/56 , A61L2300/254 , A61L2300/256 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/624 , A61L2400/12 , A61M2037/0007 , C12M23/20 , C12M23/34 , C12M25/00
摘要： The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and/or nanotubes.
摘要翻译：本发明提供包含生物相容性纳米结构的生物相容性纳米结构的制品，其包括用于例如器官，组织和/或细胞生长的纳米管和纳米孔，例如用于骨，肾或肝生长，及其用途，例如体外测试，体内植入，包括用于制造和使用人造器官以及相关疗法。本发明提供了包含多个纳米孔或纳米管的锁定纳米结构，其中纳米孔或纳米管入口具有比纳米孔或纳米管的其余部分（内部）更小的直径或尺寸。本发明还提供包含微孔或大孔和纳米孔的双结构生物材料。本发明提供具有包括多个扩大直径的纳米孔和/或纳米管的表面的生物材料。

6. 发明申请

US20100303716A1 SWITCHABLE NANO-VEHICLE DELIVERY SYSTEMS, AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：可切换的纳米交付系统及其制造和使用方法
公开(公告)号：US20100303716A1
公开(公告)日：2010-12-02
申请号：US12741590
申请日：2008-11-14
申请人： Sungho Jin , Seunghan Oh , Karla Brammer , Seong Kong
发明人： Sungho Jin , Seunghan Oh , Karla Brammer , Seong Kong
IPC分类号： A61F2/00 , A61K39/395 , A61K38/28 , A61K38/22 , A61K31/56 , A61K31/573 , A61K31/337 , A61K31/175 , A61K51/00 , A61K31/715 , A61K48/00 , A61P25/00
CPC分类号： A61N2/00 , A61M37/0092 , A61N7/00
摘要： The invention provides nanodevices or products of manufacture for use as drug delivery vehicles. In one aspect, the invention provides nanodevices or products of manufacture having on-off release mechanisms, e.g., that are “switchable”, or “actuatable” (for example magnetically or ultrasonically switchable), for compounds contained within, e.g., for use as drug delivery nano-vehicles having on-off drug release mechanisms, and their therapeutic applications.
摘要翻译：本发明提供用作药物递送载体的纳米装置或制造产品。在一个方面，本发明提供了具有开关释放机构的纳米器件或制品，例如“可切换”或“可激活”（例如磁性或超声可切换的），其包含在例如用于具有开关药物释放机制的药物递送纳米载体及其治疗应用。

7. 发明申请

US20090220561A1 COMPOSITIONS COMPRISING NANOSTRUCTURES FOR CELL, TISSUE AND ARTIFICIAL ORGAN GROWTH, AND METHODS FOR MAKING AND USING SAME 有权
标题翻译：包含细胞，组织和人工器官生长的纳米结构的组合物，以及制备和使用它们的方法
公开(公告)号：US20090220561A1
公开(公告)日：2009-09-03
申请号：US11913062
申请日：2006-04-28
申请人： Sungho Jin , Seunghan Oh
发明人： Sungho Jin , Seunghan Oh
IPC分类号： A61F2/00 , C12N5/06 , C40B60/12 , C25D11/34 , C12M3/00 , A61C13/08
CPC分类号： A61M37/0092 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61L27/06 , A61L27/306 , A61L27/54 , A61L27/56 , A61L2300/254 , A61L2300/256 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/624 , A61L2400/12 , A61M2037/0007 , C12M23/20 , C12M23/34 , C12M25/00
摘要： The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and/or nanotubes.
摘要翻译：本发明提供包含生物相容性纳米结构的生物相容性纳米结构的制品，其包括用于例如器官，组织和/或细胞生长的纳米管和纳米孔，例如用于骨，肾或肝生长，及其用途，例如体外测试，体内植入，包括用于制造和使用人造器官以及相关疗法。本发明提供了包含多个纳米孔或纳米管的锁定纳米结构，其中纳米孔或纳米管入口具有比纳米孔或纳米管的其余部分（内部）更小的直径或尺寸。本发明还提供包含微孔或大孔和纳米孔的双结构生物材料。本发明提供具有包括多个扩大直径的纳米孔和/或纳米管的表面的生物材料。

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