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1. 发明授权

US08390345B2 Apparatus and method for generating ramp waveform 失效
标题翻译：用于产生斜坡波形的装置和方法
公开(公告)号：US08390345B2
公开(公告)日：2013-03-05
申请号：US13049149
申请日：2011-03-16
申请人： Sung Nam Kim , Cha Kwang Kim , Young Sik Lee
发明人： Sung Nam Kim , Cha Kwang Kim , Young Sik Lee
IPC分类号： H03K4/06
CPC分类号： G09G3/296 , G09G2320/041 , G09G2330/028
摘要： A ramp waveform generating apparatus generates a reference waveform by using an input signal and generates a driving control signal for turning on and off a switch having a first terminal connected to a load and a second terminal connected to a power supply by comparing the voltage of the reference waveform with the voltage of the load. While the switch is repetitively turned on and off in accordance with the driving control signal, a ramp waveform may be generated.
摘要翻译：斜坡波形发生装置通过使用输入信号生成参考波形，并产生用于接通和断开具有连接到负载的第一端子的开关的驱动控制信号，以及连接到电源的第二端子，通过比较参考波形与负载电压。当根据驱动控制信号重复地打开和关闭开关时，可以产生斜坡波形。

2. 发明授权

US08318688B2 Compositions and methods for altering RNAi 有权
标题翻译：用于改变RNAi的组合物和方法
公开(公告)号：US08318688B2
公开(公告)日：2012-11-27
申请号：US11641937
申请日：2006-12-19
申请人： Richard William Carthew , Young Sik Lee , Dinari Harris
发明人： Richard William Carthew , Young Sik Lee , Dinari Harris
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/85
CPC分类号： C12N5/0601 , C07K14/43581 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12N2320/50 , G01N33/5023 , G01N33/5041
摘要： The present invention relates to compositions and methods for altering (e.g., enhancing) RNAi. In particular, the present invention provides systems and methods for identifying regulators of RNAi. For example, the present invention provides RNAi regulators (e.g., HPS1 and HPS4) and methods of altering (e.g., inhibiting) these regulators in order to alter (e.g., enhance) RNAi. The present invention also provides methods of identifying inhibitors (e.g., small molecule, nucleic acid (e.g., siRNA), and antibody) of RNAi regulators and methods of using the same (e.g., to enhance RNAi). Compositions and methods of the present invention find use in research (e.g., functional genomics), therapeutic (e.g., drug discovery and delivery) and clinical applications.
摘要翻译：本发明涉及用于改变（例如增强）RNAi的组合物和方法。特别地，本发明提供用于鉴定RNAi调节剂的系统和方法。例如，本发明提供RNAi调节剂（例如HPS1和HPS4）以及改变（例如抑制）这些调节剂以改变（例如，增强）RNAi的方法。本发明还提供鉴定RNAi调节剂的抑制剂（例如小分子，核酸（例如siRNA）和抗体）以及使用其的方法（例如增强RNAi）的方法。本发明的组合物和方法可用于研究（例如，功能基因组学），治疗（例如药物发现和递送）和临床应用。

3. 发明申请

US20110080205A1 Switch Driving Circuit And Driving Method Thereof 有权
标题翻译：开关驱动电路及其驱动方法
公开(公告)号：US20110080205A1
公开(公告)日：2011-04-07
申请号：US12874415
申请日：2010-09-02
申请人： Young Sik Lee
发明人： Young Sik Lee
IPC分类号： H03K17/16
CPC分类号： H03K17/0822 , H03K17/165
摘要： The present invention relates to a switch driving circuit and a driving method thereof.The switch driving circuit according to the present invention is supplied with a first voltage and a second voltage, is driven by a voltage difference between the first and second voltages, controls a switching operation of a power switch according to a switch driving control signal, generates a sense voltage corresponding to the second voltage, compares a predetermined reference voltage with the sense voltage, and stops the switching operation of the power switch according to the comparison result.
摘要翻译：开关驱动电路及其驱动方法技术领域本发明涉及开关驱动电路及其驱动方法。根据本发明的开关驱动电路被提供有由第一和第二电压之间的电压差驱动的第一电压和第二电压，根据开关驱动控制信号控制电源开关的开关操作，产生对应于第二电压的感测电压将预定的参考电压与感测电压进行比较，并根据比较结果停止电源开关的切换操作。

4. 发明授权

US08487602B2 Switch driving circuit and driving method thereof 有权
标题翻译：开关驱动电路及其驱动方法
公开(公告)号：US08487602B2
公开(公告)日：2013-07-16
申请号：US12874415
申请日：2010-09-02
申请人： Young Sik Lee
发明人： Young Sik Lee
IPC分类号： G05F1/40
CPC分类号： H03K17/0822 , H03K17/165
摘要： The present invention relates to a switch driving circuit and a driving method thereof. The switch driving circuit according to the present invention is supplied with a first voltage and a second voltage, is driven by a voltage difference between the first and second voltages, controls a switching operation of a power switch according to a switch driving control signal, generates a sense voltage corresponding to the second voltage, compares a predetermined reference voltage with the sense voltage, and stops the switching operation of the power switch according to the comparison result.
摘要翻译：开关驱动电路及其驱动方法技术领域本发明涉及开关驱动电路及其驱动方法。根据本发明的开关驱动电路被提供有由第一和第二电压之间的电压差驱动的第一电压和第二电压，根据开关驱动控制信号控制电源开关的开关操作，产生对应于第二电压的感测电压将预定的参考电压与感测电压进行比较，并根据比较结果停止电源开关的切换操作。

5. 发明授权

US10738845B2 Monoblock brake caliper and manufacturing method thereof 有权
公开(公告)号：US10738845B2
公开(公告)日：2020-08-11
申请号：US16016806
申请日：2018-06-25
申请人： SUNGWOO-AUTOTECH. CO., LTD. , Young Sik Lee
发明人： Young Sik Lee
IPC分类号： B22D19/00 , B22D29/00 , F16D65/00 , F16D55/228 , F16D55/00 , F16D121/04
摘要： A monoblock brake caliper has a caliper body including an arcuate section in an arc shape to partially surround a brake disc, and a side section formed at both sides of the arcuate section and positioned in close proximity to both sides of the brake disc; a brake hydraulic line disposed inside the caliper body and configured to be insert-cast during the casting of the caliper body so as to be formed as a U-shaped pipe; and a metal core disposed on the inner side of the side section of the caliper body so as to be positioned adjoining the brake hydraulic line at a portion where a piston is to be disposed during the casting of the caliper body so that the metal core is removed from the caliper body after the casting of the caliper body to form a cylinder in the caliper body.

6. 发明申请

US20130131145A1 COMPOSITIONS AND METHODS FOR ALTERING RNAi 有权
标题翻译：用于改变RNAi的组合物和方法
公开(公告)号：US20130131145A1
公开(公告)日：2013-05-23
申请号：US13668441
申请日：2012-11-05
申请人： Richard William Carthew , Young Sik Lee , Dinari Harris
发明人： Richard William Carthew , Young Sik Lee , Dinari Harris
IPC分类号： C12N5/07 , C12N15/113
CPC分类号： C12N5/0601 , C07K14/43581 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12N2320/50 , G01N33/5023 , G01N33/5041
摘要： The present invention relates to compositions and methods for altering (e.g., enhancing) RNAi. In particular, the present invention provides systems and methods for identifying regulators of RNAi. For example, the present invention provides RNAi regulators (e.g., HPS1 and HPS4) and methods of altering (e.g., inhibiting) these regulators in order to alter (e.g., enhance) RNAi. The present invention also provides methods of identifying inhibitors (e.g., small molecule, nucleic acid (e.g., siRNA), and antibody) of RNAi regulators and methods of using the same (e.g., to enhance RNAi). Compositions and methods of the present invention find use in research (e.g., functional genomics), therapeutic (e.g., drug discovery and delivery) and clinical applications.
摘要翻译：本发明涉及用于改变（例如增强）RNAi的组合物和方法。特别地，本发明提供用于鉴定RNAi调节剂的系统和方法。例如，本发明提供RNAi调节剂（例如HPS1和HPS4）以及改变（例如抑制）这些调节剂以改变（例如，增强）RNAi的方法。本发明还提供鉴定RNAi调节剂的抑制剂（例如小分子，核酸（例如siRNA）和抗体）以及使用其的方法（例如增强RNAi）的方法。本发明的组合物和方法可用于研究（例如，功能基因组学），治疗（例如药物发现和递送）和临床应用。

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