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    • 4. 发明申请
    • Reverse-turn mimetics and method relating thereto
    • 反转模拟物及其相关方法
    • US20070021425A1
    • 2007-01-25
    • US10826972
    • 2004-04-16
    • Sung MoonJae ChungSung LeeMasakatsu EguchiMichael KahnKwang JeongCu Nguyen
    • Sung MoonJae ChungSung LeeMasakatsu EguchiMichael KahnKwang JeongCu Nguyen
    • A61K31/53C07D487/04
    • C07D487/04A61K31/4985Y02A50/467
    • Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
    • 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性,包括用作诊断和治疗剂。 还公开了含有本发明的反转模拟结构的文库以及筛选该文库以鉴定生物活性成员的方法。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病,例如癌症,特别是结肠直肠癌,与血管成形术,多囊肾病,异常血管生成疾病,类风湿性关节炎疾病,结节性硬化综合征相关的再狭窄 ,阿尔茨海默氏病,过度毛发生长或损失,或溃疡性结肠炎。
    • 9. 发明申请
    • In-plane switching mode liquid crystal display panel
    • 平面切换模式液晶显示面板
    • US20050128417A1
    • 2005-06-16
    • US10878113
    • 2004-06-29
    • Hong SongSung MoonGun Do
    • Hong SongSung MoonGun Do
    • G02F1/13G02F1/1343G02F1/1345
    • G02F1/13452G02F1/134363G02F1/1345
    • An in-plane switching mode liquid crystal display panel includes an array substrate; a plurality of gate lines and a plurality of data lines defining a plurality of pixel regions; a switching device; a pixel electrode and a common electrode; a number N of data Tape Carrier Packages (TCPs) applying image information to the data lines and the M number of gate TCPs; a first contact hole formed at an outer edge of the image display part; a first common voltage supply line electrically connected to the common electrode through the first contact hole at a predetermined, e.g., right, end portion; a second contact hole formed at an outer lower end portion of the image display part and electrically connecting the first common voltage supply line and the common electrode; and a color filter. A method of making the display panel is also disclosed.
    • 面内切换模式液晶显示面板包括阵列基板; 多个栅极线和限定多个像素区域的多条数据线; 开关装置; 像素电极和公共电极; N个数据磁带载体包(TCP),将图像信息应用于数据线和M个门TCP; 形成在图像显示部的外缘的第一接触孔; 第一公共电压供应线,其在预定的例如右端部处通过第一接触孔电连接到公共电极; 第二接触孔,形成在所述图像显示部的外侧下端部,并且电连接所述第一公共电压供给线和所述公共电极; 和滤色片。 还公开了制造显示面板的方法。