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1. 发明授权

US6048847A Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this 失效
标题翻译：使用桦木酸及其衍生物抑制癌症生长及其监测方法
公开(公告)号：US6048847A
公开(公告)日：2000-04-11
申请号：US40856
申请日：1998-03-18
申请人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmad Siddiqui
发明人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmad Siddiqui
IPC分类号： A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , C07J63/00
CPC分类号： C07J63/008 , A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , Y10S514/908
摘要： The invention relates to use of betulinic acid and/or its derivatives for treating, inhibiting, and/or preventing tumors or cancer growth more particularly, to treating leukemia, lymphomas, lung, prostate and ovarian cancer. This invention also relates to novel betulinic acid derivatives and a composition containing betulinic acid derivatives with or without betulinic acid.
摘要翻译：本发明涉及桦木酸和/或其衍生物用于治疗，抑制和/或预防肿瘤或癌症生长，特别是治疗白血病，淋巴瘤，肺，前列腺和卵巢癌的用途。本发明还涉及新颖的桦木酸衍生物和含有或不含桦木酸的桦木酸衍生物的组合物。

2. 发明授权

US06228850B1 Antiangiogenic activity of betulinic acid and its derivatives 失效
标题翻译：桦木酸及其衍生物的抗血管生成活性
公开(公告)号：US06228850B1
公开(公告)日：2001-05-08
申请号：US09166809
申请日：1998-10-06
申请人： Manu Jaggi , Sunder Ramadoss , Praveen Rajendran , Mohammad Jamshed Ahmad Siddiqui
发明人： Manu Jaggi , Sunder Ramadoss , Praveen Rajendran , Mohammad Jamshed Ahmad Siddiqui
IPC分类号： A61K3115
CPC分类号： C07J63/008 , A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , Y10S514/908 , A61K2300/00
摘要： Use of betulinic acid and/or its derivatives for inhibiting and/or preventing angiogenesis is described. Compositions containing betulinic acid derivatives with or without betulinic acid can be used for these purposed.
摘要翻译：描述了桦木酸和/或其衍生物用于抑制和/或预防血管生成的用途。含有或不含桦木酸的含桦木酸衍生物的组合物可用于这些用途。

3. 发明授权

US06670345B1 Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid 失效
标题翻译：用于抑制癌症生长的桦木酸衍生物和用于制备桦木酸的方法
公开(公告)号：US06670345B1
公开(公告)日：2003-12-30
申请号：US09431905
申请日：1999-11-02
申请人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmad Siddiqui , Achla Behl Khanna
发明人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmad Siddiqui , Achla Behl Khanna
IPC分类号： C07J5300
CPC分类号： C07J53/00 , C07J63/008
摘要： The invention relates to the use of betulinic acid derivatives for the inhibition and or prevention of cancer growth. The invention also relates to novel betulinic acid derivatives useful for inhibition of tumor cancer cells and a process for the preparation of the derivatives. The invention also relates to anti-leukemic and anti-lymphoma activity of the betulinic acid derivatives, and the use of the derivatives for the treatment of prostate, lung, laryngeal, colon and ovarian cancer.
摘要翻译：本发明涉及桦木酸衍生物用于抑制和/或预防癌症生长的用途。本发明还涉及可用于抑制肿瘤癌细胞的新型桦木酸衍生物和制备衍生物的方法。本发明还涉及桦木酸衍生物的抗白血病和抗淋巴瘤活性，以及该衍生物用于治疗前列腺，肺，喉，结肠和卵巢癌的用途。

4. 发明授权

US06403816B1 Betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis 失效
标题翻译：具有抗血管生成活性的桦木酸衍生物，制备这些衍生物的方法及其用于治疗肿瘤相关血管生成的用途
公开(公告)号：US06403816B1
公开(公告)日：2002-06-11
申请号：US09399617
申请日：1999-09-20
申请人： Manu Jaggi , Sunder Ramadoss , Praveen Rajendran , Mohammad Jamshed Ahmad Siddiqui
发明人： Manu Jaggi , Sunder Ramadoss , Praveen Rajendran , Mohammad Jamshed Ahmad Siddiqui
IPC分类号： C07J5300
CPC分类号： C07J63/008 , A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , A61K2300/00
摘要： The invention relates to novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis.
摘要翻译：本发明涉及具有抗血管生成活性的新颖的桦木酸衍生物，用于制备此类衍生物的方法及其用于治疗肿瘤相关血管生成的用途。

5. 发明授权

US06395771B1 Paclitaxel derivatives for the treatment of cancer 失效
标题翻译：紫杉醇衍生物用于治疗癌症
公开(公告)号：US06395771B1
公开(公告)日：2002-05-28
申请号：US09584113
申请日：2000-05-31
申请人： Sunder Ramadoss , Anand Vardhan , Manu Jaggi , Arvind Kumar Sharma
发明人： Sunder Ramadoss , Anand Vardhan , Manu Jaggi , Arvind Kumar Sharma
IPC分类号： A61K31337
CPC分类号： C07D305/14
摘要： The invention provides novel paclitaxel derivatives obtained by effecting modifications at C2′, C3′ and/or C7 positions of paclitaxel, said derivatives being useful in inhibiting the growth of cancer of lung, breast, ovary, cervix or leukemia, and pharmaceutical compositions comprising such derivatives.
摘要翻译：本发明提供了通过在紫杉醇的C2'，C3'和/或C7位置进行修饰而获得的新型紫杉醇衍生物，所述衍生物可用于抑制肺，乳腺，卵巢，子宫颈或白血病的癌症生长，衍生品

6. 发明授权

US06214814B1 Use of betulinic acid derivatives for inhibiting cancer growth 失效
标题翻译：使用桦木酸衍生物抑制癌症生长
公开(公告)号：US06214814B1
公开(公告)日：2001-04-10
申请号：US09251309
申请日：1999-02-17
申请人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmed Siddiqui , Achla B. Khanna
发明人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmed Siddiqui , Achla B. Khanna
IPC分类号： A61K3156
CPC分类号： C07J63/008 , A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , A61K2300/00
摘要： The invention relates to the use of betulinic acid and its derivatives for the inhibition and/or prevention or cancer growth. The invention also relates to novel betulinic acid derivatives useful for the inhibition of tumor/cancer cells and a process for the preparation of the derivatives. The invention also relates to the antileukemic, and anti-lymphoma activity of the betulinic acid derivatives, and the use of the derivatives for the treatment of prostate, ovarian and lung cancer.
摘要翻译：本发明涉及桦木酸及其衍生物用于抑制和/或预防或癌症生长的用途。本发明还涉及可用于抑制肿瘤/癌细胞的新型桦木酸衍生物和制备衍生物的方法。本发明还涉及桦木酸衍生物的抗白血病和抗淋巴瘤活性，以及该衍生物用于治疗前列腺癌，卵巢癌和肺癌的用途。

7. 发明授权

US06264998B1 Extracting betulinic acid from Ziziphus jujuba 失效
标题翻译：从枣树提取桦木酸
公开(公告)号：US06264998B1
公开(公告)日：2001-07-24
申请号：US09516032
申请日：2000-03-01
申请人： Sunder Ramadoss , Mohammad Jamshed Ahmed Siddiqui
发明人： Sunder Ramadoss , Mohammad Jamshed Ahmed Siddiqui
IPC分类号： A61K3578
CPC分类号： A61K36/725
摘要： A process for isolating betulinic acid from Ziziphus jujuba is disclosed. The process involves the steps of: a) extracting bark of Ziziphus jujuba in a solvent to obtain an extract containing betulinic acid, b) semi-concentrating the extract containing betulinic acid, c) chilling said semi-concentrated extract overnight to obtain a solid in the extract, d) separating the solid from the extract by filtration or centrifugation, e) dissolving the separated solid from step d) in hot methanol, refluxing with activated charcoal and filtering through a celite bed to obtain a methanolic solution, f) partially concentrating the methanolic solution of step e), adding halogenated hydrocarbon solvent and chilling overnight to obtain a solid in the solution, g) separating the solid of step f) by filtration or centrifugation and drying the solid to obtain a solid enriched in betulinic acid, h) dissolving the dried solid step g) in a solvent containing pyridine and acetic anhydride, separating an organic layer and drying to obtain a crude 3-acetoxy betulinic acid, i) washing the crude solid 3-acetoxy betulinic acid obtained in step h) with an alcohol to yield pure solid 3-acetoxy betulinic acid obtained in step i) in an aqueous alcoholic alkali solution to yield pure betulinic acid.
摘要翻译：公开了一种从枣树中分离桦木酸的方法。该方法包括以下步骤：a）在溶剂中提取枣子的树皮以获得含有桦木酸的提取物，b）半浓缩含有桦木酸的提取物，c）将所述半浓缩提取物冷却过夜以获得固体提取物，d）通过过滤或离心从提取物中分离固体，e）将步骤d）中分离的固体溶解在热甲醇中，与活性炭回流并通过硅藻土床过滤以获得甲醇溶液，f）部分浓缩步骤e）的甲醇溶液，加入卤代烃溶剂并冷却过夜以在溶液中获得固体，g）通过过滤或离心分离步骤f）的固体，并干燥固体，得到富含桦木酸的固体，h ）将干燥的固体步骤g）溶解在含有吡啶和乙酸酐的溶剂中，分离有机层并干燥，得到粗品3-乙酰氧基桦木酸，i）洗涤cr 在步骤h）中获得的固体3-乙酰氧基桦木酸与醇在步骤i）中获得的纯固体3-乙酰氧基桦木酸在醇水溶液中混合，得到纯的桦木酸。

8. 发明授权

US6124482A Process for isolation of 10-deacetyl baccatin-III 失效
标题翻译： 10-脱乙酰浆果赤霉素III的分离方法
公开(公告)号：US6124482A
公开(公告)日：2000-09-26
申请号：US392763
申请日：1999-09-07
申请人： Sunder Ramadoss , Anand Vardhan
发明人： Sunder Ramadoss , Anand Vardhan
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： A novel process for isolation of 10-deacetyl baccatin-III (10-DAB) and also complete separation of paclitaxel present in the primary extract, on a commercial scale from plant extract of Taxus species by solvent crystallization without employing chromatographic separation.
摘要翻译：一种用于分离10-脱乙酰基浆果赤霉素III（10-DAB）的新方法，并且还通过溶剂结晶在商业规模上从Taxus物种的植物提取物中完全分离存在于初级提取物中的紫杉醇，而不使用色谱分离。

9. 发明授权

US6002024A Process for the isolation of 14.beta.-hydroxy-10-deacetyl baccatin-III 失效
标题翻译：分离14β-羟基-10-脱乙酰浆果赤霉素III的方法
公开(公告)号：US6002024A
公开(公告)日：1999-12-14
申请号：US212321
申请日：1998-12-15
申请人： Sunder Ramadoss , Anand Vardhan
发明人： Sunder Ramadoss , Anand Vardhan
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： Novel process for isolation of 14.beta.-hydroxy 10-deacetyl baccatin-III (14.beta.-OH-DAB) on a commercial scale from plant extract by solvent crystallization without employing chromatographic separation.
摘要翻译：用于通过溶剂结晶从植物提取物以商业规模分离14β-羟基10-脱乙酰浆果赤霉素III（14β-OH-DAB）的新方法，而不使用色谱分离。

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