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1. 发明授权

US06174514B1 Breath Freshening chewing gum with encapsulations 失效
标题翻译：呼吸清新口香糖包装
公开(公告)号：US06174514B1
公开(公告)日：2001-01-16
申请号：US09290317
申请日：1999-04-12
申请人： Subraman R. Cherukuri , Amrik L. Khurana , Martin K. Schaller, Jr. , Tommy L. Chau , Matthew J. Strait
发明人： Subraman R. Cherukuri , Amrik L. Khurana , Martin K. Schaller, Jr. , Tommy L. Chau , Matthew J. Strait
IPC分类号： A61K968
CPC分类号： A23G4/06 , A23G4/20
摘要： A chewing gum composition for instant and extended release breath freshening has a gum base, at least one wetting agent, at least one immediate release flavor ingredient, and at least on encapsulation. The encapsulations include flavor encapsulations, metallic ion encapsulations, and organic substance encapsulations.
摘要翻译：用于即时和延长释放呼吸清新的口香糖组合物具有胶基，至少一种润湿剂，至少一种立即释放风味成分，并且至少在包封上。封装包括风味包封，金属离子封装和有机物质封装。

2. 发明授权

US5059416A Zinc compound delivery system with improved taste and texture 失效
标题翻译：锌复合物输送系统具有改善的味道和质感
公开(公告)号：US5059416A
公开(公告)日：1991-10-22
申请号：US372394
申请日：1989-06-26
申请人： Subraman R. Cherukuri , Tommy L. Chau
发明人： Subraman R. Cherukuri , Tommy L. Chau
IPC分类号： A23G3/00 , A23G3/34 , A23G4/00 , A23L1/304 , A61K8/00 , A61K8/02 , A61K8/11 , A61K8/19 , A61K8/20 , A61K8/21 , A61K8/23 , A61K8/24 , A61K8/27 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/37 , A61K8/44 , A61K8/60 , A61K8/65 , A61K8/73 , A61K8/86 , A61K8/92 , A61K8/97 , A61K8/98 , A61K9/00 , A61K9/42 , A61K9/50 , A61K9/68 , A61K31/315 , A61K33/30 , A61Q11/00 , C01G9/00
CPC分类号： A61Q11/00 , A61K33/30 , A61K8/11 , A61K8/27 , A61K9/5073 , A61K2800/412 , Y10S514/974
摘要： A new delivery system for zinc compounds and the process for its preparation is disclosed, which has use in a variety of products including comestibles such as chewing gum compositions, confections, pharmaceuticals, food products such as vitamin preparations, dentifrice compositions and throat lozenges. More particularly, this invention relates to a process for preparing a zinc compound delivery system comprised of a zinc core material coated with a first hydrophilic coating comprising a hydrocolloid material and a second hydrophobic coating selected from the group consisting of fats, waxes and mixtures thereof. The delivery system provides enhanced masking of the bitter flavor characteristic of zinc compounds, as well as reduced grittiness with retained stability at the elevated temperatures of product formulation.
摘要翻译：公开了一种用于锌化合物的新的递送系统及其制备方法，其用于包括诸如口香糖组合物，糖果，药物，食品如维生素制剂，洁齿剂组合物和咽喉锭剂等食品的各种产品。更具体地，本发明涉及一种制备锌化合物递送系统的方法，该方法包括涂覆有第一亲水涂层的锌芯材料，所述第一亲水涂层包含水胶体材料和选自脂肪，蜡及其混合物的第二疏水涂层。递送系统提供增强的锌化合物的苦味特征的掩蔽，以及在产品配方的升高的温度下具有保持的稳定性的降低的砂砾性。

3. 发明授权

US5108763A Microencapsulated high intensity sweetening agents having prolonged sweetness release and methods for preparing same 失效
标题翻译：具有延长甜度释放的微胶囊化高强度甜味剂及其制备方法
公开(公告)号：US5108763A
公开(公告)日：1992-04-28
申请号：US679865
申请日：1991-04-03
申请人： Tommy L. Chau , Subraman R. Cherukuri , Elnoria Tolliver
发明人： Tommy L. Chau , Subraman R. Cherukuri , Elnoria Tolliver
IPC分类号： A23G3/34 , A23G4/00 , A23G4/10 , A23G4/20 , A23L27/00 , A23L27/30
CPC分类号： A23G3/346 , A23G4/10 , A23G4/20 , A23L27/32 , A23L27/74 , A23G2200/06 , A23G2220/20 , Y10S426/804
摘要： The present invention is a directed at a sweetening agent delivery system having prolonged sweetness release prepared by a method which comprises the steps of (A) providing the following ingredients in percentages by weight of the sweetening agent delivery system (a) a solution of a high intensity sweetening agent, wherein the sweetening agent is present in an amount from about 0.01% to about 60%, (b) polyvinyl acetate present in an amount from about 40% to about 93% and having a molecular weight in the range from about 2,000 to about 100,000, (c) a plasticizing agent present in an amount from about 0.1% to about 20%, (d) a waxy material having a melting point from about 30.degree. C. to about 120.degree. C. present in an amount from about 0.5% to about 40%, and (e) an emulsifying agent present in an amount from about 0.1% to about 20%, (B) melting and blending the polyvinyl acetate with the plasticizing agent to form a uniform mixture, (C) admixing the solution of high intensity sweetening agent with the melted mixture from step (B) and evaporating the solvent to form a uniform mixture, (D) admixing the waxy material and the emulsifying agent with the mixture from step (C) to form a uniform mixture, (E) cooling and blending the mixture from step (D), and (F) granulating the mixture from step (E).
摘要翻译：本发明涉及一种具有延长的甜味释放的甜味剂递送系统，其通过包括以下步骤的方法制备，所述方法包括以下步骤：（A）以甜味剂递送系统的重量百分比提供以下成分（a）高强度甜味剂，其中甜味剂的存在量为约0.01％至约60％，（b）聚乙酸乙烯酯的存在量为约40％至约93％，分子量为约2,000 至约100,000，（c）以约0.1％至约20％的量存在的增塑剂，（d）熔点为约30℃至约120℃的蜡质材料，其量为约0.5％至约40％，和（e）以约0.1％至约20％的量存在的乳化剂，（B）将聚乙酸乙烯酯与增塑剂熔融并共混以形成均匀的混合物，（C）混合高强度甜味剂的溶液与步骤（B）的熔融混合物蒸发并蒸发溶剂以形成均匀的混合物，（D）将蜡质材料和乳化剂与来自步骤（C）的混合物混合以形成均匀的混合物，（E）冷却和混合来自步骤（D）的混合物，和（F）将来自步骤（E）的混合物制粒。

4. 发明授权

US5043169A Stabilized Sweetner Composition 失效
标题翻译：稳定甜味剂组合物
公开(公告)号：US5043169A
公开(公告)日：1991-08-27
申请号：US530769
申请日：1990-05-25
申请人： Subraman R. Cherukuri , Tommy L. Chau , Gul Mansukhani , Angel M. Orama
发明人： Subraman R. Cherukuri , Tommy L. Chau , Gul Mansukhani , Angel M. Orama
IPC分类号： A23G4/00 , A23G4/10 , A23G4/20 , A23L1/00 , A23L1/22 , A23L1/236 , A23P1/04
CPC分类号： A23G4/10 , A23G4/20 , A23L27/32 , A23L27/72
摘要： A stabilized dipeptide sweetening composition useful in chewing gum applications provides longer shelf life stability and improved longer lasting sweetness. A dipeptide sweetner such as appartame is encapsulated through an anhydrous process that compresses the crystals with a mixture of inert binder ingredients so as to form a solid tablet or sheet which is then ground into fine granular particles. These particles may then be coated with a hydrophobic material such as a fat or wax and then incorporated into a variety of food applications such as chewing gum. The sweetener composition is thereby protected from adverse environmental conditions such as high temperature, moisture and pH.

5. 发明授权

US5004595A Multiple encapsulated flavor delivery system and method of preparation 失效
标题翻译：多重包封香料输送系统及其制备方法
公开(公告)号：US5004595A
公开(公告)日：1991-04-02
申请号：US503331
申请日：1990-03-30
申请人： Subraman R. Cherukuri , Tommy L. Chau , Krishna P. Raman , Angel M. Orama
发明人： Subraman R. Cherukuri , Tommy L. Chau , Krishna P. Raman , Angel M. Orama
IPC分类号： A23G3/00 , A23G3/34 , A23G4/00 , A23G4/02 , A23G4/06 , A23G4/10 , A23G4/14 , A23G4/20 , A23L1/00 , A23L1/03 , A23L1/22 , A23L2/00 , A23L2/60 , A61K8/00 , A61K8/11 , A61K8/34 , A61K8/49 , A61K8/65 , A61K8/73 , A61K8/97 , A61K9/00 , A61K9/58 , A61K9/62 , A61K9/64 , A61K9/68 , A61K47/46 , A61Q11/00
CPC分类号： A23G4/20 , A23G4/02 , A23G4/066 , A23G4/10 , A23G4/14 , A23L27/72 , A23V2002/00 , Y10S426/804
摘要： A free-flowing particulate delivery system for providing enhanced flavor and sweetness to comestible compositions comprising a powdered flavor composition encapsulated in a matrix comprising an outer hydrophilic coating containing up to the solubility limit of the coating of an intense sweetener. The delivery system is particularly useful in chewing gums, confectioneries and pharmaceutical preparations as well as other food products.
摘要翻译：一种自由流动的颗粒递送系统，用于为可食用组合物提供增强的风味和甜度，其包含包封在基质中的粉末状风味组合物，其包含含有高达甜味剂的涂层的溶解度极限的外部亲水涂层。递送系统在口香糖，糖果和药物制剂以及其他食品中特别有用。

6. 发明授权

US4954353A Anhydrous chewing gum with improved stability 失效
标题翻译：无水口香糖具有改善的稳定性
公开(公告)号：US4954353A
公开(公告)日：1990-09-04
申请号：US291707
申请日：1988-12-29
申请人： Subraman R. Cherukuri , Gul Mansukhani , Tommy L. Chau
发明人： Subraman R. Cherukuri , Gul Mansukhani , Tommy L. Chau
IPC分类号： A23G4/00 , A23G4/02 , A23G4/06 , A23G4/20
CPC分类号： A23G4/06 , A23G4/02 , A23G4/066 , A23G4/20 , A23V2002/00
摘要： Chewing gum compositions resistant to moisture pickup and hardening and having a moisture content less than about 1.0% and preferably less than about 0.3% by weight of the final composition, including a hard or a soft gum base, flavoring agent, sweetening agent, and a hydrophobic softening agent. The present composition may be formed without cooling and does not require conditioning prior to wrapping. Prior to wrapping the gum pieces may be coated with a sweetening agent in the known manner at ambient temperatures and up to 80% relative humidity.

7. 发明授权

US06517886B1 Positive hydration method of preparing confectionery and the resulting product 有权
标题翻译：正确的水合方法制备糖果和所得产品
公开(公告)号：US06517886B1
公开(公告)日：2003-02-11
申请号：US09609121
申请日：2000-06-30
申请人： Tommy L. Chau , Khoa Nguyen , Aradhana Sasan , Peter King , Paul Croushorn
发明人： Tommy L. Chau , Khoa Nguyen , Aradhana Sasan , Peter King , Paul Croushorn
IPC分类号： A23G300
CPC分类号： A23G3/36 , A23G3/0205 , A23G3/10 , A23G3/362 , A23G3/368 , A23G3/40 , A23G3/42 , A23G3/44 , A23G3/48 , A23G3/50 , A23G3/52 , A23G3/54 , A61K9/0056 , A61K9/2018 , A61K9/2095
摘要： The invention provides an uncooked, unspun intimately mixed confectionery composition having sufficient internal cohesively to be handled without losing its integrity as a mass, said composition being substantially free of unbound water and having substantially no phase separation of moisture, containing:(i) a saccharide based component; (ii) a hydrated hydrobinding component having a water activity substantially less than about 0.75, in combination with a humectant, and a (iii) fat component having a melting point substantially in the range of about 28 to about 45 degrees centigrade for providing a soft yet substantially unsticky chew texture for the composition.
摘要翻译：本发明提供了一种未蒸发的，非旋转的紧密混合的糖食组合物，其具有足够的内部粘合性以便处理而不丧失其质量的完整性，所述组合物基本上不含未结合的水并且基本上没有水分的相分离，其含有：（i）基于组件; （ii）与湿润剂组合的具有大约小于约0.75的水活度的水合氢化结合组分和（iii）熔点基本上在约28至约45摄氏度范围内的脂肪组分，用于提供柔软的但是对于组合物，基本上不起皱的咀嚼纹理。

8. 发明申请

US20080187589A1 MULTI-MODAL DELIVERY VIA TRANSMUCOSAL AND GASTRO-INTESTINAL ABSORPTION OF ANTIHISTAMINES AND SYMPTOM RELIEF 审中-公开
标题翻译：通过转移和胃肠外吸收抗体和症状缓解的多模式递送
公开(公告)号：US20080187589A1
公开(公告)日：2008-08-07
申请号：US12026303
申请日：2008-02-05
申请人： JOHN M. PINNEY , Edward J. Cone , Tommy L. Chau , August R. Buchhalter
发明人： JOHN M. PINNEY , Edward J. Cone , Tommy L. Chau , August R. Buchhalter
IPC分类号： A61K9/24 , A61K9/20 , A61P37/08 , A61K31/4545
CPC分类号： A61K9/0056 , A61K31/135 , A61K31/4545
摘要： A multi-modal absorption, medicine-delivery lozenge is provided. The lozenge includes a lozenge base for oral administration into a user's mouth, a medicinal active ingredient including an antihistamine convertible between ionized and non-ionized states, and a buffer present in an effective amount for establishing a pH in the individual's mouth which is characterized by a simultaneous presence of a first pharmacologically effective dose of the non-ionized form of the medicinal active ingredient for transmucosal absorption, and a second pharmacologically effective dose of the ionized form of the medicinal active ingredient for gastro-intestinal absorption.
摘要翻译：提供了一种多模式吸收药物递送锭剂。锭剂包括用于口服给药于使用者口中的锭剂基料，包括可在电离和非离子化状态之间转化的抗组胺剂的药物活性成分和以个体口中建立pH的有效量的缓冲剂，其特征在于：同时存在用于经粘膜吸收的第一药理有效剂量的非电离形式的药用活性成分，以及用于胃肠吸收的第二药理学有效剂量的电离形式的药用活性成分。

9. 发明授权

US08642016B2 Medicinal delivery system, and related methods 有权
标题翻译：药物输送系统及相关方法
公开(公告)号：US08642016B2
公开(公告)日：2014-02-04
申请号：US11878163
申请日：2007-07-20
申请人： Tommy L. Chau , John M. Pinney , Jack E. Henningfield , Edward J. Cone , Saul M. Shiffman , Joseph G. Gitchell
发明人： Tommy L. Chau , John M. Pinney , Jack E. Henningfield , Edward J. Cone , Saul M. Shiffman , Joseph G. Gitchell
IPC分类号： A61K9/68
CPC分类号： A61K9/0058 , A61K9/0056 , A61K31/4406 , A61K31/465
摘要： A method is provided of making a medicinal delivery system which satiates a craving in an individual when the medicinal delivery system is administered orally to the individual. A coating composition is applied on a saliva-soluble powder to establish a coated powder, the coating composition featuring an at least partially solubilized craving satiation medicinal compound. The coated powder is combined with an edible carrier base to establish a medicinal delivery system that rapidly releases medicine and buffer preferably followed by slower, sustained release.
摘要翻译：提供了一种制备药物递送系统的方法，该药物递送系统当药物递送系统被口服给予个人时，使个体的渴望变得饱满。将涂料组合物施加到唾液可溶性粉末上以建立涂覆粉末，所述涂料组合物的特征在于至少部分溶解的渴望饱和药物化合物。将涂覆的粉末与可食用载体基质结合以建立药物递送系统，其快速释放药物并缓冲，优选缓慢，持续释放。

10. 发明授权

US5637313A Chewable dosage forms 失效
标题翻译：咀嚼剂型
公开(公告)号：US5637313A
公开(公告)日：1997-06-10
申请号：US357506
申请日：1994-12-16
申请人： Tommy L. Chau , Nicholas A. La Bella, Jr.
发明人： Tommy L. Chau , Nicholas A. La Bella, Jr.
IPC分类号： A61K9/20 , A61K9/00 , A61K31/52 , A61K31/59 , A61K31/80 , A61K33/08 , A61K47/36
CPC分类号： A61K31/59 , A61K31/52 , A61K31/714 , A61K31/80 , A61K33/08 , A61K9/0056
摘要： Disclosed is a soft, chewable dosage form, including a matrix of hydrogenated starch hydrolysate, a water soluble bulking agent, and a water insoluble bulking agent. The present invention also includes a method of preparing a soft, chewable dosage form, including the steps of mixing under high shear force, a hydrogenated starch hydrolysate, a water soluble bulking agent, and a water insoluble bulking agent until a uniformly blended matrix is obtained. Active ingredients may optionally be incorporated in the matrix.
摘要翻译：公开了一种软的咀嚼剂型，包括氢化淀粉水解物基质，水溶性填充剂和水不溶性填充剂。本发明还包括一种制备柔软的咀嚼剂型的方法，包括在高剪切力下混合氢化淀粉水解物，水溶性填充剂和水不溶性填充剂的步骤，直到获得均匀混合的基质。活性成分可以任选地并入基质中。

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