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1. 发明授权

US08246977B2 Transdermal delivery systems 有权
标题翻译：透皮递送系统
公开(公告)号：US08246977B2
公开(公告)日：2012-08-21
申请号：US11665813
申请日：2005-10-21
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

2. 发明申请

US20080260811A1 Transdermal delivery systems 有权
标题翻译：透皮递送系统
公开(公告)号：US20080260811A1
公开(公告)日：2008-10-23
申请号：US11888661
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K31/4436 , A61K9/70 , A61P43/00
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

3. 发明申请

US20080175890A1 Transdermal delivery systems 有权
公开(公告)号：US20080175890A1
公开(公告)日：2008-07-24
申请号：US11888650
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K31/4535 , A61K9/70 , A61P31/00
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

4. 发明授权

US5312389A Osmotically driven syringe with programmable agent delivery 失效
标题翻译：具有可编程代理输送的渗透式注射器
公开(公告)号：US5312389A
公开(公告)日：1994-05-17
申请号：US863649
申请日：1992-04-03
申请人： Felix Theeuwes , Su Il Yum
发明人： Felix Theeuwes , Su Il Yum
IPC分类号： A61K9/22 , A61M5/145 , A61M5/155
CPC分类号： A61M5/155 , A61M5/1452 , A61M2005/14513
摘要： An osmotically driven syringe (20, 60) is disclosed which can be used to deliver a beneficial agent such as a drug, at varying pre-determined rates over multiple periods of time. The syringe (20, 60) is driven by an osmotic engine (10) having a shaped wall (12) containing an osmotic agent (17) and/or a gas generating means (19), such as an effervescent couple. The wall (12) is composed of a semipermeable and/or microporous material which is permeable to an external liquid (e.g., water) but which is substantially impermeable to the osmotic agent (17) and the gas generated by the gas generating means (19). The wall (12) has a passageway (13) therethrough to provide a flow path for the driving fluid generated by the engine (10). The osmotic agent(s) (17) and/or the gas generating means (19) are placed in the engine (10) in such a way as to drive engine (10) at different pumping rates (R.sub.1, R.sub.2) over sequential periods of time (t.sub.0 to t.sub.1 and t.sub.1 to t.sub.2).
摘要翻译：公开了一种渗透驱动的注射器（20,60），其可以用于在多个时间段内以变化的预定速率递送有益剂例如药物。注射器（20,60）由渗透引擎（10）驱动，渗透引擎（10）具有包含渗透剂（17）的成形壁（12）和/或诸如泡腾对之类的气体发生装置（19）。壁（12）由半渗透和/或微孔材料组成，该材料可透过外部液体（例如水），但是渗透剂（17）和由气体发生装置（19）产生的气体基本上是不可渗透的）。壁（12）具有穿过其中的通道（13），以为由发动机（10）产生的驱动流体提供流路。渗透剂（17）和/或气体发生装置（19）以这样的方式被放置在发动机（10）中，以便在不同的泵送速率（R1，R2）上连续驱动发动机（10）的时间（t0至t1和t1至t2）。

5. 发明授权

US07438701B2 Local concentration management system 失效
标题翻译：本地集中管理制度
公开(公告)号：US07438701B2
公开(公告)日：2008-10-21
申请号：US09917181
申请日：2001-07-26
申请人： Felix Theeuwes , Su Il Yum
发明人： Felix Theeuwes , Su Il Yum
IPC分类号： A61M29/00
CPC分类号： A61M25/00 , A61M25/0043 , A61M2025/0057 , A61M2025/105 , A61M2025/1086
摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body defining a lumen between its proximal and distal ends, and a diffuser element, a dilutor element, or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.
摘要翻译：本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括装置，其包括在其近端和远端之间限定内腔的细长主体，以及扩散器元件，稀释元件或两者。对试剂选择性渗透的扩散器元件可与细长体可操作地连接，使得试剂流过细长体并进入并通过扩散器元件以离开系统。稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。

6. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

7. 发明授权

US08252320B2 Transdermal delivery system for sufentanil 有权
标题翻译：舒芬太尼透皮给药系统
公开(公告)号：US08252320B2
公开(公告)日：2012-08-28
申请号：US11888661
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61K31/445 , A61K31/4468 , A61K31/4535
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

8. 发明授权

US08252319B2 Transdermal delivery system for sufentanil 有权
公开(公告)号：US08252319B2
公开(公告)日：2012-08-28
申请号：US11888650
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61K31/445 , A61K31/4468 , A61K31/4535
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

9. 发明申请

US20050070883A1 Devices and methods for controlled delivery from a drug delivery device 审中-公开
标题翻译：用于从药物递送装置控制递送的装置和方法
公开(公告)号：US20050070883A1
公开(公告)日：2005-03-31
申请号：US10433196
申请日：2001-11-21
申请人： James Brown , John Culwell , James Filice , Edward Gillis , Felix Theeuwes , Peter Wickman , Su Il Yum
发明人： James Brown , John Culwell , James Filice , Edward Gillis , Felix Theeuwes , Peter Wickman , Su Il Yum
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61M5/142 , A61M5/168 , A61M5/36 , A61M31/00
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译：本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。

10. 发明授权

US5795591A Osmotic drug delivery devices with hydrophobic wall materials 失效
标题翻译：具有疏水壁材料的渗透性药物输送装置
公开(公告)号：US5795591A
公开(公告)日：1998-08-18
申请号：US299867
申请日：1994-09-01
申请人： Eun Soo Lee , Scott A. Bura , Su Il Yum , Patrick S.-L. Wong , Felix Theeuwes
发明人： Eun Soo Lee , Scott A. Bura , Su Il Yum , Patrick S.-L. Wong , Felix Theeuwes
IPC分类号： A61M37/00 , A61K9/00 , A61K9/52 , A61K9/26
CPC分类号： A61K9/0004
摘要： Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of osmotically active species in the interior of the device, despite pores which by their hydrophobic character do not permit the passage of liquid water, and despite the absence of a cellulosic semi-permeable membrane, the devices absorb water by osmosis without loss of the osmotically active species, and function in a manner analogous to osmotic pumps of the prior art. By permitting the use of hydrophobic substances as the wall material, the invention permits the device to be constructed entirely from biodegradable materials.
摘要翻译：公开了具有作为唯一扩散限制壁部件的多孔疏水材料壁的渗透驱动药物输送装置。尽管孔远远大于装置内部的渗透活性物质的分子尺寸，尽管孔具有疏水性，但不允许液态水通过，尽管不存在纤维素半透膜，装置通过渗透吸收水分而不损失渗透活性物质，并且以类似于现有技术的渗透泵的方式起作用。通过允许使用疏水物质作为壁材料，本发明允许该装置完全由可生物降解的材料构成。

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