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1. 发明申请

US20070054919A1 Pyrazinyl substituted piperazine-piperidines with CXCR3 antagonist activity 有权
标题翻译：吡嗪基取代的哌嗪 - 哌啶与CXCR3拮抗剂活性
公开(公告)号：US20070054919A1
公开(公告)日：2007-03-08
申请号：US11354138
申请日：2006-02-14
申请人： Stuart Rosenblum , Seong Kim , Qingbei Zeng , Michael Wong , Gopinadhan Anilkumar , Yueheng Jiang , Wensheng Yu , Joseph Kozlowski , Neng-Yang Shih , Bandarpalle Shankar , Brian McGuinness , Guizhen Dong , Lisa Zawacki , Douglas Hobbs , John Baldwin , Yuefei Shao
发明人： Stuart Rosenblum , Seong Kim , Qingbei Zeng , Michael Wong , Gopinadhan Anilkumar , Yueheng Jiang , Wensheng Yu , Joseph Kozlowski , Neng-Yang Shih , Bandarpalle Shankar , Brian McGuinness , Guizhen Dong , Lisa Zawacki , Douglas Hobbs , John Baldwin , Yuefei Shao
IPC分类号： A61K31/497 , C07D403/14
CPC分类号： C07D405/14 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构：及其药学上可接受的盐，溶剂化物和酯。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括，同种异体移植排斥反应，异种移植物排斥），感染性疾病（例如结核性麻风病），固定药物爆发，皮肤迟发型超敏反应应答，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

2. 发明申请

US20070021611A1 Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity 有权
标题翻译：具有CXCR3拮抗活性的吡啶基和苯基取代的哌嗪 - 哌啶
公开(公告)号：US20070021611A1
公开(公告)日：2007-01-25
申请号：US11353697
申请日：2006-02-14
申请人： Brian McGuinness , Stuart Rosenblum , Joseph Kozlowski , Gopinadhan Anilkumar , Seong Kim , Neng-Yang Shih , Chung-Her Jenh , Paul Zavodny , Douglas Hobbs , Guizhen Dong , Yuefei Shao , Lisa Zawacki , Cangming Yang , Carolyn Carroll
发明人： Brian McGuinness , Stuart Rosenblum , Joseph Kozlowski , Gopinadhan Anilkumar , Seong Kim , Neng-Yang Shih , Chung-Her Jenh , Paul Zavodny , Douglas Hobbs , Guizhen Dong , Yuefei Shao , Lisa Zawacki , Cangming Yang , Carolyn Carroll
IPC分类号： C07D401/00
CPC分类号： C07D401/12 , C07D211/58 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构：及其药学上可接受的盐，溶剂化物和酯。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括，同种异体移植排斥反应，异种移植物排斥），感染性疾病（例如结核性麻风病），固定药物爆发，皮肤迟发型超敏反应应答，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

3. 发明申请

US20080039474A1 NOVEL HETEROCYCLIC SUBSTITUTED PYRIDINE COMPOUNDS WITH CXCR3 ANTAGONIST ACTIVITY 有权
标题翻译：具有CXCR3拮抗剂活性的新型杂环取代的吡啶化合物
公开(公告)号：US20080039474A1
公开(公告)日：2008-02-14
申请号：US11688014
申请日：2007-03-19
申请人： STUART ROSENBLUM , Joseph Kozlowski , Neng-Yang Shih , Brian McGuinness , Douglas Hobbs
发明人： STUART ROSENBLUM , Joseph Kozlowski , Neng-Yang Shih , Brian McGuinness , Douglas Hobbs
IPC分类号： A61K31/497 , A61P29/00 , C07D401/02
CPC分类号： C07D401/14 , C07D413/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1. or a pharmaceutically acceptable salt, solvate or ester thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, zenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构或其药学上可接受的盐，溶剂合物或酯。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化），移植物排斥（非限制性实例，包括同种异体移植物排斥，移植排斥），感染性疾病（例如结核性麻风病），固定药物喷发，皮肤迟发型超敏反应应答，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

4. 发明申请

US20080058343A1 HETEROCYCLIC SUBSTITUTED PIPERAZINE COMPOUNDS WITH CXCR3 ANTAGONIST ACTIVITY 有权
标题翻译：具有CXCR3拮抗剂活性的杂环取代的哌嗪化合物
公开(公告)号：US20080058343A1
公开(公告)日：2008-03-06
申请号：US11776901
申请日：2007-07-12
申请人： Stuart Rosenblum , Joseph Kozlowski , Neng-Yang Shih , Brian McGuinness , Douglas Hobbs
发明人： Stuart Rosenblum , Joseph Kozlowski , Neng-Yang Shih , Brian McGuinness , Douglas Hobbs
IPC分类号： A61K31/497 , A61P25/00 , C07D401/02
CPC分类号： C07D401/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: or a pharmaceutically acceptable salt, solvate or ester thereof Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, zenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构：或其药学上可接受的盐，溶剂合物或酯还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，治疗性治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例）包括牛皮癣），自身免疫疾病（非限制性实例包括类风湿性关节炎，多发性硬化症），移植物排斥（非限制性实例，包括同种异体移植物排斥，移植排斥），感染性疾病（例如，结节性麻风病），固定药物喷发，皮肤迟发型超敏反应，眼部炎症，I型糖尿病，病毒性脑膜炎和使用组合物的肿瘤和式1。

5. 发明申请

US20060276448A1 Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity 有权
标题翻译：具有CXCR3拮抗活性的杂芳基取代的吡嗪基 - 哌嗪 - 哌啶
公开(公告)号：US20060276448A1
公开(公告)日：2006-12-07
申请号：US11353474
申请日：2006-02-14
申请人： Qingbei Zeng , De-Yi Yang , Stuart Rosenblum , Michael Wong , Gopinadhan Anilkumar , Seong Kim , Wensheng Yu , Joseph Kozlowski , Neng-Yang Shih , Brian McGuinness , Lisa Guise-Zawacki , Doublas Hobbs
发明人： Qingbei Zeng , De-Yi Yang , Stuart Rosenblum , Michael Wong , Gopinadhan Anilkumar , Seong Kim , Wensheng Yu , Joseph Kozlowski , Neng-Yang Shih , Brian McGuinness , Lisa Guise-Zawacki , Doublas Hobbs
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/497 , C07D413/14 , C07D403/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: and the pharmaceutically acceptable salts, solvates or esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前药的所述化合物或其对映异构体，立体异构体，旋转异构体，互变异构体，外消旋体或前药，或所述前药的所述化合物，所述化合物具有式1所示的一般结构：和其药学上可接受的盐，溶剂合物或酯。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括同种异体移植排斥反应，异种移植排斥），感染性疾病（例如结核性麻风病），固定药物喷发，皮肤迟发型超敏反应应答，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

6. 发明申请

US20060276480A1 Amine-linked pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity 有权
公开(公告)号：US20060276480A1
公开(公告)日：2006-12-07
申请号：US11354328
申请日：2006-02-14
申请人： Michael Wong , Youheng Shu , Wensheng Yu , Stuart Rosenblum , Joseph Kozlowski , Brian McGuinness , Yuefei Shao , Douglas Hobbs
发明人： Michael Wong , Youheng Shu , Wensheng Yu , Stuart Rosenblum , Joseph Kozlowski , Brian McGuinness , Yuefei Shao , Douglas Hobbs
IPC分类号： A61K31/496 , C07D403/14
CPC分类号： C07D401/14 , C07D211/58 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.

7. 发明申请

US20060217392A1 Novel heterocyclic substituted pyridine or phenyl compounds with CXCR3 antagonist activity 有权
标题翻译：新型杂环取代吡啶或具有CXCR3拮抗活性的苯基化合物
公开(公告)号：US20060217392A1
公开(公告)日：2006-09-28
申请号：US11353609
申请日：2006-02-14
申请人： Gopinadhan Anilkumar , Qingbei Zeng , Stuart Rosenblum , Joseph Kozlowski , Brian McGuinness , Douglas Hobbs
发明人： Gopinadhan Anilkumar , Qingbei Zeng , Stuart Rosenblum , Joseph Kozlowski , Brian McGuinness , Douglas Hobbs
IPC分类号： C07D403/14 , A61K31/496
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D413/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prod rug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: or a pharmaceutically acceptable salt, solvate or ester thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, zenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前药的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体，产物，所述化合物具有式 1：或其药学上可接受的盐，溶剂化物或酯。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化），移植物排斥（非限制性实例，包括同种异体移植排斥，移植排斥），感染性疾病（例如结核性麻风病），固定药物喷发，皮肤迟发型超敏反应应答，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

8. 发明申请

US20060276479A1 Heterocyclic substituted piperazines with CXCR3 antagonist activity 有权
标题翻译：具有CXCR3拮抗剂活性的杂环取代哌嗪
公开(公告)号：US20060276479A1
公开(公告)日：2006-12-07
申请号：US11353641
申请日：2006-02-14
申请人： Seong Kim , Gopinadhan Anilkumar , Michael Wong , Qingbei Zeng , Stuart Rosenblum , Joseph Kozlowski , Yuefei Shao , Brian McGuinness , Douglas Hobbs
发明人： Seong Kim , Gopinadhan Anilkumar , Michael Wong , Qingbei Zeng , Stuart Rosenblum , Joseph Kozlowski , Yuefei Shao , Brian McGuinness , Douglas Hobbs
IPC分类号： A61K31/497 , C07D413/14 , C07D403/14
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构：或其药学上可接受的盐，溶剂合物或酯，其中各种部分在本文中定义。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括，同种异体移植排斥反应，异种移植物排斥），感染性疾病（例如结核性麻风病），固定药物爆发，皮肤迟发型超敏反应应答，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

9. 发明申请

US20070082913A1 Substituted heterocyclic compounds with CXCR3 antagonist activity 有权
标题翻译：取代的具有CXCR3拮抗剂活性的杂环化合物
公开(公告)号：US20070082913A1
公开(公告)日：2007-04-12
申请号：US11545201
申请日：2006-10-10
申请人： Seong Kim , Bandarpalle Shankar , Joseph Kozlowski , Stuart Rosenblum , Neng-Yang Shih
发明人： Seong Kim , Bandarpalle Shankar , Joseph Kozlowski , Stuart Rosenblum , Neng-Yang Shih
IPC分类号： A61K31/497 , A61K31/496 , C07D403/14
CPC分类号： C07D401/14 , C07D401/08 , C07D413/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构：或其药学上可接受的盐，溶剂合物或酯，其中各种部分在本文中定义。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括，同种异体移植排斥反应，异种移植物排斥），感染性疾病（例如结核性麻风病），固定药物爆发，皮肤迟发型超敏反应应答，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

10. 发明授权

US07598242B2 Compounds for the treatment of inflammatory disorders 失效
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US07598242B2
公开(公告)日：2009-10-06
申请号：US11255130
申请日：2005-10-20
申请人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
发明人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
IPC分类号： A61K31/535 , A61K31/497 , C07D401/12 , C07D413/04 , C07D295/02 , C07D217/06 , C07C255/03 , C07C69/76
CPC分类号： C07D213/30 , C07C62/34 , C07C69/757 , C07C235/40 , C07C255/54 , C07C259/08 , C07C279/08 , C07C311/29 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/40 , C07D213/73 , C07D213/74 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/233 , C07D215/26 , C07D215/38 , C07D219/02 , C07D221/16 , C07D233/60 , C07D233/64 , C07D251/10 , C07D277/24 , C07D277/64 , C07D311/04 , C07D311/58 , C07D317/08 , C07D317/64 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMP，TNF-α或其组合介导的疾病或病症。

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