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1. 发明授权

US5633000A Subcutaneous implant 失效
标题翻译：皮下植入
公开(公告)号：US5633000A
公开(公告)日：1997-05-27
申请号：US264689
申请日：1994-06-23
申请人： Stuart A. Grossman , Kam W. Leong , Glenn J. Lesser , Hungnan Lo
发明人： Stuart A. Grossman , Kam W. Leong , Glenn J. Lesser , Hungnan Lo
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61K31/485 , A61L27/14 , A61L27/54 , A61P23/00 , A61P25/04 , A61P25/30 , A61K9/24
CPC分类号： A61K9/0024 , A61K31/485
摘要： A non-abusable, non-inflammatory, biocompatible, non-biodegradable, subcutaneous, polymeric implant for the prolonged, controlled release of hydromorphone with near zero-order kinetics is described. Methods of alleviating cancer pain and treating opioid drug addiction with the implant are also described.
摘要翻译：描述了不可滥用的，非炎性的，生物相容的，不可生物降解的，皮下的聚合物植入物，用于长期控制释放近似零级动力学的氢吗啡酮。还描述了减轻癌症疼痛并用植入物治疗阿片类药物成瘾的方法。

2. 发明授权

US6126956A Subcutaneous implant 有权
标题翻译：皮下植入
公开(公告)号：US6126956A
公开(公告)日：2000-10-03
申请号：US218081
申请日：1998-12-22
申请人： Stuart A. Grossman , Kam W. Leong , Glenn J. Lesser , Hungnan Lo
发明人： Stuart A. Grossman , Kam W. Leong , Glenn J. Lesser , Hungnan Lo
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61K31/485 , A61L27/14 , A61L27/54 , A61P23/00 , A61P25/04 , A61P25/30 , A61K47/32
CPC分类号： A61K9/0024 , A61K31/485
摘要： A non-abusable, non-inflammatory, biocompatible, non-biodegradable, subcutaneous, polymeric implant for the prolonged, controlled release of hydromorphone with near zero-order kinetics is described. Methods of alleviating cancer pain and treating opioid drug addiction with the implant are also described.
摘要翻译：描述了不可滥用的，非炎性的，生物相容的，不可生物降解的，皮下的聚合物植入物，用于长期控制释放近似零级动力学的氢吗啡酮。还描述了减轻癌症疼痛并用植入物治疗阿片类药物成瘾的方法。

3. 发明授权

US5858388A Subcutaneous implant for delivery of hydromorphone 失效
标题翻译：用于输送氢吗啡酮的皮下植入物
公开(公告)号：US5858388A
公开(公告)日：1999-01-12
申请号：US791404
申请日：1997-01-30
申请人： Stuart A. Grossman , Kam W. Leong , Glenn J. Lesser , Hungnan Lo
发明人： Stuart A. Grossman , Kam W. Leong , Glenn J. Lesser , Hungnan Lo
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61K31/485 , A61L27/14 , A61L27/54 , A61P23/00 , A61P25/04 , A61P25/30 , A61K47/32
CPC分类号： A61K9/0024 , A61K31/485
摘要： A non-abusable, non-inflammatory, biocompatible, non-biodegradable, subcutaneous, polymeric implant for the prolonged, controlled release of hydromorphone with near zero-order kinetics is described. Methods of alleviating cancer pain and treating opioid drug addiction with the implant are also described.
摘要翻译：描述了不可滥用的，非炎性的，生物相容的，不可生物降解的，皮下的聚合物植入物，用于长期控制释放近似零级动力学的氢吗啡酮。还描述了减轻癌症疼痛并用植入物治疗阿片类药物成瘾的方法。

4. 发明授权

US06322797B1 Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same 失效
标题翻译：可生物降解的对苯二甲酸酯聚酯 - 聚（磷酸酯）聚合物，组合物，制品及其制备和使用方法
公开(公告)号：US06322797B1
公开(公告)日：2001-11-27
申请号：US09053648
申请日：1998-04-02
申请人： Hai-Quan Mao , Kam W. Leong , Wenbin Dang , Hungnan Lo , Zhong Zhao , David P. Nowotnik , James P. English
发明人： Hai-Quan Mao , Kam W. Leong , Wenbin Dang , Hungnan Lo , Zhong Zhao , David P. Nowotnik , James P. English
IPC分类号： C08G7902
CPC分类号： C08G63/6926 , A61K9/1647 , A61L17/12 , A61L26/0019 , A61L27/18 , Y10T428/2938 , Y10T442/3545 , C08L85/02
摘要： Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; R′ is an aliphatic, aromatic or heterocyclic residue; x is ≧1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.
摘要翻译：描述了可生物降解的对苯二甲酸酯聚合物，其包含式I所示的重复单体单元：其中R是二价有机部分; R'是脂族，芳族或杂环残基; x是> = 1; andn为0-5,000，其中生物可降解聚合物在生物降解之前和之后是生物相容的。用于制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及可控制的方法还使用聚合物释放生物活性物质。

5. 发明授权

US06600010B2 Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same 有权
标题翻译：可生物降解的对苯二甲酸酯聚酯 - 聚（磷酸酯）聚合物，组合物，制品及其制备和使用方法
公开(公告)号：US06600010B2
公开(公告)日：2003-07-29
申请号：US09921297
申请日：2001-08-02
申请人： Hai-Quan Mao , Kam W. Leong , Wenbin Dang , Hungnan Lo , Zhong Zhao , David P. Nowotnik , James P. English
发明人： Hai-Quan Mao , Kam W. Leong , Wenbin Dang , Hungnan Lo , Zhong Zhao , David P. Nowotnik , James P. English
IPC分类号： C08G7902
CPC分类号： C08G63/6926 , A61K9/1647 , A61L17/12 , A61L26/0019 , A61L27/18 , Y10T428/2938 , Y10T442/3545 , C08L85/02
摘要： Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; R′ is an aliphatic, aromatic or heterocyclic residue; x is ≧1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.
摘要翻译：描述了可生物降解的对苯二甲酸酯聚合物，其包含式I所示的重复单体单元：其中R是二价有机部分; R'是脂族，芳族或杂环残基; x是> = 1; andn为0-5,000，其中生物可降解聚合物在生物降解之前和之后是生物相容的。还描述了制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及使用该聚合物可控地释放生物活性物质的方法。

6. 发明授权

US5686091A Biodegradable foams for cell transplantation 失效
标题翻译：可生物降解的泡沫用于细胞移植
公开(公告)号：US5686091A
公开(公告)日：1997-11-11
申请号：US219017
申请日：1994-03-28
申请人： Kam W. Leong , Hungnan Lo , Sudhakar Kadiyala
发明人： Kam W. Leong , Hungnan Lo , Sudhakar Kadiyala
IPC分类号： A61F2/02 , A61F2/00
CPC分类号： A61F2/022 , Y10T428/249955 , Y10T428/249958 , Y10T428/249978
摘要： A structurally rigid biodegradable foam scaffold useful for cell transplantation is provided. The foam can be loaded with nutrients and/or drugs that elute from the foam during transplant to promote growth of the cells. The foam, which features a continuous network of pores, is fabricated using a novel method involving phase separation and consequent expansion upon sublimation of a liquid solvent, preferably naphthalene.
摘要翻译：提供了可用于细胞移植的结构刚性可生物降解泡沫支架。泡沫可以装载在移植期间从泡沫中洗脱的营养物和/或药物以促进细胞的生长。具有连续的孔孔网的泡沫体使用涉及液相溶剂（优选萘）升华的相分离和随后膨胀的新方法制造。

7. 发明申请

US20070031498A1 GEL COMPOSITION FOR CELLULAR ADHESION INHIBITION 审中-公开
标题翻译：凝胶组合物用于细胞粘附抑制
公开(公告)号：US20070031498A1
公开(公告)日：2007-02-08
申请号：US11461800
申请日：2006-08-02
申请人： Xinhua Zong , Hungnan Lo
发明人： Xinhua Zong , Hungnan Lo
IPC分类号： A61K31/737 , A61K31/727 , A61K9/14
CPC分类号： A61L31/16 , A61L31/145 , A61L2300/232 , A61L2300/424
摘要： The invention includes compositions for inhibiting cellular adhesion, methods of preparation of such compositions, and methods for preventing cell adhesion at a surgical site comprising application of such compositions. The compositions generally comprise a cellular adhesion inhibitory agent, such as dextran sulfate, and a crosslinked hydrogel matrix, preferentially physically entrapping the adhesion inhibitory agent. The hydrogel matrix can include a first gel component, such as an electrophilically functionalized polyethylene glycol polymer, and at least one additional gel component, preferably nucleophilically functionalized, and preferentially selected from the group consisting of polyethylene glycol polymers, polypeptides, and polysaccharides. The compositions are useful for delivering the cellular adhesion inhibitory agent to a site in need of adhesion inhibition and providing either immediate or metered delivery of the inhibitory agent.
摘要翻译：本发明包括用于抑制细胞粘附的组合物，这种组合物的制备方法，以及用于在外科手术部位预防细胞粘附的方法，包括施用这样的组合物。组合物通常包含细胞粘附抑制剂，例如硫酸葡聚糖和交联的水凝胶基质，优选物理地截留粘附抑制剂。水凝胶基质可以包括第一凝胶组分，例如亲电子官能化的聚乙二醇聚合物，和至少一种另外的凝胶组分，优选亲核功能化，优选选自聚乙二醇聚合物，多肽和多糖。该组合物可用于将细胞粘附抑制剂递送至需要粘附抑制的部位并提供立即或计量的递送抑制剂。

8. 发明授权

US07407511B2 Methods and materials for connective tissue repair 有权
标题翻译：结缔组织修复的方法和材料
公开(公告)号：US07407511B2
公开(公告)日：2008-08-05
申请号：US10845402
申请日：2004-05-13
申请人： Cary P. Hagan , Rick P. Swaim , Kelly W. Schlachter , James J. Chao , Hungnan Lo
发明人： Cary P. Hagan , Rick P. Swaim , Kelly W. Schlachter , James J. Chao , Hungnan Lo
IPC分类号： A61F2/08
CPC分类号： A61F2/0811 , A61B17/1146 , A61F2002/087
摘要： This invention is generally directed to methods and materials for connective tissue repair. The invention is more specifically related to methods and materials for the repair of tendons and ligaments, especially in the hand. Methods and materials for rotator cuff repair are also disclosed. The use of extraoperatively obtained scaffolding matrices is promoted when reapproximating the connective tissue.
摘要翻译：本发明一般涉及结缔组织修复的方法和材料。本发明更具体地涉及用于修复腱和韧带的方法和材料，特别是在手中。还公开了肩袖修复的方法和材料。当重新接近结缔组织时，促进使用外科手术获得的支架基质。

9. 发明申请

US20050255140A1 Methods and materials for connective tissue repair 有权
标题翻译：结缔组织修复的方法和材料
公开(公告)号：US20050255140A1
公开(公告)日：2005-11-17
申请号：US10845402
申请日：2004-05-13
申请人： Cary Hagan , Rick Swaim , Kelly Schlachter , James Chao , Hungnan Lo
发明人： Cary Hagan , Rick Swaim , Kelly Schlachter , James Chao , Hungnan Lo
IPC分类号： A61F2/00 , A61F2/08
CPC分类号： A61F2/0811 , A61B17/1146 , A61F2002/087
摘要： This invention is generally directed to methods and materials for connective tissue repair. The invention is more specifically related to methods and materials for the repair of tendons and ligaments, especially in the hand. Methods and materials for rotator cuff repair are also disclosed. The use of extraoperatively obtained scaffolding matrices is promoted when reapproximating the connective tissue.
摘要翻译：本发明一般涉及结缔组织修复的方法和材料。本发明更具体地涉及用于修复腱和韧带的方法和材料，特别是在手中。还公开了肩袖修复的方法和材料。当重新接近结缔组织时，促进使用外科手术获得的支架基质。

10. 发明申请

US20080294256A1 Methods and Materials for Connective Tissue Repair 审中-公开
标题翻译：结缔组织修复的方法和材料
公开(公告)号：US20080294256A1
公开(公告)日：2008-11-27
申请号：US12185519
申请日：2008-08-04
申请人： Cary P. Hagan , Rick P. Swaim , Kelly W. Schlachter , James J. Chao , Hungnan Lo
发明人： Cary P. Hagan , Rick P. Swaim , Kelly W. Schlachter , James J. Chao , Hungnan Lo
IPC分类号： A61F2/08 , A61B19/00 , A61B17/08 , A61B17/04
CPC分类号： A61F2/0811 , A61B17/1146 , A61F2002/087
摘要： Methods for tendon and ligament repair using a scaffolding matrix material. The scaffolding matrix material is an off-the-shelf organic dermis from an unknown source which has been extra-operatively prepared so as to be devoid of viable cells which normally express antigens, and to promote natural healing of soft tissue via revascularization and repopulation. The scaffolding matrix material is used to join ruptured tendons or ligaments together and to join ligaments to bone.
摘要翻译：使用脚手架基质材料进行肌腱和韧带修复的方法。脚手架基质材料是来自未知来源的现成的有机真皮，其已经被外切地制备以便没有通常表达抗原的活细胞，并且通过血运重建和再灌注促进软组织的自然愈合。脚手架基质材料用于将断裂的肌腱或韧带连在一起，并将韧带连接到骨上。

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