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1. 发明授权

US08488857B2 Automated diagnosis and alignment supplemented with positron emission tomography (PET) and magnetic resonance (MR) flow estimation 有权
标题翻译：自动诊断和对准补充了正电子发射断层扫描（PET）和磁共振（MR）流量估计
公开(公告)号：US08488857B2
公开(公告)日：2013-07-16
申请号：US12529195
申请日：2008-02-14
申请人： Stewart M. Young , Michael Kuhn , Fabian Wenzel , Ingwer C. Carlsen , Kirsten Meetz , Ralph Buchert
发明人： Stewart M. Young , Michael Kuhn , Fabian Wenzel , Ingwer C. Carlsen , Kirsten Meetz , Ralph Buchert
IPC分类号： G06K9/00 , G06K9/62 , A61B5/02
CPC分类号： A61B6/5247 , A61B5/0035 , A61B5/055 , A61B5/4088 , A61B6/037 , A61B6/507
摘要： A scanner (10) is used to provide images for automated diagnoses of neurodegenerative diseases, such as Alzheimers disease. The images are registered (90) to a template (78). The aligned image is analyzed (60) in relation to reference image data (76, 80) which has been registered to the template which is contained in a knowledge maintenance engine (70) for similar patterns of hypo-intensity that would indicate (in the case of an FDG tracer) reduced glucose uptake in the brain. The most appropriate reference images for the analysis of the present study are chosen by a filter (74). The present study is then given a dementia score (84) as a diagnostic feature vector that indicates to a clinician the type and severity of the ailment based on the analysis. The scanner (10) can produce PET or other metabolic and MR images for diagnosis. The MR can be used to measure blood flow rate into the brain. From the blood flow rate and the metabolic image, tracer, e.g. FDG, uptake maps can be generated for use in the automated diagnoses.
摘要翻译：扫描仪（10）用于提供自动诊断神经变性疾病如阿尔茨海默病的图像。将图像（90）注册到模板（78）。对已经注册到包含在知识维护引擎（70）中的模板的参考图像数据（76,80）进行对准的图像的分析（60），用于类似的低强度模式，其将指示（在 FDG示踪剂的情况）降低了脑中的葡萄糖摄取。用于本研究分析的最合适的参考图像由滤波器（74）选择。然后，本研究给予痴呆评分（84）作为诊断特征向量，其基于分析向临床医生指示疾病的类型和严重程度。扫描仪（10）可以产生PET或其他代谢和MR图像进行诊断。 MR可用于测量进入脑部的血液流量。从血流速度和代谢图像，示踪剂，例如，可以生成FDG，摄影图可用于自动诊断。

2. 发明申请

US20100152577A1 AUTOMATED DIAGNOSIS AND ALIGNMENT SUPPLEMENTED WITH PET/MR FLOW ESTIMATION 有权
标题翻译：用PET / MR流量估计补充的自动诊断和对齐
公开(公告)号：US20100152577A1
公开(公告)日：2010-06-17
申请号：US12529195
申请日：2008-02-14
申请人： Stewart M. Young , Michael Kuhn , Fabian Wenzel , Ingwer C. Carlsen , Kirsten Meetz , Ralph Bucheri
发明人： Stewart M. Young , Michael Kuhn , Fabian Wenzel , Ingwer C. Carlsen , Kirsten Meetz , Ralph Bucheri
IPC分类号： A61B6/00 , G06K9/62
CPC分类号： A61B6/5247 , A61B5/0035 , A61B5/055 , A61B5/4088 , A61B6/037 , A61B6/507
摘要： A scanner (10) is used to provide images for automated diagnoses of neurodegenerative diseases, such as Alzheimers disease. The images are registered (90) to a template (78). The aligned image is analyzed (60) in relation to reference image data (76, 80) which has been registered to the template which is contained in a knowledge maintenance engine (70) for similar patterns of hypo-intensity that would indicate (in the case of an FDG tracer) reduced glucose uptake in the brain. The most appropriate reference images for the analysis of the present study are chosen by a filter (74). The present study is then given a dementia score (84) as a diagnostic feature vector that indicates to a clinician the type and severity of the ailment based on the analysis. The scanner (10) can produce PET or other metabolic and MR images for diagnosis. The MR can be used to measure blood flow rate into the brain. From the blood flow rate and the metabolic image, tracer, e.g. FDG, uptake maps can be generated for use in the automated diagnoses.
摘要翻译：扫描仪（10）用于提供自动诊断神经变性疾病如阿尔茨海默病的图像。将图像（90）注册到模板（78）。对已经注册到包含在知识维护引擎（70）中的模板的参考图像数据（76,80）进行对准的图像的分析（60），用于类似的低强度模式，其将指示（在 FDG示踪剂的情况）降低了脑中的葡萄糖摄取。用于本研究分析的最合适的参考图像由滤波器（74）选择。然后，本研究给予痴呆评分（84）作为诊断特征向量，其基于分析向临床医生指示疾病的类型和严重程度。扫描仪（10）可以产生PET或其他代谢和MR图像进行诊断。 MR可用于测量进入脑部的血液流量。从血流速度和代谢图像，示踪剂，例如，可以生成FDG，摄影图可用于自动诊断。

3. 发明申请

US20100317967A1 COMPUTER ASSISTED THERAPY MONITORING 审中-公开
标题翻译：计算机辅助治疗监测
公开(公告)号：US20100317967A1
公开(公告)日：2010-12-16
申请号：US12521601
申请日：2007-12-05
申请人： Ingwer-Curt Carlsen , Stewart M. Young , Kirsten R. Meetz
发明人： Ingwer-Curt Carlsen , Stewart M. Young , Kirsten R. Meetz
IPC分类号： A61B5/05
CPC分类号： G06T7/20 , A61B6/037 , G06F19/321 , G06F19/3481 , G06T7/0016 , G06T2207/30004 , G16H50/20 , G16H50/50
摘要： A computer assisted therapy apparatus (100) uses data from functional medical imaging examinations of a patient to evaluate the response of a patient to an applied therapy. A lesion tracker (112) tracks lesion(s) detected in the medical imaging examinations, and a lesion quantifier (114) generates quantitative information indicative of functional characteristic of the lesion(s). A trend analyzer (116) uses the quantitative information to determine trends in the functional characteristic.
摘要翻译：计算机辅助治疗装置（100）使用来自患者的功能性医学成像检查的数据来评估患者对所施用的治疗的反应。损伤跟踪器（112）跟踪在医学成像检查中检测到的病变，病变量化器（114）产生指示病变的功能特征的定量信息。趋势分析器（116）使用定量信息来确定功能特征的趋势。

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