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1. 发明申请

US20100163721A1 SERUM PROTEOMICS SYSTEM AND ASSOCIATED METHODS 失效
标题翻译：血清保护系统及相关方法
公开(公告)号：US20100163721A1
公开(公告)日：2010-07-01
申请号：US12521027
申请日：2007-12-26
申请人： Steven William Graves , Craig Dan Thulin , Michael Sean Esplin
发明人： Steven William Graves , Craig Dan Thulin , Michael Sean Esplin
IPC分类号： H01J49/26 , G01N30/00
CPC分类号： G01N33/6848 , G01N33/6818
摘要： Methods for proteomic analysis are provided. For example, in one aspect a method for identifying and sequencing a peptide may include fractionating a biological sample containing a peptide of interest to at least partially isolate the peptide, obtaining mass spectra of the peptide, and accelerating the peptide into a collision chamber at a plurality of discrete collision energies for a discrete period of time to form a plurality of peptide fragments for each of the plurality of discrete collision energies. The method may further include obtaining a plurality of fragmentation mass spectra from the plurality of peptide fragments for each of the plurality of discrete collision energies, summing the plurality of fragmentation mass spectra from each of the plurality of discrete collision energies to form a plurality of discrete collision energy mass spectra, one discrete collision energy mass spectra from each discrete collision energy, summing the plurality of discrete collision energy mass spectra to form a final mass spectrum for the peptide fragments, and identifying a sequence of amino acids corresponding to the peptide from the final mass spectrum.
摘要翻译：提供蛋白质组学分析方法。例如，在一个方面，用于鉴定和测序肽的方法可以包括将含有目的肽的生物样品分级至少部分分离肽，获得肽的质谱图，并将肽加速到碰撞室中多个离散碰撞能量在离散的时间段内形成用于多个离散碰撞能量中的每一个的多个肽片段。该方法还可以包括从多个肽片段获得多个离散碰撞能量中的每一个的多个碎裂质谱，将来自多个离散碰撞能量中的每一个的多个分裂质谱相加以形成多个离散碰撞能量碰撞能量质谱，来自每个离散碰撞能量的一个离散碰撞能量质谱，对多个离散的碰撞能量质谱进行求和，以形成肽片段的最终质谱，并鉴定与肽片段相对应的氨基酸序列最终质谱。

2. 发明申请

US20100297679A1 IDENTIFICATION AND QUANTIFICATION OF BIOMARKERS FOR EVALUATING THE RISK OF PRETERM BIRTH 审中-公开
标题翻译：用于评估前期生物风险的生物标志物的识别和定量
公开(公告)号：US20100297679A1
公开(公告)日：2010-11-25
申请号：US12669343
申请日：2008-07-17
申请人： Steven William Graves , Michael Sean Esplin , Craig Dan Thulin
发明人： Steven William Graves , Michael Sean Esplin , Craig Dan Thulin
IPC分类号： G01N33/543 , C07K7/08 , C07K16/18 , C07K14/47
CPC分类号： G01N33/6893 , G01N33/68 , G01N2333/811 , G01N2800/368
摘要： Described herein are methods for evaluating the risk of preterm birth in pregnant subjects. The methods involve detecting and quantifying one or more biomarkers associated with preterm birth in a biological sample from the subject. Also described herein are isolated biomarkers and kits useful in predicting the risk of preterm birth.
摘要翻译：这里描述的是评估孕妇早产风险的方法。所述方法涉及检测和定量来自受试者的生物样品中与早产相关的一种或多种生物标志物。本文还描述了可用于预测早产风险的分离的生物标志物和试剂盒。

3. 发明授权

US10247736B2 Identification and quantification of biomarkers for evaluating the risk of preterm birth 有权
公开(公告)号：US10247736B2
公开(公告)日：2019-04-02
申请号：US12669343
申请日：2008-07-17
申请人： Steven William Graves , Michael Sean Esplin , Craig Dan Thulin
发明人： Steven William Graves , Michael Sean Esplin , Craig Dan Thulin
IPC分类号： G01N33/68
摘要： Described herein are methods for evaluating the risk of preterm birth in pregnant subjects. The methods involve detecting and quantifying one or more biomarkers associated with preterm birth in a biological sample from the subject. Also described herein are isolated biomarkers and kits useful in predicting the risk of preterm birth.

4. 发明授权

US08552364B2 Serum proteomics system and associated methods 失效
标题翻译：血清蛋白质组学系统及相关方法
公开(公告)号：US08552364B2
公开(公告)日：2013-10-08
申请号：US12521027
申请日：2007-12-26
申请人： Steven W. Graves , Craig Dan Thulin , Michael Sean Esplin
发明人： Steven W. Graves , Craig Dan Thulin , Michael Sean Esplin
IPC分类号： H01J49/00
CPC分类号： G01N33/6848 , G01N33/6818
摘要： Methods for proteomic analysis are provided. For example, in one aspect a method for identifying and sequencing a peptide may include fractionating a biological sample containing a peptide of interest to at least partially isolate the peptide, obtaining mass spectra of the peptide, and accelerating the peptide into a collision chamber at a plurality of discrete collision energies for a discrete period of time to form a plurality of peptide fragments for each of the plurality of discrete collision energies. The method may further include obtaining a plurality of fragmentation mass spectra from the plurality of peptide fragments for each of the plurality of discrete collision energies, summing the plurality of fragmentation mass spectra from each of the plurality of discrete collision energies to form a plurality of discrete collision energy mass spectra, one discrete collision energy mass spectra from each discrete collision energy, summing the plurality of discrete collision energy mass spectra to form a final mass spectrum for the peptide fragments, and identifying a sequence of amino acids corresponding to the peptide from the final mass spectrum.
摘要翻译：提供蛋白质组学分析方法。例如，在一个方面，用于鉴定和测序肽的方法可以包括将含有目的肽的生物样品分级至少部分分离肽，获得肽的质谱图，并将肽加速到碰撞室中多个离散碰撞能量在离散的时间段内形成用于多个离散碰撞能量中的每一个的多个肽片段。该方法还可以包括从多个肽片段获得多个离散碰撞能量中的每一个离散碰撞能量的多个碎裂质谱，将来自多个离散碰撞能量中的每一个的多个分裂质谱相加，以形成多个离散碰撞能量碰撞能量质谱，来自每个离散碰撞能量的一个离散碰撞能量质谱，对多个离散的碰撞能量质谱进行求和，以形成肽片段的最终质谱，并鉴定与肽片段相对应的氨基酸序列最终质谱。

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