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1. 发明授权

US08366311B2 Systems and devices for mixing substances and methods of making same 有权
公开(公告)号：US08366311B2
公开(公告)日：2013-02-05
申请号：US12297821
申请日：2007-04-21
申请人： Steven Vanhamel , Jean-Pascal Zambaux , Tom Claes
发明人： Steven Vanhamel , Jean-Pascal Zambaux , Tom Claes
IPC分类号： B01F7/16
CPC分类号： B01F15/00831 , B01F7/001 , B01F7/00975 , B01F11/04 , B01F15/0085 , B01F15/00974 , B01F15/065 , B01L3/505 , C12M23/26 , C12M23/28
摘要： A mixing apparatus including a kinetic energy source, a mixing tank, a pivot guide, and transfer shaft is used to drive a mixing paddle through a circular path within a tank without substantial shaft rotation. Sleeved and sleeveless mixing paddles are provided in combination with sealable mixing tanks. A volumetric compensation system responsive to tank wall deflection is used to maintain the internal volume of a mixing tank within predetermined limits. One mixing apparatus includes multiple mixing shafts and paddles coupled to at least one kinetic energy source. Methods for fabricating sleeved paddle-containing mixing apparatuses are further provided.

2. 发明申请

US20090323466A1 SYSTEMS AND DEVICES FOR MIXING SUBSTANCES AND METHODS OF MAKING SAME 有权
标题翻译：用于混合物质的系统和装置及其制备方法
公开(公告)号：US20090323466A1
公开(公告)日：2009-12-31
申请号：US12297821
申请日：2007-04-21
申请人： Steven Vanhamel , Jean-Pascal Zambaux , Tom Claes
发明人： Steven Vanhamel , Jean-Pascal Zambaux , Tom Claes
IPC分类号： B01F13/00
CPC分类号： B01F15/00831 , B01F7/001 , B01F7/00975 , B01F11/04 , B01F15/0085 , B01F15/00974 , B01F15/065 , B01L3/505 , C12M23/26 , C12M23/28
摘要： A mixing apparatus including a kinetic energy source, a mixing tank, a pivot guide, and transfer shaft is used to drive a mixing paddle through a circular path within a tank without substantial shaft rotation. Sleeved and sleeveless mixing paddles are provided in combination with sealable mixing tanks. A volumetric compensation system responsive to tank wall deflection is used to maintain the internal volume of a mixing tank within predetermined limits. One mixing apparatus includes multiple mixing shafts and paddles coupled to at least one kinetic energy source. Methods for fabricating sleeved paddle-containing mixing apparatuses are further provided.
摘要翻译：使用包括动能源，混合罐，枢转引导件和输送轴的混合设备来驱动混合桨通过罐内的圆形路径而没有实质的轴旋转。与可密封的混合罐组合提供袖子和无袖混合桨。使用响应于罐壁偏转的体积补偿系统来将混合罐的内部容积保持在预定的限度内。一个混合装置包括耦合到至少一个动能源的多个混合轴和桨叶。还提供了用于制造带套筒式混合搅拌设备的方法。

3. 发明申请

US20100015696A1 DISPOSABLE BIOREACTOR 审中-公开
标题翻译：可处理的生物反应器
公开(公告)号：US20100015696A1
公开(公告)日：2010-01-21
申请号：US12299271
申请日：2007-05-12
申请人： Tom Claes , Jean-Pascal Zambaux , Steven Vanhamel , Christophe Braet , Florence Bosco , Jose Castillo
发明人： Tom Claes , Jean-Pascal Zambaux , Steven Vanhamel , Christophe Braet , Florence Bosco , Jose Castillo
IPC分类号： C12M1/02
CPC分类号： B01F13/1013 , B01F3/04269 , B01F7/0005 , B01F11/0088 , B01F11/04 , B01F13/1022 , B01F15/00831 , B01F15/0085 , B01F15/00915 , B01F2003/04148 , B01F2003/04219 , B01F2003/04312 , B01F2003/04319 , B01F2003/04361 , B01F2003/0439 , C12M23/26 , C12M23/28 , C12M27/04
摘要： A disposable material processing apparatus, useable as a bioreactor or fermenter, includes a hollow tank (101) and a mixing paddle (110) disposed within the interior of the tank and adapted to mix contents therein. The paddle may be isolated within a flexible sleeve (140). Various functional elements, such as a sparger, sensor, material extraction conduit, material addition conduit, and/or heat exchange element may be provided, and optionally arranged to travel with the paddle within the tank interior. Baffles may protrude into a mixing tank to enhance mixing. A tank and/or sleeve may comprise polymeric film materials.
摘要翻译：可用作生物反应器或发酵罐的一次性材料处理设备包括设置在罐内部并适于在其中混合内容物的中空罐（101）和混合桨（110）。桨可以在柔性套筒（140）内隔离。可以提供各种功能元件，例如分布器，传感器，材料提取导管，材料添加导管和/或热交换元件，并且可选地布置成与罐内的桨一起行进。挡板可以突出到混合罐中以增强混合。罐和/或套筒可以包括聚合物膜材料。

4. 发明授权

US09079319B2 Disposable production line 有权
标题翻译：一次性生产线
公开(公告)号：US09079319B2
公开(公告)日：2015-07-14
申请号：US13516153
申请日：2010-12-20
申请人： Jean-Pascal Zambaux
发明人： Jean-Pascal Zambaux
IPC分类号： B01L99/00 , B25J21/02 , C12M1/12 , B08B15/02
CPC分类号： B25J21/02 , B08B15/023 , C12M37/00 , Y10T29/49826
摘要： The invention relates to a disposable production line. The invention relates notably to a process for manipulating, manufacturing or packaging products or devices under inert atmosphere, and/or sterile conditions and/or pyrogen free environment.In particular the invention relates to a closed disposable equipment comprising at least two separate disposable isolators including a first disposable isolator and a last disposable isolator, wherein said separate disposable isolator is connected to at least one other separate disposable isolator by at least one connecting means, wherein each separate disposable isolator comprises a working place, said working place being located inside said separate disposable isolator, said working place being under inert atmosphere, and/or disinfected, and/or sterile and/or pyrogen free conditions, said working place enabling the manipulation of containers, products or devices, wherein said closed disposable equipment comprises at least one inlet for introducing containers, products or devices into said closed disposable equipment and at least one outlet for discharging said containers, products or devices from said closed disposable equipment.
摘要翻译：本发明涉及一次性生产线。本发明特别涉及在惰性气氛和/或无菌条件和/或无热原环境下操作，制造或包装产品或装置的方法。特别地，本发明涉及一种封闭的一次性设备，其包括至少两个分离的一次性隔离器，其包括第一一次性隔离器和最后一次隔离器，其中所述单独的一次性隔离器通过至少一个连接装置连接到至少一个其它分离的一次性隔离器，其中每个单独的一次性隔离器包括工作场所，所述工作场所位于所述单独的一次性隔离器内，所述工作场所处于惰性气氛和/或消毒，和/或无菌和/或无热原条件下，所述工作场所操纵容器，产品或装置，其中所述封闭的一次性设备包括用于将容器，产品或装置引入所述封闭的一次性设备的至少一个入口和用于从所述封闭的一次性设备排出所述容器，产品或装置的至少一个出口。

5. 发明申请

US20070087598A1 Interconnect and method for joining receptacles 审中-公开
标题翻译：用于连接插座的互连和方法
公开(公告)号：US20070087598A1
公开(公告)日：2007-04-19
申请号：US11581652
申请日：2006-10-16
申请人： Jean-Pascal Zambaux
发明人： Jean-Pascal Zambaux
IPC分类号： H01R13/44
CPC分类号： F16L23/00 , B01F11/04 , B01F15/0205 , B01F15/0212 , B01F15/0213 , B01F15/0225
摘要： A connector is provided for forming a substance transfer pathway between two or more volumes without exposing the interior contents of the volumes to an exterior environment. A removable cover is provided over a flap-defining membrane or boundary element, wit h the flap including an adhesive. Two receptacles and/or conduits may be connected to one another with corresponding connectors by removing the covers, registering the flaps, joining the receptacles and/or conduits, and then freeing the flaps from the surrounding membranes.
摘要翻译：提供连接器用于在两个或多个体积之间形成物质转移路径，而不将体积的内部内容物暴露于外部环境。可拆卸的盖子设置在翼片限定膜或边界元件上方，并且翼片包括粘合剂。两个容器和/或导管可以通过移除盖子，对准翼片，连接插座和/或导管，然后将翼片从周围隔膜释放而彼此连接到相应的连接器。

6. 发明申请

US20050050854A1 Sterile, pyrogen-free, polymeric film-based heating bag 审中-公开
标题翻译：无菌，无热原，聚合物膜基加热袋
公开(公告)号：US20050050854A1
公开(公告)日：2005-03-10
申请号：US10658034
申请日：2003-09-09
申请人： Jean-Pascal Zambaux
发明人： Jean-Pascal Zambaux
IPC分类号： A61J1/00 , A61J1/05 , A61L2/26 , B29K105/00 , B31B19/64 , B31B19/84 , B31B23/00 , B32B27/08 , B65B55/02 , B65B55/06
CPC分类号： B32B27/08 , A61J1/10 , A61L2/26 , A61L2202/22 , A61M2207/00 , B29C65/08 , B29C65/18 , B29C66/1122 , B29C66/133 , B29C66/43 , B29C66/53262 , B29C66/71 , B29K2023/0683 , B29K2027/12 , B29K2027/16 , B29K2027/18 , B29K2071/00 , B29L2031/7148 , B31B70/00 , B31B70/642 , B31B70/844 , B31B2155/00 , B31B2155/002 , B31B2160/10 , B32B1/02 , B32B37/0076 , B32B2310/028 , B32B2439/46 , B65B55/022 , Y10T428/13 , Y10T428/1334 , Y10T428/3154 , Y10T428/31544 , B29K2079/00 , B29K2023/18
摘要： In one embodiment, there is a method for storing fluids in a bag that has an inner lining that is essentially sterilized and essentially free of pyrogen. The method comprises heating the bag that is comprised of a polymeric film to at least approximately 253° Celsius. The polymeric film includes a polymer selected from the group of poly(oxy-1,4-phenylene-oxy-1,4-phenylene-carbonyl-1,4-phenylene) (PEEK); polytetrafluoroethylene (PTFE); a perfluoroalkoxy (PFA) polymer; poly(tetrafluoroethylene-co-perfluoromethyl vinyl ether) (MFA); polyperfluoro(ethylene-co-propylene) (FEP); poly(ethylene-alt-chlorotrifluoroethylene) (ECTFE); poly(ethylene-co-tetrafluoroethylene) (ETFE); poly(vinylidene fluoride) (PDVF); tetrafluoroethylene-co-hexafluoropropylene-co-vinylidene fluoride terpolymer (THV); ultra-high molecular weight polyethylene (UHMW PE); (poly(bisphenol A-co-4-nitrophthalic anhydride-co-1,3-phenylenediamine) (PEI); poly(4-methyl-1-pentene) (PMP); and suitable mixtures thereof.
摘要翻译：在一个实施方案中，存在一种用于将流体存储在袋中的方法，所述袋具有基本上消毒且基本上不含热原的内衬。该方法包括将由聚合物膜组成的袋加热至至少约253℃。聚合物膜包括选自聚（氧基-1,4-亚苯基 - 氧基-1,4-亚苯基 - 羰基-1,4-亚苯基）（PEEK）的聚合物; 聚四氟乙烯（PTFE）; 全氟烷氧基（PFA）聚合物; 聚（四氟乙烯 - 共 - 全氟甲基乙烯基醚）（MFA）; （全氟（乙烯 - 共 - 丙烯）（FEP））; 聚（乙烯 - 高氯三氟乙烯）（ECTFE）; 聚（乙烯 - 共四氟乙烯）（ETFE）; 聚（偏二氟乙烯）（PDVF）; 四氟乙烯 - 共 - 六氟丙烯 - 共 - 偏二氟乙烯三元共聚物（THV）; 超高分子量聚乙烯（UHMW PE）; （聚（双酚A-共-4-硝基邻苯二甲酸酐 - 共-1,3-苯二胺）（PEI）;聚（4-甲基-1-戊烯）（PMP））及其合适的混合物。

7. 发明授权

US08986623B2 Disposable membrane 有权
标题翻译：一次性膜
公开(公告)号：US08986623B2
公开(公告)日：2015-03-24
申请号：US13322054
申请日：2010-05-27
申请人： Jean-Pascal Zambaux
发明人： Jean-Pascal Zambaux
IPC分类号： A61L2/26 , F26B5/06 , F26B9/00 , F26B25/00 , F26B25/08
CPC分类号： A61L2/04 , A61L2/18 , A61L2/206 , A61L2/208 , A61L2/26 , F26B5/06 , F26B9/006 , F26B25/008 , F26B25/08 , F27D1/18
摘要： The invention relates mainly to an apparatus comprising a chamber for physically and/or chemically treating one or more samples or products, said apparatus comprising a door for introducing samples inside the apparatus chamber or bringing samples outside the apparatus, said apparatus comprising a membrane or film defining a chamber wall inside said apparatus when the door is closed.
摘要翻译：本发明主要涉及一种包括用于物理和/或化学处理一个或多个样品或产品的室的装置，所述装置包括用于将样品引入装置室内或将样品带到装置外部的门，所述装置包括膜或膜当门关闭时，在所述设备内限定室壁。

8. 发明授权

US08950579B2 Sterilized or depyrogened packaging 有权
标题翻译：灭菌或去热灭菌包装
公开(公告)号：US08950579B2
公开(公告)日：2015-02-10
申请号：US13257554
申请日：2010-03-19
申请人： Jean-Pascal Zambaux
发明人： Jean-Pascal Zambaux
IPC分类号： A61L2/26 , A61L2/04 , B65B31/04 , B65B55/02
CPC分类号： A61L2/04 , A61L2/26 , B65B31/04 , B65B55/02
摘要： The invention relates mainly to a packaging which may be sterilized and/or depyroged. The invention relates in particular to a packaging for the sterilization or pyrogen free packaging for one or more packaged devices, said packaging comprising a valve or outlet tube.
摘要翻译：本发明主要涉及可以灭菌和/或去角质的包装。本发明特别涉及一种用于一种或多种包装装置的灭菌或无热原包装的包装，所述包装包括阀或出口管。

9. 发明申请

US20120294697A1 DISPOSABLE PRODUCTION LINE 有权
标题翻译：可生产生产线
公开(公告)号：US20120294697A1
公开(公告)日：2012-11-22
申请号：US13516153
申请日：2010-12-20
申请人： Jean-Pascal Zambaux
发明人： Jean-Pascal Zambaux
IPC分类号： B25J11/00 , B23P11/00 , B65B55/02
CPC分类号： B25J21/02 , B08B15/023 , C12M37/00 , Y10T29/49826
摘要： The invention relates to a disposable production line. The invention relates notably to a process for manipulating, manufacturing or packaging products or devices under inert atmosphere, and/or sterile conditions and/or pyrogen free environment.In particular the invention relates to a closed disposable equipment comprising at least two separate disposable isolators including a first disposable isolator and a last disposable isolator, wherein said separate disposable isolator is connected to at least one other separate disposable isolator by at least one connecting means, wherein each separate disposable isolator comprises a working place, said working place being located inside said separate disposable isolator, said working place being under inert atmosphere, and/or disinfected, and/or sterile and/or pyrogen free conditions, said working place enabling the manipulation of containers, products or devices, wherein said closed disposable equipment comprises at least one inlet for introducing containers, products or devices into said closed disposable equipment and at least one outlet for discharging said containers, products or devices from said closed disposable equipment.
摘要翻译：本发明涉及一次性生产线。本发明特别涉及在惰性气氛和/或无菌条件和/或无热原环境下操作，制造或包装产品或装置的方法。特别地，本发明涉及一种封闭的一次性设备，其包括至少两个分离的一次性隔离器，其包括第一一次性隔离器和最后一次隔离器，其中所述单独的一次性隔离器通过至少一个连接装置连接到至少一个其它分离的一次性隔离器，其中每个单独的一次性隔离器包括工作场所，所述工作场所位于所述单独的一次性隔离器内，所述工作场所处于惰性气氛和/或消毒，和/或无菌和/或无热原条件下，所述工作场所操纵容器，产品或装置，其中所述封闭的一次性设备包括用于将容器，产品或装置引入所述封闭的一次性设备的至少一个入口和用于从所述封闭的一次性设备排出所述容器，产品或装置的至少一个出口。

10. 发明授权

US09149939B2 Disposable isolator comprising means for filling containers 有权
标题翻译：一次性隔离器包括用于填充容器的装置
公开(公告)号：US09149939B2
公开(公告)日：2015-10-06
申请号：US13255001
申请日：2010-03-04
申请人： Jean-Pascal Zambaux
发明人： Jean-Pascal Zambaux
IPC分类号： B67C3/26 , B25J21/02 , B65B3/00 , B65B3/04
CPC分类号： B25J21/02 , B65B3/003 , B65B3/04
摘要： The invention relates mainly to a disposable working place or chamber and in particular to a disposable isolator.The invention relates to a disposable isolator (1) defining a top portion (10) and a bottom portion (20), said top and bottom portions being linked together by one or more side walls (30) forming all together an inside portion (40), wherein said bottom portion (20) comprises at least one support area (21) for positioning at least one container (80), wherein said disposable isolator (1) comprises at least one filling means (12), wherein said filling means (12) and said support area (21) cooperating, independently or not, to position at least one container substantially in front of said filling means to fill said container by a product.
摘要翻译：本发明主要涉及一次性工作场所或室，特别涉及一次性隔离器。本发明涉及限定顶部（10）和底部（20）的一次性隔离器（1），所述顶部和底部通过一个或多个侧壁（30）连接在一起，所述侧壁一起形成内部（40）），其中所述底部部分（20）包括用于定位至少一个容器（80）的至少一个支撑区域（21），其中所述一次性隔离器（1）包括至少一个填充装置（12），其中所述填充装置 12）和所述支撑区域（21）独立地或不协调地将基本上位于所述填充装置前面的至少一个容器定位，以通过产品填充所述容器。

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