专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5045242A Removal of cholesterol from edible fats 失效
标题翻译：从食用脂肪中去除胆固醇
公开(公告)号：US5045242A
公开(公告)日：1991-09-03
申请号：US463588
申请日：1990-01-11
申请人： Steven Roczniak , John B. Hill , Robert A. Erickson
发明人： Steven Roczniak , John B. Hill , Robert A. Erickson
IPC分类号： A23D9/007 , A23C15/14 , C11B3/00 , C11B3/02 , C11B11/00
CPC分类号： A23C15/145 , C11B3/006 , C11B3/02
摘要： A process for reducing the amount of cholesterol in an edible fat capable of being solubilized comprising the steps of:(a) providing an edible fat in a liquid state;(b) adding an ionic salt selected from the group consisting of CaBr.sub.2 and MgBr.sub.2 to and edible fat;(c) mixing said ionic salt and edible fat for a time sufficient to cause said ionic salt to react with cholesterol present in said edible fat and form a precipitate; and(d) removing said precipitate from said mixtureand the product produced by the process are disclosed. The process is capable of reducing cholesterol in edible fats by about 30% to about 100%.
摘要翻译：一种减少能够溶解的食用脂肪中胆固醇含量的方法，包括以下步骤：（a）提供液态的食用脂肪; （b）将选自CaBr 2和MgBr 2的离子盐与可食用脂肪相加; （c）将所述离子盐和食用脂肪混合足以使所述离子盐与存在于所述食用脂肪中的胆固醇反应并形成沉淀物的时间; 和（d）从所述混合物中除去所述沉淀物，并公开由该方法生产的产物。该方法能够将食用脂肪中的胆固醇降低约30％至约100％。

2. 发明授权

US4529811A Process for isolating organic compounds and lithium salt complexes useful in said process 失效
标题翻译：用于分离在所述方法中有用的有机化合物和锂盐络合物的方法
公开(公告)号：US4529811A
公开(公告)日：1985-07-16
申请号：US577424
申请日：1984-02-06
申请人： John B. Hill , Robert A. Erickson
发明人： John B. Hill , Robert A. Erickson
IPC分类号： C07C37/86 , C07C45/85 , C07C51/41 , C07C405/00 , C07D207/40 , C07D207/408 , C07D233/94 , C07J1/00 , C07J21/00 , C07C177/00
CPC分类号： C07D207/408 , C07C37/86 , C07C405/00 , C07C45/85 , C07C51/418 , C07D233/94 , C07J1/0011 , C07J1/0037 , C07J21/003
摘要： An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid metal salt complex, separating, and thereafter recovering a pure product by decomposing the lithium salt complex.
摘要翻译：通过将所述粗产物或反应混合物溶解在合适的溶剂中来分离有机化合物与粗产物或反应混合物的一种改进方法，使所得溶液与锂盐接触以形成固体金属盐络合物，然后分离纯化产物通过分解锂盐络合物。

3. 发明授权

US4452994A Process for isolating organic compounds and lithium salt complexes useful in said process 失效
标题翻译：用于分离在所述方法中有用的有机化合物和锂盐络合物的方法
公开(公告)号：US4452994A
公开(公告)日：1984-06-05
申请号：US239822
申请日：1981-03-02
申请人： John B. Hill , Robert A. Erickson
发明人： John B. Hill , Robert A. Erickson
IPC分类号： C07B31/00 , C07B63/02 , C07C29/74 , C07C37/84 , C07C37/86 , C07C39/14 , C07C45/00 , C07C45/77 , C07C45/78 , C07C45/85 , C07C47/575 , C07C49/403 , C07C49/743 , C07C51/41 , C07C51/42 , C07C51/487 , C07C59/90 , C07C63/06 , C07C67/00 , C07C69/736 , C07C209/84 , C07C211/42 , C07C231/24 , C07C233/02 , C07C233/06 , C07C315/06 , C07C317/00 , C07C317/14 , C07C405/00 , C07D207/40 , C07D207/404 , C07D207/408 , C07D233/94 , C07F1/02 , C07J1/00 , C07J19/00 , C07J21/00 , C07J75/00 , C07C177/00
CPC分类号： C07D207/408 , C07C317/00 , C07C37/86 , C07C405/00 , C07C45/85 , C07C51/418 , C07D233/94 , C07J1/0011 , C07J1/0037 , C07J21/003
摘要： An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid metal salt complex, separating, and thereafter recovering a pure product by decomposing the lithium salt complex.
摘要翻译：通过将所述粗产物或反应混合物溶解在合适的溶剂中来分离有机化合物与粗产物或反应混合物的一种改进方法，使所得溶液与锂盐接触以形成固体金属盐络合物，然后分离纯化产物通过分解锂盐络合物。

4. 发明授权

US4946988A Process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride 失效
标题翻译：通过使用分离的N-甲酰基L-天冬氨酸酐制备α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐的方法
公开(公告)号：US4946988A
公开(公告)日：1990-08-07
申请号：US219613
申请日：1988-07-14
申请人： John B. Hill , Yefim Gelman
发明人： John B. Hill , Yefim Gelman
IPC分类号： C07K5/06 , A23L27/30 , C07C229/00 , C07C229/24 , C07C229/36 , C07K1/00 , C07K1/06 , C07K1/10 , C07K5/075
CPC分类号： C07K5/0613
摘要： A process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride (.alpha.-APM(HCl)) is disclosed. .alpha.-APM(HCl) is an intermediate in the preparation of aspartame.
摘要翻译：公开了制备α-L-天冬氨酰-L-苯丙氨酸甲酯盐酸盐（α-APM（HCl））的方法。 α-APM（HCl）是制备阿斯巴甜的中间体。

5. 发明授权

US4555362A Method and intermediates for producing .alpha.-L-aspartyl-L-phenylalanine 失效
标题翻译：生产α-L-天冬氨酰-L-苯丙氨酸的方法和中间体
公开(公告)号：US4555362A
公开(公告)日：1985-11-26
申请号：US610376
申请日：1984-05-15
申请人： Hugh L. Dryden, Jr , John B. Hill
发明人： Hugh L. Dryden, Jr , John B. Hill
IPC分类号： C07D263/42 , C07K5/075 , C07C101/20
CPC分类号： C07D263/42 , C07K5/0613 , Y10S530/80
摘要： This invention encompasses a method and intermediates for preparing a commercial sweetening agent, .alpha.-L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester which is converted to .alpha.-L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.
摘要翻译：本发明包括制备商业甜味剂α-L-天冬氨酰基-L-苯丙氨酸甲酯的方法和中间体。该方法包括使L-天冬氨酸与双烯酮反应形成N-乙酰乙酰基-L-天冬氨酸，其通过与乙酸酐反应转化为N-乙酰乙酰基-L-天冬氨酸酐。 N-乙酰乙酰基-L-天冬氨酸酐与L-苯丙氨酸甲酯反应，得到N-乙酰乙酰基-α-L-天冬氨酰基-L-苯丙氨酸甲酯，通过反应转化成α-L-天冬氨酰-L-苯丙氨酸甲酯与盐酸羟胺。

6. 发明授权

US4892820A Solvent system for enzymatic coupling process 失效
标题翻译：酶联合工艺溶剂体系
公开(公告)号：US4892820A
公开(公告)日：1990-01-09
申请号：US60286
申请日：1987-06-10
申请人： John B. Hill , Steven O. Roczniak
发明人： John B. Hill , Steven O. Roczniak
IPC分类号： C12P1/00 , C12P21/02 , C12P21/04
CPC分类号： C12P21/02 , C12P1/00
摘要： Alkylphosphate solvents are disclosed for use in an amino acid and amino acid ester enzymatic coupling process. .alpha.-Aspartylphenylalanine methyl ester and intermediates thereof are prepared enzymatically in an alkylphosphate solvent or cosolvent.
摘要翻译：公开了烷基磷酸酯溶剂用于氨基酸和氨基酸酯酶偶联过程。 α-烷基苯丙氨酸甲酯及其中间体在磷酸烷基酯溶剂或共溶剂中酶促制备。

7. 发明授权

US4480112A Method and intermediates for producing .alpha.-L-aspartyl-L-phenylalanine 失效
标题翻译：生产α-L-天冬氨酰-L-苯丙氨酸的方法和中间体
公开(公告)号：US4480112A
公开(公告)日：1984-10-30
申请号：US580912
申请日：1984-02-16
申请人： Hugh L. Dryden , John B. Hill
发明人： Hugh L. Dryden , John B. Hill
IPC分类号： C07D263/42 , C07K5/075 , C07C101/20 , C07D307/60
CPC分类号： C07K5/0613 , C07D263/42
摘要： This invention encompasses a method and intermediates for preparing a commercial sweetening agent, .alpha.-L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester which is converted to .alpha.-L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.
摘要翻译：本发明包括制备商业甜味剂α-L-天冬氨酰基-L-苯丙氨酸甲酯的方法和中间体。该方法包括使L-天冬氨酸与双烯酮反应形成N-乙酰乙酰基-L-天冬氨酸，其通过与乙酸酐反应转化为N-乙酰乙酰基-L-天冬氨酸酐。 N-乙酰乙酰基-L-天冬氨酸酐与L-苯丙氨酸甲酯反应，得到N-乙酰乙酰基-α-L-天冬氨酰基-L-苯丙氨酸甲酯，通过反应转化成α-L-天冬氨酰-L-苯丙氨酸甲酯与盐酸羟胺。

8. 发明授权

US3968866A Fluid coupling 失效
标题翻译：流体联轴器
公开(公告)号：US3968866A
公开(公告)日：1976-07-13
申请号：US528542
申请日：1974-11-29
申请人： Wayne K. Leichliter , Rodney H. Detty , John B. Hill
发明人： Wayne K. Leichliter , Rodney H. Detty , John B. Hill
IPC分类号： F16D35/00 , F16D35/02 , F16D13/72 , F16D43/25
CPC分类号： F16D35/025
摘要： A fluid coupling for driving a cooling fan associated with a vehicle in a ram air stream. The coupling comprises relatively rotatable input and output members. The output member defines a chamber within which the input member rotates. The members have lands and grooves which define a shear space therebetween, and are cooperable with viscous shear fluid to transmit torque therebetween. The output member defines a reservoir chamber located forwardly of the lands and grooves in the ram air stream. An impact pumping ramp on the output member directs fluid from the shear space into the reservoir chamber during rotation of the input member. A temperature-responsive valve arrangement controls the flow of fluid from the reservoir chamber to the shear space. The output member has mounting pads against which fan blades are secured. The mounting pads are located axially on the output member between the lands and grooves, and the reservoir chamber and at least, in part, radially outwardly in the lands and grooves. This mounting results in an air cooling chamber being located axially adjacent the land and groove area and radially outwardly of the reservoir chamber. The output coupling member on the backside thereof has a unique construction which minimizes the overall axial length of the unit.
摘要翻译：一种用于在冲压气流中驱动与车辆相关联的冷却风扇的流体联接器。联接器包括相对可旋转的输入和输出构件。输出构件限定了输入构件旋转的腔室。构件具有在两者之间限定剪切空间的平台和凹槽，并且可与粘性剪切流体配合以在其间传递扭矩。输出构件限定位于压头空气流中的平台和凹槽前方的储存室。输出构件上的冲击泵送斜坡在输入构件旋转期间将流体从剪切空间引导到储存室中。温度响应阀装置控制从储存室到剪切空间的流体流动。输出构件具有固定风扇叶片的安装垫。安装垫轴向位于输出构件之间，位于平台和凹槽之间，以及储存室，并且至少部分地在凸台和凹槽中径向向外。这种安装导致空气冷却室位于轴向邻近槽脊和槽区域并且在储存室的径向外侧。其背面的输出连接构件具有使单元的总体轴向长度最小化的独特结构。

9. 发明授权

US5476961A One-pot process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride 失效
标题翻译：制备α-L-天冬氨酰-L-苯丙氨酸甲酯盐酸盐的一锅法
公开(公告)号：US5476961A
公开(公告)日：1995-12-19
申请号：US80445
申请日：1993-06-21
申请人： John B. Hill , Yefim Gelman , Hugh L. Dryden, Jr. , Robert Erickson , Kuang Hsu , Mark R. Johnson
发明人： John B. Hill , Yefim Gelman , Hugh L. Dryden, Jr. , Robert Erickson , Kuang Hsu , Mark R. Johnson
IPC分类号： B41M3/14 , B41M5/00 , B42D15/00 , B42D15/10 , C07C231/02 , C07C237/12 , C07C237/22 , C07K5/06 , C07K5/075 , H04N1/40 , H04N1/405 , C07C229/34
CPC分类号： C07K5/0613 , B42D25/29
摘要： A one-pot process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride is disclosed (.alpha.-APM(HCl)). .alpha.-APM(HCl) is an intermediate in the preparation of aspartame.
摘要翻译：公开了一种用于制备α-L-天冬氨酰-L-苯丙氨酸甲酯盐酸盐的单锅法（α-APM（HCl））。 α-APM（HCl）是制备阿斯巴甜的中间体。

10. 发明授权

US4945172A Preparation of N-formyl-L-aspartic anhydride 失效
标题翻译： N-甲酰基-L-天冬氨酸酐的制备
公开(公告)号：US4945172A
公开(公告)日：1990-07-31
申请号：US442040
申请日：1989-11-28
申请人： John B. Hill , Hugh L. Dryden, Jr. , Robert Erickson
发明人： John B. Hill , Hugh L. Dryden, Jr. , Robert Erickson
IPC分类号： C07D307/66 , C07K5/075
CPC分类号： C07D307/66
摘要： N-formyl-L-aspartic anhydride is prepared using a minimum excess of formic acid. Acetic anhydride and a C.sub.3 -C.sub.6 secondary alcohol are added to the reaction mixture to consume excess formic acid. The reaction is suitable for further reactions without modification.
摘要翻译：使用最少过量的甲酸制备N-甲酰基-L-天冬氨酸酐。将乙酸酐和C 3 -C 6仲醇加入到反应混合物中以消耗过量的甲酸。该反应适合进一步的反应而无需改性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式