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1. 发明授权

US5373972A Preservative-free sterile fluid dispensing system 失效
标题翻译：无防腐剂的无菌液体分配系统
公开(公告)号：US5373972A
公开(公告)日：1994-12-20
申请号：US39655
申请日：1993-03-30
申请人： Steven R. Bystrom , Peter W. Chan , F. Jesus Martinez
发明人： Steven R. Bystrom , Peter W. Chan , F. Jesus Martinez
IPC分类号： B65D83/00 , A61F9/00 , A61J1/05 , A61J1/14 , B05B11/00 , B05B11/04 , B65D47/18 , B65D81/24 , B65D37/00
CPC分类号： B05B11/047 , A61F9/0008 , B05B11/0021 , B05B11/0075 , B05B11/3052 , B65D47/18 , B65D81/24 , A61J1/145 , A61J1/1468 , Y10T137/7838 , Y10T137/7882
摘要： A fluid dispensing system for delivering sterile preservative-free solution is disclosed. The system uses double self-sealing valves mounted in series inside a tip compartment which fits on the outlet of a multiple dosage squeeze container to prevent undesirable retrograde flow of the dispensed liquid back into the bottle during the decompression cycle. The valves used are either positive acting, normally closed duckbill and/or umbrella valve(s) which open to express solution from the container when squeezing pressure is applied to the bottle and which automatically close when the pressure is released. The fluid dispensing system with an umbrella valve near the system outlet has close to zero dead space volume thereby practically eliminated possible contamination of the sterile fluid under the circumferential seal head portion of the umbrella valve and in the container. A hydrophobic filter is provided to sterilize the replacement air which enters the container upon release of the squeezing pressure.
摘要翻译：公开了用于输送无菌防腐剂溶液的流体分配系统。该系统使用双重自密封阀，其串联安装在尖端隔室内，该末端隔室装配在多次剂量挤压容器的出口上，以防止在减压循环期间将分配的液体反向流入瓶中。所使用的阀是正压作用，常闭鸭嘴和/或伞形阀，当压力施加到瓶子时，该阀门打开以从容器表达溶液，并且当压力释放时自动关闭。具有靠近系统出口的伞阀的流体分配系统具有接近零的死空间体积，从而实际上消除了在伞形阀的圆周密封头部分和容器内的无菌流体的可能污染。提供疏水过滤器以在释放挤压压力时对进入容器的置换空气进行消毒。

2. 发明授权

US5310094A Preservative free sterile fluid dispensing system 失效
标题翻译：防腐剂无菌液体分配系统
公开(公告)号：US5310094A
公开(公告)日：1994-05-10
申请号：US792989
申请日：1991-11-15
申请人： F. Jesus Martinez , Steven R. Bystrom , Peter W. Chan
发明人： F. Jesus Martinez , Steven R. Bystrom , Peter W. Chan
IPC分类号： A61J1/05 , A61J1/14 , B05B11/00 , B05B11/04 , B05C17/00 , B65D47/18 , B65D81/24 , B65D37/00
CPC分类号： B65D81/24 , B05B11/0021 , B05B11/0075 , B05B11/047 , B65D47/18 , A61J1/145 , Y10T137/7838 , Y10T137/7882
摘要： A fluid dispensing system for delivering sterile preservative free solution is disclosed. The system uses double self-sealing valves mounted in series inside a tip compartment which fits on the outlet of a multiple dosage squeeze container to prevent undesirable retrograde flow of the dispensed liquid back into the bottle during the decompression cycle. The valves used are positive acting, normally closed duckbill valves which open to express solution from the container when squeezing pressure is applied to the bottle and which automatically close when the pressure is released. A hydrophobic filter is provided to sterilize the replacement air which enters the container upon release of the squeezing pressure.
摘要翻译：公开了用于递送无菌防腐剂溶液的流体分配系统。该系统使用双重自密封阀，其串联安装在尖端隔室内，该末端隔室装配在多次剂量挤压容器的出口上，以防止在减压循环期间将分配的液体反向流入瓶中。所使用的阀是正向作用的常闭鸭嘴阀，当挤压压力施加到瓶子上时，打开以从容器表达溶液，并且当压力释放时自动关闭。提供疏水过滤器以在释放挤压压力时对进入容器的置换空气进行消毒。

3. 发明授权

US5105993A Disposable medical dispenser with a filtering dispenser nozzle 失效
标题翻译：具有过滤分配器喷嘴的一次性医用分配器
公开(公告)号：US5105993A
公开(公告)日：1992-04-21
申请号：US458891
申请日：1989-12-29
申请人： Peter G. La Haye , Peter W. Chan
发明人： Peter G. La Haye , Peter W. Chan
IPC分类号： A61F9/00 , A61J1/14 , B65D47/18
CPC分类号： B65D47/18 , A61F9/0008 , A61J1/145 , A61J1/1456 , A61J1/1468
摘要： There is disclosed a dispensing container for dispensing sterile liquid medicament, for example into the eyes, e.g., liquid artificial tears, in which a filter is provided in the dispensing nozzle or in a closure member for the container having pores which are sufficiently small to filter out microorganisms, whereby an antibacterial agent need not be included in the medicament. A cap is provided for the dispensing nozzle, which cap may have an absorbent pad impregnated with an antibacterial agent to maintain the exit port of the dispensing nozzle sterile. The container may also have a filter provided in a vent in a wall thereof, whereby air drawn into the container to replace liquid medicament ejected through the nozzle thereof will be sterilized. The filter preferably comprises a plurality of hollow elongated filter fibers or tubes bent back on themselves and secured in the nozzle or closure member by a suitable potting material, having in any case pores not larger than about 0.2 micron in diameter.
摘要翻译：公开了一种用于分配无菌液体药物的分配容器，例如在眼睛中，例如液体人造泪液，其中在分配喷嘴中设置过滤器，或者在容器的封闭构件中具有足够小的过滤孔从而不需要在药物中包含抗菌剂。为分配喷嘴提供盖，该盖可以具有浸渍有抗菌剂的吸收垫，以将分配喷嘴的出口保持无菌。容器还可以具有设置在其壁的通风口中的过滤器，由此吸入容器中的空气以取代通过其喷嘴喷射的液体药物将被消毒。过滤器优选地包括多个中空细长的过滤纤维或管，其自身弯曲并通过合适的灌封材料固定在喷嘴或封闭构件中，在任何情况下孔径不大于直径约0.2微米。

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