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1. 发明授权

US09120711B2 Carboxylation catalysts 有权
标题翻译：羧化催化剂
公开(公告)号：US09120711B2
公开(公告)日：2015-09-01
申请号：US13702886
申请日：2011-06-09
申请人： Steven P. Nolan , Catherine Cazin
发明人： Steven P. Nolan , Catherine Cazin
IPC分类号： C07B41/08 , C07D233/02 , C07D233/04 , C07D233/90 , C07D207/04 , C07D207/18 , B01J23/66 , B01J23/72 , B01J31/22 , B01J31/18 , B01J31/24 , C07B59/00 , C07D235/24 , C07D237/24 , C07D249/10 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D275/03 , C07D277/56 , C07D277/68 , C07D307/68 , C07D473/00 , C07F1/08 , C07F1/10
CPC分类号： C07B41/08 , B01J31/185 , B01J31/2226 , B01J31/2265 , B01J31/2269 , B01J31/2273 , B01J31/24 , B01J2531/16 , B01J2531/17 , B01J2531/18 , C07B59/002 , C07D233/90 , C07D235/24 , C07D237/24 , C07D249/10 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D275/03 , C07D277/56 , C07D277/68 , C07D307/68 , C07D473/00 , C07F1/08 , C07F1/10
摘要： The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.
摘要翻译：描述了在底物羧化中使用Z-M-OR形式的络合物。基团Z是双电子供体配体，M是金属，OR选自OH，烷氧基和芳氧基。底物可以在C-H或N-H键被羧化。金属M可以是铜，银或金。双电子供体配体可以是膦，卡宾或亚磷酸酯配体。还描述了制备复合物的方法和用于制备同位素标记的木糖酸和羧酸衍生物的方法。

2. 发明申请

US20130085276A1 CARBOXYLATION CATALYSTS 有权
标题翻译：羧氧化催化剂
公开(公告)号：US20130085276A1
公开(公告)日：2013-04-04
申请号：US13702886
申请日：2011-06-09
申请人： Steven P. Nolan , Catherine Cazin
发明人： Steven P. Nolan , Catherine Cazin
IPC分类号： C07B41/08 , C07D263/34 , C07D261/18 , C07D263/58 , C07D277/56 , C07D275/03 , C07D277/68 , C07D233/90 , C07D235/24 , C07D237/24 , C07D249/10 , C07D253/07 , C07D473/00 , C07F1/08 , C07F1/10 , C07B59/00 , C07D307/68
CPC分类号： C07B41/08 , B01J31/185 , B01J31/2226 , B01J31/2265 , B01J31/2269 , B01J31/2273 , B01J31/24 , B01J2531/16 , B01J2531/17 , B01J2531/18 , C07B59/002 , C07D233/90 , C07D235/24 , C07D237/24 , C07D249/10 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D275/03 , C07D277/56 , C07D277/68 , C07D307/68 , C07D473/00 , C07F1/08 , C07F1/10
摘要： The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.
摘要翻译：描述了在底物羧化中使用Z-M-OR形式的络合物。基团Z是双电子供体配体，M是金属，OR选自OH，烷氧基和芳氧基。底物可以在C-H或N-H键被羧化。金属M可以是铜，银或金。双电子供体配体可以是膦，卡宾或亚磷酸酯配体。还描述了制备复合物的方法和用于制备同位素标记的木糖酸和羧酸衍生物的方法。

3. 发明授权

US07622590B1 Catalyst complex with carbene ligand 有权
标题翻译：催化剂配合物与卡宾配体
公开(公告)号：US07622590B1
公开(公告)日：2009-11-24
申请号：US09392869
申请日：1999-09-09
申请人： Steven P. Nolan , Jinkun Huang
发明人： Steven P. Nolan , Jinkun Huang
IPC分类号： C07F15/00 , B01J31/00 , C08F4/44
CPC分类号： B01J31/2278 , B01J31/2265 , B01J31/2273 , B01J31/2295 , B01J31/2404 , B01J2231/10 , B01J2231/4205 , B01J2231/54 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/04 , C07C67/30 , C07C2531/22 , C07D207/46 , C07D223/04 , C07D225/02 , C07D313/00 , C07D498/04 , C07F15/00 , C07F15/002 , C07F15/0046
摘要： Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbene ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.
摘要翻译：包括具有阴离子配体的金属原子，至少一个亲核卡宾配体和亚烷基，亚乙烯基或亚烯基亚基配体的催化络合物。该配合物对空气，水分和热降解高度稳定。复合物被设计为有效地进行各种烯烃复分解反应。

4. 发明授权

US07205424B2 Preparation of ruthenium-based olefin metathesis catalysts 有权
标题翻译：钌基烯烃复分解催化剂的制备
公开(公告)号：US07205424B2
公开(公告)日：2007-04-17
申请号：US10873026
申请日：2004-06-21
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： B01J31/00
CPC分类号： B01J31/2265 , B01J31/2273 , B01J31/2404 , B01J2231/54 , B01J2231/543 , B01J2531/821
摘要： A synthetic method leading to the isolation of ruthenium-based olefin metathesis catalysts relies on the cross metathesis reaction between (L1)Ru(L2)(3-phenylindenylid-1-ene)Cl2 (where L1 and L2 can be two-electron donors) and an olefin. This method leads to the isolation of numerous ruthenium olefin metathesis catalysts.
摘要翻译：导致分离钌基烯烃复分解催化剂的合成方法依赖于（L 1 H 2）Ru（L 2 N 2）（3-苯基茚基）-1 烯）Cl 2（其中L 1和L 2可以是双电子给体）和烯烃。这种方法导致许多钌烯烃复分解催化剂的分离。

5. 发明授权

US06774274B2 Metal complexes for hydrogenation of unsaturated compounds 失效
标题翻译：用于氢化不饱和化合物的金属络合物
公开(公告)号：US06774274B2
公开(公告)日：2004-08-10
申请号：US10011680
申请日：2001-12-04
申请人： Steven P. Nolan , Hon Man Lee , Anna C. Hillier
发明人： Steven P. Nolan , Hon Man Lee , Anna C. Hillier
IPC分类号： C07C500
CPC分类号： C07F15/0033 , B01J31/181 , B01J31/2273 , B01J31/2291 , B01J31/2295 , B01J2231/645 , B01J2531/0288 , B01J2531/827 , C07C5/03 , C07C2531/22
摘要： The cationic iridium carbene complexes [Ir(cod)(N)(L)]X have been synthesized by reaction of [Ir(cod)(py)2]PF6 with L or NL ligands. Complexes of this type are active hydrogenation catalysts capable of hydrogenating simple olefins at room temperature and atmospheric pressure of hydrogen or by transfer hydrogenation.
摘要翻译：通过[Ir（cod）（py）2] PF6与L或NL配体的反应合成了阳离子铱卡宾配合物[Ir（cod）（N）（L）] X。这种类型的络合物是能够在室温和氢气的大气压下或通过转移氢化使单烯烃氢化的活性氢化催化剂。

6. 发明申请

US20160016976A2 GOLD COMPLEXES 有权
标题翻译：金复合体
公开(公告)号：US20160016976A2
公开(公告)日：2016-01-21
申请号：US13580772
申请日：2011-03-02
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： C07F1/00 , C07F15/00 , C07D207/16 , C07C69/74 , C07C231/06 , C07C45/26 , B01J31/18 , A61P35/00 , C07C67/333 , C07C231/10 , C07D207/06 , C07D213/81 , C07C17/37
CPC分类号： C07F1/12 , B01J31/0211 , B01J31/181 , B01J31/2273 , B01J31/24 , B01J2531/18 , C07C45/26 , C07C67/333 , C07C231/065 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07D207/06 , C07D213/81 , C07F1/00
摘要： Gold (I) hydroxide complexes of the form Z—Au—OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.
摘要翻译：提供Z-Au-OH形式的金（I）氢氧化物络合物和Z-Au-（μOH）-Au-Z形式的二价配合物，其中基团Z是两个电子给体。基团Z可以是卡宾，例如含氮杂环卡宾（NHC），膦或亚磷酸酯。络合物可以用作催化剂，例如在诸如腈水合，烯炔的骨架排列，烯炔的烷基环化，炔烃水合，Meyer-Shuster反应，烯丙基乙酸酯的3,3'重排，炔丙基乙酸酯的环化，贝克曼重排和水文。该复合物可用于医学中，例如用于治疗癌症。

7. 发明授权

US07902389B2 Catalyst complex with carbene ligand 有权
标题翻译：催化剂配合物与卡宾配体
公开(公告)号：US07902389B2
公开(公告)日：2011-03-08
申请号：US12622225
申请日：2009-11-19
申请人： Steven P. Nolan , Jinkun Huang
发明人： Steven P. Nolan , Jinkun Huang
IPC分类号： C07F15/00 , B01J31/00
CPC分类号： B01J31/2278 , B01J31/2265 , B01J31/2273 , B01J31/2295 , B01J31/2404 , B01J2231/10 , B01J2231/4205 , B01J2231/54 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/04 , C07C67/30 , C07C2531/22 , C07D207/46 , C07D223/04 , C07D225/02 , C07D313/00 , C07D498/04 , C07F15/00 , C07F15/002 , C07F15/0046
摘要： Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbine ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.
摘要翻译：包括具有阴离子配体的金属原子，至少一个亲核卡宾配体和亚烷基，亚乙烯基或亚烯基亚基配位体的催化络合物。该配合物对空气，水分和热降解高度稳定。复合物被设计为有效地进行各种烯烃复分解反应。

8. 发明授权

US07442800B2 Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions 有权
标题翻译： Pd（acac）2的亲核杂环卡宾衍生物用于交叉偶联反应
公开(公告)号：US07442800B2
公开(公告)日：2008-10-28
申请号：US11441825
申请日：2006-05-26
申请人： Dino Amoroso , Andrew Bell , Oscar Navarro Fernandez , Steven P. Nolan , Nicolas Marion
发明人： Dino Amoroso , Andrew Bell , Oscar Navarro Fernandez , Steven P. Nolan , Nicolas Marion
IPC分类号： C07F15/00
CPC分类号： C07B43/04 , C07B37/04 , C07C45/68 , C07D233/10 , C07F15/006 , C07C49/813 , C07C49/782 , C07C49/67 , C07C49/84 , C07C49/657
摘要： Embodiments in accordance with the present invention provide for a palladium complex characterized by the general formula: where A is a bidentate monoanionic ligand, NHC is a nucleophilic heterocyclic carbene, and Z is an anionic ligand. Such palladium complexes are useful in initiating cross-coupling reactions.
摘要翻译：根据本发明的实施方案提供了一种钯络合物，其特征在于以下通式：其中A是双齿单阴离子配体，NHC是亲核性杂环卡宾，Z是阴离子配体。这种钯络合物可用于引发交叉偶联反应。

9. 发明授权

US06362357B1 Use a catalyst system comprising nickel palladium or platinum and imidazoline-2-ylidene or imidazolidine-2-ylidene in stille coupling reactions 失效
标题翻译：在偶联反应中使用包含钯钯或铂和咪唑啉-2-亚基或咪唑烷-2-亚基的催化剂体系
公开(公告)号：US06362357B1
公开(公告)日：2002-03-26
申请号：US09511654
申请日：2000-02-22
申请人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
发明人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
IPC分类号： C07C30929
CPC分类号： C07D295/096 , B01J31/2265 , B01J31/2273 , B01J2231/4255 , B01J2531/824 , B01J2531/828 , B01J2531/847 , C07B37/04 , C07B43/04 , C07B49/00 , C07C1/321 , C07C41/30 , C07C67/293 , C07C67/343 , C07C209/10 , C07C213/08 , C07D295/023 , C07D295/073 , C07C69/76 , C07C69/157 , C07C43/20
摘要： This invention provides a process for conducting Stille coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Stille couplings of aryl halides. A Stille coupling can be carried out by mixing, in a liquid medium, at least one strong base; at least one aryl halide or aryl pseudohalide in which all substituents are other than stannyl groups, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one organotin compound wherein the tin atom is quaternary, wherein one group bound to the tin atom is unsaturated at the alpha or beta position, and wherein each of the remaining groups bound to the tin atom is a saturated group; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene. One preferred type of N-heterocyclic carbene is an imidazoline-2-ylidene of the formula wherein R1 and R2 are each, independently, alkyl or aryl groups having at least 3 carbon atoms, R3 and R4 are each, independently, a hydrogen atom, a halogen atom, or a hydrocarbyl group.
摘要翻译：本发明提供了进行Stille偶联反应的方法。本发明的方法利用N-杂环卡宾作为芳基卤化物的Stille偶联中的辅助配位体。 Stille耦合可以通过在液体介质中混合至少一个强碱来进行; 至少一种芳基卤或芳基拟卤化物，其中所有取代基都不是甲锡烷基，其中所述芳基卤具有直接键合到所述芳族环上的至少一个卤素原子，所述卤素原子选自氯原子，溴原子和碘原子; 至少一种有机锡化合物，其中锡原子是季铵，其中与锡原子结合的基团在α或β位是不饱和的，其中与锡原子结合的剩余基团中的每一个都是饱和基团; 至少一种金属化合物，其包含至少一种选自镍，钯和铂的金属原子，其中所述金属的形式氧化态为零或二; 和至少一个N-杂环卡宾。 N-杂环卡宾的一种优选类型是式R 2的咪唑啉-2-亚基，R 2各自独立地为具有至少3个碳原子的烷基或芳基，R 3和R 4各自独立地为氢原子，卤素原子或烃基。

10. 发明授权

US06316380B1 Catalyst system comprising transition metal and imidazoline-2-ylidene or imidazolidine-2-ylidene 有权
标题翻译：包含过渡金属和咪唑啉-2-亚基或咪唑烷-2-亚基的催化剂体系
公开(公告)号：US06316380B1
公开(公告)日：2001-11-13
申请号：US09507958
申请日：2000-02-22
申请人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
发明人： Steven P. Nolan , Jinkun Huang , Mark L. Trudell , Chunming Zhang
IPC分类号： B01J3100
CPC分类号： C07F15/0046 , B01J31/2265 , B01J31/2273 , B01J2231/4211 , B01J2231/4233 , B01J2231/4283 , B01J2531/824 , B01J2531/847 , C07B37/04 , C07B43/04 , C07B49/00 , C07C1/321 , C07C41/30 , C07C209/10 , C07C213/08 , C07D295/023 , C07D295/073 , C07D295/096 , C07F15/002 , C07C43/20
摘要： This invention provides a catalyst system useful in many coupling reactions, such as Suzuki, Kumada, Heck, and amination reactions. The catalyst system of the present invention makes use of N-heterocyclic carbenes or their protonated salts. The composition of the catalyst system comprises at least one transition metal compound and at least one N-heterocyclic carbene or its protonated salt. This invention further provides novel N-heterocyclic carbenes and their protonated salts. One type of N-heterocyclic carbene used in this invention is an imidazolinc-2-ylidene wherein the 1 and 3 positions are each, independently, substituted by an aromatic group in which each ortho position is, independently, substituted by a secondary or tertiary group which has at least three atoms.
摘要翻译：本发明提供了一种可用于许多偶联反应的催化剂体系，例如铃木，Kumada，Heck和胺化反应。本发明的催化剂体系利用N-杂环卡宾或其质子化盐。催化剂体系的组成包含至少一种过渡金属化合物和至少一种N-杂环卡宾或其质子化盐。本发明还提供新的N-杂环卡宾及其质子化盐。用于本发明的一种类型的N-杂环卡宾是咪唑啉-2-亚基，其中1和3位各自独立地被芳族基团取代，其中每个邻位独立地被二级或三级基团取代其具有至少三个原子。

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