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1. 发明申请

US20080221395A1 SELF-ORGANIZING MAPS IN CLINICAL DIAGNOSTICS 审中-公开
标题翻译：临床诊断中的自组织药物
公开(公告)号：US20080221395A1
公开(公告)日：2008-09-11
申请号：US11617303
申请日：2006-12-28
申请人： Steven J. Potts , Beryl Crossley , Rong Chen , Kevin Z. Qu , Richard A. Bender
发明人： Steven J. Potts , Beryl Crossley , Rong Chen , Kevin Z. Qu , Richard A. Bender
IPC分类号： A61B5/00
CPC分类号： G16H50/20 , Y02A90/22 , Y02A90/26
摘要： The present invention provides methods for the diagnosis of a disease or condition in an individual. The methods employ a primary self-organizing map trained with biological marker profiles from tissues having known diseases or conditions, in combination with a secondary self-organizing map which displays a representation of a subset of the primary self-organizing map with sample data obtained from an individual in need of diagnosis. A result is prepared from the secondary SOM(s) that reveals the extent of similarity between the known diseases or conditions with the sample data set of the individual. The result can be provided to a practitioner to aid in the diagnosis of the individual.
摘要翻译：本发明提供了用于诊断个体疾病或病症的方法。该方法采用了具有来自具有已知疾病或病症的组织的生物学标志谱的主要自组织图，以及次级自组织图，其显示了主自组织图的子集的表示，其中获得的样本数据需要诊断的个体。从辅助SOM制备结果，其显示已知疾病或病症与个体样本数据集之间的相似程度。结果可以提供给从业者来帮助个体的诊断。

2. 发明申请

US20080161652A1 SELF-ORGANIZING MAPS IN CLINICAL DIAGNOSTICS 审中-公开
标题翻译：临床诊断中的自组织药物
公开(公告)号：US20080161652A1
公开(公告)日：2008-07-03
申请号：US11690745
申请日：2007-03-23
申请人： Steven J. Potts , Beryl Crossley , Rong X. Chen , Kevin Z. Qu , Richard A. Bender
发明人： Steven J. Potts , Beryl Crossley , Rong X. Chen , Kevin Z. Qu , Richard A. Bender
IPC分类号： A61B5/00
CPC分类号： G16H50/20 , Y02A90/22 , Y02A90/26
摘要： The present invention provides methods for the diagnosis of a disease or condition in an individual. The methods employ a primary self-organizing map trained with biological marker profiles from tissues having known diseases or conditions, in combination with a secondary self-organizing map which displays a representation of a subset of the primary self-organizing map with sample data obtained from an individual in need of diagnosis. A result is prepared from the secondary SOM(s) that reveals the extent of similarity between the known diseases or conditions with the sample data set of the individual. The result can be provided to a practitioner to aid in the diagnosis or prognosis of the individual. The result can additionally be used to select an individual for a clinical trial to evaluate a treatment.
摘要翻译：本发明提供了用于诊断个体疾病或病症的方法。该方法采用了具有来自具有已知疾病或病症的组织的生物学标志谱的主要自组织图，以及辅助自组织图，其显示了主自组织图的子集的表示，需要诊断的个体。从辅助SOM制备结果，其显示已知疾病或病症与个体样本数据集之间的相似程度。结果可以提供给从业者以帮助个体的诊断或预后。结果还可用于选择临床试验的个体以评估治疗。

3. 发明申请

US20090181378A1 NUCLEIC ACID DETECTION COMBINING AMPLIFICATION WITH FRAGMENTATION 有权
标题翻译：核酸检测与分散放大组合
公开(公告)号：US20090181378A1
公开(公告)日：2009-07-16
申请号：US12035356
申请日：2008-02-21
申请人： Heather R. Sanders , Kevin Z. Qu , Charles M. Strom , Richard A. Bender
发明人： Heather R. Sanders , Kevin Z. Qu , Charles M. Strom , Richard A. Bender
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2531/113 , C12Q2521/301
摘要： Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. The methods have high sensitivity even in the presence of a large amount of non-target nucleic acid. Also provided are oligonucleotides and kits useful in the method. Exemplary nucleic acid targets are those with mutant gene sequence such as mutant sequence of the EGFR, APC, TMPRSS2, ERG and ETV1 genes.
摘要翻译：本文提供了用于检测样品中核酸靶的方法和组合物。该方法和组合物使用引物定向扩增与核酸碎裂相结合。即使在存在大量非靶核酸的情况下，该方法也具有高灵敏度。还提供了在该方法中有用的寡核苷酸和试剂盒。示例性核酸靶是具有突变基因序列的突变体序列，例如EGFR，APC，TMPRSS2，ERG和ETV1基因的突变序列。

4. 发明授权

US08999634B2 Nucleic acid detection combining amplification with fragmentation 有权
标题翻译：核酸检测结合扩增与碎裂
公开(公告)号：US08999634B2
公开(公告)日：2015-04-07
申请号：US12035356
申请日：2008-02-21
申请人： Heather R. Sanders , Kevin Z. Qu , Charles M. Strom , Richard A. Bender
发明人： Heather R. Sanders , Kevin Z. Qu , Charles M. Strom , Richard A. Bender
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2531/113 , C12Q2521/301
摘要： Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. The methods have high sensitivity even in the presence of a large amount of non-target nucleic acid. Also provided are oligonucleotides and kits useful in the method. Exemplary nucleic acid targets are those with mutant gene sequence such as mutant sequence of the EGFR, APC, TMPRSS2, ERG and ETV1 genes.
摘要翻译：本文提供了用于检测样品中核酸靶的方法和组合物。该方法和组合物使用引物定向扩增与核酸碎裂相结合。即使在存在大量非靶核酸的情况下，该方法也具有高灵敏度。还提供了在该方法中有用的寡核苷酸和试剂盒。示例性核酸靶是具有突变基因序列的突变体序列，例如EGFR，APC，TMPRSS2，ERG和ETV1基因的突变序列。

5. 发明申请

US20100291554A1 COMPOSITIONS AND METHODS FOR DETERMINING GENOTYPES 审中-公开
标题翻译：用于确定基因组的组合物和方法
公开(公告)号：US20100291554A1
公开(公告)日：2010-11-18
申请号：US12398341
申请日：2009-03-05
申请人： Kevin Z. Qu , Anthony Sferruzza
发明人： Kevin Z. Qu , Anthony Sferruzza
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides methods for determining the genotype of a selected gene present in at least two alleles in a sample. The methods involve amplifying DNA from the sample with a first pair of flanking primers that hybridize to nucleic acid sequences flanking a variant-specific gene sequence, the presence of which indicates the presence of a first gene variant, and the absence of which indicates the presence of a second gene variant. The DNA is also amplified with a third primer that specifically binds to the variant-specific sequence and together with one of the flanking primers forms a second pair of primers. Detection of one or more nucleic acid products of the amplification reaction is indicative of the genotype present in the sample.
摘要翻译：本发明提供了确定样品中至少两个等位基因中存在的所选基因的基因型的方法。所述方法包括用第一对侧翼引物扩增来自样品的DNA，所述第一对侧翼引物与变体特异性基因序列侧翼的核酸序列杂交，其存在表示存在第一基因变体，并且其不存在表示存在的第二个基因变体。还用与特异性结合变体特异性序列的第三引物扩增DNA，并与其中一个侧翼引物形成第二对引物。扩增反应的一种或多种核酸产物的检测指示样品中存在的基因型。

6. 发明授权

US07514213B2 Compositions and methods for determining genotypes 有权
标题翻译：用于确定基因型的组合物和方法
公开(公告)号：US07514213B2
公开(公告)日：2009-04-07
申请号：US10714508
申请日：2003-11-14
申请人： Kevin Z. Qu , Anthony Sferruzza
发明人： Kevin Z. Qu , Anthony Sferruzza
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides methods for determining the genotype of a selected gene present in at least two alleles in a sample. The methods involve amplifying DNA from the sample with a first pair of flanking primers that hybridize to nucleic acid sequences flanking a variant-specific gene sequence, the presence of which indicates the presence of a first gene variant, and the absence of which indicates the presence of a second gene variant. The DNA is also amplified with a third primer that specifically binds to the variant-specific sequence and together with one of the flanking primers forms a second pair of primers. Detection of one or more nucleic acid products of the amplification reaction is indicative of the genotype present in the sample.
摘要翻译：本发明提供了确定样品中至少两个等位基因中存在的所选基因的基因型的方法。所述方法包括用第一对侧翼引物扩增来自样品的DNA，所述第一对侧翼引物与变体特异性基因序列侧翼的核酸序列杂交，其存在表示存在第一基因变体，并且其不存在表示存在的第二个基因变体。还用与特异性结合变体特异性序列的第三引物扩增DNA，并与其中一个侧翼引物形成第二对引物。扩增反应的一种或多种核酸产物的检测指示样品中存在的基因型。

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