会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明授权
    • Dye conjugates of template-fixed peptidomimetics
    • 模板固定肽模拟物的染料缀合物
    • US09073973B2
    • 2015-07-07
    • US11913511
    • 2005-05-02
    • Steven J. DeMarcoFrank GombertDaniel ObrechtChristian LudinBarbara Romagnoli
    • Steven J. DeMarcoFrank GombertDaniel ObrechtChristian LudinBarbara Romagnoli
    • A61K38/10C07K5/00C07K7/64A61K38/48
    • C07K7/64A61K38/4886
    • Dye conjugates of template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 14 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties, and are useful for cancer therapy; diagnostic imaging; for detection of tumors and other abnormalities; for photoacoustic tumor imaging, detection and therapy; and for sonofluorescence tumor imaging, detection and therapy. The various dyes forming part of these conjugates are useful over the range of 300-1200 nm, the exact range being dependent upon the particular dye. These dye conjugates of β-hairpin peptidomimetic can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
    • 通式(I)的模板固定和平滑肽模拟物的染料缀合物,其中Z是14个α-氨基酸残基的模板固定链,这取决于它们在链中的位置(从N-末端计数 氨基酸)是Gly或Pro或某些类型,其作为上述式中的其余符号在说明书和权利要求书中定义,及其盐具有CXCR4拮抗性质,并且可用于癌症治疗; 诊断成像; 用于检测肿瘤等异常; 用于光声肿瘤成像,检测和治疗; 并用于超声荧光肿瘤成像,检测和治疗。 形成这些共轭物的一部分的各种染料在300-1200nm的范围内是有用的,确切的范围取决于特定的染料。 这些染色偶联物,可以通过基于混合固相和溶液相合成策略的方法制造。
    • 3. 发明申请
    • DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS
    • 模板固定肽的DYE结合
    • US20110135576A1
    • 2011-06-09
    • US11913511
    • 2005-05-02
    • Steven J. DeMarcoFrank GombertDaniel ObrechtChristian LudinBarbara Romagnoli
    • Steven J. DeMarcoFrank GombertDaniel ObrechtChristian LudinBarbara Romagnoli
    • A61K38/12C07K7/64C07K7/54A61K49/22A61P35/00A61K49/00
    • C07K7/64A61K38/4886
    • Dye conjugates of template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 14 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties, and are useful for cancer therapy; diagnostic imaging; for detection of tumors and other abnormalities; for photoacoustic tumor imaging, detection and therapy; and for sonofluorescence tumor imaging, detection and therapy. The various dyes forming part of these conjugates are useful over the range of 300-1200 nm, the exact range being dependent upon the particular dye. These dye conjugates of β-hairpin peptidomimetic can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
    • 通式(I)的模板固定和平滑肽模拟物的染料缀合物,其中Z是14个α-氨基酸残基的模板固定链,这取决于它们在链中的位置(从N-末端计数 氨基酸)是Gly或Pro或某些类型,其作为上述式中的其余符号在说明书和权利要求书中定义,及其盐具有CXCR4拮抗性质,并且可用于癌症治疗; 诊断成像; 用于检测肿瘤等异常; 用于光声肿瘤成像,检测和治疗; 并用于超声荧光肿瘤成像,检测和治疗。 形成这些共轭物的一部分的各种染料在300-1200nm的范围内是有用的,确切的范围取决于特定的染料。 这些染色偶联物,可以通过基于混合固相和溶液相合成策略的方法制造。