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1. 发明授权

US06387037B1 Implantable heart assist system and method of applying same 有权
标题翻译：植入式心脏辅助系统及其应用方法
公开(公告)号：US06387037B1
公开(公告)日：2002-05-14
申请号：US09470841
申请日：1999-12-23
申请人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
发明人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
IPC分类号： A61M110
CPC分类号： A61M1/3621 , A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/107 , A61M1/122 , A61M1/127 , A61M1/3655 , A61M25/0026 , A61M25/007
摘要： An extracardiac pumping system and method for using it supplement the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart. A battery powered pump may be implanted subcutaneously and attached to an inflow conduit fluidly coupled to a patient's femoral artery via a subcutaneous anastomosis connection. The pump draws blood from the inflow conduit and discharges it through an outflow conduit fluidly coupled to a second peripheral artery via another subcutaneous anastomosis connection. The battery may be charged extracorporeally and the pump may be operated in either a continuous or pulsatile fashion in synchronization with the patient's heart. The conduits can be housed in a multi-lumen catheter and a reservoir may be provided which fluidly communicates with the inflow conduits. An additional feature may keep blood traveling extracorporeally within the system at or near body temperature. The system is capable of adjusting outflow from the pump to optimize the mixing of red blood cells in the aorta and thereby enhance oxygen delivery to tissues by minimizing blood cell concentration in the center of the aorta.
摘要翻译：心外抽气系统及其使用方法补充患者的血液循环，包括心输出量，而不将其任何组分连接到患者的心脏。电池供电的泵可以被皮下植入并附着到通过皮下吻合连接流体地联接到患者的股动脉的流入导管。泵从流入管中抽取血液，并通过另外的皮下吻合连接通过流体连接到第二外周动脉的流出管排出。电池可以体外充电，并且泵可以以与患者心脏同步的连续或脉动方式操作。导管可以容纳在多腔导管中，并且可以设置与流入管道流体连通的储存器。额外的特征可以使血液在体温或体温附近体外流动到体内。该系统能够调节泵的流出，以优化主动脉中红细胞的混合，从而通过使主动脉中心的血细胞浓度最小化来增强对组织的氧输送。

2. 发明授权

US07513863B2 Implantable heart assist system and method of applying same 失效
公开(公告)号：US07513863B2
公开(公告)日：2009-04-07
申请号：US10878591
申请日：2004-06-28
申请人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
发明人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
IPC分类号： A61N1/362
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2230/04
摘要： An extracardiac pumping system and method for using it supplement the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart. A battery powered pump may be implanted subcutaneously and attached to an inflow conduit fluidly coupled to a patient's femoral artery via a subcutaneous anastomosis connection. The pump draws blood from the inflow conduit and discharges it through an outflow conduit fluidly coupled to a second peripheral artery via another subcutaneous anastomosis connection. The battery may be charged extracorporeally and the pump may be operated in either a continuous or pulsatile fashion in synchronization with the patient's heart. The conduits can be housed in a multi-lumen catheter and a reservoir may be provided which fluidly communicates with the inflow conduits. An additional feature may keep blood traveling extracorporeally within the system at or near body temperature. The system is capable of adjusting outflow from the pump to optimize the mixing of red blood cells in the aorta and thereby enhance oxygen delivery to tissues by minimizing blood cell concentration in the center of the aorta.

3. 发明授权

US08900115B2 Implantable heart assist system and method of applying same 有权
标题翻译：植入式心脏辅助系统及其应用方法
公开(公告)号：US08900115B2
公开(公告)日：2014-12-02
申请号：US13175735
申请日：2011-07-01
申请人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
发明人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
IPC分类号： A61M1/10 , A61M1/12 , A61M1/36 , A61M25/00
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2230/04
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment provides a vascular graft that has a first end that is sized and configured to couple to a non-primary blood vessel and a second end that is fluidly coupled to a pump to conduct blood between the pump and the non-primary blood vessel. An outflow conduit is also provided that has a first end sized and configured to be positioned within the same or different blood vessel, whether primary or non-primary, through the vascular graft. The outflow conduit is fluidly coupled to the pump to conduct blood between the pump and the patient. The vascular graft may be connected to the blood vessel subcutaneously to permit application of the extracardiac pumping system in a minimally-invasive procedure.
摘要翻译：用于补充患者的血液循环（包括心输出量）的心外泵送，而不将其任何组分连接到患者的心脏，以及使用它们的方法。一个实施例提供一种血管移植物，其具有第一端的尺寸和构造以耦合到非原发性血管和流体耦合到泵以在泵和非原发性血管之间进行血液的第二端。还提供了流出管道，其具有第一端的尺寸和构造以通过血管移植物定位在相同或不同的血管内，无论是初级的还是非原发的。流出管道流体耦合到泵以在泵和患者之间进行血液。血管移植物可以皮下连接到血管，以允许将心脏内泵送系统应用于微创手术。

4. 发明申请

US20120004495A1 IMPLANTABLE HEART ASSIST SYSTEM AND METHOD OF APPLYING SAME 有权
标题翻译：可植入心脏辅助系统及其应用方法
公开(公告)号：US20120004495A1
公开(公告)日：2012-01-05
申请号：US13175735
申请日：2011-07-01
申请人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
发明人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
IPC分类号： A61M1/12
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2230/04
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment provides a vascular graft that has a first end that is sized and configured to couple to a non-primary blood vessel and a second end that is fluidly coupled to a pump to conduct blood between the pump and the non-primary blood vessel. An outflow conduit is also provided that has a first end sized and configured to be positioned within the same or different blood vessel, whether primary or non-primary, through the vascular graft. The outflow conduit is fluidly coupled to the pump to conduct blood between the pump and the patient. The vascular graft may be connected to the blood vessel subcutaneously to permit application of the extracardiac pumping system in a minimally-invasive procedure.
摘要翻译：用于补充患者的血液循环（包括心输出量）的心外泵送，而不将其任何组分连接到患者的心脏，以及使用它们的方法。一个实施例提供一种血管移植物，其具有第一端的尺寸和构造以耦合到非原发性血管和流体耦合到泵的第二端，以在泵和非原发性血管之间引导血液。还提供了流出管道，其具有第一端的尺寸和构造以通过血管移植物定位在相同或不同的血管内，无论是初级的还是非原发的。流出管道流体耦合到泵以在泵和患者之间进行血液。血管移植物可以皮下连接到血管，以允许将心脏内泵送系统应用于微创手术。

5. 发明授权

US07144365B2 Implantable heart assist system and method of applying same 有权
标题翻译：植入式心脏辅助系统及其应用方法
公开(公告)号：US07144365B2
公开(公告)日：2006-12-05
申请号：US10729026
申请日：2003-12-05
申请人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
发明人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony J. Viole
IPC分类号： A61M1/10
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2230/04
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and method of using same. One embodiment of the extracardiac system comprises a pump configured to be implanted subcutaneously in a minimally-invasive procedure, wherein the pump can draw blood through an inflow conduit, and can discharge blood through an outflow conduit. The pump may be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart. The conduits can be housed in a multi-lumen catheter.
摘要翻译：用于补充患者的血液循环（包括心输出量）的心外泵送，而不将其任何组分连接到患者的心脏，以及使用它们的方法。心外系统的一个实施例包括构造成以微创程序皮下植入的泵，其中泵可以通过流入导管吸取血液，并且可以通过流出导管排出血液。泵可以连续地或以脉动方式操作，与患者的心脏同步，从而潜在地减少心脏的后负荷。导管可以容纳在多腔导管中。

6. 发明授权

US06390969B1 Implantable heart assist system and method of applying same 有权
标题翻译：植入式心脏辅助系统及其应用方法
公开(公告)号：US06390969B1
公开(公告)日：2002-05-21
申请号：US09552979
申请日：2000-04-21
申请人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony Viole
发明人： Steven F. Bolling , Morteza Gharib , Gabriel Aldea , Mary Lynn Gaddis , Anthony Viole
IPC分类号： A61M110
CPC分类号： A61M1/3621 , A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/107 , A61M1/122 , A61M1/127 , A61M1/3655 , A61M25/0026 , A61M25/007
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and method of using same. One embodiment of the extracardiac system comprises an implantable or portable subcardiac pump, whereby the pump draws blood through an inflow conduit fluidly coupled to a non-primary artery via a cannula and discharges blood through an outflow conduit fluidly coupled to a second non-primary artery via a cannula, wherein at least one of the cannulas projects well into the patient's vascular system. The pump may be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart.
摘要翻译：用于补充患者的血液循环（包括心输出量）的心外泵送，而不将其任何组分连接到患者的心脏，以及使用它们的方法。心脏外系统的一个实施例包括可植入或便携式的心脏心脏泵，其中泵通过经由套管流体耦合到非主动脉的流入管吸取血液，并通过与第二非主动脉流体耦合的流出导管排出血液通过套管，其中至少一个插管伸入病人的血管系统中。泵可以连续地或以脉动方式操作，与患者的心脏同步，从而潜在地减少心脏的后负荷。

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