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1. 发明申请

US20070012683A1 Device including inductively heatable fluid retainment region, and method 失效
标题翻译：装置包括电感可加热流体保留区域和方法
公开(公告)号：US20070012683A1
公开(公告)日：2007-01-18
申请号：US11417756
申请日：2006-05-04
申请人： Steven Boege , Mark Oldham , Marc Haberstroh , Stephen Gunstream , Adrian Fawcett , Douglas Grunewald
发明人： Steven Boege , Mark Oldham , Marc Haberstroh , Stephen Gunstream , Adrian Fawcett , Douglas Grunewald
IPC分类号： H05B6/02
CPC分类号： H05B6/108 , B01F13/0818 , B01L3/50851 , B01L2300/0803 , B01L2300/0809 , B01L2300/1816 , H05B6/109 , H05B2214/04 , Y10T137/6606
摘要： A device is provided that comprises one or more fluid retainment regions each having at least one wall, and one or more loops in heat-transfer communication with the at least one wall. Each of the loops can comprise an electrical conductor that surrounds the same or a different fluid retainment region. A device is provided that comprises one or more fluid retainment regions each having particulates disposed therein. A system is provided that includes a platen adapted to hold a device including fluid retainment regions and one or more electrical conductors in heat-transfer communication with the fluid retainment regions. Methods of heating a sample are also provided.
摘要翻译：提供了一种装置，其包括一个或多个流体保持区域，每个流体保持区域各自具有至少一个壁，以及与所述至少一个壁热传递连通的一个或多个环路。每个环可以包括围绕相同或不同流体保持区域的电导体。提供了一种装置，其包括一个或多个流体保持区域，每个流体保持区域各自具有设置在其中的微粒。提供了一种系统，其包括适于保持包括流体保持区域的装置和与流体保持区域传热连通的一个或多个电导体的压板。还提供了加热样品的方法。

2. 发明申请

US20110086763A1 METHODS FOR MULTIPLEX AMPLIFICATION 审中-公开
标题翻译：多重放大的方法
公开(公告)号：US20110086763A1
公开(公告)日：2011-04-14
申请号：US12510232
申请日：2009-07-27
申请人： John Bodeau , Stephen Gunstream , Mark Oldham
发明人： John Bodeau , Stephen Gunstream , Mark Oldham
IPC分类号： C40B30/00 , C40B50/06
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q2537/143 , C12Q2527/149 , C12Q2527/137 , C12Q2565/501 , C12Q2545/114 , C12Q2565/629
摘要： Methods for multiplex amplification of target nucleic acid sequences are provided.
摘要翻译：提供靶核酸序列的多重扩增方法。

3. 发明申请

US20060216737A1 Methods for multiplex amplification 审中-公开
标题翻译：多重扩增方法
公开(公告)号：US20060216737A1
公开(公告)日：2006-09-28
申请号：US11372242
申请日：2006-03-08
申请人： John Bodeau , Stephen Gunstream , Mark Oldham
发明人： John Bodeau , Stephen Gunstream , Mark Oldham
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q2537/143 , C12Q2527/149 , C12Q2527/137 , C12Q2565/501 , C12Q2545/114 , C12Q2565/629
摘要： Methods for multiplex amplification of target nucleic acid sequences are provided.
摘要翻译：提供靶核酸序列的多重扩增方法。

4. 发明申请

US20060138344A1 Spectral calibration method and system for multiple instruments 有权
标题翻译：多种仪器的光谱校准方法和系统
公开(公告)号：US20060138344A1
公开(公告)日：2006-06-29
申请号：US11286071
申请日：2005-11-23
申请人： Stephen Gunstream , Mark Oldham
发明人： Stephen Gunstream , Mark Oldham
IPC分类号： G01N21/64
CPC分类号： G01J1/58 , G01N21/278 , G01N21/6452 , Y10T436/10 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： Implementations of the present invention describe an apparatus for generating calibration factors for a spectral detector instrument. The calibration factors are derived from a calibration plate containing one or more spectral species in each well of the calibration plate. Each well is then exposed to an excitation source that causes the one or more spectral species in each of the wells to fluoresce. The signal response is measured and associated with each spectral species at each different well position in the calibration plate. Next, the measured signal response from each spectral species at each well position in the calibration plate is compared with a predetermined signal response for each spectral species. The results of this comparison can be used to determine a calibration factor for each well and spectral species to compensate for the difference between the measured signal response and the predetermined signal response.
摘要翻译：本发明的实施方式描述了一种用于产生光谱检测器仪器的校准因子的装置。校准因子来源于校准板的每个孔中含有一个或多个光谱种类的校准板。然后将每个孔暴露于激发源，使得每个孔中的一个或多个光谱物质发荧光。测量信号响应并与校准板中每个不同孔位置处的每个光谱种类相关联。接下来，将来自校准板中每个孔位置处的每个光谱种类的测量信号响应与每个光谱种类的预定信号响应进行比较。该比较的结果可用于确定每个孔和光谱种类的校准因子，以补偿测量的信号响应与预定信号响应之间的差异。

5. 发明申请

US20080018898A1 Minimizing Effects of Dye Crosstalk 有权
标题翻译：最小化染色串扰的影响
公开(公告)号：US20080018898A1
公开(公告)日：2008-01-24
申请号：US11770443
申请日：2007-06-28
申请人： Stephen Gunstream , David Woo , John Bodeau , Mark McCoy
发明人： Stephen Gunstream , David Woo , John Bodeau , Mark McCoy
IPC分类号： G01N21/25 , C12Q1/68 , G01J3/46
CPC分类号： G01N21/6428 , G01N21/274 , G01N2021/6421
摘要： Methods and systems for processing signals to minimize the effects of dye crosstalk. Deconvolution of multiplexed dye signals can include corrections for residual error determined from experimental measurements. Residual error corrections can account for reaction or assay specific factors and modify the subsequent filtering of signals. Correction values can be determined for specific dye-probe conjugates to minimize dye crosstalk and may be combined with residual error correction to further minimize errors in spectral deconvolution. Apparatus, systems, and computer-readable media can process signals and modify filters based on values obtained using the methods.
摘要翻译：用于处理信号的方法和系统，以最小化染料串扰的影响。多重染料信号的去卷积可以包括由实验测量确定的残差的校正。残留误差校正可以解释反应或测定特异性因素，并修改随后的信号过滤。可以针对特定的染料 - 探针缀合物确定校正值以最小化染料串扰，并可与残留误差校正组合以进一步最小化光谱去卷积中的误差。装置，系统和计算机可读介质可以基于使用这些方法获得的值处理信号和修改滤波器。

6. 发明申请

US20060029948A1 Sealing cover and dye compatibility selection 审中-公开
标题翻译：密封盖和染料兼容性选择
公开(公告)号：US20060029948A1
公开(公告)日：2006-02-09
申请号：US11086259
申请日：2005-03-22
申请人： Gary Lim , Albert Carrillo , Stephen Gunstream , Patrick Kinney , Aldrich K. Lau
发明人： Gary Lim , Albert Carrillo , Stephen Gunstream , Patrick Kinney , Aldrich K. Lau
IPC分类号： C12Q1/68
CPC分类号： G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L9/523 , B01L9/56 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , C12Q1/6816 , G01N21/274 , G01N21/6452 , G01N21/648 , G01N2035/00366 , C12Q2531/113 , C12Q2563/173
摘要： A method of testing compatibility of a detection probe comprising an oligonucleotide and a fluorophore to a composition of a sealing cover, can comprise (a) depositing a quantity of the fluorophore into a plurality of containers; (b) providing a plurality of sealing covers; (c) sealing the plurality of containers with each of the plurality of the sealing covers; (d) exciting the fluorophore; (e) measuring an emission intensity from the fluorophore; and (f) evaluating the emission intensity from the fluorophore to determine the relative compatibility of each of the plurality of sealing covers with the fluorophore.
摘要翻译：将包含寡核苷酸和荧光团的检测探针的相容性测试到密封盖组合物的方法可以包括（a）将一定数量的荧光团沉积到多个容器中; （b）提供多个密封盖; （c）用多个密封盖中的每一个密封多个容器; （d）激发荧光团; （e）从荧光团测量发射强度; 和（f）评估来自荧光团的发射强度，以确定多个密封盖中的每一个与荧光团的相对相容性。

7. 发明申请

US20070105126A1 Device for monitoring polymerase chain reactions 有权
标题翻译：监测聚合酶链反应的装置
公开(公告)号：US20070105126A1
公开(公告)日：2007-05-10
申请号：US11270841
申请日：2005-11-09
申请人： Stephen Gunstream , Patrick Kinney
发明人： Stephen Gunstream , Patrick Kinney
IPC分类号： C12Q1/68
CPC分类号： B01L7/52 , B01L2200/147 , B01L2200/148 , B01L2300/0829 , C12Q1/6851 , C12Q2561/113 , C12Q2527/101
摘要： A method for calibrating temperature can include cycling temperatures of a set of wells, wherein each well of the set comprises a sample with a spectrally distinguishable species. The method can further include measuring a signal from the spectrally distinguishable species for each well at a temperature during a first temperature cycle, and calibrating the temperatures for measuring the signal from each well during subsequent temperature cycles.
摘要翻译：用于校准温度的方法可以包括一组孔的循环温度，其中该组的每个孔包含具有光谱可区分物种的样品。该方法还可以包括在第一温度循环期间的温度下测量来自每个孔的光谱可区分物质的信号，并且在随后的温度循环期间校准用于测量来自每个孔的信号的温度。

8. 发明申请

US20060291706A1 Method of extracting intensity data from digitized image 审中-公开
标题翻译：从数字化图像中提取强度数据的方法
公开(公告)号：US20060291706A1
公开(公告)日：2006-12-28
申请号：US11166957
申请日：2005-06-23
申请人： Stephen Gunstream , Patrick Kinney
发明人： Stephen Gunstream , Patrick Kinney
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G06T5/003 , G01N21/253 , G01N21/6452 , G01N21/6456 , G06T2207/20224 , G06T2207/30072
摘要： A method for reducing optical crosstalk in an optical array detector is provided. In various embodiments, the method can include measuring optical emission within a first region of interest (ROI) using a first plurality of pixels of the optical array detector, wherein each of the first plurality of pixels provides a value for optical signal intensity within the first ROI. An ROI sum signal can then be calculated by summing the values for optical signal intensity measured by the first plurality of pixels. An optical emission within a second ROI can be measured using a second plurality of pixels of the optical array detector, wherein each of the second plurality of pixels provides a value for optical signal intensity within the second ROI. The values for optical signal intensity provided by the second plurality of pixels can be algebraically manipulated to determine an optical crosstalk signal. A corrected ROI optical signal intensity can then be determined by multiplying the optical crosstalk signal by a number of pixels of the first plurality of pixels and subtracting the multiplied optical crosstalk signal from the ROI sum signal.
摘要翻译：提供了一种用于减少光学阵列检测器中的光学串扰的方法。在各种实施例中，该方法可以包括使用光学阵列检测器的第一多个像素测量第一感兴趣区域（ROI）内的光发射，其中第一多个像素中的每一个为第一多个像素内的光信号强度提供值投资回报率然后可以通过对由第一多个像素测量的光信号强度的值相加来计算ROI和信号。可以使用光学阵列检测器的第二多个像素来测量第二ROI内的光发射，其中第二多个像素中的每一个为第二ROI内的光信号强度提供一个值。可以代数地操作由第二多个像素提供的光信号强度的值以确定光串扰信号。然后可以通过将光学串扰信号乘以第一多个像素的像素数量并从ROI和信号中减去相乘的光学串扰信号来确定校正的ROI光信号强度。

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