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1. 发明申请

US20060166866A1 Cell adhesion inhibitors 审中-公开
公开(公告)号：US20060166866A1
公开(公告)日：2006-07-27
申请号：US10679478
申请日：2003-10-07
申请人： Steven Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo Castro , Craig Zimmerman , Charles Hammond , Yu-Sheng Liao , Julio Cuervo , Juswinder Singh
发明人： Steven Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo Castro , Craig Zimmerman , Charles Hammond , Yu-Sheng Liao , Julio Cuervo , Juswinder Singh
IPC分类号： A61K38/04 , C07K5/04
CPC分类号： C07D213/75 , A61K38/00 , C07C237/22 , C07C255/19 , C07C271/22 , C07C275/28 , C07C275/42 , C07C275/54 , C07C311/06 , C07C311/21 , C07C317/50 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D213/55 , C07D215/48 , C07D277/48 , C07D317/60 , C07D405/12 , C07K7/06
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.

2. 发明授权

US06376538B1 Cell adhesion inhibitors 失效
标题翻译：细胞粘附抑制剂
公开(公告)号：US06376538B1
公开(公告)日：2002-04-23
申请号：US08875321
申请日：1997-09-19
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao , Julio Hernan Cuervo , Juswinder Singh
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao , Julio Hernan Cuervo , Juswinder Singh
IPC分类号： A61K31357
CPC分类号： C07D213/75 , A61K38/00 , C07C237/22 , C07C255/19 , C07C271/22 , C07C275/28 , C07C275/42 , C07C275/54 , C07C311/06 , C07C311/21 , C07C317/50 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D213/55 , C07D215/48 , C07D277/48 , C07D317/60 , C07D405/12 , C07K7/06
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
摘要翻译：本发明涉及可用于抑制和预防细胞粘附和细胞粘附介导的病理学的新型化合物。本发明还涉及包含这些化合物的药物制剂及其用于抑制和预防细胞粘附和细胞粘附介导的病理学的方法。本发明的化合物和药物组合物可用作治疗剂或预防剂。它们特别适用于治疗许多炎性和自身免疫性疾病。

3. 发明授权

US06630512B2 Cell adhesion inhibitors 失效
公开(公告)号：US06630512B2
公开(公告)日：2003-10-07
申请号：US10002341
申请日：2001-10-23
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao , Julio Hernan Cuervo , Juswinder Singh
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao , Julio Hernan Cuervo , Juswinder Singh
IPC分类号： A61K31197
CPC分类号： C07D213/75 , A61K38/00 , C07C237/22 , C07C255/19 , C07C271/22 , C07C275/28 , C07C275/42 , C07C275/54 , C07C311/06 , C07C311/21 , C07C317/50 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D213/55 , C07D215/48 , C07D277/48 , C07D317/60 , C07D405/12 , C07K7/06
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.

4. 发明授权

US06624152B2 Cell adhesion inhibitors 失效
公开(公告)号：US06624152B2
公开(公告)日：2003-09-23
申请号：US09935461
申请日：2001-08-22
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
IPC分类号： A61K3166
CPC分类号： C07D213/75 , A61K38/00 , C07C237/22 , C07C255/19 , C07C271/22 , C07C275/28 , C07C275/42 , C07C275/54 , C07C311/06 , C07C311/21 , C07C317/50 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D213/55 , C07D215/48 , C07D277/48 , C07D317/60 , C07D405/12 , C07K7/06
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.

5. 发明授权

US07001921B1 Cell adhesion inhibitors 失效
公开(公告)号：US07001921B1
公开(公告)日：2006-02-21
申请号：US10625626
申请日：2003-07-24
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
IPC分类号： A61K31/195 , C07C233/00
CPC分类号： A61K31/195
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.

6. 发明授权

US06306840B1 Cell adhesion inhibitors 失效
公开(公告)号：US06306840B1
公开(公告)日：2001-10-23
申请号：US08376372
申请日：1995-01-23
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
IPC分类号： A61K3136
CPC分类号： C07D213/75 , A61K38/00 , C07C237/22 , C07C255/19 , C07C271/22 , C07C275/28 , C07C275/42 , C07C275/54 , C07C311/06 , C07C311/21 , C07C317/50 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D213/55 , C07D215/48 , C07D277/48 , C07D317/60 , C07D405/12 , C07K7/06
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.

7. 发明申请

US20140010411A1 AUTOMATIC AIRVIEW CORRECTION METHOD 有权
标题翻译：自动空气净化方法
公开(公告)号：US20140010411A1
公开(公告)日：2014-01-09
申请号：US13597662
申请日：2012-08-29
申请人： Li-You HSU , Yu-Sheng Liao , Tzu-Chien Hsu
发明人： Li-You HSU , Yu-Sheng Liao , Tzu-Chien Hsu
IPC分类号： G06K9/32
CPC分类号： G06T7/0018 , G06K9/00805 , G06T3/4038 , G06T7/33 , G06T7/80 , G06T2207/30208 , G06T2207/30252
摘要： An automatic airview correction method comprises steps: moving a vehicle to an airview alignment pattern; capturing a plurality of airview alignment images of the surroundings of the vehicle; correcting distortion of the airview alignment images to obtain a plurality of corrected images; performing alignment compensation on the corrected images; searching for corner points of the corrected images and converting view point s to obtain a plurality of view angle-converted images; and searching for corner points of the view angle-converted images, and seaming the view angle-converted images to form a panoramic airview and obtain parameters corresponding to the panoramic airview. The present invention can automatically align images and can also automatically detect corner points to seam the images of the surroundings of a vehicle, whereby to form a panoramic airview.
摘要翻译：一种自动风景校正方法，包括以下步骤：将车辆移动到气道对准模式; 捕获车辆周围环境的多个气视对准图像; 校正气视对准图像的失真以获得多个校正图像; 对校正图像执行对准补偿; 搜索校正图像的角点并转换视点s以获得多个视角转换图像; 并且搜索视角转换图像的角点，并且将视角转换图像接合以形成全景视野并获得与全景视野对应的参数。本发明可以自动对准图像，还可以自动检测角点以缝合车辆周围的图像，从而形成全景视野。

8. 发明授权

US08310355B2 Vehicular collision warning system 有权
标题翻译：车辆碰撞预警系统
公开(公告)号：US08310355B2
公开(公告)日：2012-11-13
申请号：US12588185
申请日：2009-10-07
申请人： Chia-Tseng Chen , Yu-Sheng Liao , Hsiang-Chun Kao
发明人： Chia-Tseng Chen , Yu-Sheng Liao , Hsiang-Chun Kao
IPC分类号： B60Q1/00
CPC分类号： B60Q9/008
摘要： A vehicular collision warning system comprises at least one image capture device capturing images of blind spots, a processing unit receiving the images of blind spots from the image capture device, and at least one alert device. The processing unit identifies at least one barrier from the images and calculates the speed and transverse displacement of the barrier according to the positional change with respect to time. The processing unit presets at least one attention area on the image, estimates whether the barrier will appear in the attention area, sends out an alert-triggering signal to trigger the alert devices to generate sound, light, or pictures to warn the driver early. Cooperating with the speed sensor, brake system and turn light system, the vehicular collision warning system can trigger different alert signals according to the grading of danger to actively warn the driver early.
摘要翻译：车辆碰撞警告系统包括：捕获盲点图像的至少一个图像捕获装置，从图像捕获装置接收盲点图像的处理单元和至少一个警报装置。处理单元从图像中识别至少一个障碍物，并且根据相对于时间的位置变化来计算屏障的速度和横向位移。处理单元预设图像上的至少一个注意区域，估计屏障是否将出现在注意区域，发出警报触发信号以触发警报装置产生声音，光线或图片，以便提早警告驾驶员。与速度传感器，制动系统和转向灯系统配合，车辆碰撞预警系统可根据危险等级触发不同的报警信号，提前主动警告驾驶员。

9. 发明授权

US08587440B2 Method and system for monitoring driver 有权
标题翻译：监控驾驶员的方法和系统
公开(公告)号：US08587440B2
公开(公告)日：2013-11-19
申请号：US12704142
申请日：2010-02-11
申请人： Ming-Cong Weng , Yu-Sheng Liao , Yu-Song Chen
发明人： Ming-Cong Weng , Yu-Sheng Liao , Yu-Song Chen
IPC分类号： G08B23/00 , H04N9/47
CPC分类号： G08B21/06 , A61B5/18 , B60K28/066 , G06K9/00248 , G06K9/00832
摘要： A method and system for monitoring a driver is disclosed. Firstly, an inner cabin image of a vehicle's cabin is continuously captured. Next, a face detection of a driver for the inner cabin image is performed to obtain a face detection result. Next, the inner cabin image and the face detection result corresponding to the inner cabin image are stored. When the system observes that either the face of the driver is not detected or the face is not shown within a reasonable face region of at least two continuous inner cabin images according to each face detection result, the system outputs a warning signal to alert the driver. The invention determines a driving state of a driver in a cabin with a method of analyzing a position of a face or a head and using an image extractor having large capture range and a low resolution.
摘要翻译：公开了一种用于监视驾驶员的方法和系统。首先，连续地捕获车厢的内舱图像。接下来，执行用于内舱图像的驾驶员的脸部检测以获得面部检测结果。接下来，存储对应于内舱图像的内舱图像和面部检测结果。当系统观察到根据每个面部检测结果，未检测到驾驶员的面部或者在至少两个连续的内舱图像的合理面部区域内未显示面部时，系统输出警告信号以警告驾驶员。本发明通过分析脸部或头部的位置并使用具有大的捕获范围和低分辨率的图像提取器来确定驾驶员在驾驶室中的驾驶状态。

10. 发明申请

US20120161954A1 METHOD AND SYSTEM FOR DETECTING A DRIVING STATE OF A DRIVER IN A VEHICLE 有权
标题翻译：用于检测车辆驾驶员的驾驶状态的方法和系统
公开(公告)号：US20120161954A1
公开(公告)日：2012-06-28
申请号：US12979939
申请日：2010-12-28
申请人： Yu-Sheng Liao , Chia-Tseng Chen , Yu-Sung Chen
发明人： Yu-Sheng Liao , Chia-Tseng Chen , Yu-Sung Chen
IPC分类号： B60Q1/00 , H04N7/18 , G06K9/00
CPC分类号： G08B21/06 , A61B5/1118 , A61B5/1176 , A61B5/18 , A61B5/6893 , G06K9/00261 , G06K9/00845
摘要： In a method and system for detecting a driving state of a driver in a vehicle, a face recognition standard corresponding to an environmental condition within the vehicle is established based on a series of image frames generated by capturing consecutively images of the driver upon movement of the vehicle. Upon detection of a variance in the environmental condition during movement of vehicle, the face recognition standard is updated with a corrected face recognition standard corresponding to the environmental condition with the variance. It is determined based on the corrected face recognition standard and the image frames whether the driving state of the driver is a dangerous state, where the driver's face does not face a front windshield of the vehicle or where the driver's face faces the front windshield of the vehicle but one of the driver's eyes is closed.
摘要翻译：在用于检测车辆驾驶员的驾驶状态的方法和系统中，基于通过在驾驶员的移动时连续捕获驾驶员的图像而生成的一系列图像帧来建立与车辆内的环境状况相对应的面部识别标准车辆。在检测到车辆移动期间环境条件的变化的情况下，使用与具有方差的环境条件对应的校正面部识别标准来更新面部识别标准。基于校正的面部识别标准和图像帧来确定驾驶员的驾驶状态是否是危险状态，其中驾驶员的面部不面对车辆的前挡风玻璃或驾驶员的面部朝向驾驶员的前挡风玻璃车辆，但驾驶员的眼睛之一是关闭的。

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