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1. 发明授权

US09371513B2 Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells 有权
标题翻译：使用少突胶质细胞祖细胞的先天性去神经系膜前纤的髓鞘形成
公开(公告)号：US09371513B2
公开(公告)日：2016-06-21
申请号：US13527099
申请日：2012-06-19
申请人： Steven A. Goldman , Neeta Singh Roy , Martha Windrem
发明人： Steven A. Goldman , Neeta Singh Roy , Martha Windrem
IPC分类号： A01N63/00 , C12N5/02 , C12N5/08 , C12N5/079 , C12N5/0797 , A61K35/30 , C12N5/0793 , A61K35/12
CPC分类号： C12N5/0623 , A61K35/12 , A61K35/30 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N2510/00 , G01N33/5005 , G01N33/56966 , Y02A50/467
摘要： One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types.
摘要翻译：本发明的一种形式涉及通过在允许轴突再髓鞘化的条件下用少突胶质祖细胞处理脱髓鞘化的轴突来再髓鞘化轴突再髓鞘的方法。本发明的另一方面涉及一种通过在有效治疗由髓磷脂损失介导的病症治疗的条件下向受试者少突胶质祖细胞施用治疗具有由髓磷脂损失或少突胶质细胞损失介导的病症的受试者的方法，或少突胶质细胞的丧失。本发明的另一方面涉及从含有其它哺乳动物脑或脊髓细胞类型的混合群体中鉴定和分离少突胶质祖细胞祖细胞的体外方法。

2. 发明申请

US20130004467A1 MYELINATION OF CONGENITALLY DYSMYELINATED FOREBRAINS USING OLIGODENDROCYTE PROGENITOR CELLS 有权
标题翻译：使用OLIGENENDROCYTE PROGENITOR CELLS进行浓缩的甲状腺素
公开(公告)号：US20130004467A1
公开(公告)日：2013-01-03
申请号：US13527099
申请日：2012-06-19
申请人： Steven A. Goldman , Neeta Singh Roy , Martha Windrem
发明人： Steven A. Goldman , Neeta Singh Roy , Martha Windrem
IPC分类号： A61K35/30 , C12N5/079 , A61P7/04 , A61P29/00 , A61P27/02 , G01N21/64 , A61P25/00
CPC分类号： C12N5/0623 , A61K35/12 , A61K35/30 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N2510/00 , G01N33/5005 , G01N33/56966 , Y02A50/467
摘要： One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types.
摘要翻译：本发明的一种形式涉及通过在允许轴突再髓鞘化的条件下用少突胶质祖细胞处理脱髓鞘化的轴突来再髓鞘化轴突再髓鞘的方法。本发明的另一方面涉及一种通过在有效治疗由髓磷脂损失介导的病症治疗的条件下向受试者少突胶质祖细胞施用治疗具有由髓磷脂损失或少突胶质细胞损失介导的病症的受试者的方法，或少突胶质细胞的丧失。本发明的另一方面涉及从含有其它哺乳动物脑或脊髓细胞类型的混合群体中鉴定和分离少突胶质祖细胞祖细胞的体外方法。

3. 发明授权

US08206699B2 Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells 有权
标题翻译：使用少突胶质细胞祖细胞的先天性去神经系膜前纤的髓鞘形成
公开(公告)号：US08206699B2
公开(公告)日：2012-06-26
申请号：US12111839
申请日：2008-04-29
申请人： Steven A. Goldman , Neeta Singh Roy , Martha Windrem
发明人： Steven A. Goldman , Neeta Singh Roy , Martha Windrem
IPC分类号： A01N63/00 , A01N65/00
CPC分类号： C12N5/0623 , A61K35/12 , A61K35/30 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N2510/00 , G01N33/5005 , G01N33/56966 , Y02A50/467
摘要： One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types. This further aspect of the present invention involves removing neurons and neuronal progenitor cells from the mixed population to produce a treated mixed population. Oligodendrocyte progenitor cells are then separated from the treated mixed population to form an enriched population of oligodendrocyte progenitor cells.
摘要翻译：本发明的一种形式涉及通过在允许轴突再髓鞘化的条件下用少突胶质祖细胞处理脱髓鞘化的轴突来再髓鞘化轴突再髓鞘的方法。本发明的另一方面涉及一种通过在有效治疗由髓磷脂损失介导的病症治疗的条件下向受试者少突胶质祖细胞施用治疗具有由髓磷脂损失或少突胶质细胞损失介导的病症的受试者的方法，或少突胶质细胞的丧失。本发明的另一方面涉及从含有其它哺乳动物脑或脊髓细胞类型的混合群体中鉴定和分离少突胶质祖细胞祖细胞的体外方法。本发明的另一方面涉及从混合群体中去除神经元和神经元祖细胞以产生经处理的混合群体。然后从处理的混合群体中分离少突胶质细胞祖细胞以形成少突胶质细胞祖细胞的富集群体。

4. 发明授权

US07524491B2 Non human animals with human-glial chimeric brains 有权
标题翻译：具有人神经胶质大脑的非人类动物
公开(公告)号：US07524491B2
公开(公告)日：2009-04-28
申请号：US12015372
申请日：2008-01-16
申请人： Steven A. Goldman , Martha Windrem
发明人： Steven A. Goldman , Martha Windrem
IPC分类号： G01N33/00 , A01K67/00 , A01K67/033 , C12N15/00
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2207/15 , A01K2217/15 , A01K2227/105 , A01K2267/0356 , C12N5/0623 , G01N33/5058 , G01N33/5088
摘要： The present invention is directed to a non-human mammal with at least 30% of all of its glial cells in its corpus callosum being human glial cells and/or at least 5% of all of its glial cells in the white matter of its brain and/or brain stem being human glial cells. Methods of producing and using the non-human mammal are also disclosed.
摘要翻译：本发明涉及一种非人类哺乳动物，其胼its体中其全部神经胶质细胞的至少30％是人神经胶质细胞和/或其脑白质中至少5％的神经胶质细胞和/或脑干是人神经胶质细胞。还公开了生产和使用非人哺乳动物的方法。

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