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1. 发明授权

US08617381B2 System and apparatus for determining temperatures in a fluid analyte system 有权
公开(公告)号：US08617381B2
公开(公告)日：2013-12-31
申请号：US12821976
申请日：2010-06-23
申请人： Steve Hoi-Cheong Sun , Swetha Chinnayelka , John P. Creaven , Andrew J. Edelbrock , Matthew B. Holzer , Narasinha C. Parasnis , Jeffery S. Reynolds , Paul M. Ripley , Steven C. Charlton , Xin Wang , Mu Wu
发明人： Steve Hoi-Cheong Sun , Swetha Chinnayelka , John P. Creaven , Andrew J. Edelbrock , Matthew B. Holzer , Narasinha C. Parasnis , Jeffery S. Reynolds , Paul M. Ripley , Steven C. Charlton , Xin Wang , Mu Wu
IPC分类号： G01N27/416 , G01N27/327 , G01N21/75
CPC分类号： G01N27/4166 , A61B5/01 , A61B5/14532 , A61B5/14546 , A61B5/1486 , G01K3/08 , G01K7/01 , G01K7/02 , G01K7/16 , G01K13/00 , G01N27/26 , G01N27/308 , G01N27/3272 , G01N27/3274 , Y10T29/49155
摘要： A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration.

2. 发明申请

US20100319436A1 System and Apparatus for Determining Temperatures in a Fluid Analyte System 有权
标题翻译：用于确定流体分析系统中温度的系统和装置
公开(公告)号：US20100319436A1
公开(公告)日：2010-12-23
申请号：US12821976
申请日：2010-06-23
申请人： Steve Hoi-Cheong Sun , Swetha Chinnayelka , John P. Creaven , Andrew J. Edelbrock , Matthew B. Holzer , Narasinha C. Parasnis , Jeffery S. Reynolds , Paul M. Ripley , Steven C. Charlton , Xin Wang , Mu Wu
发明人： Steve Hoi-Cheong Sun , Swetha Chinnayelka , John P. Creaven , Andrew J. Edelbrock , Matthew B. Holzer , Narasinha C. Parasnis , Jeffery S. Reynolds , Paul M. Ripley , Steven C. Charlton , Xin Wang , Mu Wu
IPC分类号： G01N25/00 , G01K7/02 , G01K7/16 , H05K3/10
CPC分类号： G01N27/4166 , A61B5/01 , A61B5/14532 , A61B5/14546 , A61B5/1486 , G01K3/08 , G01K7/01 , G01K7/02 , G01K7/16 , G01K13/00 , G01N27/26 , G01N27/308 , G01N27/3272 , G01N27/3274 , Y10T29/49155
摘要： A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration.
摘要翻译：测试传感器包括主体，第一导电迹线，第二导电迹线和第三导电迹线。主体包括具有流体接收区域的第一区域，与第一区域分离的第二区域以及设置在流体接收区域处或邻近流体接收区域的第一温度感测界面。流体接收区域接收样品。第一迹线设置在主体上，并且第一迹线的至少一部分设置在第一区域中。第二和第三迹线设置在身体上。第三个痕迹从第一个区域延伸到第二个区域。第三个迹线连接到第一个温度检测界面的第一条迹线。第三个跟踪包含与第一个跟踪不同的材料。在第一温度感测界面处形成第一热电偶。热电偶提供温度数据以确定分析物浓度。

3. 发明授权

US09188556B2 Temperature sensing analyte sensors, systems, and methods of manufacturing and using same 有权
标题翻译：温度传感分析物传感器，系统及其制造和使用方法
公开(公告)号：US09188556B2
公开(公告)日：2015-11-17
申请号：US13884694
申请日：2011-11-07
申请人： Hoi-Cheong Steve Sun , John P. Creaven , Mu Wu , Paul M. Ripley , Steven C. Charlton
发明人： Hoi-Cheong Steve Sun , John P. Creaven , Mu Wu , Paul M. Ripley , Steven C. Charlton
IPC分类号： G01N27/327 , G01N25/00 , A61B5/145 , A61B5/1486
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/1486 , A61B2560/0252 , A61B2560/0285 , A61B2562/12 , C12Q1/001 , G01K7/02 , G01K13/00 , G01N25/00 , G01N27/3272 , Y10T29/49117
摘要： An analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.
摘要翻译：提供分析物传感器用于检测生物流体样品中的分析物浓度水平。分析物传感器具有基座，第一电极和第二电极，其中热电偶部分与第二电极一体设置，从而实现传感器温度测量能力。在一些实施例中，提供两个且仅两个电接触接合部分，从而简化电接触。提供了利用分析物传感器的制造方法和系统，以及许多其它方面。

4. 发明申请

US20130298648A1 TEMPERATURE SENSING ANALYTE SENSORS, SYSTEMS, AND METHODS OF MANUFACTURING AND USING SAME 有权
标题翻译：温度感测分析仪传感器，系统及其制造方法及使用方法
公开(公告)号：US20130298648A1
公开(公告)日：2013-11-14
申请号：US13884694
申请日：2011-11-07
申请人： Hoi-Cheong Steve Sun , John P. Creaven , Mu Wu , Paul M. Ripley , Steven C. Charlton
发明人： Hoi-Cheong Steve Sun , John P. Creaven , Mu Wu , Paul M. Ripley , Steven C. Charlton
IPC分类号： G01N27/327 , G01N25/00
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/1486 , A61B2560/0252 , A61B2560/0285 , A61B2562/12 , C12Q1/001 , G01K7/02 , G01K13/00 , G01N25/00 , G01N27/3272 , Y10T29/49117
摘要： An analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.
摘要翻译：提供分析物传感器用于检测生物流体样品中的分析物浓度水平。分析物传感器具有基座，第一电极和第二电极，其中热电偶部分与第二电极一体设置，从而实现传感器温度测量能力。在一些实施例中，提供两个且仅两个电接触接合部分，从而简化电接触。提供了利用分析物传感器的制造方法和系统，以及许多其它方面。

5. 发明授权

US08424763B2 Method of forming an auto-calibration circuit or label 有权
标题翻译：形成自动校准电路或标签的方法
公开(公告)号：US08424763B2
公开(公告)日：2013-04-23
申请号：US12551654
申请日：2009-09-01
申请人： Steven C. Charlton , Matthew Holzer , Mu Wu , Andrew J. Edelbrock
发明人： Steven C. Charlton , Matthew Holzer , Mu Wu , Andrew J. Edelbrock
IPC分类号： G06K7/08 , G01N21/00 , G01N1/10 , B44C1/17
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B2562/0295 , G01N33/48771 , Y10T436/2575
摘要： A method of forming and using an auto-calibration circuit or label on a test sensor includes providing a label or circuit. The label or circuit includes a first layer, a second layer and a lamination portion. The second layer is located between the first layer and the lamination portion. The first layer includes polymeric material. The second layer includes conductive material. The label or circuit is applied to the test sensor via the lamination portion. After applying the label or circuit to the test sensor, portions of the second layer are ablated using a laser to form an auto-calibration pattern on the label or circuit.
摘要翻译：在测试传感器上形成和使用自动校准电路或标签的方法包括提供标签或电路。标签或电路包括第一层，第二层和层压部分。第二层位于第一层和层压部之间。第一层包括聚合材料。第二层包括导电材料。标签或电路通过层压部分施加到测试传感器。在将标签或电路应用于测试传感器之后，使用激光烧蚀第二层的部分以在标签或电路上形成自动校准图案。

6. 发明申请

US20100084466A1 METHOD OF FORMING AN AUTO-CALIBRATION CIRCUIT OR LABEL 有权
标题翻译：形成自动校准电路或标签的方法
公开(公告)号：US20100084466A1
公开(公告)日：2010-04-08
申请号：US12551654
申请日：2009-09-01
申请人： Steven C. Charlton , Matthew Holzer , Mu Wu , Andrew J. Edelbrock
发明人： Steven C. Charlton , Matthew Holzer , Mu Wu , Andrew J. Edelbrock
IPC分类号： G06K7/08 , G06K7/10 , G06K19/02
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B2562/0295 , G01N33/48771 , Y10T436/2575
摘要： A method of forming and using an auto-calibration circuit or label on a test sensor includes providing a label or circuit. The label or circuit includes a first layer, a second layer and a lamination portion. The second layer is located between the first layer and the lamination portion. The first layer includes polymeric material. The second layer includes conductive material. The label or circuit is applied to the test sensor via the lamination portion. After applying the label or circuit to the test sensor, portions of the second layer are ablated using a laser to form an auto-calibration pattern on the label or circuit.
摘要翻译：在测试传感器上形成和使用自动校准电路或标签的方法包括提供标签或电路。标签或电路包括第一层，第二层和层压部分。第二层位于第一层和层压部之间。第一层包括聚合材料。第二层包括导电材料。标签或电路通过层压部分施加到测试传感器。在将标签或电路应用于测试传感器之后，使用激光烧蚀第二层的部分以在标签或电路上形成自动校准图案。

7. 发明授权

US08617367B2 Electrochemical test sensor with reduced sample volume 有权
标题翻译：电化学测试传感器，减少样品体积
公开(公告)号：US08617367B2
公开(公告)日：2013-12-31
申请号：US12226796
申请日：2007-05-03
申请人： Andrew J. Edelbrock , Steven C. Charlton
发明人： Andrew J. Edelbrock , Steven C. Charlton
IPC分类号： G01N33/487
CPC分类号： G01N27/327 , B01L3/5027 , G01N27/3272
摘要： An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer and a lid. The base provides a flow path for the test sample having on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. At least a portion of the width of the counter electrode is greater than the width of the working electrode.
摘要翻译：用于检测流体测试样品的分析物浓度的电化学测试传感器包括基底，电介质层，试剂层和盖。基座为测试样品提供了一个流动路径，该流程在其表面上具有一个反电极和一个适用于与电流检测器电连通的工作电极。电介质层形成通过其的电介质窗口。试剂层包括适于与分析物反应的酶。盖子适于与基座配合，并有助于形成具有用于将测试样品引入其上的开口的毛细管空间。对电极的宽度的至少一部分大于工作电极的宽度。

8. 发明授权

US08470604B2 Transient decay amperometry 有权
标题翻译：瞬态衰变电流分析法
公开(公告)号：US08470604B2
公开(公告)日：2013-06-25
申请号：US13210738
申请日：2011-08-16
申请人： Huan-Ping Wu , Steven C. Charlton , Amy H. Chu , Andrew J. Edelbrock , Sung-Kwon Jung , Dijia Huang
发明人： Huan-Ping Wu , Steven C. Charlton , Amy H. Chu , Andrew J. Edelbrock , Sung-Kwon Jung , Dijia Huang
IPC分类号： G01N27/333 , G01N33/66
CPC分类号： C12Q1/54 , A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B5/1495 , C12Q1/004 , G01N27/3271 , G01N27/3272
摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.
摘要翻译：生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

9. 发明申请

US20120132542A1 Methods Of Using An Electrochemical Biosensor 有权
标题翻译：电化学生物传感器的使用方法
公开(公告)号：US20120132542A1
公开(公告)日：2012-05-31
申请号：US13367801
申请日：2012-02-07
申请人： Dijia Huang , Steven C. Charlton , Suny J. George , Andrew J. Edelbrock
发明人： Dijia Huang , Steven C. Charlton , Suny J. George , Andrew J. Edelbrock
IPC分类号： G01N33/66 , G01N27/26
CPC分类号： G01N27/3272 , C12Q1/006 , G01N27/3274 , G01N27/3275 , G01N27/4163 , Y10T29/49082 , Y10T29/49099
摘要： According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.
摘要翻译：根据本发明的一个实施例，公开了一种用于检测流体测试样品中分析物浓度的电化学传感器（10）。传感器（10）包括具有高电阻部分的对电极，用于检测测试传感器是否已接收到预定量的样本。

10. 发明授权

US07919045B2 Auto-calibration label and methods of forming the same 有权
标题翻译：自动校准标签及其形成方法
公开(公告)号：US07919045B2
公开(公告)日：2011-04-05
申请号：US11918828
申请日：2006-04-18
申请人： Joseph E. Perry , Dijia Huang , Steven C. Charlton , Andrew J. Edelbrock , Russell J. Micinski
发明人： Joseph E. Perry , Dijia Huang , Steven C. Charlton , Andrew J. Edelbrock , Russell J. Micinski
IPC分类号： G01N21/00
CPC分类号： A61B5/14532 , A61B5/1486 , A61B2560/0223 , A61B2562/0295 , G01N33/48771 , Y10T436/2575
摘要： An auto-calibration circuit or label is adapted to be used with different instruments. The auto-calibration circuit comprises a first plurality of electrical connections and at least one electrical connection. The first plurality of electrical connections is utilized by the different instruments to auto-calibrate. The first plurality of electrical connections includes a first plurality of contact areas. At least one electrical connection is utilized solely by the second instrument to auto-calibrate and includes at least one contact area. This electrical connection is distinct from the first plurality of electrical connections. The first plurality of electrical connections is routed directly from each of the first plurality of contact areas to a respective first or second common connection. The at least one electrical connection is routed directly from the at least one contact area to the respective first common connection, the second common connection or a no-contact area.
摘要翻译：自动校准电路或标签适用于不同的仪器。自动校准电路包括第一多个电连接和至少一个电连接。第一组多个电气连接被不同的仪器用于自动校准。第一多个电连接包括第一多个接触区域。至少一个电连接仅由第二仪器用于自动校准并且包括至少一个接触区域。该电连接不同于第一多个电连接。第一组多个电连接件从第一多个接触区域中的每一个直接路由到相应的第一或第二公共连接。至少一个电连接从至少一个接触区域直接路由到相应的第一公共连接，第二公共连接或无接触区域。

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