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1. 发明授权

US07427489B1 Screening assay to identify modulators of the sleep/wake cycle 失效
标题翻译：筛选测定以识别睡眠/唤醒周期的调节剂
公开(公告)号：US07427489B1
公开(公告)日：2008-09-23
申请号：US10464817
申请日：2003-06-17
申请人： Steve A. Kay , John B. Hogenesch , M. Fernanda Ceriani , Satchidananda Panda
发明人： Steve A. Kay , John B. Hogenesch , M. Fernanda Ceriani , Satchidananda Panda
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/502 , G01N2500/00
摘要： Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.
摘要翻译：提供了用于鉴定调节受试者的BK通道活性并进一步调节受试者的睡眠/唤醒周期的试剂的筛选测定，或者两者的昼夜节律调节的运动活性，或者两者，以及使用这种筛选测定法鉴定的试剂。还提供了调节受试者的睡眠/觉醒周期的方法以及通过施用调节受试者的BK通道活性的试剂（例如通过如所公开的筛选测定法鉴定的试剂）来调节受试者中昼夜节律调节的运动活性的方法。

2. 发明申请

US20090142793A1 SCREENING ASSAY TO IDENTIFY MODULATORS OF THE SLEEP/WAKE CYCLE 审中-公开
标题翻译：筛选/清除周期调查器的筛选测试
公开(公告)号：US20090142793A1
公开(公告)日：2009-06-04
申请号：US12236374
申请日：2008-09-23
申请人： Steve A. Kay , John B. Hogenesch , M. Fernanda Ceriani , Satchidananda Panda
发明人： Steve A. Kay , John B. Hogenesch , M. Fernanda Ceriani , Satchidananda Panda
IPC分类号： C12Q1/02 , G01N33/68
CPC分类号： G01N33/6872 , G01N33/502 , G01N2500/00
摘要： Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.
摘要翻译：提供了用于鉴定调节受试者的BK通道活性并进一步调节受试者的睡眠/唤醒周期的试剂的筛选测定，或者两者的昼夜节律调节的运动活性，或者两者，以及使用这种筛选测定法鉴定的试剂。还提供了调节受试者的睡眠/觉醒周期的方法以及通过施用调节受试者的BK通道活性的试剂（例如通过如所公开的筛选测定法鉴定的试剂）来调节受试者中昼夜节律调节的运动活性的方法。

3. 发明授权

US5902241A Large-aperture imaging using transducer array with adaptive element pitch control 失效
标题翻译：使用具有自适应元件俯仰控制的换能器阵列的大孔径成像
公开(公告)号：US5902241A
公开(公告)日：1999-05-11
申请号：US977082
申请日：1997-11-24
申请人： Mir Said Seyed-Bolorforosh , Anne Lindsay Hall , Satchidananda Panda
发明人： Mir Said Seyed-Bolorforosh , Anne Lindsay Hall , Satchidananda Panda
IPC分类号： G01N29/24 , A61B8/00 , G01S7/52 , G01S15/89 , G10K11/34 , H04N7/18
CPC分类号： G01S7/52046 , G01S15/8909 , G10K11/341 , G01N2291/02491 , G01S7/52071
摘要： An adaptive transducer array in which the element pitch is controlled by the imaging system depending on the mode of operation. A multiplicity of transducer elements are connected to a multiplicity of beamformer channels by a multiplexing arrangement having multiple states. In one multiplexer state, successive transducer elements are respectively connected to successive beamformer channels to produce an aperture having a small element pitch equal to the distance separating the centerlines of two adjacent transducer elements. In another multiplexer state, selected transducer elements are respectively connected to successive beamformer channels to produce an aperture having an increased element pitch equal to the small pitch multiplied by a factor of two or more. The aperture is increased by connecting together pairs of adjacent elements to a respective beamformer channel or by connecting every other element to a respective beamformer channel to form a sparse array.
摘要翻译：一种自适应换能器阵列，其中元件间距由成像系统根据操作模式来控制。多个换能器元件通过具有多个状态的复用装置连接到多个波束形成器通道。在一个复用器状态中，连续的换能器元件分别连接到相继的波束形成器通道以产生具有等于两个相邻的换能器元件的中心线分开的距离的小元件间距的孔。在另一个多路复用器状态下，选择的换能器元件分别连接到相继的波束成形器通道，以产生具有等于小间距乘以因子2或更大的元件间距增加的孔。通过将相邻元件的对连接到相应的波束形成器通道或通过将每个其它元件连接到相应的波束形成器通道以形成稀疏阵列来增加孔径。

4. 发明申请

US20120264796A1 METHODS FOR MODULATING CIRCADIAN RHYTHMS 审中-公开
标题翻译：调整CIRCADIAN RHYTHMS的方法
公开(公告)号：US20120264796A1
公开(公告)日：2012-10-18
申请号：US13257745
申请日：2010-03-22
申请人： Ronald Evans , Katja A. Lamia , Reuben J. Shaw , Luciano Ditacchio , Satchidananda Panda
发明人： Ronald Evans , Katja A. Lamia , Reuben J. Shaw , Luciano Ditacchio , Satchidananda Panda
IPC分类号： A61K31/4164 , G01N33/573
CPC分类号： C12Q1/485 , A61K31/155 , A61K31/7056 , A61K38/2264 , A61K45/06 , G01N2500/04 , G01N2800/2864
摘要： This disclosure described the role of AMPK in circadian rhythms and methods of screening for agents that modulate such rhythms, compositions that are useful for modulating such rhythms and uses thereof.
摘要翻译：本公开描述了AMPK在昼夜节律中的作用以及筛选调节这种节律的药剂的方法，可用于调节这种节律的组合物及其用途。

5. 发明申请

US20050149993A1 Methods for treating circadian rhythm phase disturbances 审中-公开
标题翻译：治疗昼夜节律相紊乱的方法
公开(公告)号：US20050149993A1
公开(公告)日：2005-07-07
申请号：US10637710
申请日：2003-08-08
申请人： Satchidananda Panda , John Hogenesch , Ignacio Provincio , Steve Kay
发明人： Satchidananda Panda , John Hogenesch , Ignacio Provincio , Steve Kay
IPC分类号： A01K67/027 , C07K14/47 , C12N20060101 , C12N5/06 , C12N15/85 , G01N33/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , C07K14/4702
摘要： The present invention provides a transgenic non-human animals comprising a disruption in the melanopsin gene as well as methods for using the animals to identify agents useful for modulating circadian rhythm in animals.
摘要翻译：本发明提供了包含黑色素蛋白基因中断的转基因非人动物以及使用动物鉴定用于调节动物中昼夜节律的药剂的方法。

6. 发明授权

US6108572A Method and apparatus for harmonic imaging using multiple focal zones 有权
标题翻译：使用多个焦点区域进行谐波成像的方法和装置
公开(公告)号：US6108572A
公开(公告)日：2000-08-22
申请号：US298814
申请日：1999-04-23
申请人： Satchidananda Panda , Richard Y. Chiao
发明人： Satchidananda Panda , Richard Y. Chiao
IPC分类号： G01N29/44 , A61B8/00 , A61B8/06 , A61B8/08 , G01N29/22 , G01P5/00 , G01P5/24 , G01S20060101 , G01S7/52 , G01S15/89
CPC分类号： G01S7/52038 , A61B8/06 , A61B8/13 , A61B8/481 , G01P5/001 , G01P5/244 , G01S7/52039 , G01S15/8959 , G01S15/8981 , G01S7/52046
摘要： A method and apparatus for performing harmonic imaging. Each transmit focal zone in the near-field is interrogated by two or more transmit firings of different phase, while each transmit focal zone in the far-field is interrogated by a single transmit firing. On receive, the respective near-field vectors are summed, thereby substantially canceling the fundamental signal components while isolating the (sub)-harmonic signal components. In the far-field, the single transmit firing has a fundamental frequency .function..sub.0. A filter isolates the signal component having a passband centered at a (sub)harmonic frequency, e.g., 2.function..sub.0. The near-field and far-field receive vectors at each scan angle are then stitched together to form a composite vector.
摘要翻译：一种执行谐波成像的方法和装置。近场中的每个发射聚焦区通过两个或更多个不同相位的发射发射进行询问，而远场中的每个发射聚焦区由单个发射发射询问。在接收时，相应的近场矢量相加，从而基本上消除基本信号分量，同时隔离（次） - 和谐信号分量。在远场中，单个发射发射具有基频f0。滤波器将具有以（亚）谐波频率为中心的通带的信号分量隔离，例如2f0。然后将每个扫描角度的近场和远场接收矢量缝合在一起以形成复合矢量。

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