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1. 发明授权

US07329225B2 Methods, devices, systems and computer program products for oscillating shafts using real time 3D ultrasound 失效
标题翻译：使用实时三维超声的摆动轴的方法，装置，系统和计算机程序产品
公开(公告)号：US07329225B2
公开(公告)日：2008-02-12
申请号：US10777441
申请日：2004-02-12
申请人： Stephen W. Smith , Matthew Fronheiser , Rebecca Booi , Patrick D. Wolf
发明人： Stephen W. Smith , Matthew Fronheiser , Rebecca Booi , Patrick D. Wolf
IPC分类号： A61B8/00 , A61B8/14 , A61B19/00
CPC分类号： A61B8/12 , A61B8/4461 , Y10S128/916
摘要： An oscillating shaft is scanned to provide images including the oscillating shaft in vivo in real-time with a real-time three-dimensional (3D) ultrasound scanner. An interventional device can be guided in vivo using an ultrasound scanner and includes a sheath having a bore therethrough from a proximal portion to a spaced-apart distal portion. A shaft has a proximal portion and a spaced-apart distal portion and is configured for insertion into the bore of the sheath. A vibrator is coupled to the proximal portion of the shaft and is configured to cause the distal portion of the shaft to oscillate at a shaft frequency. An isolator is coupled to the proximal portion of the sheath and to the vibrator, wherein the isolator is configured to reduce damping of an oscillation of the shaft by the sheath.
摘要翻译：通过实时三维（3D）超声扫描仪扫描振荡轴以实时提供包括摆动轴在内的图像。可以使用超声波扫描器在体内引导介入装置，并且包括具有从近端部分到间隔开的远端部分穿过其中的孔的护套。轴具有近端部分和间隔开的远侧部分，并且构造成用于插入护套的孔中。振动器联接到轴的近端部分并且被配置为使得轴的远端部分以轴的频率摆动。隔离器耦合到护套的近端部分和耦合到振动器，其中隔离器构造成减小由护套引起的轴的振荡的阻尼。

2. 发明授权

US06754525B1 Reduction of defibrillation requirements through active pre-shock pacing with depolarization verification 失效
标题翻译：通过有效的预激动起搏降低除颤需求，并进行去极化验证
公开(公告)号：US06754525B1
公开(公告)日：2004-06-22
申请号：US10033740
申请日：2001-12-27
申请人： Rose Anne Province , Patrick D. Wolf
发明人： Rose Anne Province , Patrick D. Wolf
IPC分类号： A61N1362
CPC分类号： A61N1/3962 , A61N1/3925
摘要： An implantable cardiac stimulation device is equipped with a sensor to obtain information indicative of tissue depolarization. The device's processor is programmed to analyze the information to determine a suitable pacing pulse regimen and/or to trigger a cardioversion level stimulus.
摘要翻译：可植入心脏刺激装置配备有传感器以获得指示组织去极化的信息。设备的处理器被编程为分析信息以确定合适的起搏脉冲方案和/或触发心脏复律水平刺激。

3. 发明授权

US07613509B2 Systems, methods, and computer program products for transmitting neural signal information 有权
标题翻译：用于传输神经信号信息的系统，方法和计算机程序产品
公开(公告)号：US07613509B2
公开(公告)日：2009-11-03
申请号：US10998385
申请日：2004-11-29
申请人： Patrick D. Wolf , Iyad Obeid
发明人： Patrick D. Wolf , Iyad Obeid
IPC分类号： A61B5/0484
CPC分类号： A61N1/37252 , A61B5/0002 , A61B5/0031 , A61B5/04001 , A61B5/726
摘要： Systems, Methods, and Computer Program Products for Transmitting Neural Signal Information. Systems, method, and computer program products are provided for neural signal transmission. A system according to one embodiment can include a signal receiver operable to receive a neural signal comprising an action potential. The system can also include an action potential detector operable to communicate with the signal receiver and detect when the action potential occurs. In addition, the system can include a transmitter in communication with the action potential detector and operable to transmit an information signal indicating the time when the action potential occurs and, in addition, can transmit samples associated with a detected action potential.
摘要翻译：用于传输神经信号信息的系统，方法和计算机程序产品。提供系统，方法和计算机程序产品用于神经信号传输。根据一个实施例的系统可以包括可操作以接收包括动作电位的神经信号的信号接收器。该系统还可以包括可操作以与信号接收器通信并检测何时发生动作电位的动作电位检测器。此外，该系统可以包括与动作电位检测器通信的发射机，并且可操作以发送指示动作电位发生时间的信息信号，并且另外可传送与检测到的动作电位相关联的样本。

4. 发明授权

US6154672A Method and apparatus for improving the probability of success of defibrillation shocks 有权
公开(公告)号：US6154672A
公开(公告)日：2000-11-28
申请号：US212033
申请日：1998-12-14
申请人： Rajesh Pendekanti , Patrick D. Wolf
发明人： Rajesh Pendekanti , Patrick D. Wolf
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： A system and method for providing improved defibrillation thresholds. In one embodiment of the invention, following the detection of fibrillation, a pacing pulse train is applied to a pacing electrode placed in the low gradient region of the left ventricular freewall to capture the tissue. In one embodiment, a pacing rate of about 80-95% of the VF cycle length is applied to achieve capture. Once capture of the tissue of the critical region is achieved, a high energy shock is delivered when the captured tissue is in the process of activation. The defibrillation shock is delivered at the end of the pacing train, with a coupling interval of either about 80-95% of the pacing rate (i.e., about 64-90% of the VF cycle length), or, alternatively, about 5-20% of the pacing rate (i.e., about 4-19% of the VF cycle length). In an alternative embodiment of the invention, a sensing electrode array is placed in the low gradient region of the left ventricular freewall to monitor such time as a substantial percentage of the tissue of the low gradient region is in the process of activation, i.e., on the downstroke of the respective EGMs, and then delivering the defibrillation shock at that instant.

5. 发明授权

US07187968B2 Apparatus for acquiring and transmitting neural signals and related methods 失效
标题翻译：用于获取和发送神经信号的装置及相关方法
公开(公告)号：US07187968B2
公开(公告)日：2007-03-06
申请号：US10692235
申请日：2003-10-23
申请人： Patrick D. Wolf , Miguel A. L. Nicolelis , James C. Morizio , John K. Chapin
发明人： Patrick D. Wolf , Miguel A. L. Nicolelis , James C. Morizio , John K. Chapin
IPC分类号： A61B5/04
CPC分类号： A61N1/08
摘要： Neurochip for Neuroprosthetic Control. According to one embodiment, a neural spike detection system is provided. The neural spike detection system can include a signal receiver operable to receive a plurality of neural signals including neural spikes. The system can also include a neural spike detector adapted to communicate with the signal receiver and detect neural spikes in the plurality of neural signals. Further, the system can include a transmitter connected to the neural spike detector and operable to transmit an information signal when a neural spike is detected.
摘要翻译：神经芯片神经元控制。根据一个实施例，提供了神经尖峰检测系统。神经尖峰检测系统可以包括可操作以接收包括神经尖峰的多个神经信号的信号接收器。该系统还可以包括适于与信号接收器通信并检测多个神经信号中的神经尖峰的神经尖峰检测器。此外，系统可以包括连接到神经尖峰检测器的发射器，并且可操作以在检测到神经尖峰时发送信息信号。

6. 发明授权

US6085116A Atrial defibrillation methods and apparatus 有权
标题翻译：心房除颤方法及装置
公开(公告)号：US6085116A
公开(公告)日：2000-07-04
申请号：US130990
申请日：1998-08-07
申请人： Rajesh Pendekanti , Patrick D. Wolf
发明人： Rajesh Pendekanti , Patrick D. Wolf
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3962 , A61N1/395
摘要： Methods and apparatus for achieving atrial defibrillation in a heart. Atrial pacing is first conducted from a single pacing site so as to have the desired effect of maximizing the extent of phase-locked area of atrial tissue. Next, an ADF shock is introduced, if still needed, to achieve atrial defibrillation. ADFT energy requirements have been shown to be dramatically reduced on account of using a pacing rate set proportionally to the atrial fibrillation cycle length such that large areas of atrial tissues are phase-locked, and consequently atrial defibrillation can be effected in the patient with greatly reduced energy requirements for ADFTs.
摘要翻译：在心脏中实现心房除颤的方法和装置。首先从单个起搏部位进行心房起搏，以达到最大限度地提高心房组织锁相面积的效果。接下来，如果仍然需要，引入ADF休克来实现心房除颤。由于使用与心房颤动周期长度成比例地设定的起搏速率，使得大面积的心房组织是锁相的，因此ADFT能量需求被显着降低，因此可以大大减少患者的心房除颤 ADFT的能源需求。

7. 发明授权

US6081746A Atrial defibrillation methods and apparatus 有权
标题翻译：心房除颤方法及装置
公开(公告)号：US6081746A
公开(公告)日：2000-06-27
申请号：US130748
申请日：1998-08-07
申请人： Rajesh Pendekanti , Patrick D. Wolf
发明人： Rajesh Pendekanti , Patrick D. Wolf
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3962 , A61N1/395
摘要： Methods and apparatus for achieving atrial defibrillation in a heart. Atrial pacing is first conducted from multiple pacing sites in a synchronous manner so as to have the desired effect of maximizing the extent of phase-locked area of atrial tissue. Next, an ADF shock is introduced, if still needed, to achieve atrial defibrillation. ADFT energy requirements have been shown to be dramatically reduced on account of using pacing rates set proportionally to the sensed atrial fibrillation cycle length(s) such that large areas of atrial tissues are phase-locked, and consequently atrial defibrillation can be effected in the patient with greatly reduced energy requirements for ADFTs.
摘要翻译：在心脏中实现心房除颤的方法和装置。首先以同步方式从多个起搏部位进行心房起搏，以达到最大限度地提高心房组织锁相面积的效果。接下来，如果仍然需要，引入ADF休克来实现心房除颤。由于使用与感测到的心房颤动循环长度成比例地设定的起搏速率，使得大面积的心房组织被锁定，因此可以在患者中进行心房除颤，所以已显示ADFT能量需求显着降低大大减少了ADFT的能源需求。

8. 发明授权

US07299089B2 Methods, systems, and computer program products for neural channel selection in a multi-channel system 有权
标题翻译：用于多通道系统神经通道选择的方法，系统和计算机程序产品
公开(公告)号：US07299089B2
公开(公告)日：2007-11-20
申请号：US10922752
申请日：2004-08-20
申请人： Patrick D. Wolf , Deborah S. Won
发明人： Patrick D. Wolf , Deborah S. Won
IPC分类号： A61F2/70 , A61B5/0476
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/0476 , A61F2/50 , A61F2/72 , G06F3/015
摘要： Methods, systems, and computer program products for transmitting neural signal information. Methods, systems, and computer programs products are disclosed for neural channel selection in a multi-channel system. A method according to one embodiment can include a step for receiving a plurality of neural signals on a first plurality of channels. The method can also include a step for calculating criterion variable value for the neural signal on each of the channels. In addition, the method can include a step for ranking the channels by the criterion variable value. The method can also include a step for calculating mutual information between a measured output and a total population activity for the first plurality of channels. Further, the method can include a step for determining a second plurality of channels that encodes a predetermined amount of the mutual information.
摘要翻译：用于传输神经信号信息的方法，系统和计算机程序产品。公开了用于多通道系统中神经通道选择的方法，系统和计算机程序产品。根据一个实施例的方法可以包括在第一多个信道上接收多个神经信号的步骤。该方法还可以包括用于在每个通道上计算神经信号的标准变量值的步骤。此外，该方法可以包括通过标准变量值对信道进行排序的步骤。该方法还可以包括用于计算第一多个信道的测量输出和总总体活动之间的相互信息的步骤。此外，该方法可以包括用于确定编码预定量的互信息的第二多个信道的步骤。

9. 发明授权

US06415179B1 Method and apparatus for improving the probability of success of defibrillation shocks 失效
标题翻译：提高除颤休克成功概率的方法和装置
公开(公告)号：US06415179B1
公开(公告)日：2002-07-02
申请号：US09684693
申请日：2000-10-04
申请人： Rajesh Pendekanti , Patrick D. Wolf
发明人： Rajesh Pendekanti , Patrick D. Wolf
IPC分类号： A61N139
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： A system and method for providing improved defibrillation thresholds. In one embodiment of the invention, following the detection of fibrillation, a pacing pulse train is applied to a pacing electrode placed in the low gradient region of the left ventricular freewall to capture the tissue. In one embodiment, a pacing rate of about 80-95% of the VF cycle length is applied to achieve capture. Once capture of the tissue of the critical region is achieved, a high energy shock is delivered when the captured tissue is in the process of activation. The defibrillation shock is delivered at the end of the pacing train, with a coupling interval of either about 80-95% of the pacing rate (i.e., about 64-90% of the VF cycle length), or, alternatively, about 5-20% of the pacing rate (i.e., about 4-19% of the VF cycle length). In an alternative embodiment of the invention, a sensing electrode array is placed in the low gradient region of the left ventricular freewall to monitor such time as a substantial percentage of the tissue of the low gradient region is in the process of activation, i.e., on the downstroke of the respective EGMs, and then delivering the defibrillation shock at that instant.
摘要翻译：一种用于提供改善的除颤阈值的系统和方法。在本发明的一个实施例中，在原纤维化检测之后，将起搏脉冲序列施加到放置在左心室冷壁的低梯度区域中的起搏电极以捕获组织。在一个实施例中，施加大约80-95％的VF循环长度的起搏速率以实现捕获。一旦实现了关键区域的组织的捕获，当被捕获的组织处于激活过程中时，传递高能量冲击。除颤休克在起搏列的末端递送，其起搏速率的约80-95％的耦合间隔（即，VF循环长度的约64-90％），或者替代地，约5- 20％的起搏率（即VF周期长度的约4-19％）。在本发明的替代实施例中，感测电极阵列被放置在左心室自由壁的低梯度区域中以监视这样的时间，因为低梯度区域的组织的相当大的百分比处于激活过程中，即，在相应的EGMs的中风，然后在那个时刻传递除颤电击。

10. 发明授权

US06292691B1 Atrial defibrillation methods and apparatus 有权
标题翻译：心房除颤方法及装置
公开(公告)号：US06292691B1
公开(公告)日：2001-09-18
申请号：US09418043
申请日：1999-10-13
申请人： Rajesh Pendekanti , Patrick D. Wolf
发明人： Rajesh Pendekanti , Patrick D. Wolf
IPC分类号： A61N139
CPC分类号： A61N1/3962 , A61N1/395
摘要： Methods and apparatus for achieving atrial defibrillation in a heart. Atrial pacing is first conducted from multiple pacing sites in an independent (asynchronous) manner so as to have the desired effect of maximizing the extent of phase-locked area of atrial tissue. Next, an ADF shock is introduced, if still needed, to achieve atrial defibrillation. ADFT energy requirements have been shown to be dramatically reduced on account of using pacing rates set proportionally to the sensed local atrial fibrillation cycle lengths such that large areas of atrial tissues are phase-locked, and consequently atrial defibrillation can be effected in the patient with greatly reduced energy requirements for ADFTs.
摘要翻译：在心脏中实现心房除颤的方法和装置。首先，以独立（异步）方式从多个起搏部位进行心房起搏，以达到最大限度地提高心房组织锁相面积的效果。接下来，如果仍然需要，引入ADF休克来实现心房除颤。由于使用与感测到的局部心房颤动循环长度成比例地设定的起搏速率，使得大面积的心房组织是锁相的，因此ADFT能量需求被显着降低，因此可以在患者中进行大量的心房除颤减少ADFT的能源需求。

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