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1. 发明申请

US20080058252A1 Use of C5A receptor antagonist in the treatment of fibrosis 失效
标题翻译：使用C5A受体拮抗剂治疗纤维化
公开(公告)号：US20080058252A1
公开(公告)日：2008-03-06
申请号：US11807651
申请日：2007-05-30
申请人： Stephen Taylor , Ian Shiels , Lindsay Brown , Michael Whitehouse
发明人： Stephen Taylor , Ian Shiels , Lindsay Brown , Michael Whitehouse
IPC分类号： A61K38/12 , A61K38/02 , A61P17/02 , A61P3/10 , A61P43/00 , A61P9/12
CPC分类号： A61K38/12
摘要： This invention relates to the use of an antagonist of a G protein-coupled receptor in the prevention and/or treatment of fibrosis, such as the treatment of fibrosis associated with myocardial infarction or diabetes or certain pulmonary conditions. In a preferred embodiment, the antagonist is a C5a receptor antagonist, more preferably a cyclic peptide antagonist of the C5a receptor. In particular, the invention provides a method of prevention, treatment or alleviation of a fibrotic condition, comprising the step of administering an effective amount of an antagonist of a G protein-coupled receptor to a subject in need of such treatment.
摘要翻译：本发明涉及G蛋白偶联受体的拮抗剂在预防和/或治疗纤维化中的用途，例如治疗与心肌梗塞或糖尿病或某些肺部病症相关的纤维化。在优选的实施方案中，拮抗剂是C5a受体拮抗剂，更优选C5a受体的环肽拮抗剂。特别地，本发明提供了预防，治疗或缓解纤维化病症的方法，其包括向需要这种治疗的受试者施用有效量的G蛋白偶联受体拮抗剂的步骤。

2. 发明申请

US20070054841A1 Method of treatment of systemic injury secondary to burns 审中-公开
标题翻译：治疗烧伤继发的全身性损伤的方法
公开(公告)号：US20070054841A1
公开(公告)日：2007-03-08
申请号：US10557498
申请日：2004-05-26
申请人： Ian Shiels , Stephen Taylor , Shelli Stocks
发明人： Ian Shiels , Stephen Taylor , Shelli Stocks
IPC分类号： A61K38/12
CPC分类号： A61K38/12
摘要： The invention relates to the prevention or treatment of a systemic injury which is secondary to a burn, such as dysfunction or failure of an organ secondary to a burn, with an antagonist of a C5a receptor. In one embodiment the invention relates to the prevention or treatment of dysfunction or failure of the lung, kidney, bowel and/or liver which is secondary to a burn.
摘要翻译：本发明涉及预防或治疗伴有C5a受体拮抗剂的烧伤继发性的全身性损伤，例如继发于烧伤的器官的功能障碍或衰竭。在一个实施方案中，本发明涉及预防或治疗继发于烧伤的肺，肾，肠和/或肝的功能障碍或失败。

3. 发明申请

US20070021329A1 Treatment of hypersensitivity conditions 审中-公开
标题翻译：治疗过敏症状
公开(公告)号：US20070021329A1
公开(公告)日：2007-01-25
申请号：US10531565
申请日：2003-10-16
申请人： Ian Shiels , Stephen Taylor
发明人： Ian Shiels , Stephen Taylor
IPC分类号： A61K38/12
CPC分类号： A61K38/12
摘要： This invention relates to methods of treatment of hypersensitivity conditions such as asthma and other allergic conditions, and especially to treatment of these conditions with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the methods of the invention are disclosed.
摘要翻译：本发明涉及治疗哮喘和其它过敏性疾病的超敏反应病症的方法，尤其涉及具有调节G蛋白偶联受体活性的能力的环状肽和拟肽化合物治疗这些病症的方法。化合物优选作为C 5 a受体的拮抗剂，并且对多形核白细胞和巨噬细胞上的C 5受体有活性。公开了用于本发明方法的特别优选的化合物。

4. 发明授权

US10899280B2 Portable workstation for a vehicle 有权
公开(公告)号：US10899280B2
公开(公告)日：2021-01-26
申请号：US16930802
申请日：2020-07-16
申请人： Stephen Taylor
发明人： Stephen Taylor
IPC分类号： B60R7/04 , B60N3/10
摘要： A portable workstation for use in a front passenger seat in an interior of a vehicle includes a body member having a plurality of walls that, together, form a box-shape configuration defining a closed bottom, an open top, and an interior area. The body member includes side walls having lower edges that are angled and increasingly offset from the bottom wall so as to be complementary to a bottom of the front passenger seat. A front wall extends downwardly from the bottom wall and in front of the front passenger seat, whereby to grip the front passenger seat. Walls extend upwardly to form compartments for receiving an article. The portable workstation includes a module attachment assembly having a plurality of upstanding side walls and a top surface defining multiple receiver slots. The workstation includes multiple accessory modules each having at least one boss removably received in a receiver slot.

5. 发明申请

US20200346584A1 Portable Workstation for a Vehicle 审中-公开
公开(公告)号：US20200346584A1
公开(公告)日：2020-11-05
申请号：US16930802
申请日：2020-07-16
申请人： Stephen Taylor
发明人： Stephen Taylor
IPC分类号： B60R7/04 , B60N3/10
摘要： A portable workstation for use in a front passenger seat in an interior of a vehicle includes a body member having a plurality of walls that, together, form a box-shape configuration defining a closed bottom, an open top, and an interior area. The body member includes side walls having lower edges that are angled and increasingly offset from the bottom wall so as to be complementary to a bottom of the front passenger seat. A front wall extends downwardly from the bottom wall and in front of the front passenger seat, whereby to grip the front passenger seat. Walls extend upwardly to form compartments for receiving an article. The portable workstation includes a module attachment assembly having a plurality of upstanding side walls and a top surface defining multiple receiver slots. The workstation includes multiple accessory modules each having at least one boss removably received in a receiver slot.

6. 发明申请

US20150226704A1 CLEANING OF CORONA DISCHARGE ION SOURCE 有权
标题翻译： CORONA放电源的清洁
公开(公告)号：US20150226704A1
公开(公告)日：2015-08-13
申请号：US14430181
申请日：2013-09-20
申请人： Matt EASTON , Stephen TAYLOR , Bruce GRANT , Henry McIntyre , Alastair CLARK
发明人： Matt Easton , Stephen Taylor , Bruce Grant , Henry McIntyre , Alastair Clark
IPC分类号： G01N27/62 , H01J49/16
CPC分类号： G01N27/622 , H01J27/022 , H01J49/16 , H01J49/168
摘要： Systems and techniques for cleaning a corona discharge point are described. A controller (150) can be operatively coupled to a corona discharge point (108) to control the operation of the corona discharge point (1089. The controller (150) and the corona discharge point (108) can be included with, for example, an ion mobility spectrometry (IMS) system (100). The controller (150) can be used to operate the corona discharge point (108) at an operating voltage for a first time interval, with or without an additional higher pulse voltage, to produce a corona discharge, and to operate the corona discharge point (108) at a cleaning voltage greater than the operating voltage for a second time interval subsequent to the first time interval to produce a corona discharge. The effectiveness of the corona discharge point (108) can be monitored by, for instance, measuring a voltage necessary to produce a corona discharge at the corona discharge point (108), measuring a current produced at the corona discharge point (108) from a corona discharge, and so forth.
摘要翻译：描述了用于清洁电晕放电点的系统和技术。控制器（150）可以可操作地耦合到电晕放电点（108）以控制电晕放电点（1089）的操作。控制器（150）和电晕放电点（108）可以包括在例如离子迁移谱（IMS）系统（100），控制器（150）可用于在第一时间间隔的操作电压下操作电晕放电点（108），具有或不具有额外的较高脉冲电压，以产生电晕放电，并且在第一时间间隔之后的第二时间间隔以大于工作电压的清洁电压操作电晕放电点（108）以产生电晕放电，电晕放电点（108）的有效性可以通过例如测量在电晕放电点（108）处产生电晕放电所需的电压来测量电晕放电点（108）产生的电流，从而进行电晕放电等。

7. 发明申请

US20050226401A1 Method and apparatus for cashless transactions via a telecommunications network 有权
标题翻译：通过电信网络进行无现金交易的方法和装置
公开(公告)号：US20050226401A1
公开(公告)日：2005-10-13
申请号：US10506919
申请日：2003-03-03
申请人： Stephen Taylor , John Cavanagh , Adrian Williams , David Harrison
发明人： Stephen Taylor , John Cavanagh , Adrian Williams , David Harrison
IPC分类号： G07G1/12 , G06Q20/00 , G07G1/14 , H04M15/00
CPC分类号： G06Q20/04 , G06Q20/20 , G06Q20/32 , G06Q20/3223 , H04M15/90 , H04M2215/016
摘要： A method of using a telecommunications network cashless transaction service is provided, in which a user accesses the service using a network access instrument, such as a mobile phone which produces a signal. The signal is forwarded to an interface device of the network, which extracts service and user identity data therefrom, and passes the data to a processing unit for the service of the network. The service processing unit processes the data, instructs the interface device to forward the access instrument signal to an input output device of the network, and instructs the input output device to request transaction details from the user. The details are sent to the input output device, which passes them to the service processing unit which processes the details and decides whether or not the transaction can proceed, causes output of a signal conveying acceptance or rejection of the transaction to the user, and, if the transaction can proceed, arranges for the transaction to be carried out. The telecommunications network may comprise a fixed network, the interface device may be a service switching point, the service processing unit may be a service control point, and the input output device may be an interactive/intelligent voice recognition unit.
摘要翻译：提供了一种使用电信网络无现金交易服务的方法，其中用户使用诸如产生信号的移动电话的网络接入仪器来访问服务。信号被转发到网络的接口设备，其从中提取服务和用户身份数据，并将该数据传送到用于网络服务的处理单元。服务处理单元对数据进行处理，指示接口装置将访问乐器信号转发到网络的输入输出装置，并且指示输入输出装置从用户请求交易细节。详细信息被发送到输入输出设备，其将它们传递到处理细节的服务处理单元，并且决定交易是否可以继续，导致向用户传达交易的接受或拒绝的信号，如果交易可以进行，则安排交易进行。电信网络可以包括固定网络，接口设备可以是服务交换点，服务处理单元可以是服务控制点，并且输入输出设备可以是交互式/智能语音识别单元。

8. 发明授权

US5048210A Device for illuminating residence information 失效
标题翻译：照明居住信息的设备
公开(公告)号：US5048210A
公开(公告)日：1991-09-17
申请号：US475678
申请日：1990-02-05
申请人： Stephen Taylor , Philip Ross
发明人： Stephen Taylor , Philip Ross
IPC分类号： G09F13/04
CPC分类号： G09F13/04 , G09F2013/045 , G09F2013/0454 , Y10T403/4685
摘要： A device for illuminating residence information. More specifically, it relates to a device which can be quickly and easily installed on a new or existing vertical lamppost and connected to a power supply for illuminating the resident's name and/or street number.
摘要翻译：用于照明居住信息的设备。更具体地说，本发明涉及一种可以快速方便地安装在新的或现有的垂直灯柱上并连接到用于照亮居民姓名和/或街道号码的电源的设备。

9. 发明授权

US09448203B2 Cleaning of corona discharge ion source 有权
标题翻译：清洁电晕放电离子源
公开(公告)号：US09448203B2
公开(公告)日：2016-09-20
申请号：US14430181
申请日：2013-09-20
申请人： Matt Easton , Stephen Taylor , Bruce Grant , Henry McIntyre , Alastair Clark
发明人： Matt Easton , Stephen Taylor , Bruce Grant , Henry McIntyre , Alastair Clark
IPC分类号： H01J49/16 , G01N27/62 , H01J27/02
CPC分类号： G01N27/622 , H01J27/022 , H01J49/16 , H01J49/168
摘要： Systems and techniques for cleaning a corona discharge point are described. A controller (150) can be operatively coupled to a corona discharge point (108) to control the operation of the corona discharge point (1089. The controller (150) and the corona discharge point (108) can be included with, for example, an ion mobility spectrometry (IMS) system (100). The controller (150) can be used to operate the corona discharge point (108) at an operating voltage for a first time interval, with or without an additional higher pulse voltage, to produce a corona discharge, and to operate the corona discharge point (108) at a cleaning voltage greater than the operating voltage for a second time interval subsequent to the first time interval to produce a corona discharge. The effectiveness of the corona discharge point (108) can be monitored by, for instance, measuring a voltage necessary to produce a corona discharge at the corona discharge point (108), measuring a current produced at the corona discharge point (108) from a corona discharge, and so forth.
摘要翻译：描述了用于清洁电晕放电点的系统和技术。控制器（150）可以可操作地耦合到电晕放电点（108）以控制电晕放电点（1089）的操作。控制器（150）和电晕放电点（108）可以包括在例如离子迁移谱（IMS）系统（100），控制器（150）可用于在第一时间间隔的操作电压下操作电晕放电点（108），具有或不具有额外的较高脉冲电压，以产生电晕放电，并且在第一时间间隔之后的第二时间间隔以大于工作电压的清洁电压操作电晕放电点（108）以产生电晕放电，电晕放电点（108）的有效性可以通过例如测量在电晕放电点（108）处产生电晕放电所需的电压来测量电晕放电点（108）产生的电流，从而进行电晕放电等。

10. 发明申请

US20150300927A1 SAMPLE PROBE INLET FLOW SYSTEM 审中-公开
标题翻译：样品探头入口流量系统
公开(公告)号：US20150300927A1
公开(公告)日：2015-10-22
申请号：US14430184
申请日：2013-09-20
申请人： Matt EASTON , Stephen TAYLOR , SMITHS DETECTION-WATTORD LIMITED
发明人： Matt Easton , Stephen Taylor
IPC分类号： G01N1/22 , G01N27/62 , G01N1/24
CPC分类号： G01N1/2273 , G01N1/24 , G01N27/622 , G01N2001/2285 , G01N2001/245
摘要： An apparatus includes a sample receiving port and an inlet assembly configured to be positioned adjacent to the sample receiving port. The inlet assembly defines a volume for receiving a sample and includes a gap that defines an extraction port. The extraction port is configured to extract one fluid flow to facilitate another fluid flow toward the sample receiving port. The extraction port can be configured as an annular flow port around the sample receiving port. In some instances, the apparatus also includes a curtain port positioned apart from the sample receiving port and the extraction port. The curtain port can be used to guide fluid away from interior surfaces of the inlet assembly and toward the sample receiving port, and/or to provide an environment of controlled air, and/or to isolate the sample receiving port from external sources of contamination.
摘要翻译：一种装置包括样品接收端口和入口组件，该入口组件被配置为邻近样品接收端口定位。入口组件限定用于接收样品的体积并且包括限定提取端口的间隙。提取端口被配置为提取一个流体流以便于朝向样品接收端口的另一流体流动。提取口可以被配置为围绕样品接收端口的环形流动端口。在一些情况下，该装置还包括一个与样品接收口和提取口分开定位的窗口。帘式端口可以用于将流体引导离开入口组件的内表面并朝向样品接收端口，和/或提供受控空气的环境和/或将样品接收端口与外部污染源隔离。

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