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1. 发明授权

US06579718B1 Carbazolylvinyl dye protein stains 有权
标题翻译：卡博基乙烯基染料蛋白污渍
公开(公告)号：US06579718B1
公开(公告)日：2003-06-17
申请号：US09632927
申请日：2000-08-04
申请人： Stephen T. Yue , Thomas H. Steinberg , Wayne F. Patton , Ching-Ying Cheung , Richard P. Haugland
发明人： Stephen T. Yue , Thomas H. Steinberg , Wayne F. Patton , Ching-Ying Cheung , Richard P. Haugland
IPC分类号： G01N3348
CPC分类号： C07D401/06 , C07D209/08 , C07D209/86 , C07D213/20 , C07D215/10 , C07D277/64 , C07D417/06 , C09B23/105 , G01N33/6809 , Y10T436/25125 , Y10T436/25375
摘要： The present invention describes a variety of substituted and unsubstituted carbazolylvinyl dyes and their use for detecting and quantifying poly(amino acids), including peptides, polypeptides and proteins. The labeled proteins or peptides are highly colored, but are also detected by their strong fluorescence enhancement. Poly(amino acids) are detected in solution, in electrophoretic gels, and on solid supports, including blots and dipsticks. The present method of staining is highly sensitive, extremely facile, and relatively non-selective and can be accomplished without the use of organic solvent additives.
摘要翻译：本发明描述了各种取代和未取代的咔唑基乙烯基染料及其用于检测和定量聚（氨基酸）的用途，包括肽，多肽和蛋白质。标记的蛋白质或肽是高度着色的，但也通过其强荧光增强来检测。聚（氨基酸）在溶液中，电泳凝胶和固体支持物上检测，包括印迹和浸渍。本发明的染色方法是高度敏感的，非常容易的和相对非选择性的，并且可以在不使用有机溶剂添加剂的情况下完成。

2. 发明授权

US07816527B2 Quinazoline-containing kits for labeling aldehyde or ketone moieties 有权
标题翻译：用于标记醛或酮部分的含喹唑啉试剂盒
公开(公告)号：US07816527B2
公开(公告)日：2010-10-19
申请号：US11182122
申请日：2005-07-15
申请人： Richard P. Haugland , Thomas H. Steinberg , Wayne F. Patton , Zhenjun Diwu
发明人： Richard P. Haugland , Thomas H. Steinberg , Wayne F. Patton , Zhenjun Diwu
IPC分类号： C07D239/72
CPC分类号： C07D265/22 , C07D239/91 , Y10T436/143333 , Y10T436/200833
摘要： Kits including novel fluorescent derivitization reagents for labeling an aldehyde- and/or ketone-containing target substance in a sample are described. In one embodiment kits are provided the novel fluorescent derivitization reagents of which have the following formula: wherein Q is carbonyl, thiocarbonyl, or sulfonyl, and R5 is -L-Z; L is arylene, or a C1-6 perfluoroalkylene; Z is a carbonyl hydrazide, hydrazide, sulfonyl hydrazide, or a thiocarbonyl hydrazide; R11-R14 are independently H, C1-16 alkyl, C1-6 alkylamino, amino, or halogen; and R21-R24 are independently H, C 1-6 alkyl, C 1-6 alkoxy, C1-6 perfluoroalkyl, C1-6 alkylamino, di(C2-12-alkyl)amino, amino, carboxy, cyano, halogen, hydroxy, nitro, phenyl, sulfo, or -L-Z. The kits and reagents described are particularly useful for labeling glycoproteins or glycopeptides, nucleic acids, and lipopolysaccharides in electrophoresis gels.
摘要翻译：描述了包括用于标记样品中含醛和/或酮的目标物质的新型荧光衍生试剂的试剂盒。在一个实施方案中提供试剂盒，其新型荧光衍生试剂具有下式：其中Q为羰基，硫代羰基或磺酰基，R5为-L-Z; L是亚芳基或C1-6全氟亚烷基; Z是羰基酰肼，酰肼，磺酰肼或硫代羰基酰肼; R11-R14独立地为H，C1-16烷基，C1-6烷基氨基，氨基或卤素; R 21 -R 24独立地为H，C 1-6烷基，C 1-6烷氧基，C 1-6全氟烷基，C 1-6烷基氨基，二（C 2-12 - 烷基）氨基，氨基，羧基，氰基，卤素，羟基，硝基，苯基，磺基或-LZ。所述的试剂盒和试剂特别可用于在电泳凝胶中标记糖蛋白或糖肽，核酸和脂多糖。

3. 发明授权

US06967251B2 Reagents for labeling biomolecules having aldehyde or ketone moieties 有权
标题翻译：用于标记具有醛或酮部分的生物分子的试剂
公开(公告)号：US06967251B2
公开(公告)日：2005-11-22
申请号：US09970215
申请日：2001-10-02
申请人： Richard P. Haugland , Thomas H. Steinberg , Wayne F. Patton , Zhenjun Diwu
发明人： Richard P. Haugland , Thomas H. Steinberg , Wayne F. Patton , Zhenjun Diwu
IPC分类号： G01N33/532 , C07D239/91 , C07D239/94 , C07D249/08 , C07D263/60 , C07D265/22 , C07D277/66 , C07D401/04 , G01N33/58 , C12Q1/68 , G01N1/30
CPC分类号： C07D265/22 , C07D239/91 , Y10T436/143333 , Y10T436/200833
摘要： Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. In one embodiment is provided reagents that have the following formula: wherein Q is carbonyl, thiocarbonyl, or sulfonyl, and R5 is -L-Z; L is arylene, or a C1-6 perfluoroalkylene, or a single covalent bond; Z is a carbonyl hydrazide, hydrazide, sulfonyl hydrazide, or a thiocarbonyl hydrazide; R11-R14 are independently H, C1-6 alkyl, C1-6 alkoxy, C1-6 perfluoroalkyl, C1-6 alklyamino, di(C2-12alkyl)amino, amino, carboxy, cyano, halogen, hydroxy, nitro, phenyl, or sulfo; and R21-R24 are independently H, C1-6 alkyl, C1-6 alkoxy, C1-6 perfluoroalkyl, C1-6 alklyamino, di(C2-12-alkyl)amino, amino, carboxy, cyano, halogen, hydroxy, nitro, phenyl, sulfo, or -L-Z. The method of treating a sample with the derivativization reagents is described. The reagents are particularly useful for labeling glycoproteins or glycopeptides, nucleic acids, and lipopolysaccharides in electrophoresis gels.
摘要翻译：描述了适用于与含有醛或酮官能团的生物分子偶联的新型荧光衍生试剂。在一个实施方案中，提供具有下式的试剂：其中Q是羰基，硫代羰基或磺酰基，R 5是-L-Z; L是亚芳基或C 1-6个全氟亚烷基，或单个共价键; Z是羰基酰肼，酰肼，磺酰肼或硫代羰基酰肼; R 11 -R 14独立地为H，C 1-6烷基，C 1-6烷氧基，C 全氟烷基，C 1-6烷基氨基，二（C 2-12烷基）氨基，氨基，羧基，氰基，卤素，C 1-6烷基氨基，羟基，硝基，苯基或磺基; R 21和R 24独立地是H，C 1-6烷基，C 1-6烷氧基， C 1-6烷基全氟烷基，C 1-6烷基氨基，二（C 2-12-12 - 烷基）氨基，氨基，羧基，氰基，卤素，羟基，硝基，苯基，磺基或-LZ。描述了用衍生化试剂处理样品的方法。这些试剂特别可用于在电泳凝胶中标记糖蛋白或糖肽，核酸和脂多糖。

4. 发明申请

US20110117659A1 QUINAZOLINE-CONTAINING KITS FOR LABELING ALDEHYDE OR KETONE MOIETIES 审中-公开
标题翻译：用于标示醛或酮类的含喹诺酮的包装盒
公开(公告)号：US20110117659A1
公开(公告)日：2011-05-19
申请号：US12906014
申请日：2010-10-15
申请人： Richard P. Haugland , Thomas H. Steinberg , Wayne F. Patton , Zhenjun Diwu
发明人： Richard P. Haugland , Thomas H. Steinberg , Wayne F. Patton , Zhenjun Diwu
IPC分类号： G01N33/68 , G01N33/00
CPC分类号： C07D265/22 , C07D239/91 , Y10T436/143333 , Y10T436/200833
摘要： Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. In one embodiment is provided reagents that have the following formula: wherein Q is carbonyl, thiocarbonyl, or sulfonyl, and R5 is -L-Z; L is arylene, or a C1-6 perfluoroalkylene, or a single covalent bond; Z is a carbonyl hydrazide, hydrazide, sulfonyl hydrazide, or a thiocarbonyl hydrazide; R11-R14 are independently H, C1-6alkyl, C1-6 alkoxy, C1-6 perfluoroalkyl, C1-6 alkylamino, di(C2-12-alkyl)amino, amino, carboxy, cyano, halogen, hydroxy, nitro, phenyl, or sulfo; and R21-R24 are independently H, C1-6 alkyl, C1-6 alkoxy, C1-6 perfluoroalkyl, C1-6 alkylamino, di(C2-12-alkyl)amino, amino, carboxy, cyano, halogen, hydroxy, nitro, phenyl, sulfo, or -L-Z. The method of treating a sample with the derivativization reagents is described. The reagents are particularly useful for labeling glycoproteins or glycopeptides, nucleic acids, and lipopolysaccharides in electrophoresis gels.
摘要翻译：描述了适用于与含有醛或酮官能团的生物分子偶联的新型荧光衍生试剂。在一个实施方案中，提供具有下式的试剂：其中Q是羰基，硫代羰基或磺酰基，R5是-L-Z; L是亚芳基或C1-6全氟亚烷基，或单个共价键; Z是羰基酰肼，酰肼，磺酰肼或硫代羰基酰肼; R11-R14独立地为H，C1-6烷基，C1-6烷氧基，C1-6全氟烷基，C1-6烷基氨基，二（C2-12 - 烷基）氨基，氨基，羧基，氰基，卤素，羟基，硝基，苯基，或磺基; 和R 21 -R 24独立地为H，C 1-6烷基，C 1-6烷氧基，C 1-6全氟烷基，C 1-6烷基氨基，二（C 2-12 - 烷基）氨基，氨基，羧基，氰基，卤素，羟基，硝基，苯基，磺基或-LZ。描述了用衍生化试剂处理样品的方法。这些试剂特别可用于在电泳凝胶中标记糖蛋白或糖肽，核酸和脂多糖。

5. 发明申请

US20080182284A1 LABELING OF IMMOBILIZED PROTEINS USING DIPYRROMETHENEBORON DIFLUORIDE DYES 审中-公开
标题翻译：使用二氯吡啶二氟乙烯染料对固定化蛋白进行标记
公开(公告)号：US20080182284A1
公开(公告)日：2008-07-31
申请号：US12060834
申请日：2008-04-01
申请人： Richard P. Haugland , Karen J. Martin , Wayne F. Patton
发明人： Richard P. Haugland , Karen J. Martin , Wayne F. Patton
IPC分类号： C12Q1/42 , G01N33/00 , C12Q1/00 , G01N33/543 , C12Q1/28
CPC分类号： G01N33/54306 , C07K1/1077 , C07K1/13 , G01N27/44726 , G01N33/581 , G01N33/583 , G01N33/6839
摘要： The invention describes methods for labeling or detecting of immobilized poly(amino acids), including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized poly(amino acids) are labeled or detected on blots or on arrays of poly(amino acids), or are attached to immobilized aptamers.
摘要翻译：本发明描述了使用荧光二吡咯亚甲基二氟化物染料在膜和其它固体支持物上标记或检测固定的聚（氨基酸），包括肽，多肽和蛋白质的方法。这种固定的聚（氨基酸）在印迹或聚（氨基酸）阵列上被标记或检测，或连接到固定的适体。

6. 发明授权

US06316267B1 Luminescent protein stains an their method of use 有权
标题翻译：发光蛋白染色其使用方法
公开(公告)号：US06316267B1
公开(公告)日：2001-11-13
申请号：US09429739
申请日：1999-10-27
申请人： Mahesh K. Bhalgat , Zhenjun Diwu , Richard P. Haugland , Wayne F. Patton
发明人： Mahesh K. Bhalgat , Zhenjun Diwu , Richard P. Haugland , Wayne F. Patton
IPC分类号： G01N3348
CPC分类号： G01N33/6803 , G01N33/533 , G01N33/582 , G01N33/68 , G01N33/683 , G01N33/6845 , G01N33/6851 , Y10T436/25125 , Y10T436/25375
摘要： The invention relates to the staining of poly(amino acids), including peptides, polypeptides and proteins in gels and on solid supports, using neutral or anionic complexes of transition metals.
摘要翻译：本发明涉及使用过渡金属的中性或阴离子复合物在凝胶和固体支持物上染色聚（氨基酸），包括肽，多肽和蛋白质。

7. 发明授权

US06972326B2 Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes 有权
标题翻译：使用二吡咯亚甲基二氟化物染料标记固定化蛋白质
公开(公告)号：US06972326B2
公开(公告)日：2005-12-06
申请号：US10005050
申请日：2001-12-03
申请人： Richard P. Haugland , Karen J. Martin , Wayne F. Patton
发明人： Richard P. Haugland , Karen J. Martin , Wayne F. Patton
IPC分类号： C07F5/02 , C07K1/107 , C07K1/13 , C07K14/47 , C07K16/46 , C07K17/06 , G01N21/76 , G01N27/447 , G01N33/00 , G01N33/53 , G01N33/533 , G01N33/537 , G01N33/543 , G01N33/58 , G01N33/68
CPC分类号： G01N33/54306 , C07K1/1077 , C07K1/13 , G01N27/44726 , G01N33/581 , G01N33/583 , G01N33/6839
摘要： The invention describes methods for labeling or detecting of immobilized poly(amino acids), including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized poly(amino acids) are labeled or detected on blots or on arrays of poly(amino acids), or are attached to immobilized aptamers.
摘要翻译：本发明描述了使用荧光二吡咯亚甲基二氟化物染料在膜和其它固体支持物上标记或检测固定的聚（氨基酸），包括肽，多肽和蛋白质的方法。这种固定的聚（氨基酸）在印迹或聚（氨基酸）阵列上被标记或检测，或连接到固定的适体。

8. 发明授权

US5534416A Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes 失效
公开(公告)号：US5534416A
公开(公告)日：1996-07-09
申请号：US148847
申请日：1993-11-08
申请人： Paul J. Millard , Bruce L. Roth , Stephen T. Yue , Richard P. Haugland
发明人： Paul J. Millard , Bruce L. Roth , Stephen T. Yue , Richard P. Haugland
IPC分类号： C07D215/22 , C07D211/76 , C07D213/60 , C07D213/61 , C07D213/64 , C07D215/16 , C07D215/18 , C07D215/227 , C07D277/64 , C07D413/06 , C07D417/06 , C07D417/14 , C09B23/00 , C09B23/02 , C09B23/04 , C09B69/06 , C12Q1/68 , G01N21/64 , G01N21/78 , G01N27/26 , G01N31/22 , G01N33/48 , G01N33/50 , G01N33/52 , G01N33/58 , G01N33/00 , C07H1/00 , C12Q1/04
CPC分类号： C07D211/76 , C07D215/18 , C07D215/227 , C07D417/06 , C07D417/14 , C09B23/02 , Y10S436/80 , Y10T436/143333
摘要： The invention relates to a method of analyzing the viability of a sample of cells using an aqueous solution comprising two fluorescent dyes. Dye I has the formula: ##STR1## where R.sup.2 is C.sub.1-6 alkyl; Z.sup.- is a biologically compatible counterion;X is O; S; Se; or NR.sup.15, where R.sup.15 is H or C.sub.1-6 alkyl; or CR.sup.16 R.sup.17, where R.sup.16 and R.sup.17, which may be the same or different, are independently H or C.sub.1-6 alkyl, or the carbons of R.sup.16 and R.sup.17 taken in combination complete a five or six membered saturated ring; and the benzazolium is optionally further substituted;n=0, 1, or 2;Y is --CR.sup.3 .dbd.CR.sup.4 --; p and m=0 or 1, such that p+m=1;R.sup.5 is a C.sub.1-6 alkyl, C.sub.1-6 alkenyl, C.sub.1-6 polyalkenyl, C.sub.1-6 alkynyl or C.sub.1-6 polyalkynyl group; or R.sup.5 is an OMEGA;R.sup.3, R.sup.4, R.sup.6 and R.sup.7, which may be the same or different, are independently H; or a C.sub.1-6 alkyl, C.sub.1-6 alkenyl, C.sub.1-6 polyalkenyl, C.sub.1-6 alkynyl or C.sub.1-6 polyalkynyl group; or halogen; or --OR.sup.8, --SR.sup.8, --(NR.sup.8 R.sup.9), where R.sup.8 and R.sup.9, which may be the same or different, are independently H; or alkyl groups having 1-6 carbons; or 1-2 substituted or unsubstituted alicyclic, heteroalicyclic, aromatic, or heteroaromatic rings, containing 1-4 heteroatoms, wherein the heteroatoms are O, N, or S; or R.sup.8 and R.sup.9 taken in combination are --(CH.sub.2).sub.2 --L--(CH.sub.2).sub.2 -- where L=--O--, --NR.sup.10 --, --CH.sub.2 -- or a single bond where R.sup.10 is H or an alkyl group having 1-6 carbons; or --OSO.sub.2 R.sup.19 where R.sup.19 is C.sub.1-6 alkyl, or C.sub.1-6 perfluoroalkyl, or aryl; or an OMEGA; or R.sup.6 and R.sup.7, taken in combination are --(CH.sub.2).sub.v -- where v=3 or 4, or R.sup.6 and R.sup.7 form a fused aromatic ring that is optionally further substituted;such that at least one of R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7, or a substituent on the aromatic ring formed by R.sup.6 and R.sup.7, is an OMEGA; where OMEGA is a cyclic substituent that is attached by a single bond.Fluorescent Dye II selectively stains either viable or non-viable cells with a detectable fluorescent response that is different from the fluorescent response of Dye I. The stained cells are illuminated at a suitable absorption wavelength, and the fluorescent response is detected to distinguish viable and non-viable cells based on the fluorescent response.

9. 发明授权

US5445946A Intravacuolar stains for yeast and other fungi 失效
标题翻译：阴道内污渍用于酵母和其他真菌
公开(公告)号：US5445946A
公开(公告)日：1995-08-29
申请号：US206081
申请日：1994-03-03
申请人： Bruce L. Roth , Paul J. Millard , Stephen T. Yue , Richard P. Haugland
发明人： Bruce L. Roth , Paul J. Millard , Stephen T. Yue , Richard P. Haugland
IPC分类号： C07D211/76 , C07D215/18 , C07D215/22 , C07D215/227 , C07D417/06 , C07D417/14 , C09B23/02 , C12Q1/04 , C07H17/00 , C12Q1/02 , C12Q1/68
CPC分类号： C07D211/76 , C07D215/18 , C07D215/227 , C07D417/06 , C07D417/14 , C09B23/02
摘要： The invention relates to a method of forming distinctive intravacuolar structures that are unique to fungal cells and can be correlated with cell viability. The preferred dyes of the present invention are described by the formula: ##STR1## wherein each R.sup.1 is independently H; or an alkyl group having from 1-6 carbons; or a trifluoromethyl; or a halogen; or --OR.sup.6, --SR.sup.6 or --(NR.sup.6 R.sup.7) where R.sup.6 and R.sup.7, which can be the same or different, are independently H; or alkyl groups having 1-6 carbons; or 1-2 alicyclic, heteroalicyclic, aromatic or heteroaromatic rings, containing 1-4 heteroatoms, wherein the heteroatoms are O, N or S; or R.sup.6 and R.sup.7 taken in combination are --(CH.sub.2).sub.2 --M--(CH.sub.2).sub.2 -- where M=a single bond, --O--, --CH.sub.2 --, or --NR.sup.8 -- where R.sup.8 is H or an alkyl having 1-6 carbons; and t=1-4;R.sup.2 is an alkyl group having 1-6 carbons;X is O, S, Se or NR.sup.9, where R.sup.9 is H or an alkyl group having 1-6 carbons; or X is CR.sup.10 R.sup.11 where R.sup.10 and R.sup.11, which may be the same or different, are independently alkyl groups having 1-6 carbons, or R.sup.10 and R.sup.11 taken in combination complete a five or six membered saturated ring;R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, are independently H; or an alkyl, alkenyl, polyalkenyl, alkynyl or polyalkynyl group having 1-6 carbons; or a halogen; or --OH, --OR.sup.6, --SR.sup.6 or --(NR.sup.6 R.sup.7); or R.sup.4 and R.sup.5, taken in combination form a quinolinium ring system that is optionally similarly substituted or unsubstituted;Z.sup.- is a biologically compatible counterion;L is a halogen or good leaving group; andOMEGA is a saturated or unsaturated, substituted or unsubstituted, cyclic substituent.
摘要翻译：本发明涉及形成与真菌细胞独特的独特的血管内结构的方法，并且可以与细胞活力相关。本发明优选的染料用下式描述：其中每个R 1独立地是H; 或具有1-6个碳原子的烷基; 或三氟甲基; 或卤素; 或-OR 6，-SR 6或 - （NR 6 R 7）其中R 6和R 7可以相同或不同，独立地为H; 或具有1-6个碳的烷基; 或1-2个含有1-4个杂原子的脂环族，杂脂环，芳族或杂芳环，其中杂原子是O，N或S; 或R 6和R 7组合是 - （CH 2）2-M-（CH 2）2 - ，其中M =单键，-O-，-CH 2 - 或-NR 8 - ，其中R 8是H或具有1- 6个碳; 和t = 1-4; R2是具有1-6个碳原子的烷基; X是O，S，Se或NR 9，其中R 9是H或具有1-6个碳的烷基; 或X为CR10R11，其中R10和R11可以相同或不同，独立地为具有1-6个碳原子的烷基，或R10和R11组合完成一个五或六元饱和环; R 3，R 4和R 5可以相同或不同，独立地为H; 或具有1-6个碳原子的烷基，链烯基，聚链烯基，炔基或聚炔基; 或卤素; 或-OH，-OR 6，-SR 6或 - （NR 6 R 7）; 或R 4和R 5组合形成任选相似取代或未取代的喹啉鎓环系; Z-是一种生物相容的抗衡离子; L是卤素或良好的离去基团; 并且OMEGA是饱和或不饱和的，取代或未取代的环状取代基。

10. 发明授权

US07226740B2 Aza-benzazolium containing cyanine dyes 有权
标题翻译：含有氰基染料的氮杂 -
公开(公告)号：US07226740B2
公开(公告)日：2007-06-05
申请号：US10683753
申请日：2003-10-13
申请人： Richard P. Haugland , Stephen T. Yue
发明人： Richard P. Haugland , Stephen T. Yue
IPC分类号： C12Q1/68 , C07D215/00 , C07D215/12
CPC分类号： C09B23/02 , C12Q1/6816 , C12Q1/6876 , G01N1/30 , G01N27/44726 , G01N33/52 , G01N33/5308 , G01N33/531 , G01N33/582 , G01N33/68 , G01N2001/302 , Y10S436/80 , Y10T436/143333 , C12Q2563/173 , C12Q2563/107
摘要： Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.
摘要翻译：描述了包含氮杂 - 苯并唑鎓环部分的不对称花青染料，包括由阳离子侧链取代的花青染料，单体和二聚花青染料，化学反应性花青染料和花青染料的缀合物。当在水溶液中稀释时，受试染料实际上是非荧光的，但当与核酸聚合物如DNA或RNA相关联时或当与洗涤剂复合的蛋白质相关时，它们显示出明亮的荧光。描述了用于检测和定量多种样品中的核酸和洗涤剂复合蛋白质的各种应用，包括溶液，电泳凝胶，细胞和微生物。

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