专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5582977A Dimers of unsymmetrical cyanine dyes 失效
标题翻译：不对称花青染料的二聚体
公开(公告)号：US5582977A
公开(公告)日：1996-12-10
申请号：US180763
申请日：1994-01-06
申请人： Stephen T. Yue , Iain D. Johnson , Richard P. Haugland
发明人： Stephen T. Yue , Iain D. Johnson , Richard P. Haugland
IPC分类号： C09B23/02 , G01N33/52 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C09B23/02 , G01N33/52
摘要： The invention relates to dimers of unsymmetrical cyanine dyes, typically dimers of benzthiazole or benzoxazole derivatives, that exhibit enhanced fluorescence on binding with DNA or RNA, The dimers generally have the formula: ##STR1## where R.sup.1 and R.sup.2, which may be the same or different, are alkyl groups having 1-6 carbons;X is O, S, or N--R.sup.3, where R.sup.3 is H or an alkyl group having 1-6 carbons;Z is O, S, or N--R.sup.4, where R.sup.4 is H or an alkyl group having 1-6 carbons;n and s, which may be the same or different, =0, 1, or 2;Y is HC.dbd.CH; andp, m, q, and r=0 or 1, such that p+m=1 and q+r=1; andwhere -BRIDGE- has the general formula:--(CH.sub.2).sub..alpha. --[A.sup.1 --(CH.sub.2).sub..beta. --].sub.I [A.sup.2 --(CH.sub.2).sub..gamma. --].sub.II A.sup.3 --(CH.sub.2).sub..delta. --where .alpha., .beta., .gamma., and .delta., which may be the same or different, are integers greater than 1 and less than 5;I and II, which may be the same or different, =0 or 1; andA.sup.1, A.sup.2, and A.sup.3, which may be the same or different, are independently O; S; (CH.sub.2).sub..mu. where .mu.=0 or 1; --(NR.sup.5)-- where R.sup.5 is H or an alkyl group having 1-6 carbons; or--(N.sup.+ R.sup.6 R.sup.7)-- where R.sup.6 and R.sup.7, which may be the same or different, are independently hydrogen or an alkyl group having 1-6 carbons.
摘要翻译：本发明涉及不对称花青染料的二聚体，通常是苯并噻唑或苯并恶唑衍生物的二聚体，其在与DNA或RNA结合时表现出增强的荧光。二聚体通常具有下式：具有下式的烷基：具有 1-6个碳; X是O，S或N-R 3，其中R 3是H或具有1-6个碳的烷基; Z是O，S或N-R 4，其中R 4是H或具有1-6个碳的烷基; n和s可以相同或不同，= 0,1或2; Y为HC = CH; 和p，m，q和r = 0或1，使得p + m = 1和q + r = 1; 并且其中-BRIDGE具有以下通式： - （CH 2）a - [A 1-（CH 2）β - ] I [A2-（CH 2）γ - ] IIA 3 - （CH 2）δ-其中α，β，γ和 δ可以相同或不同，是大于1且小于5的整数; I和II可以相同或不同，= 0或1; 和可以相同或不同的A1，A2和A3独立地为O; S; （CH 2）m，其中mu = 0或1; - （NR5） - 其中R5是H或具有1-6个碳原子的烷基; 或 - （N + R6R7） - 其中R6和R7可以相同或不同，独立地为氢或具有1-6个碳原子的烷基。

2. 发明授权

US5321130A Unsymmetrical cyanine dyes with a cationic side chain 失效
标题翻译：具有阳离子侧链的不对称花青染料
公开(公告)号：US5321130A
公开(公告)日：1994-06-14
申请号：US833006
申请日：1992-02-10
申请人： Stephen T. Yue , Iain D. Johnson , Zhijian Huang , Richard P. Haugland
发明人： Stephen T. Yue , Iain D. Johnson , Zhijian Huang , Richard P. Haugland
IPC分类号： C09B23/02 , C07H21/02 , C07H21/04
CPC分类号： C09B23/02 , Y10S435/968 , Y10S436/80
摘要： The invention relates to unsymmetrical cyanine dyes with a cationic side chain, typically benzothiazole or benzoxazole derivatives, that exhibit enhanced fluorescence on binding with DNA or RNA, where such fluorescence can be used for evaluating the presence of nucleic acid polymers. The dyes generally have the formula: ##STR1## where R.sup.1 is an alkyl group having 1-6 carbons; X is 0, S, or NR.sup.2, where R.sup.2 is an alkyl group having 1-6 carbons, or CR.sup.3 R.sup.4, where R.sup.3 and R.sup.4, which may be the same or different, are alkyl groups having 1-6 carbons;n=0, 1, or 2;Z.sup.1 and Z.sup.2, which may be the same or different, are independently hydrogen, an alkyl group having 1-6 carbons, or aryl, or Z.sup.1 and Z.sup.2 taken in combination complete a 6-membered aromatic ring;Y is HC.dbd.CH; andeach of P and M=0 or 2, such that P+M=1; andTAIL is an aminoalkyl chain containing a backbone of 3-42 carbons and 1-5 positively charged nitrogens intermittently or equally spaced within the backbone, such that there are at least two carbons between sequential nitrogens.
摘要翻译：本发明涉及具有阳离子侧链（通常为苯并噻唑或苯并恶唑衍生物）的不对称花青染料，其在与DNA或RNA结合时表现出增强的荧光，其中该荧光可用于评估核酸聚合物的存在。染料通常具有下式：其中R1是具有1-6个碳原子的烷基; X是0，S或NR2，其中R2是具有1-6个碳原子的烷基，或CR3R4，其中R3和R4可以相同或不同，是具有1-6个碳原子的烷基; n = 0,1或2; Z 1和Z 2可以相同或不同，独立地为氢，具有1-6个碳的烷基或芳基，或Z 1和Z 2组合形成6元芳环; Y为HC = CH; 并且P和M中的每一个= 0或2，使得P + M = 1; 并且TAIL是含有3-42个碳原子的主链和1-5个带正电荷的氮在主链内间歇或等间隔的氨基烷基链，使得在相继的氮之间存在至少两个碳。

3. 发明申请

US20120107844A1 IMMUNOSORBENT ASSAY SUPPORT AND METHOD OF USE 审中-公开
标题翻译：免疫测定支持和使用方法
公开(公告)号：US20120107844A1
公开(公告)日：2012-05-03
申请号：US13277969
申请日：2011-10-20
申请人： Schuyler B. Corry , Yue Ge , Iain D. Johnson , Peter A. Smalley
发明人： Schuyler B. Corry , Yue Ge , Iain D. Johnson , Peter A. Smalley
IPC分类号： G01N21/64 , G01N21/75
CPC分类号： G01N33/54393
摘要： Embodiments of the present invention provide an immunosorbent assay support immobilized with an intermediate binding antibody and their method of use in an improved immunoassay format.
摘要翻译：本发明的实施方案提供了固定有中间结合抗体的免疫吸附测定支持物及其以改进的免疫测定方法使用的方法。

4. 发明授权

US07432372B2 Fluorinated resorufin compounds and their application 有权
标题翻译：氟化合物及其应用
公开(公告)号：US07432372B2
公开(公告)日：2008-10-07
申请号：US10980139
申请日：2004-11-01
申请人： Robert Hardy Batchelor , Yue Ge , Iain D. Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Aaron Emrys Smalley , Thomas Harry Steinberg
发明人： Robert Hardy Batchelor , Yue Ge , Iain D. Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Aaron Emrys Smalley , Thomas Harry Steinberg
IPC分类号： C07D265/38
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译：本发明提供可用于各种测定形式的新型氟化聚砜化合物。还提供了使用包括本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。

5. 发明申请

US20130102014A1 FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION 有权
标题翻译：氟化修饰化合物及其应用
公开(公告)号：US20130102014A1
公开(公告)日：2013-04-25
申请号：US13612681
申请日：2012-09-12
申请人： Robert Harley Batchelor , Yue Ge , Iain D. Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg
发明人： Robert Harley Batchelor , Yue Ge , Iain D. Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg
IPC分类号： C07D265/38 , C07D495/04 , C07D413/12
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译：本发明提供可用于各种测定形式的新型氟化聚砜化合物。还提供了使用包括本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式