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1. 发明授权

US5453698A Method and system for testing an implantable defibrillator output stage and high voltage lead integrity 失效
标题翻译：用于测试可植入除颤器输出级和高电压引线完整性的方法和系统
公开(公告)号：US5453698A
公开(公告)日：1995-09-26
申请号：US314025
申请日：1994-09-28
申请人： Michael O. Williams , Stephen T. Archer
发明人： Michael O. Williams , Stephen T. Archer
IPC分类号： A61N1/08 , A61N1/37 , A61N1/39 , G01R31/02 , G01R27/26
CPC分类号： G01R31/026 , A61N1/3706 , A61N1/3931 , A61N1/3912 , A61N2001/083
摘要： A method and system for testing the integrity of a high voltage output stage and high voltage leads of an implantable cardioverter/defibrillator. The method and system comprises charging one or more high voltage capacitors associated with the high voltage output stage to a predetermined relatively low voltage on the order of 10-20 volts, discharging the high voltage capacitors synchronous with a sensed cardiac event for a predetermined time period, measuring a residual voltage on the high voltage capacitors, and then comparing the residual voltage to a reference voltage to assess the integrity of the output stage and high voltage leads.
摘要翻译：一种用于测试植入式心律转复除颤器的高压输出级和高压引线的完整性的方法和系统。该方法和系统包括将与高压输出级相关联的一个或多个高电压电容器充电到大约10-20伏特的预定相对低的电压，将高电压电容器与感测到的心脏事件同步预定的时间段测量高压电容器上的残余电压，然后将剩余电压与参考电压进行比较，以评估输出级和高压引线的完整性。

2. 发明授权

US5431684A Implantable defibrillator output stage test circuit and method 失效
标题翻译：植入式除颤器输出级测试电路及方法
公开(公告)号：US5431684A
公开(公告)日：1995-07-11
申请号：US172510
申请日：1993-12-22
申请人： Stephen T. Archer , Michael O. Williams
发明人： Stephen T. Archer , Michael O. Williams
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/3931 , A61N1/3912
摘要： A method and apparatus for testing the integrity of biphasic and monophasic defibrillator switches in an implantable defibrillator without delivering a shock to the patient. The test circuitry is integrated with and implantable with the defibrillator and provides for the testing of the defibrillator switches without shocking the patient by charging the capacitive defibrillation voltage source to a predetermined level and discharging it through a resistive network and shunting one of the switches to provide an alternate current path to ground, while isolating the test circuitry from the patient. Switch conditions are capable of ascertainment by measuring residual charge, i.e., voltage, on the capacitive voltage source at selected measurement times.
摘要翻译：一种用于测试可植入除颤器中的双相和单相除颤器开关的完整性的方法和装置，而不会给患者带来冲击。测试电路与除颤器集成并可植入，并且提供对除颤器开关的测试，而不会通过将电容式除颤电压源充电到预定水平并将其放电通过电阻网络并分流其中一个开关来提供患者，以提供将测试电路与患者隔离的地电路径。开关条件能够通过在所选择的测量时间测量电容性电压源上的剩余电荷即电压来确定。

3. 发明授权

US07094051B2 Orthodontic appliance 有权
公开(公告)号：US07094051B2
公开(公告)日：2006-08-22
申请号：US10439638
申请日：2003-05-16
申请人： Michael O. Williams
发明人： Michael O. Williams
IPC分类号： A61C3/00
CPC分类号： A61C7/36 , A61C7/10
摘要： A mandibular and maxillary arch expansion apparatus having a first and second forward orthodontic bands and first and second rear orthodontic bands. The respective forward and rear orthodontic bands are interconnected by an expansion sheath element. The two forward bands are connected by a substantially straight, solid rod. The expansion sheaths exert lengthening forces while the solid rod resists lateral or widening forces. Also provided is a maxillary apparatus connected to a mandibular apparatus by a telescoping contraction connector. The device is positioned to exert adjustable contracting pressure for the correction of Class II malocclusions or overbite. Also provided is an arch expansion apparatus with a centrally disposed expansion element having two forward connector wires extending outwardly therefrom and two rearward connector wires extending outwardly. Each connector wire has an orthodontic band on the terminal end. The expansion element can be actuated so as to elongate the expansion element so as to exert arch expansion pressure.

4. 发明授权

US5941830A System and method for optimal sensing of cardiac events 失效
标题翻译：用于心脏事件的最佳感测的系统和方法
公开(公告)号：US5941830A
公开(公告)日：1999-08-24
申请号：US049786
申请日：1998-03-27
申请人： Michael O. Williams
发明人： Michael O. Williams
IPC分类号： A61N1/37 , A61B5/04
CPC分类号： A61N1/3704
摘要： A system and method for optimal sensing of cardiac events includes registering electrical activity from a cardiac event in a patient's heart and entering a refractory period after the cardiac event has been registered. The system and method further includes detecting when the electrical activity from the cardiac event has settled into a baseline region for a predetermined period of time, whereby the refractory period is ended at such time. The method may also implement a minimum backup timer and a maximum backup timer, which are set to predetermined minimum and maximum time periods, respectively, when the refractory period begins. In this case, the system ends the refractory period, either: (1) when the electrical activity settles into a baseline region for a predetermined period of time and the minimum time period elapses, or (2) when the maximum time period elapses, whichever occurs first. The method for controlling the length of the refractory period can be used to control sensing, pacing and defibrillator systems.
摘要翻译：用于心脏事件的最佳感测的系统和方法包括从心脏事件在患者的心脏中注册电活动并且在心脏事件已被登记之后进入不应期。该系统和方法还包括检测何时来自心脏事件的电活动已经在预定时间段内已经结束到基线区域，由此不适期在此时结束。该方法还可以实现最小备用计时器和最大备用计时器，其在不耐期开始时分别被设置为预定的最小和最大时间段。在这种情况下，系统结束不应期，或者：（1）当电活动在预定时间段内进入基线区域并且经过最小时间时，或者（2）当经过最大时间段时，先发生用于控制不应期的长度的方法可用于控制感测，起搏和除颤器系统。

5. 发明授权

US5919042A Mandibular and maxillary arch expander and jaw repositioner 失效
标题翻译：下颌和上颌弓扩张器和下颌重新定位器
公开(公告)号：US5919042A
公开(公告)日：1999-07-06
申请号：US65344
申请日：1998-04-23
申请人： Michael O. Williams
发明人： Michael O. Williams
IPC分类号： A61C7/00 , A61C7/10 , A61C7/36 , A61C3/00
CPC分类号： A61C7/36 , A61C7/10
摘要： An orthodontic appliance includes a mandibular arch expander and a maxillary arch expander which are interconnected by a pair of adjustable connector assemblies. The maxillary and mandibular arch expanders each include front and rear orthodontic bands which have bosses to facilitate connection of the connector assemblies to the arch expanders. The connector assemblies include an expandable tube assembly and a rod which extends through said expandable tube assembly. The expandable tube assembly has a mount at a first end thereof adapted to connect the connector to the rear orthodontic band of the maxillary arch. The rod has a mount adjacent a second end of the expandable tube assembly adapted to be connected to the front orthodontic bands of the mandibular arch expander. The tube assemblies each include a hollow posterior tube and an anterior tube which are telescopically connected. Preferably, the anterior tube has a hollow body which is externally threaded at its back end. The posterior tube has a hollow body defining a bore and is internally threaded at its front end of said tube. The posterior tube bore is sized to accept the anterior tube so that the two tubes can be threadedly connected together. The posterior tube includes holes adapted to receive a tool to facilitate adjustment of the position of the posterior tube relative to the anterior tube to alter the overall length of the retractable, extendible tube assembly. Further, anterior tube includes indicators, in the form of spaced apart tick marks, to inform a practitioner as to the length of the connector assembly.
摘要翻译：正畸器具包括通过一对可调连接器组件互连的下颌弓扩张器和上颌弓扩张器。上颌和下颌弓扩张器各自包括具有凸起的前后正畸带，以便于将连接器组件连接到拱扩张器。连接器组件包括可扩张管组件和延伸穿过可膨胀管组件的杆。可扩张管组件在其第一端具有适于将连接器连接到上颌弓的后正畸带的安装座。该杆具有邻近可扩张管组件的第二端的安装件，其适于连接到下颌弓扩张器的前正畸带。管组件各自包括可伸缩地连接的中空后管和前管。优选地，前管具有在其后端处是外螺纹的中空体。后管具有限定孔的中空体，并且在其前端处具有内螺纹。后管孔的尺寸适于接纳前管，使得两个管可以螺纹连接在一起。后管包括适于容纳工具以便于调整后管相对于前管的位置的孔，以改变可伸缩的可延伸的管组件的总长度。此外，前管包括以间隔开的刻度标记的形式的指示器，以通知从业者关于连接器组件的长度。

6. 发明授权

US5732708A Method for storing EGM and diagnostic data in a read/write memory of an implantable cardiac therapy device 失效
标题翻译：用于将EGM和诊断数据存储在可植入式心脏治疗装置的读/写存储器中的方法
公开(公告)号：US5732708A
公开(公告)日：1998-03-31
申请号：US689419
申请日：1996-08-09
申请人： Peter Nau , Lisa M. Clem , Michael O. Williams , Glen Crawford
发明人： Peter Nau , Lisa M. Clem , Michael O. Williams , Glen Crawford
IPC分类号： A61N1/37 , A61B5/0432
CPC分类号： A61N1/3702
摘要： A method for storing digitized electrogram and diagnostic data in a read/write memory of an implantable cardiac therapy device which includes the steps of configuring the memory into first and second memory blocks, configuring the first memory block into a plurality of successive EGM data records for storage of the electrogram data, and the second memory block into a plurality of successive diagnostic data records for storage of the diagnostic data, storing successive electrogram data corresponding to successive EGM trigger events in respective, successive ones of the EGM data records, and, storing successive diagnostic data corresponding to successive diagnostic trigger events in respective, successive ones of the diagnostic data records. The electrogram data is preferably written into the EGM data records in a wraparound, FIFO manner. The memory preferably includes an EGM directory having a plurality of cross-indexed entries each containing several fields of relational data concerning associated ones of the electrogram data records, and a diagnostic directory having a plurality of cross-indexed entries each containing several fields of relational data concerning associated ones of the diagnostic data records, to thereby provide a relational database of electrogram and diagnostic data for subsequent telemetric interrogation by an external instrument.
摘要翻译：一种用于将数字化电描记图和诊断数据存储在可植入式心脏治疗装置的读/写存储器中的方法，其包括以下步骤：将存储器配置到第一和第二存储器块中，将第一存储器块配置成多个连续的EGM数据记录，将电图数据和第二存储块存储成多个连续的诊断数据记录，用于存储诊断数据，将相应的EGM触发事件的连续电描记图数据存储在相应的连续的EGM数据记录中，并存储连续的诊断数据对应于相应的，连续的诊断数据记录中的连续诊断触发事件。电报数据优选以环绕FIFO格式写入EGM数据记录。存储器优选地包括具有多个交叉索引条目的EGM目录，每个条目包含关于电描记数据记录中的相关联的数据的关系数据的几个字段，以及具有多个交叉索引条目的诊断目录，每个包含多个关系数据字段涉及相关的诊断数据记录，从而提供用于随后通过外部仪器进行的遥测询问的电描记图和诊断数据的关系数据库。

7. 发明授权

US5413594A Method and apparatus for interrogating an implanted cardiac device 失效
标题翻译：用于询问植入式心脏装置的方法和装置
公开(公告)号：US5413594A
公开(公告)日：1995-05-09
申请号：US164315
申请日：1993-12-09
申请人： Michael O. Williams
发明人： Michael O. Williams
IPC分类号： A61N1/37 , A61N1/372 , A61N1/362
CPC分类号： A61N1/37211 , A61N1/3702 , A61N1/37247
摘要： An implantable cardiac therapy device collects patient ECG and device status information, including cardiac event interval information, why therapy was or was not applied, and patient response to therapy, in connection with an arrhythmic episode and correlates such information in a data frame that may be stored for later telemetric transmission to an external instrument or that may be transmitted in real time to the external instrument. The data frame is decoded by the external instrument for presentation to an attending physician in a time correlated format.
摘要翻译：植入式心脏治疗装置收集患者ECG和装置状态信息，包括心脏事件间隔信息，为什么治疗被应用或未被应用，以及患者对治疗的响应，与心律不齐事件有关，并将这些信息与可能在存储用于以后的遥测传输到外部仪器或可以实时传输到外部仪器。数据帧由外部仪器解码，用于以时间相关格式呈现给主治医师。

8. 发明授权

US08113826B2 Biased palatal bone expander 有权
标题翻译：偏瘫骨扩张器
公开(公告)号：US08113826B2
公开(公告)日：2012-02-14
申请号：US12384799
申请日：2009-04-09
申请人： Michael O. Williams
发明人： Michael O. Williams
IPC分类号： A61C3/00
CPC分类号： A61C7/10
摘要： A biased palatal bone expander attaches directly to the palatal bone in the roof of the mouth of a patient. The expander has dual, biased, mutually parallel rods. The rods extend from coaxial tubes and have coaxial springs. The expansion of the springs urges the rod outwardly from the center of the expander thus widening the maxillary arch incrementally without a connection upon the teeth. The tubes and rods each attach to two mutually parallel bars perpendicular to the rods. Each bar has two opposite ends with an eyelet upon each end. The eyelets receive screws for securing the expander to a patient. Additionally, the appliance may include a thermoformed shell that a surgeon or orthodontist uses to guide positioning the appliance for installation.
摘要翻译：偏瘫骨扩张器直接附着在患者口腔顶部的腭骨上。膨胀机具有双重，偏压，相互平行的杆。杆从同轴管延伸并具有同轴弹簧。弹簧的膨胀将杆从膨胀机的中心向外推动，从而增加上颌弓，而不用连接在牙齿上。管和杆各自连接到垂直于杆的两个相互平行的杆。每个条具有两个相对端，每端有孔眼。孔眼接收用于将膨胀器固定到患者的螺钉。此外，器具可以包括外科医生或正牙医生用于引导将器具定位以进行安装的热成形外壳。

9. 发明授权

US06564097B1 Methods for sensing arrhythmias in a pacemaker/defibrillator and a pacemaker/defibrillator programmed to implement the same 有权
公开(公告)号：US06564097B1
公开(公告)日：2003-05-13
申请号：US10251282
申请日：2002-09-20
申请人： Michael O. Williams , Timothy Olson
发明人： Michael O. Williams , Timothy Olson
IPC分类号： A61N1362
CPC分类号： A61N1/3622 , A61N1/3962
摘要： A method for detecting an arrhythmia hidden by rapid pacing in a rate adaptive pacemaker/defibrillator. Unmasking a potential arrhythmia is accomplished by lengthening the pace cycle length by a small amount for a number of cycles followed by a shortening of the pace cycle length for the same number of cycles giving an average pacing rate equivalent to the desired rate. This can occur at all times or only when conditions make arrhythmia masking possible. Changing the pace cycle by a small amount over a number of cycles will move the arrhythmia and paced rhythm out of synchronization. Forcing the pacer to continue sensing the arrhythmia is accomplished by insuring that the pacer's sense refractory is less than one half of the pacing cycle length. This is done by constraining the programming of that value to one half the minimum pacing cycle length or using an adaptive sense refractory period. In another embodiment, a hidden arrhythmia is detected by periodically checking a relative refractory portion of the pace refractory period to see if a signal indicative of arrhythmia can be detected. This relative refractory period is produced by shortening the established refractory period by a calculated adaptive relative refractory period.

10. 发明授权

US6036488A Pivotal mounting boss for mandibular and maxillary arch expander and jaw repositioner 有权
标题翻译：用于下颌和上颌弓扩张器和下颌复位器的枢转安装凸台
公开(公告)号：US6036488A
公开(公告)日：2000-03-14
申请号：US143071
申请日：1998-08-28
申请人： Michael O. Williams
发明人： Michael O. Williams
IPC分类号： A61C7/00 , A61C7/10 , A61C7/36 , A61C3/00
CPC分类号： A61C7/36 , A61C7/10
摘要： An improved pivotal mounting boss for attachment to front or rear orthodontic bands on a mandibular arch expander and a maxillary arch expander. The pivotal mounting boss includes a base casing that is soldered or welded to the orthodontic band. A screw is threadedly engaged in the base casing. The base casing has an opening formed therein for the insertion of an arch wire. The opening can be preangulated to assist in root angulation when the arch wire is inserted.
摘要翻译：一个改进的枢转安装凸台，用于连接在下颌弓扩张器和上颌弓扩张器上的前后正畸带。枢转安装凸台包括焊接或焊接到正畸带的基座壳体。螺丝螺纹地接合在基座壳体中。基部壳体具有形成在其中的用于插入拱形线的开口。当插入拱形线时，可以打开开口以辅助根角度。

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