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1. 发明申请

US20090264478A1 SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER 审中-公开
标题翻译：生物可降解聚合物载体中的磺胺嘧啶配方
公开(公告)号：US20090264478A1
公开(公告)日：2009-10-22
申请号：US12105375
申请日：2008-04-18
申请人： Stephen M. Cox , Christopher M. Hobot , John M. Zanella , Vanja M. King , William F. McKay , Kathy L. Remsen
发明人： Stephen M. Cox , Christopher M. Hobot , John M. Zanella , Vanja M. King , William F. McKay , Kathy L. Remsen
IPC分类号： A61K31/4402 , A61P29/00
CPC分类号： A61K31/635 , A61K9/0024 , A61K47/34
摘要： Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译：提供了长时间的急性疼痛和/或炎症的有效治疗。通过在目标部位或其附近施用有效量的柳氮磺吡啶可以减轻由不同来源引起的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛作为手术附带的疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

2. 发明申请

US20090264531A1 SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL 有权
标题翻译：生物可降解材料中的SULINDAC配方
公开(公告)号：US20090264531A1
公开(公告)日：2009-10-22
申请号：US12413236
申请日：2009-03-27
申请人： John M. Zanella , Vanja M. King , Christopher M. Hobot , S. Mark Cox , Danielle Biggs , Katara Shaw , William F. McKay , Kathy L. Remsen
发明人： John M. Zanella , Vanja M. King , Christopher M. Hobot , S. Mark Cox , Danielle Biggs , Katara Shaw , William F. McKay , Kathy L. Remsen
IPC分类号： A61K31/192 , A61P25/00 , A61P29/00
CPC分类号： A61K31/255 , A61K9/0024 , A61K9/204
摘要： Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译：提供了长时间疼痛和/或炎症的有效治疗。通过在目标部位处或附近施用有效量的舒林酸或其药学上可接受的盐，可以减轻由不同来源引起的疼痛和/或炎症，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛以及手术附带的疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天，至少二十五天。在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

3. 发明授权

US09492461B2 Methods and compositions for treating intervertebral disc herniations 有权
标题翻译：用于治疗椎间盘突出症的方法和组合物
公开(公告)号：US09492461B2
公开(公告)日：2016-11-15
申请号：US12396122
申请日：2009-03-02
申请人： Vanja M. King , John M. Zanella , Jared Wilsey
发明人： Vanja M. King , John M. Zanella , Jared Wilsey
IPC分类号： A61L31/16 , A61K31/573 , A61P19/00
CPC分类号： A61K31/573 , A61L2430/38
摘要： Methods and compositions are provided for treating an intervertebral disc herniation by local administration of one or more biodegradable drug depots comprising a therapeutically effective amount of a glucocorticoid at or near the intervertebral disc herniation to reduce the size of the intervertebral disc herniation.
摘要翻译：提供了方法和组合物，用于通过局部施用一个或多个可生物降解的药物贮库来治疗椎间盘突出症，所述药物贮库在椎间盘突出处或其附近包含治疗有效量的糖皮质激素以减小椎间盘突出的大小。

4. 发明申请

US20090263459A1 METHODS AND COMPOSITIONS FOR TREATING INTERVERTEBRAL DISC HERNIATIONS 有权
标题翻译：治疗椎间盘突出症的方法和组合
公开(公告)号：US20090263459A1
公开(公告)日：2009-10-22
申请号：US12396122
申请日：2009-03-02
申请人： Vanja M. King , John M. Zanella , Jared Wilsey
发明人： Vanja M. King , John M. Zanella , Jared Wilsey
IPC分类号： A61L31/16 , A61K31/573 , A61P19/00
CPC分类号： A61K31/573 , A61L2430/38
摘要： Methods and compositions are provided for treating an intervertebral disc herniation by local administration of one or more biodegradable drug depots comprising a therapeutically effective amount of a glucocorticoid at or near the intervertebral disc herniation to reduce the size of the intervertebral disc herniation.
摘要翻译：提供了方法和组合物，用于通过局部施用一个或多个可生物降解的药物贮库来治疗椎间盘突出症，所述药物贮库在椎间盘突出处或其附近包含治疗有效量的糖皮质激素以减小椎间盘突出的大小。

5. 发明申请

US20080114465A1 Surface treatments of an allograft to improve binding of growth factors and cells 审中-公开
标题翻译：同种异体移植物的表面处理以改善生长因子和细胞的结合
公开(公告)号：US20080114465A1
公开(公告)日：2008-05-15
申请号：US11598900
申请日：2006-11-14
申请人： John M. Zanella , William F. McKay
发明人： John M. Zanella , William F. McKay
IPC分类号： A61F2/28
CPC分类号： A61L27/365 , A61L27/3608 , A61L27/3847 , A61L27/40
摘要： A method for enhancing the binding of growth factors and/or cells to an allograft structure by applying an effective quantity of a coating material to the surface of the allograft structure, producing a thin coated allograft structure, administering to the thin coated allograft structure a growth factor, cells or a combination thereof, and implanting the thin coated allograft structure into a host bone.
摘要翻译：一种通过将有效量的涂层材料施用于同种异体移植物结构的表面来增强生长因子和/或细胞与同种异体移植物结构的结合的方法，产生薄涂层的同种异体移植结构，向薄涂层的同种异体移植结构施用生长因子，细胞或其组合，以及将薄涂层的同种异体移植物结构植入宿主骨中。

6. 发明授权

US08828354B2 Pharmaceutical gels and methods for delivering therapeutic agents to a site beneath the skin 有权
标题翻译：用于将治疗剂递送至皮肤下方部位的药物凝胶和方法
公开(公告)号：US08828354B2
公开(公告)日：2014-09-09
申请号：US12056511
申请日：2008-03-27
申请人： John M. Zanella , William F. McKay
发明人： John M. Zanella , William F. McKay
IPC分类号： A61F2/00 , A61K51/00 , A61K47/10 , A61K9/00
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/14 , A61K9/50 , A61K31/573 , A61K38/1875 , A61K51/1213 , C07K16/241 , C07K2317/21
摘要： Pharmaceutical gels and methods for delivering a therapeutic agent to a target tissue site beneath the skin of a patient are provided, the gel being capable of adhering to the target tissue site and comprising one or more biodegradable depots containing an effective amount of the therapeutic agent. In various embodiments, the gel is sprayable and hardens after contacting the target tissue site.
摘要翻译：提供了用于将治疗剂递送到患者皮肤下面的靶组织部位的药用凝胶和方法，所述凝胶能够粘附到靶组织部位并且包含含有有效量的治疗剂的一个或多个可生物降解的贮库。在各种实施方案中，凝胶在与靶组织部位接触后是可喷雾的和硬化的。

7. 发明授权

US08092548B2 Osteograft treatment to promote osteoinduction and osteograft incorporation 有权
标题翻译：骨质疏松治疗促进骨诱导和骨移植并发
公开(公告)号：US08092548B2
公开(公告)日：2012-01-10
申请号：US11158924
申请日：2005-06-22
申请人： William F. McKay , John M. Zanella , Jeffrey M. Gross
发明人： William F. McKay , John M. Zanella , Jeffrey M. Gross
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/4601 , A61F2/4644 , A61F2/468 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/3021 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30677 , A61F2002/3068 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2250/0068 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/602 , A61L2300/64 , A61L2430/02
摘要： The invention provides a bone implant, or osteograft, with improved retention of bioactive agents within the surface of the osteograft. Pits or pits formed within the surface of the osteograft have porous plugs placed within them to retain fluid comprising bioactive agents. Pits can also be formed so that the dimensions of the pits facilitate retention of fluid within a pit by hydrostatic attraction of fluid molecules within the pit.
摘要翻译：本发明提供了骨移植物或骨移植物，其具有改善的生物活性剂在骨移植物表面内的保留性。形成在骨移植物表面内的凹坑或凹坑具有放置在其内的多孔塞子以保持包含生物活性剂的流体。还可以形成凹坑，使得凹坑的尺寸通过液体分子在凹坑内的静水吸引而促进流体在凹坑内的保留。

8. 发明授权

US07749555B2 Modification of chemical forces of bone constructs 有权
标题翻译：骨构建体化学力的修改
公开(公告)号：US07749555B2
公开(公告)日：2010-07-06
申请号：US11339781
申请日：2006-01-25
申请人： John M. Zanella , Sean M. Haddock , Catherine E. Taylor , Kathryn J. Kitching
发明人： John M. Zanella , Sean M. Haddock , Catherine E. Taylor , Kathryn J. Kitching
IPC分类号： B05D3/04 , A61F2/28
CPC分类号： A61L27/50 , A61F2/4644 , A61F2/468 , A61F2002/2817 , A61F2002/2821 , A61F2002/2835 , A61L2430/02 , Y10S623/919
摘要： The present invention relates to a method for enhancing ingrowth of host bone comprising: modifying a bone graft structure to provide an ionic gradient to produce a modified bone graft structure; and implanting the modified bone graft structure. The present invention also relates to a method of enhancing the binding of growth factors and cell cultures to a bone graft structure comprising: applying ex vivo an effective quantity of an ionic force change agent to the surface of a bone graft structure to produce a binding-sensitized bone graft structure; implanting the binding-sensitized bone graft structure into a host bone; and administering to the binding-sensitized bone graft structure a molecule, a cell culture or a combination thereof.
摘要翻译：本发明涉及一种用于增强宿主骨向内生长的方法，包括：修饰骨移植结构以提供离子梯度以产生修饰的骨移植结构; 并植入修饰的骨移植结构。本发明还涉及增强生长因子和细胞培养物与骨移植结构的结合的方法，其包括：将有效量的离子力变化剂离体施加到骨移植结构的表面以产生结合 - 敏化骨移植结构; 将结合敏化的骨移植结构植入宿主骨中; 以及向结合敏化的骨移植结构施用分子，细胞培养物或其组合。

9. 发明申请

US20080064626A1 Methods of treating tendonitis in a subject by using an anti-cytokine agent 审中-公开
标题翻译：通过使用抗细胞因子剂治疗受试者的腱炎的方法
公开(公告)号：US20080064626A1
公开(公告)日：2008-03-13
申请号：US11517772
申请日：2006-09-08
申请人： John M. Zanella
发明人： John M. Zanella
IPC分类号： A61K38/17
CPC分类号： C07K16/24 , A61K2039/505
摘要： A method for treating tendonitis and bursitis in a subject involves providing an effective amount of an anti-cytokine agent to a musculo-tendinious structure. Anti-cytokine agents, such as, TNF-α inhibitors, NF-κB inhibitors, IL-1 inhibitors, IL-6 inhibitors, IL-8 inhibitors, IL-12 inhibitors, IL-15 inhibitors, IL-10, Interferon-gamma (IFN-gamma) act to prevent further inflammation initiated by cytokine factors. One embodiment includes, adding with the anti-cytokine agent one or more of an antibiotic or analgesic. Delivery of the anti-cytokine agent may be provided to the affected musculo-tendinious structure by injection, implantation, or a transdermal patch. These agents, individually or in combination directly address the underlying causes of tendonitis, bursitis and associated tendinopathies that result in inflammation and pain.
摘要翻译：用于治疗受试者的腱炎和滑囊炎的方法涉及向肌肉倾向结构提供有效量的抗细胞因子试剂。抗细胞因子剂如TNF-α抑制剂，NF-κB抑制剂，IL-1抑制剂，IL-6抑制剂，IL-8抑制剂，IL-12抑制剂，IL-15抑制剂，IL-10，干扰素-γ （IFN-γ）用于预防由细胞因子因子引起的进一步炎症。一个实施方案包括用抗细胞因子剂加入抗生素或止痛剂中的一种或多种。可以通过注射，植入或经皮贴片向受影响的肌肉结构结构提供抗细胞因子剂的递送。这些药物单独或组合直接解决导致炎症和疼痛的腱炎，滑囊炎和相关性肌腱炎的根本原因。

10. 发明申请

US20070293428A1 Methods of treating joint pain in a subject by using an anti-angiogenic agent 审中-公开
标题翻译：通过使用抗血管生成剂治疗受试者的关节疼痛的方法
公开(公告)号：US20070293428A1
公开(公告)日：2007-12-20
申请号：US11455335
申请日：2006-06-19
申请人： John M. Zanella , Sean M. Haddock
发明人： John M. Zanella , Sean M. Haddock
IPC分类号： A61K38/22 , A61K38/17 , A61K31/485 , A61K31/454 , A61K31/353
CPC分类号： A61K31/353 , A61K31/454 , A61K31/485 , A61K35/12 , A61K38/1875
摘要： A method for treating a joint pain in a subject comprising providing an effective amount of an anti-angiogenic agent to a synovial capsule adjacent to the joint.
摘要翻译：一种治疗受试者关节疼痛的方法，包括向邻近关节的滑膜提供有效量的抗血管生成剂。

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