专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09150577B2 Heterocyclic compounds containing an indole core 有权
标题翻译：含有吲哚核的杂环化合物
公开(公告)号：US09150577B2
公开(公告)日：2015-10-06
申请号：US13513954
申请日：2010-11-30
申请人： Stephen J. Boyer , Donghong Amy Gao , Xin Guo , Thomas Martin Kirrane, Jr. , Christopher Ronald Sarko , Roger John Snow , Fariba Soleymanzadeh , Yunlong Zhang
发明人： Stephen J. Boyer , Donghong Amy Gao , Xin Guo , Thomas Martin Kirrane, Jr. , Christopher Ronald Sarko , Roger John Snow , Fariba Soleymanzadeh , Yunlong Zhang
IPC分类号： C07D487/04 , C07D487/20 , C07D491/20
CPC分类号： C07D487/04 , C07D487/20 , C07D491/20
摘要： Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.
摘要翻译：公开了抑制RSK的新化合物，制备这些化合物的方法和包含这些化合物的药物组合物。还公开了使用本发明化合物治疗RSK2调节性疾病的方法。

2. 发明申请

US20130109679A1 HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE 有权
标题翻译：含有核心的杂环化合物
公开(公告)号：US20130109679A1
公开(公告)日：2013-05-02
申请号：US13513954
申请日：2010-11-30
申请人： Stephen James Boyer , Donghong Amy Gao , Xin Guo , Thomas Martin Kirrane, JR. , Christopher Ronald Sarko , Roger John Snow , Fariba Soleymanzadeh , Yunlong Zhang
发明人： Stephen James Boyer , Donghong Amy Gao , Xin Guo , Thomas Martin Kirrane, JR. , Christopher Ronald Sarko , Roger John Snow , Fariba Soleymanzadeh , Yunlong Zhang
IPC分类号： C07D487/04 , C07D487/20 , C07D491/20
CPC分类号： C07D487/04 , C07D487/20 , C07D491/20
摘要： Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.
摘要翻译：公开了抑制RSK的新化合物，制备这些化合物的方法和包含这些化合物的药物组合物。还公开了使用本发明化合物治疗RSK2调节性疾病的方法。

3. 发明授权

US09073926B2 Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core 有权
标题翻译：含有吡咯并吡啶或苯并咪唑核的杂环化合物
公开(公告)号：US09073926B2
公开(公告)日：2015-07-07
申请号：US13513973
申请日：2010-12-01
申请人： Stephen James Boyer , Jennifer Burke , Xin Guo , Thomas Martin Kirrane, Jr. , Roger John Snow , Yunlong Zhang
发明人： Stephen James Boyer , Jennifer Burke , Xin Guo , Thomas Martin Kirrane, Jr. , Roger John Snow , Yunlong Zhang
IPC分类号： A61K31/55 , C07D487/04 , C07D471/04 , C07D471/14
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14
摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和n如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

4. 发明申请

US20130137680A1 HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE 有权
标题翻译：含有吡咯烷酮或苯并咪唑核的杂环化合物
公开(公告)号：US20130137680A1
公开(公告)日：2013-05-30
申请号：US13513973
申请日：2010-12-01
申请人： Stephen James Boyer , Jennifer Burke , Xin Guo , Thomas Martin Kirrane, JR. , Roger John Snow , Yunlong Zhang
发明人： Stephen James Boyer , Jennifer Burke , Xin Guo , Thomas Martin Kirrane, JR. , Roger John Snow , Yunlong Zhang
IPC分类号： C07D487/04 , C07D471/04 , C07D471/14
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14
摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和n如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

5. 发明授权

US09403830B2 Inhibitors of leukotriene production 有权
标题翻译：抑制白三烯生产
公开(公告)号：US09403830B2
公开(公告)日：2016-08-02
申请号：US13942988
申请日：2013-07-16
申请人： Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
发明人： Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
IPC分类号： C07D487/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D405/12 , C07D497/08 , C07D498/04
CPC分类号： C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中A1，A2，L1和B如本文所定义。式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。

6. 发明授权

US08258301B2 Urotensin II receptor antagonists 有权
标题翻译：促肾上腺素II受体拮抗剂
公开(公告)号：US08258301B2
公开(公告)日：2012-09-04
申请号：US12527973
申请日：2008-05-12
申请人： Brian Nicholas Cook , Anne Bettina Eldrup , Ingo Andreas Mugge , Fariba Soleymanzadeh , Sanxing Sun , Yunlong Zhang
发明人： Brian Nicholas Cook , Anne Bettina Eldrup , Ingo Andreas Mugge , Fariba Soleymanzadeh , Sanxing Sun , Yunlong Zhang
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，R 6，W和Y如本文所述的式（I）化合物，或其互变异构体，前药，溶剂化物或盐。这些化合物可用作促进罗素素II的抑制剂，因此可用于治疗通过促肾上腺素II与其受体（包括心血管疾病）的相互作用介导或维持的各种疾病和病症。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

7. 发明授权

US08697911B2 Rho kinase inhibitors 有权
标题翻译： Rho激酶抑制剂
公开(公告)号：US08697911B2
公开(公告)日：2014-04-15
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A01N37/18 , A61K31/165 , C07C239/00 , C07C279/16 , C07D473/00 , C07D417/00 , C07C45/78 , C07C271/06 , C07D271/12 , C07D413/00 , C07D271/00 , C07D285/02 , C07D285/04 , C07D498/00 , C07D513/00 , C07D277/82 , C07D263/60 , C07D249/04 , C07D249/08 , C07D233/02 , C07D231/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

8. 发明申请

US20100121051A1 UROTENSIN II RECEPTOR ANTAGONISTS 有权
标题翻译： UROTENSIN II受体拮抗剂
公开(公告)号：US20100121051A1
公开(公告)日：2010-05-13
申请号：US12527973
申请日：2008-05-12
申请人： Brian Nicholas Cook , Anne Bettina Eldrup , Ingo Andreas Mugge , Fariba Soleymanzadeh , Sanxing Sun , Yunlong Zhang
发明人： Brian Nicholas Cook , Anne Bettina Eldrup , Ingo Andreas Mugge , Fariba Soleymanzadeh , Sanxing Sun , Yunlong Zhang
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，R 6，W和Y如本文所述的式（I）化合物，或其互变异构体，前药，溶剂化物或盐。这些化合物可用作促进罗素素II的抑制剂，因此可用于治疗通过促肾上腺素II与其受体（包括心血管疾病）的相互作用介导或维持的各种疾病和病症。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

9. 发明申请

US20120165322A1 RHO KINASE INHIBITORS 有权
标题翻译： RHO激酶抑制剂
公开(公告)号：US20120165322A1
公开(公告)日：2012-06-28
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A61K31/472 , A61K31/4725 , C07D471/04 , C07D487/04 , A61K31/4985 , C07D417/14 , C07D417/12 , A61K31/5415 , A61K31/541 , C07D413/12 , C07D413/14 , C07D401/12 , A61K31/506 , C07D405/12 , A61K31/5377 , A61K31/538 , A61K31/497 , A61K31/4439 , C07D513/04 , A61K31/428 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P15/10 , A61P13/12 , A61P11/06 , A61P27/06 , A61P35/00 , A61P25/28 , A61P29/00 , A61P17/06 , A61P1/00 , A61K31/437 , C07D217/02
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

10. 发明授权

US08527064B2 System for stimulating autonomic targets from pulmonary artery 有权
标题翻译：从肺动脉刺激自主神经系统
公开(公告)号：US08527064B2
公开(公告)日：2013-09-03
申请号：US12327601
申请日：2008-12-03
申请人： Yunlong Zhang , Haresh G. Sachanandani , Dan Li , Bin Mi
发明人： Yunlong Zhang , Haresh G. Sachanandani , Dan Li , Bin Mi
IPC分类号： A61N1/36
CPC分类号： A61N1/0587 , A61B5/4035 , A61B5/6862 , A61B5/6876 , A61N1/057 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/37211 , A61N1/37288
摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.
摘要翻译：各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式