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1. 发明申请

US20050048511A1 GSK3 polypeptides 有权
标题翻译： GSK3多肽
公开(公告)号：US20050048511A1
公开(公告)日：2005-03-03
申请号：US10689461
申请日：2003-10-20
申请人： Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
发明人： Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/10 , A61P25/28 , A61P29/00 , A61P43/00 , C12N9/12 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要： The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
摘要翻译：本发明提供能够结晶的截短的GSK3多肽，包括GSK3α和GSK3β多肽，以及使用这些多肽来鉴定和优化GSK3抑制剂。还提供了具有与野生型GSK3不同的至少一个取代的氨基酸的GSK3多肽，其中取代的氨基酸不能被磷酸化。本发明用于提供鉴定和优化用于治疗由GSK3活性介导的疾病（包括阿尔茨海默病，2型糖尿病和炎症）的化合物的方法。

2. 发明申请

US20060088932A1 GSK3 polypeptides 有权
公开(公告)号：US20060088932A1
公开(公告)日：2006-04-27
申请号：US10733816
申请日：2003-12-10
申请人： Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
发明人： Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
IPC分类号： C12P21/06 , C07H21/04 , C12N9/12
CPC分类号： C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要： The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.

3. 发明申请

US20070249004A1 GSK3 polypeptides 失效
标题翻译： GSK3多肽
公开(公告)号：US20070249004A1
公开(公告)日：2007-10-25
申请号：US11704724
申请日：2007-02-08
申请人： Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
发明人： Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
IPC分类号： G01N33/53
CPC分类号： C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要： The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
摘要翻译：本发明提供能够结晶的截短的GSK3多肽，包括GSK3α和GSK3β多肽，以及使用这些多肽来鉴定和优化GSK3抑制剂。还提供了具有与野生型GSK3不同的至少一个取代的氨基酸的GSK3多肽，其中取代的氨基酸不能被磷酸化。本发明用于提供鉴定和优化用于治疗由GSK3活性介导的疾病（包括阿尔茨海默病，2型糖尿病和炎症）的化合物的方法。

4. 发明申请

US20100144991A1 Electron Donor Composition For A Solid Catalyst, Solid Catalyst Composition Used In The Polymerisation Of A-Olefins, And Process For The Production Of A Polymer Consisting Of A-Olefin Units Using The Solid Catalyst Composition 审中-公开
标题翻译：用于固体催化剂的电子给体组合物，用于聚合α-烯烃的固体催化剂组合物，以及使用固体催化剂组合物制备由α-烯烃单元组成的聚合物的方法
公开(公告)号：US20100144991A1
公开(公告)日：2010-06-10
申请号：US12630412
申请日：2009-12-03
申请人： BOCHAO ZHU , Xutao Zhao , Junji Jia , Meinolf Kersting , Christian Gueckel , Chen Wei , Eric Fang
发明人： BOCHAO ZHU , Xutao Zhao , Junji Jia , Meinolf Kersting , Christian Gueckel , Chen Wei , Eric Fang
IPC分类号： C08F4/52 , C08F2/00 , B01J31/02
CPC分类号： C08F10/00 , C08F4/651
摘要： An electron donor composition comprising a dihydroanthracene derivative and a phthalate ester. Furthermore, a solid catalyst composition comprising the electron donor composition for use in α-olefin polymerisation. Further, a process for the production of a polymer containing α-olefin monomer units with the electron donor composition.
摘要翻译：包含二氢蒽衍生物和邻苯二甲酸酯的电子给体组合物。此外，还包括一种包含用于α-烯烃聚合的电子给体组合物的固体催化剂组合物。此外，制备含有电子给体组合物的含有α-烯烃单体单元的聚合物的方法。

5. 发明申请

US20170236226A1 COMPUTERIZED SYSTEMS, PROCESSES, AND USER INTERFACES FOR GLOBALIZED SCORE FOR A SET OF REAL-ESTATE ASSETS 审中-公开
公开(公告)号：US20170236226A1
公开(公告)日：2017-08-17
申请号：US15270407
申请日：2016-09-20
申请人： Ashutosh Malaviya , Fan Jiang , Eric Fang , Jason Hiver Tondu
发明人： Ashutosh Malaviya , Fan Jiang , Eric Fang , Jason Hiver Tondu
IPC分类号： G06Q50/16 , G06F17/30 , G06N5/04 , G06Q30/02 , G06Q10/06
CPC分类号： G06Q50/16 , G06N5/003 , G06N5/04 , G06N7/005 , G06N20/20 , G06Q10/067 , G06Q30/0202
摘要： In one aspect, a computerized method for determining a probability value that a real-estate asset is to be placed on the market for sale includes the step of obtaining a database of real-estate assets. The method includes the step of merging a set of similar near real-estate tracts using a breadth-first search. The method, includes the step of creating a submarket of real-estate assets by performing duster analysis with a hierarchal-clustering method in a county context. The method includes the step of identifying a set of datasets of real-estate assets on a per-county level. The method includes the step of identifying a set of datasets of real-estate assets on a per-state level. The method includes the step of determining a probability that each real-estate asset will be placed for sale based on a set of geo-models. The method includes the step of mapping the probability that each real-estate asset will be placed for sale to a score. The method includes the step of implementing one or more weighting methods on the probability for each geo-model to smooth. The method includes the step of calculating a set of ensemble probabilities for each geo-model. The method includes the step of generating a globalized score for each real-estate asset in the database of real-estate assets.

6. 发明申请

US20150356576A1 COMPUTERIZED SYSTEMS, PROCESSES, AND USER INTERFACES FOR TARGETED MARKETING ASSOCIATED WITH A POPULATION OF REAL-ESTATE ASSETS 审中-公开
标题翻译：与房地产资产人口相关的针对性营销的计算机系统，流程和用户界面
公开(公告)号：US20150356576A1
公开(公告)日：2015-12-10
申请号：US14722151
申请日：2015-05-27
申请人： Ashutosh Malaviya , Jason Hiver Tondu , Aniruddha Banerjee , Anita Narra , Yu Pan , Eric Fang , Fan Jiang
发明人： Ashutosh Malaviya , Jason Hiver Tondu , Aniruddha Banerjee , Anita Narra , Yu Pan , Eric Fang , Fan Jiang
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0202 , G06Q50/16
摘要： In one aspect, a method of generating a prediction list of real-estate assets that have a specified probability of being placed for sale within a specified period of time includes the step of providing a list of real-estate assets. Each real-estate asset is associated with one or more real-estate assets attributes. The method includes the step of providing a training data set wherein the training data set comprises a past population of data associated with a plurality of real-estate assets and a set of training-data set attributes for each real-estate asset in the plurality of real-estate assets. The method includes providing a testing data set wherein the testing data set comprises another past population of data associated with the plurality of real-estate assets and a set testing-data set attributes for each real-estate asset in the plurality of real-estate assets, wherein the set of testing data set attributes comprises an updated version of the training data set attributes from a specified later time.
摘要翻译：一方面，在特定时间段内生成具有规定的出售概率的房地产资产的预测列表的方法包括提供房地产资产清单的步骤。每个房地产资产都与一个或多个不动产资产属性相关联。该方法包括提供训练数据集的步骤，其中训练数据集包括与多个不动产资产相关联的过去的数据群，以及多个不动产资产中的每个不动产资产的一组训练数据集属性房地产资产。该方法包括提供测试数据集，其中测试数据集包括与多个不动产资产相关联的另外过去的数据群，以及多个房地产资产中的每个房地产资产的集合测试数据集属性，其中所述测试数据集属性集合包括来自指定的较晚时间的所述训练数据集属性的更新版本。

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