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    • 7. 发明授权
    • Dry powder cells and cell culture reagents and methods of production thereof
    • 干粉细胞和细胞培养试剂及其生产方法
    • US07572632B2
    • 2009-08-11
    • US10685802
    • 2003-10-16
    • Richard FikeWilliam WhitfordWilliam Biddle
    • Richard FikeWilliam WhitfordWilliam Biddle
    • C12N6/00C12N1/00C12N1/20C12N5/00
    • C12N5/0018C12N1/14C12N1/16C12N1/20C12N5/0025
    • Methods and compositions involving nutritive media, media supplements, media subgroup and buffer formulations are provided. Powder buffer formulations that produce particular ionic and pH conditions upon reconstitution with a solvent are also disclosed. Methods of producing these media, media supplements, media subgroups and buffer formulations as well as kits and methods for cultivation of procaryotic and eukaryotic cells (including human cells) are also provided. Also disclosed are methods of producing sterile powdered media, media supplements, powdered growth factors, media subgroup and buffer formulations. Methods of sterilization include gamma irradiation. Methods for producing dry cell powders where spray-drying a cell suspension may be used are disclosed. Cells, media, media supplements, media subgroups and buffer powders produced by these methods are also disclosed.
    • 提供了涉及营养介质,培养基补充剂,培养基亚组和缓冲液制剂的方法和组合物。 还公开了在用溶剂重构时产生特定离子和pH条件的粉末缓冲剂制剂。 还提供了生产这些培养基,培养基,培养基和缓冲液制剂的方法以及用于培养原核和真核细胞(包括人细胞)的试剂盒和方法。 还公开了生产无菌粉末培养基,培养基补充剂,粉末生长因子,培养基亚组和缓冲液制剂的方法。 灭菌方法包括γ照射。 公开了可以使用喷雾干燥细胞悬浮液的干细胞粉末的制造方法。 还公开了通过这些方法生产的细胞,培养基,培养基,培养基和缓冲粉。
    • 9. 发明授权
    • Method for delivering oxygen to a cell culture medium
    • 将氧气输送到细胞培养基的方法
    • US5364784A
    • 1994-11-15
    • US972366
    • 1992-11-05
    • Richard FikeJames M. Kubiak
    • Richard FikeJames M. Kubiak
    • C12M1/04C12M1/12C12N5/00
    • C12M29/04C12M29/24Y10S435/818
    • An apparatus and method for delivering oxygen to a cell culture medium is disclosed. In one embodiment, the apparatus includes a transfer chamber placed within the cell culture medium. The transfer chamber is adapted to allow the cell culture medium to come in substantial contact with a liquid chemical that is passing through transfer chamber. The apparatus further includes a vessel placed outside the cell culture medium that serves to contain and continually recharge the liquid chemical. The apparatus further includes a plurality of pumps and tubes for circulating the liquid chemical through the transfer chamber and back to the vessel. When the liquid chemical comes into contact with the cell culture medium, oxygen is transferred from the liquid chemical to the cell culture medium.
    • 公开了一种将氧递送至细胞培养基的装置和方法。 在一个实施方案中,该装置包括置于细胞培养基内的转移室。 转移室适于使细胞培养基与通过转移室的液体化学品基本接触。 该装置还包括放置在细胞培养基外部的容器,其用于容纳并持续对液体化学品进行再充电。 该装置还包括多个泵和管,用于使液体化学品循环通过传送室并返回容器。 当液体化学品与细胞培养基接触时,氧气从液体化学品转移到细胞培养基中。
    • 10. 发明申请
    • COMPOSITIONS AND METHODS FOR STABILIZING SUSCEPTIBLE COMPOUNDS
    • 用于稳定可疑化合物的组合物和方法
    • US20130316004A1
    • 2013-11-28
    • US13984263
    • 2012-02-07
    • Richard FikeBruce BranchaudShawn Barrett
    • Richard FikeBruce BranchaudShawn Barrett
    • C12N5/00
    • Methods for increasing the stability of, or protecting, labile components such as ethanolamine, growth factors, vitamins, etc., in compositions such as a cell culture medium. Stability of the labile compound is increased either, by derivatization of the labile compound with chemicals, or by sequestering the labile compound. Sequestering can be done either by encapsulation within a microcapsule, or by the use of sequestering agents. Encapsulation includes the encapsulation of dendrimers complexes of susceptible compounds within the microcapsule, thereby providing the controlled release of the susceptible compound that was protected.These methods may improve and extend storage conditions of compositions comprising the labile compounds, improve shipping and handling of compositions comprising the labile compounds, such as dry media formulations, at room temperature rather than at lower temperatures thereby decreasing shipping costs. Stabilization of labile compounds in compositions such as dry format media can be viewed as a contribution to green technology.
    • 在诸如细胞培养基的组合物中增加不稳定组分如乙醇胺,生长因子,维生素等的稳定性或保护的方法。 不稳定化合物的稳定性也通过不稳定化合物与化学品的衍生化或通过螯合不稳定化合物而增加。 螯合可以通过在微胶囊内包封或通过使用螯合剂进行。 封装包括在微胶囊中包封易感化合物的树枝状大分子复合物,从而提供受保护的易感化合物的受控释放。 这些方法可以改善和延长包含不稳定化合物的组合物的储存条件,改善运送和处理包含不稳定化合物(例如干燥介质制剂)的组合物,而不是在较低的温度下降低运输成本。 不稳定化合物在组合物如干式培养基中的稳定可被视为对绿色技术的贡献。