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1. 发明授权

US06553317B1 Relational database and system for storing information relating to biomolecular sequences and reagents 失效
标题翻译：用于存储与生物分子序列和试剂有关的信息的关系数据库和系统
公开(公告)号：US06553317B1
公开(公告)日：2003-04-22
申请号：US09034807
申请日：1998-03-04
申请人： Stephen E. Lincoln , Tod M. Klingler , Landes C. Wong , Scott R. Panzer , David M. Hodgson , Laura Y. Ito , Andrew D. Ament , Richard Cathcart , Helen E. Jolley , Ingrid E. Akerblom , Brian M. McKelligon , Mayank K. Thanawala
发明人： Stephen E. Lincoln , Tod M. Klingler , Landes C. Wong , Scott R. Panzer , David M. Hodgson , Laura Y. Ito , Andrew D. Ament , Richard Cathcart , Helen E. Jolley , Ingrid E. Akerblom , Brian M. McKelligon , Mayank K. Thanawala
IPC分类号： G01N3348
CPC分类号： G06F19/28 , Y10S707/99945
摘要： The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.
摘要翻译：本发明提供了用于存储生物分子序列信息的关系数据库系统以及详细描述序列信息的来源的生物学注释和相关的试剂信息。与数据库生物分子序列信息相关的试剂信息的获取，存储和获取是本发明的特别优点。这样的试剂信息确定了本发明的关系数据库系统的用户可获得的遗传信息和材料，用于进一步应用于研究，治疗药物开发或其他领域。本发明的试剂信息方面优选与生物分子序列关系数据库系统一起使用。

2. 发明授权

US06303297B1 Database for storage and analysis of full-length sequences 失效
标题翻译：数据库用于存储和分析全长序列
公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译：本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。

3. 发明授权

US6023659A Database system employing protein function hierarchies for viewing biomolecular sequence data 失效
标题翻译：数据库系统采用蛋白质功能层次来观察生物分子序列数据
公开(公告)号：US6023659A
公开(公告)日：2000-02-08
申请号：US812290
申请日：1997-03-06
申请人： Jeffrey J. Seilhamer , Ingrid E. Akerblom , Christina M. Altus , Tod M. Klingler , Frank Russo , Janice Au-Young , Jennifer L. Hillman , Timothy J. Maslyn
发明人： Jeffrey J. Seilhamer , Ingrid E. Akerblom , Christina M. Altus , Tod M. Klingler , Frank Russo , Janice Au-Young , Jennifer L. Hillman , Timothy J. Maslyn
IPC分类号： G06F17/30 , G06F19/18 , G06F19/22 , G06F19/28 , G06F7/08
CPC分类号： G06F19/28 , G06F19/18 , G06F19/22
摘要： Disclosed is a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. The hierarchies allow searches for sequences based upon a protein's biological function or molecular function. Also disclosed is a mechanism for automatically grouping new sequences into protein function hierarchies. This mechanism uses descriptive information obtained from "external hits" which are matches of stored sequences against gene sequences stored in an external database such as GenBank. The descriptive information provided with the external database is evaluated according to a specific algorithm and used to automatically group the external hits (or the sequences associated with the hits) in the categories. Ultimately, the biomolecular sequences stored in databases of this invention are provided with both descriptive information from the external hit and category information from a relevant hierarchy or hierarchies.
摘要翻译：公开了一种用于以允许根据一个或多个蛋白质功能层级对序列进行编目和搜索的方式存储生物分子序列信息的关系数据库系统。层次结构允许基于蛋白质的生物学功能或分子功能搜索序列。还公开了一种用于将新序列自动分组成蛋白质功能层级的机制。该机制使用从“外部命中”获得的描述性信息，其是存储在存储在诸如GenBank的外部数据库中的基因序列的存储序列的匹配。根据特定算法对外部数据库提供的描述性信息进行评估，并用于在类别中自动分组外部命中（或命中关联的序列）。最终，存储在本发明的数据库中的生物分子序列具有来自相关层级或等级的外部命中和类别信息的描述性信息。

4. 发明授权

US07932363B2 Antibody that binds human eosinophil-derived basic protein 失效
标题翻译：结合人嗜酸性粒细胞衍生的碱性蛋白的抗体
公开(公告)号：US07932363B2
公开(公告)日：2011-04-26
申请号：US11200125
申请日：2005-09-07
申请人： Ingrid E. Akerblom
发明人： Ingrid E. Akerblom
IPC分类号： C07K16/00 , C07K16/24 , A61K39/395 , A61K39/00
CPC分类号： C07K14/47 , A61K38/00 , Y10S530/829 , Y10S530/851
摘要： The present invention provides a human eosinophil-derived basic protein (EBPH) and polynucleotides which identify and encode EBPH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding EBPH and a method for producing EBPH. The invention also provides for use of EBPH and agonists, antibodies or antagonists specifically binding EBPH, in the prevention and treatment of diseases associated with expression of EBPH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding EBPH for the treatment of diseases associated with the expression of EBPH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding EBPH.
摘要翻译：本发明提供了人嗜酸性粒细胞衍生的碱性蛋白（EBPH）和识别和编码EBPH的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码EBPH的核酸序列和生产EBPH的方法。本发明还提供使用EBPH和激动剂，特异性结合EBPH的抗体或拮抗剂来预防和治疗与EBPH表达相关的疾病。另外，本发明提供反义分子用于编码EBPH的多核苷酸用于治疗与EBPH表达相关的疾病。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合EBPH的抗体的诊断测定法。

5. 发明授权

US5840870A Polynucleotides PANC1A and PANC1B associated with pancreatic cancer 失效
标题翻译：与胰腺癌相关的多核苷酸PANC1A和PANC1B
公开(公告)号：US5840870A
公开(公告)日：1998-11-24
申请号：US581240
申请日：1995-12-29
申请人： Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer
发明人： Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer
IPC分类号： C07K14/82 , C07K16/30 , C12N15/12 , C12N15/11 , C07H21/04 , C12N15/66 , C12N15/85
CPC分类号： C07K14/82 , C07K16/303
摘要： The present invention provides polynucleotide sequences designated PANC1A and PANC1B which are associated with a genomic sequence related to pancreatic cancer as well as other cancers. The present invention also provides for PANC1A and PANC1B antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified PANC1A and PANC1B polypeptide; antibodies, antagonists and inhibitors of PANC1A and PANC1B polypeptide; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, antagonists and inhibitors. The invention specifically provides for use of the polypeptide as a diagnostic composition for the detection of pancreatic cancer in individuals at risk for and subject to pancreatic cancer. The invention also relates to therapeutic methods and compositions based upon the nucleotide sequences for PANC1A and PANC1B.
摘要翻译：本发明提供了称为PANC1A和PANC1B的多核苷酸序列，其与与胰腺癌以及其他癌症相关的基因组序列相关。本发明还提供PANC1A和PANC1B反义分子。本发明进一步提供用于产生纯化的PANC1A和PANC1B多肽的遗传工程表达载体和宿主细胞; PANC1A和PANC1B多肽的抗体，拮抗剂和抑制剂; 以及基于多肽，其抗体，拮抗剂和抑制剂的药物组合物和治疗方法。本发明特别提供了多肽作为诊断组合物用于在患有胰腺癌的风险和患有胰腺癌的个体中检测胰腺癌的用途。本发明还涉及基于PANC1A和PANC1B的核苷酸序列的治疗方法和组合物。

6. 发明授权

US06492507B1 Polynucleotides encoding human eosinophil-derived basic protein 失效
标题翻译：编码人嗜酸性粒细胞衍生的碱性蛋白的多核苷酸
公开(公告)号：US06492507B1
公开(公告)日：2002-12-10
申请号：US08740036
申请日：1996-10-23
申请人： Ingrid E. Akerblom
发明人： Ingrid E. Akerblom
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00 , Y10S530/829 , Y10S530/851
摘要： The present invention provides a human eosinophil-derived basic protein (EBPH) and polynucleotides which identify and encode EBPH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding EBPH and a method for producing EBPH. The invention also provides for use of EBPH and agonists, antibodies or antagonists specifically binding EBPH, in the prevention and treatment of diseases associated with expression of EBPH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding EBPH for the treatment of diseases associated with the expression of EBPH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding EBPH.
摘要翻译：本发明提供了人嗜酸性粒细胞衍生的碱性蛋白（EBPH）和识别和编码EBPH的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码EBPH的核酸序列和生产EBPH的方法。本发明还提供使用EBPH和激动剂，特异性结合EBPH的抗体或拮抗剂来预防和治疗与EBPH表达相关的疾病。另外，本发明提供反义分子用于编码EBPH的多核苷酸用于治疗与EBPH表达相关的疾病。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合EBPH的抗体的诊断测定法。

7. 发明授权

US5998165A Polynucleotides encoding a protein associated with pancreatic cancer 失效
标题翻译：编码与胰腺癌相关的蛋白质的多核苷酸
公开(公告)号：US5998165A
公开(公告)日：1999-12-07
申请号：US616392
申请日：1996-03-15
申请人： Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Roger Coleman
发明人： Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Roger Coleman
IPC分类号： G01N33/53 , C07K14/82 , C07K16/30 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , G01N33/574
CPC分类号： C07K14/82 , C07K16/303
摘要： The present invention provides polynucleotides and related reagents which are associated with pancreatic and other cancers. These polynucleotides are designated PANC1A.
摘要翻译：本发明提供了与胰腺癌和其他癌症相关的多核苷酸和相关试剂。这些多核苷酸被指定为PANC1A。

8. 发明授权

US08153398B2 Polynucleotides encoding signal peptide-containing molecules 有权
标题翻译：编码含有信号肽的分子的多核苷酸
公开(公告)号：US08153398B2
公开(公告)日：2012-04-10
申请号：US12457389
申请日：2009-06-09
申请人： Preeti G. Lal , Y. Tom Tang , Gina A. Gorgone Simone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice K. Au-Young , Henry Yue , Chandra S. Arvizu , Roopa M. Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti G. Lal , Y. Tom Tang , Gina A. Gorgone Simone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice K. Au-Young , Henry Yue , Chandra S. Arvizu , Roopa M. Reddy , Jennifer L. Hillman , Olga Bandman
IPC分类号： C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74 , C07H21/04
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译：本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。

9. 发明申请

US20110053217A1 Polynucleotides encoding signal peptide-containing molecules 有权
标题翻译：编码含有信号肽的分子的多核苷酸
公开(公告)号：US20110053217A1
公开(公告)日：2011-03-03
申请号：US12457389
申请日：2009-06-09
申请人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
IPC分类号： C12P21/00 , C07H21/04 , C12N1/21 , C07H21/02 , C07K14/435
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译：本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。

10. 发明授权

US08716445B2 Compositions comprising signal peptide-containing proteins 失效
标题翻译：包含含信号肽的蛋白质的组合物
公开(公告)号：US08716445B2
公开(公告)日：2014-05-06
申请号：US13397592
申请日：2012-02-15
申请人： Preeti G. Lal , Y. Tom Tang , Gina A. Gorgone Simone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice K. Au-Young , Henry Yue , Chandra S. Arvizu , Roopa M. Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti G. Lal , Y. Tom Tang , Gina A. Gorgone Simone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice K. Au-Young , Henry Yue , Chandra S. Arvizu , Roopa M. Reddy , Jennifer L. Hillman , Olga Bandman
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译：本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。

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