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    • 8. 发明授权
    • Compositions and methods of diagnosis and treatment using casein kinase I
    • 使用酪蛋白激酶I的组合物和诊断和治疗方法
    • US06512102B1
    • 2003-01-28
    • US09472112
    • 1999-12-23
    • Licen XuStephen D. HarrisonLewis T. Williams
    • Licen XuStephen D. HarrisonLewis T. Williams
    • C07H2104
    • C12N15/1137A61K31/00A61K38/45A61K48/00
    • The invention is generally directed to compositions and methods for affecting signal transduction using the casein kinase I (CKI) gene or gene product. The invention is more specifically directed to affecting the Wnt signal pathway using the CKI gene or gene product. The invention is particularly directed to using the CKI gene or gene product to treat and diagnose cancer, particularly breast and colon cancer. CKI&egr; is the preferred species. The field of the invention is compositions and methods for modulating signal transduction using the (CKI) gene or gene products and variants thereof. The invention is more specifically directed to modulating the Wnt signal pathway using the CKI gene or gene product. The invention is particularly directed to using the CKI gene or gene product to treat and diagnose disorders mediated by the Wnt signal pathway, especially hyperproliferative disorders, particularly breast and colon cancer.
    • 本发明一般涉及使用酪蛋白激酶I(CKI)基因或基因产物影响信号转导的组合物和方法。 本发明更具体地涉及使用CKI基因或基因产物影响Wnt信号通路。 本发明特别涉及使用CKI基因或基因产物来治疗和诊断癌症,特别是乳腺癌和结肠癌。 CKIepsi是首选品种。 本发明的领域是使用(CKI)基因或其基因产物及其变体调节信号转导的组合物和方法。 本发明更具体地涉及使用CKI基因或基因产物调节Wnt信号通路。 本发明特别涉及使用CKI基因或基因产物来治疗和诊断由Wnt信号通路介导的疾病,特别是过度增殖性疾病,特别是乳腺癌和结肠癌。
    • 10. 发明授权
    • Method and apparatus for permitting radio unit roaming between trunked
RF transmission sites over a wide area that encompasses plural
multisite networks
    • 允许无线电单元漫游在包含多个多站点网络的广泛区域的中继RF传输站点之间的方法和装置
    • US5475683A
    • 1995-12-12
    • US178548
    • 1994-01-07
    • Stephen D. HarrisonCharles P. Brame
    • Stephen D. HarrisonCharles P. Brame
    • H04W84/08H04J3/14
    • H04W84/08
    • Digitally trunked radio transceivers are permitted to roam over an extended coverage area including two or more digitally trunked radio frequency communication networks. Each network includes at least one digital repeater site having a corresponding site coverage area and serving digitally trunked radio transceivers disposed within or near the site coverage area. Each network also includes a local multisite switch for routing communications between the digital repeater sites within the networks. Site adjacency information is established for each site and communicated between the networks. Each digitally trunked transceiver maintains a site adjacency list for its currently selected site and modifies that list when the transceiver roams into a new site coverage area and selects a new repeater site.
    • 数字集群无线电收发机被允许漫游在包括两个或多个数字集群的射频通信网络的扩展覆盖区域内。 每个网络包括至少一个具有对应的站点覆盖区域的数字中继站站点,以及设置在站点覆盖区域内或附近的数字集群无线电收发器。 每个网络还包括用于在网络内的数字中继站之间路由通信的本地多站点交换机。 为每个站点建立站点邻接信息,并在网络之间进行通信。 每个数字集群收发器为其当前选定的站点维护一个站点邻接列表,并且当收发器漫游到新的站点覆盖区域并选择一个新的中继站点时修改该列表。