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1. 发明授权

US08735413B2 Compound 有权
标题翻译：复合
公开(公告)号：US08735413B2
公开(公告)日：2014-05-27
申请号：US13546444
申请日：2012-07-11
申请人： Stephen Connolly , Mark Richard Ebden , Iain Alastair Stewart Walters , Thomas Langer , Alan Robert Steven , Craig Robert Stewart , Paula Margaret Tomlin , Andrew John Williams
发明人： Stephen Connolly , Mark Richard Ebden , Iain Alastair Stewart Walters , Thomas Langer , Alan Robert Steven , Craig Robert Stewart , Paula Margaret Tomlin , Andrew John Williams
IPC分类号： A01N43/54 , A61K31/505 , A61K31/506 , C07D239/56
CPC分类号： C07D403/12 , A61K31/506 , C07C65/21 , C07C69/78 , C07C69/92 , C07D205/04 , C07D239/56 , C07D307/12 , C07D317/18 , C07D317/20 , C07D317/24 , C07D317/26
摘要： There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
摘要翻译：提供了化合物，其为（a）式（I）或（b）的嘧啶磺酰胺或其药学上可接受的盐，化合物的结晶形式，获得化合物的方法，用于制备化合物的药物中间体，和含有该化合物的药物组合物。该化合物可用于治疗调节趋化因子受体活性有益的疾病/病症。

2. 发明申请

US20140031379A1 Camsylate Salt 审中-公开
标题翻译：甘氨酸盐
公开(公告)号：US20140031379A1
公开(公告)日：2014-01-30
申请号：US13916754
申请日：2013-06-13
申请人： Martin Hans Bohlin , Craig Robert Stewart
发明人： Martin Hans Bohlin , Craig Robert Stewart
IPC分类号： A61K31/4439 , A61K45/06
摘要： A camsylate salt of (1r,1′R,4R)-4-methoxy-5″-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3′H-dispiro[cyclohexane-1,2′-inden-1′2′-imidazole]-4″-amine, pharmaceutical compositions containing the salt and therapeutic uses of the salt for treating Aβ-related pathologies such as Alzheimer's Disease, Down's syndrome, β-amyloid angiopathy and conditions such as dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
摘要翻译：（1r，1'R，4R）-4-甲氧基-5'-甲基-6' - [5-（丙-1-炔-1-基）吡啶-3-基] -3' H-difiro [环己烷-1,2'-茚-1'2' - 咪唑] -4“ - 胺，含有盐的药物组合物和盐的治疗用途，用于治疗阿尔茨海默氏病相关的病症如阿尔茨海默氏病综合征，β-淀粉样变性血管病和诸如痴呆的病症，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮层基底变性。

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