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1. 发明授权

US07718386B1 Methods for the diagnosis of diabetes 失效
标题翻译：糖尿病诊断方法
公开(公告)号：US07718386B1
公开(公告)日：2010-05-18
申请号：US08452053
申请日：1995-05-25
申请人： Steinunn Baekkeskov , Henk-Jan Aanstoot , Pietro Decamilli , Franco Folli , Michele Solimena
发明人： Steinunn Baekkeskov , Henk-Jan Aanstoot , Pietro Decamilli , Franco Folli , Michele Solimena
IPC分类号： G01N33/564
CPC分类号： A61K35/17 , A61K38/00 , C07K14/7051 , C12N9/88 , G01N33/564 , G01N33/573 , G01N2800/042 , Y10S436/811
摘要： Assays for the detection of diabetes and prediabetic status rely on exposing patient serum samples to purified ligand capable of binding autoantibodies specific for a 64kD autoantigen present on pancreatic β-cells. The purified ligand is usually purified glutamic acid decarboxylase (GAD) or a fragment or analog thereof. Preferably, the assays will detect the presence of antibodies to both lower molecular weight GAD and higher molecular weight GAD since diabetic and prediabetic status may be associated with only one of these two forms. The assays can be performed using conventional protocols, such as radioimmunoassay, enzyme-linked immunosorbent assay, and enzyme assay. Methods for treating diabetes comprise administering pharmaceutical compositions including the purified ligand, particularly when coupled to an immunoglobulin or lymphoid cell to induce tolerance. Alternatively, tolerance may be induced by administering attenuated T-helper cells, or isolated T-cell receptors, where the T-helper cells have been isolated based on their reactivity with GAD or equivalent ligand.
摘要翻译：用于检测糖尿病和糖尿病前状态的测定依赖于将患者血清样品暴露于能够结合存在于胰腺细胞上的64kD自身抗原特异性的自身抗体的纯化配体。纯化的配体通常是纯化的谷氨酸脱羧酶（GAD）或其片段或类似物。优选地，测定法将检测低分子量GAD和较高分子量GAD两者的抗体的存在，因为糖尿病和糖尿病状态可能仅与这两种形式中的一种相关联。可以使用常规方案进行测定，例如放射免疫测定，酶联免疫吸附测定和酶测定。用于治疗糖尿病的方法包括施用包含纯化的配体的药物组合物，特别是当与免疫球蛋白或淋巴细胞偶联以诱导耐受性时。或者，可以通过施用减毒的T辅助细胞或分离的T细胞受体诱导耐受性，其中已经基于它们与GAD或等同配体的反应性分离了T-辅助细胞。

2. 发明授权

US5512447A Methods for the diagnosis and treatment of diabetes 失效
标题翻译：糖尿病诊断和治疗方法
公开(公告)号：US5512447A
公开(公告)日：1996-04-30
申请号：US174550
申请日：1993-12-28
申请人： Steinunn Baekkeskov , Henk-Jan Aanstoot , Pietro Decamilli , Franco Folli , Michele Solimena
发明人： Steinunn Baekkeskov , Henk-Jan Aanstoot , Pietro Decamilli , Franco Folli , Michele Solimena
IPC分类号： A61K35/14 , A61K38/00 , C07K14/725 , C12N9/88 , G01N33/564 , G01N33/573
CPC分类号： C12N9/88 , C07K14/7051 , G01N33/564 , G01N33/573 , A61K38/00 , G01N2800/042 , Y10S436/811
摘要： Assays for the detection of diabetes and prediabetic status rely on exposing patient serum samples to purified ligand capable of binding autoantibodies specific for a 64 kD autoantigen present on pancreatic .beta.-cells. The purified ligand is usually purified glutamic acid decarboxylase (GAD) or a fragment or analog thereof. Preferably, the assays will detect the presence of antibodies to both lower molecular weight GAD and higher molecular weight GAD since diabetic and prediabetic status may be associated with only one of these two forms. The assays can be performed using conventional protocols, such as radioimmunoassay, enzyme-linked immunosorbent assay, and enzyme assay. Methods for treating diabetes comprise administering pharmaceutical compositions including the purified ligand, particularly when coupled to an immunoglobulin or lymphoid cell to induce tolerance. Alternatively, tolerance may be induced by administering attenuated T-helper cells, or isolated T-cell receptors, where the T-helper cells have been isolated based on their reactivity with GAD or equivalent ligand.
摘要翻译：用于检测糖尿病和糖尿病前状态的测定依赖于将患者血清样品暴露于能够结合存在于胰腺β细胞上的64kD自身抗原特异性的自身抗体的纯化配体。纯化的配体通常是纯化的谷氨酸脱羧酶（GAD）或其片段或类似物。优选地，测定法将检测低分子量GAD和较高分子量GAD两者的抗体的存在，因为糖尿病和糖尿病状态可能仅与这两种形式中的一种相关联。可以使用常规方案进行测定，例如放射免疫测定，酶联免疫吸附测定和酶测定。用于治疗糖尿病的方法包括施用包含纯化的配体的药物组合物，特别是当与免疫球蛋白或淋巴细胞偶联以诱导耐受性时。或者，可以通过施用减毒的T辅助细胞或分离的T细胞受体诱导耐受性，其中已经基于它们与GAD或等同配体的反应性分离了T-辅助细胞。

3. 发明授权

US5674692A Methods for diabetes susceptibility assessment in asymptomatic patients 失效
标题翻译：无症状患者糖尿病易感性评估方法
公开(公告)号：US5674692A
公开(公告)日：1997-10-07
申请号：US346313
申请日：1994-10-28
申请人： Steinunn Baekkeskov , Henk-Jan Aanstoot
发明人： Steinunn Baekkeskov , Henk-Jan Aanstoot
IPC分类号： A61K38/00 , C07K16/40 , G01N33/564 , G01N33/567
CPC分类号： C07K16/40 , G01N33/564 , A61K38/00 , G01N2800/042 , G01N2800/24
摘要： Assays for identifying human patients at risk for developing insulin-dependent diabetes mellitus rely on detection of autoantibodies to a 38 kD autoantigen present in pancreatic .beta.-cells in patient sera. It has been found that autoantibodies to this particular autoantigen developed in patients well before clinical onset of the disease in a significant subpopulation of prediabetic patients. Useful assays will frequently combine detection of autoantibodies to the 38 kD autoantigen with detection of other known markers of IDDM, such as autoantibodies to a 64 kD autoantigen (glutamic acid decarboxylase).
摘要翻译：用于鉴定发生胰岛素依赖性糖尿病风险的人类患者的检测依赖于检测患者血清中存在于胰腺β-细胞中的38kD自身抗原的自身抗体。已经发现，这种特异性自身抗原的自身抗体在患有疾病临床发生之前的患者中发生在前列腺疾病患者的重要亚群中。有用的测定法将经常将自身抗体检测与38kD自身抗原的检测结合，同时检测其他已知的IDDM标记，例如64kD自身抗原（谷氨酸脱羧酶）的自身抗体。

4. 发明授权

US06960448B2 Methods for diabetes susceptibility assessment in asymptomatic patients 失效
标题翻译：无症状患者糖尿病易感性评估方法
公开(公告)号：US06960448B2
公开(公告)日：2005-11-01
申请号：US09993371
申请日：2001-11-13
申请人： Steinunn Baekkeskov , Henk-Jan Aanstoot
发明人： Steinunn Baekkeskov , Henk-Jan Aanstoot
IPC分类号： A61K39/00 , A61K39/395 , G01N33/564
CPC分类号： G01N33/564 , G01N2800/042 , G01N2800/24
摘要： Assays for identifying human patients at risk for developing insulin-dependent diabetes mellitus rely on detection of autoantibodies to a 38 kD autoantigen present in pancreatic β-cells in patient sera. It has been found that autoantibodies to this particular autoantigen developed in patients well before clinical onset of the disease in a significant subpopulation of prediabetic patients. Useful assays will frequently combine detection of autoantibodies to the 38 kD autoantigen with detection of other known markers of IDDM, such as autoantibodies to a 64 kD autoantigen (glutamic acid decarboxylase).
摘要翻译：鉴定患有胰岛素依赖型糖尿病风险的患者的检测依赖于检测患者血清中胰腺β细胞中存在的38 kD自身抗原的自身抗体。已经发现，这种特异性自身抗原的自身抗体在患有疾病临床发生之前的患者中发生在前列腺疾病患者的重要亚群中。有用的测定法将经常将自身抗体检测与38kD自身抗原的检测结合，同时检测其他已知的IDDM标记，例如64kD自身抗原（谷氨酸脱羧酶）的自身抗体。

5. 发明申请

US20050106633A1 METHODS FOR DIABETES SUSCEPTIBILITY ASSESSMENT IN ASYMPTOMATIC PATIENTS 失效
标题翻译：方法用于在ASYMPTOMATIC患者中进行糖尿病的可靠性评估
公开(公告)号：US20050106633A1
公开(公告)日：2005-05-19
申请号：US09993371
申请日：2001-11-13
申请人： Steinunn Baekkeskov , Henk-Jan Aanstoot
发明人： Steinunn Baekkeskov , Henk-Jan Aanstoot
IPC分类号： A61K39/00 , A61K39/395 , G01N33/564 , C12Q1/70 , C07K16/42 , G01N33/53 , G01N33/567
CPC分类号： G01N33/564 , G01N2800/042 , G01N2800/24
摘要： Assays for identifying human patients at risk for developing insulin-dependent diabetes mellitus rely on detection of autoantibodies to a 38 kD autoantigen present in pancreatic β-cells in patient sera. It has been found that autoantibodies to this particular autoantigen developed in patients well before clinical onset of the disease in a significant subpopulation of prediabetic patients. Useful assays will frequently combine detection of autoantibodies to the 38 kD autoantigen with detection of other known markers of IDDM, such as autoantibodies to a 64 kD autoantigen (glutamic acid decarboxylase).
摘要翻译：鉴定患有胰岛素依赖型糖尿病风险的患者的检测依赖于检测患者血清中胰腺β细胞中存在的38 kD自身抗原的自身抗体。已经发现，这种特异性自身抗原的自身抗体在患有疾病临床发生之前的患者中发生在前列腺疾病患者的重要亚群中。有用的测定法将经常将自身抗体检测与38kD自身抗原的检测结合，同时检测其他已知的IDDM标记，例如64kD自身抗原（谷氨酸脱羧酶）的自身抗体。

6. 发明授权

US06316209B1 Methods for diabetes susceptibility assessment in asymptomatic patients 失效
标题翻译：无症状患者糖尿病易感性评估方法
公开(公告)号：US06316209B1
公开(公告)日：2001-11-13
申请号：US08937955
申请日：1997-09-25
申请人： Steinunn Baekkeskov , Henk-Jan Aanstoot
发明人： Steinunn Baekkeskov , Henk-Jan Aanstoot
IPC分类号： G01N33564
CPC分类号： G01N33/564 , G01N2800/042 , G01N2800/24
摘要： Assays for identifying human patients at risk for developing insulin-dependent diabetes mellitus rely on detection of autoantibodies to a 38 kD autoantigen present in pancreatic &bgr;-cells in patient sera. It has been found that autoantibodies to this particular autoantigen developed in patients well before clinical onset of the disease in a significant subpopulation of prediabetic patients. Useful assays will frequently combine detection of autoantibodies to the 38 kD autoantigen with detection of other known markers of IDDM, such as autoantibodies to a 64 kD autoantigen (glutamic acid decarboxylase).
摘要翻译：鉴定患有胰岛素依赖型糖尿病风险的患者的检测依赖于检测患者血清中胰腺β细胞中存在的38 kD自身抗原的自身抗体。已经发现，这种特异性自身抗原的自身抗体在患有疾病临床发生之前的患者中发生在前列腺疾病患者的重要亚群中。有用的测定法将经常将自身抗体检测与38kD自身抗原的检测结合，同时检测其他已知的IDDM标记，例如64kD自身抗原（谷氨酸脱羧酶）的自身抗体。

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