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1. 发明申请

US20120316167A1 SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES 有权
标题翻译：二次8-羟基喹啉-7-羧酰胺衍生物
公开(公告)号：US20120316167A1
公开(公告)日：2012-12-13
申请号：US13519686
申请日：2010-12-28
申请人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
发明人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
IPC分类号： A61K31/5377 , A61K31/47 , A61K31/4709 , C07D409/12 , C07D215/04 , C07D401/12 , C07D417/12 , C07D405/12 , A61K31/4965 , C07D413/12
CPC分类号： C07D417/12 , C07D215/48 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata.
摘要翻译：本发明提供了通式（I）的新的仲羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地说，这些化合物被测试针对红纹枯菌（Tricophyton Rubrum），三孢球菌（Tricophyton Mentagrophytes），黑曲霉（Aspergillus Niger）和Scopulariopsis Brevicaulis（Scopulariopsis Brevicaulis）。这些化合物中的许多对假丝酵母属（Candida Albicans）和念珠菌（Candida Glabrata）是有活性的。

2. 发明申请

US20120309751A1 TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF 有权
标题翻译：第八代8-羟基喹啉-7-羧酰胺衍生物及其用途
公开(公告)号：US20120309751A1
公开(公告)日：2012-12-06
申请号：US13519206
申请日：2010-12-28
申请人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
发明人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
IPC分类号： A61K31/47 , C07D413/10 , C07D401/10 , C07D405/12 , C07D401/12 , A61P31/10 , C07D491/113 , A61K31/5377 , A61K31/4709 , A61K31/4725 , A61K31/541 , A61K31/538 , C07D215/48 , C07D417/10
CPC分类号： C07D215/48 , C07D401/06 , C07D401/12 , C07D407/06 , C07D407/12 , C07D417/06 , C07D491/113
摘要： New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are also active against Candida species such as Candida Albicans and Candida Glabrata.
摘要翻译：公开了通式（I）的新的8-羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地说，这些化合物被测试针对红纹枯菌（Tricophyton Rubrum），三孢球菌（Tricophyton Mentagrophytes），黑曲霉（Aspergillus Niger）和Scopulariopsis Brevicaulis（Scopulariopsis Brevicaulis）。这些化合物对假丝酵母属（Candida albicans）和假丝酵母（Candida Glabrata）也是有活性的。

3. 发明授权

US08969380B2 Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents 有权
标题翻译：用作抗真菌剂的次级8-羟基喹啉-7-甲酰胺衍生物
公开(公告)号：US08969380B2
公开(公告)日：2015-03-03
申请号：US13519439
申请日：2010-12-28
申请人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
发明人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
IPC分类号： C07D417/12 , C07D401/12 , C07D405/12 , C07D413/12 , C07D409/12 , C07D215/48
CPC分类号： C07D401/12 , C07D215/48 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are active against Candida species such as Candida Albicans and Candida Glabrata.
摘要翻译：本发明提供通式（I）的第二8-羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地说，这些化合物被测试针对红纹枯菌（Tricophyton Rubrum），三孢球菌（Tricophyton Mentagrophytes），黑曲霉（Aspergillus Niger）和Scopulariopsis Brevicaulis（Scopulariopsis Brevicaulis）。这些化合物对假丝酵母属（Candida albicans）和念珠菌（Candida Glabrata）有活性。

4. 发明申请

US20120329797A1 SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS 有权
标题翻译：用作抗真菌剂的二级8-羟基喹啉-7-羧酰胺衍生物
公开(公告)号：US20120329797A1
公开(公告)日：2012-12-27
申请号：US13519439
申请日：2010-12-28
申请人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
发明人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
IPC分类号： A61K31/4709 , C07D401/12 , A61K31/497 , A61K31/47 , A61P31/10 , A61K31/5377
CPC分类号： C07D401/12 , C07D215/48 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are active against Candida species such as Candida Albicans and Candida Glabrata.
摘要翻译：本发明提供通式（I）的第二8-羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地说，这些化合物被测试针对红纹枯菌（Tricophyton Rubrum），三孢球菌（Tricophyton Mentagrophytes），黑曲霉（Aspergillus Niger）和Scopulariopsis Brevicaulis（Scopulariopsis Brevicaulis）。这些化合物对假丝酵母属（Candida albicans）和念珠菌（Candida Glabrata）有活性。

5. 发明授权

US08729098B2 Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof 有权
标题翻译：第三8-羟基喹啉-7-甲酰胺衍生物及其用途
公开(公告)号：US08729098B2
公开(公告)日：2014-05-20
申请号：US13519206
申请日：2010-12-28
申请人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
发明人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/48 , C07D401/06 , C07D401/12 , C07D407/06 , C07D407/12 , C07D417/06 , C07D491/113
摘要： New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are also active against Candida species such as Candida Albicans and Candida Glabrata.
摘要翻译：公开了通式（I）的新的8-羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地说，这些化合物被测试针对红纹枯菌（Tricophyton Rubrum），三孢球菌（Tricophyton Mentagrophytes），黑曲霉（Aspergillus Niger）和Scopulariopsis Brevicaulis（Scopulariopsis Brevicaulis）。这些化合物对假丝酵母属（Candida albicans）和假丝酵母（Candida Glabrata）也是有活性的。

6. 发明授权

US08729076B2 Secondary 8-hydroxyquinoline-7-carboxamide derivatives 有权
标题翻译：次级8-羟基喹啉-7-甲酰胺衍生物
公开(公告)号：US08729076B2
公开(公告)日：2014-05-20
申请号：US13519686
申请日：2010-12-28
申请人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
发明人： Stefania Gagliardi , Simone Del Sordo , Federico Mailland , Michela Legora
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/47 , C07D403/02 , C07D413/02 , C07D215/00
CPC分类号： C07D417/12 , C07D215/48 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata.
摘要翻译：本发明提供了通式（I）的新的仲羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地说，这些化合物被测试针对红纹枯菌（Tricophyton Rubrum），三孢球菌（Tricophyton Mentagrophytes），黑曲霉（Aspergillus Niger）和Scopulariopsis Brevicaulis（Scopulariopsis Brevicaulis）。这些化合物中的许多对假丝酵母属（Candida Albicans）和念珠菌（Candida Glabrata）是有活性的。

7. 发明申请

US20070197603A1 Substituted indole ligands for the orl-1 receptor 审中-公开
标题翻译：用于orl-1受体的取代的吲哚配体
公开(公告)号：US20070197603A1
公开(公告)日：2007-08-23
申请号：US10561282
申请日：2004-07-01
申请人： Alessandra Consonni , Simone Del Sordo , Carlo Farina , Stefania Gagliardi , Silvano Ronzoni , Stefania Vallese
发明人： Alessandra Consonni , Simone Del Sordo , Carlo Farina , Stefania Gagliardi , Silvano Ronzoni , Stefania Vallese
IPC分类号： A61K31/44 , C07D401/06
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14 , C07D405/14
摘要： New ligands for the ORL-1 receptor are described, useful for modulating the activity of said receptors in a patient in need thereof, and for preventing and treating illnesses dependent on the stimulation of this receptor. The new compounds conform to structural formula (I), wherein Q is a moiety of formula: and R, R0, R1, R2, R3, R4, R5, R6 are further defined in the description.
摘要翻译：描述了ORL-1受体的新配体，可用于调节有需要的患者中所述受体的活性，以及用于预防和治疗依赖于该受体刺激的疾病。新化合物符合结构式（I），其中Q是下式的部分：R 1，R 0，R 1，R 2， >，R 3，R 4，R 5，R 6，6在说明书中进一步定义。

8. 发明申请

US20130203904A1 STERICALLY HINDERED POLYMERIC AMINES AND THEIR USE AS POLYMER STABILIZERS 有权
标题翻译：多异性聚合物聚合物及其作为聚合物稳定剂的用途
公开(公告)号：US20130203904A1
公开(公告)日：2013-08-08
申请号：US13879973
申请日：2011-10-27
申请人： Francesco Maestri , Simone Del Sordo , Ferruccio Berte
发明人： Francesco Maestri , Simone Del Sordo , Ferruccio Berte
IPC分类号： C08K5/3492 , C07D413/14 , C07D401/14
CPC分类号： C08K5/3492 , C07D401/14 , C07D413/14 , C08K5/34926 , C09K15/30
摘要： The present invention relates to polypiperidine compounds of polymeric type which are capable of conferring to the polymeric materials, particularly to polyolefins, a high stability against photodegradation and oxidative action of air, belong to the HALS category and have general formula (I): wherein p is from 3 to 20;n is from 2 to 12;R and R1, which are the same or different, are selected in the group consisting of hydrogen, linear and branched C1-C12 alkyl groups, alkenyl groups having 3 to 8 carbon atoms and aralkyl groups having 7 to 19 carbon atoms;X and X1, which are the same or different, are selected in the group consisting oxygen and groups of formula (II) wherein R2 is selected in the group consisting of hydrogen, linear and branched C1-C12 alkyl groups, cycloalkyl groups having, 5 to 12 carbon atoms and aralkyl groups having 7 to 12 carbon atoms; A represents a —(CH2)a— group wherein a is from 2 to 12, with the proviso that a is different from n;Z is selected in the group consisting of C1-C18 alkyl groups, groups of formula (III) wherein n, X, X1, R and R1 are as above defined, and groups of formula (IV) wherein R is as above defined; Y represents a substituent selected in the group consisting of the groups of general formula (V) the groups O—R4 and S—R4, wherein R3 and R4, which may be the same or different, represent hydrogen, a linear and branched C1-C18 alkyl group, a cycloakyl group having 5 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms, an aryl group having 6 to 12 carbon atoms or may form, together with the nitrogen atom to which they are linked, a heterocycle containing 5 to 7 carbon atoms; and the piperidine group (VI) wherein R and X are as above defined.The invention further relates to the processes for preparation of the compounds according to the invention.
摘要翻译：本发明涉及能够赋予聚合物材料，特别是赋予聚烯烃，对光降解和空气氧化作用的高稳定性的聚合型聚哌啶化合物，属于HALS类别，并具有通式（I）：其中p 从3到20; n为2至12; R和R 1相同或不同，选自氢，直链和支链C 1 -C 12烷基，具有3至8个碳原子的烯基和具有7至19个碳原子的芳烷基; X和X 1相同或不同，选自氧和式（II）基团，其中R2选自氢，直链和支链C 1 -C 12烷基，环烷基具有5 至12个碳原子和具有7至12个碳原子的芳烷基; A表示 - （CH 2）a - 基团，其中a为2至12，条件是a不同于n; Z选自C 1 -C 18烷基，式（III）基团，其中n，X，X 1，R和R 1如上所定义，和式（Ⅳ）基团，其中R如上所定义; Y表示选自通式（Ⅴ）基团O-R4和S-R4的取代基，其中R3和R4可以相同或不同，表示氢，直链和支链C1- C18烷基，碳原子数5〜12的环烷酰基，碳原子数7〜12的芳烷基，碳原子数6〜12的芳基，可以与它们所连接的氮原子一起形成杂环含有5至7个碳原子; 和其中R和X如上所定义的哌啶基（Ⅵ）。本发明还涉及本发明化合物的制备方法。

9. 发明授权

US09725578B2 Sterically hindered polymeric amines and their use as polymer stabilizers 有权
公开(公告)号：US09725578B2
公开(公告)日：2017-08-08
申请号：US13879973
申请日：2011-10-27
申请人： Francesco Maestri , Simone Del Sordo , Ferruccio Berte
发明人： Francesco Maestri , Simone Del Sordo , Ferruccio Berte
IPC分类号： C07D413/00 , C08K5/34 , C08K5/3492 , C07D403/00 , C07D401/14 , C09K15/30 , C07D413/14
CPC分类号： C08K5/3492 , C07D401/14 , C07D413/14 , C08K5/34926 , C09K15/30
摘要： The present invention relates to polypiperidine compounds of polymeric type which are capable of conferring to the polymeric materials, particularly to polyolefins, a high stability against photodegradation and oxidative action of air, belong to the HALS category and have general formula (I): wherein p is from 3 to 20; n is from 2 to 12; R and R1, which are the same or different, are selected in the group consisting of hydrogen, linear and branched C1-C12 alkyl groups, alkenyl groups having 3 to 8 carbon atoms and aralkyl groups having 7 to 19 carbon atoms; X and X1, which are the same or different, are selected in the group consisting oxygen and groups of formula (II) wherein R2 is selected in the group consisting of hydrogen, linear and branched C1-C12 alkyl groups, cycloalkyl groups having 5 to 12 carbon atoms and aralkyl groups having 7 to 12 carbon atoms; A represents a —(CH2)a— group wherein a is from 2 to 12, with the proviso that a is different from n; Z is selected in the group consisting of C1-C18 alkyl groups, groups of formula (III) wherein n, X, X1, R and R1 are as above defined, and groups of formula (IV) wherein R is as above defined; Y represents a substituent selected in the group consisting of the groups of general formula (V) the groups O—R4 and S—R4, wherein R3 and R4, which may be the same or different, represent hydrogen, a linear and branched C1-C18 alkyl group, a cycloakyl group having 5 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms, an aryl group having 6 to 12 carbon atoms or may form, together with the nitrogen atom to which they are linked, a heterocycle containing 5 to 7 carbon atoms; and the piperidine group (VI) wherein R and X are as above defined. The invention further relates to the processes for preparation of the compounds according to the invention.

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