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1. 发明申请

US20070133086A1 Method and apparatus for the examination of probes 有权
标题翻译：用于检测探针的方法和装置
公开(公告)号：US20070133086A1
公开(公告)日：2007-06-14
申请号：US11330384
申请日：2006-01-12
申请人： Stefan Wilhelm , Eva Simburger , Michael Kempe
发明人： Stefan Wilhelm , Eva Simburger , Michael Kempe
IPC分类号： G02B21/06
CPC分类号： G01N21/6458 , G02B21/0032 , G02B21/0076 , G02B21/008 , G02B21/16 , Y10S359/90
摘要： A method in which probes are examined by means a microscope. For an illuminated sample, spatially coherent light with at least one continuous wavelength range or a continuously tunable wavelength range is generated, and one or more wavelengths or wavelength ranges in the illumination light are selected in dependence on the prespecified method of examination. The probe is then illuminated with the illumination light with the selected wavelengths or wavelength ranges, the illumination light and the emission light coming from the probe are then subsequently separated, whereby the back radiated illumination light is suppressed in the detection beam before the detection and the emission light is detected. In such a method, the selection of the wavelengths or the wavelength ranges of the illumination light is tuned by means of the separation of the detection light and the illumination light and the suppression of the illumination light in such a manner that a prespecified control variable (R) is optimized.
摘要翻译：通过显微镜检查探针的方法。对于照明样品，产生具有至少一个连续波长范围或连续可调波长范围的空间相干光，并且根据预先指定的检查方法来选择照明光中的一个或多个波长或波长范围。然后用所选择的波长或波长范围的照明光照射探针，随后分离照明光和来自探针的发射光，从而在检测之前在检测光束中抑制背面照射的照明光，并且检测出发光。在这种方法中，通过检测光和照明光的分离以及照明光的抑制来调节照明光的波长或波长范围的选择，使得预先指定的控制变量（ R）优化。

2. 发明授权

US07593158B2 Method and apparatus for the examination of specimens 有权
标题翻译：检测标本的方法和装置
公开(公告)号：US07593158B2
公开(公告)日：2009-09-22
申请号：US11330384
申请日：2006-01-12
申请人： Stefan Wilhelm , Eva Simbürger , Michael Kempe
发明人： Stefan Wilhelm , Eva Simbürger , Michael Kempe
IPC分类号： G02B21/06
CPC分类号： G01N21/6458 , G02B21/0032 , G02B21/0076 , G02B21/008 , G02B21/16 , Y10S359/90
摘要： A method in which specimens are examined using a microscope. For an illuminated specimen, spatially coherent light with at least one continuous wavelength range or a continuously tunable wavelength range is generated, and one or more wavelengths or wavelength ranges in the illumination light are selected in dependence on the prespecified method of examination. The specimen is then illuminated with the illumination light with the selected wavelengths or wavelength ranges, the illumination light and the emission light coming from the specimen are then subsequently separated, whereby the back radiated illumination light is suppressed in the detection beam before the detection and the emission light is detected. In such a method, the selection of the wavelengths or the wavelength ranges of the illumination light is tuned by means of the separation of the detection light and the illumination light and the suppression of the illumination light in such a manner that a prespecified control variable (R) is optimized.
摘要翻译：使用显微镜检查样品的方法。对于照射的样本，产生具有至少一个连续波长范围或连续可调波长范围的空间相干光，并且根据预先指定的检查方法来选择照明光中的一个或多个波长或波长范围。然后用所选择的波长或波长范围的照明光照射样本，随后分离照明光和来自样本的发射光，从而在检测之前在检测光束中抑制背面照射光，并且检测出发光。在这种方法中，通过检测光和照明光的分离以及照明光的抑制来调节照明光的波长或波长范围的选择，使得预先指定的控制变量（ R）优化。

3. 发明申请

US20110176206A1 Microscope Having an Adjustment Device for the Focus Range 有权
标题翻译：具有调焦装置的显微镜用于对焦范围
公开(公告)号：US20110176206A1
公开(公告)日：2011-07-21
申请号：US13121886
申请日：2009-09-22
申请人： Ralf Wolleschensky , Michael Kempe
发明人： Ralf Wolleschensky , Michael Kempe
IPC分类号： G02B21/00
CPC分类号： G02B21/006 , G02B21/0068 , G02B21/241 , G02B2207/114
摘要： A microscope with means for adjusting the focal range, comprising a first objective lens for transmitting the object light of an illuminated object in the direction of a detector, with a second objective lens being disposed in the direction of the light upstream of the detector, which second objective lens is followed by a first mirror that can be adjusted in the direction of the optical axis, with at least one second mirror for transmitting light from the first objective lens in the direction of the second objective lens and from the second objective lens to the detector being disposed in the optical path, which second mirror is a fully reflective mirror, or a microscope with means for adjusting the focal range, comprising a first objective lens for transmitting the object light of an illuminated object in the direction of a detector, with a second objective lens being disposed in the direction of light upstream of the detector, which second objective lens is followed by a first mirror that can be adjusted in the direction of the optical axis, with a polarizing beam splitter for splitting the object light into two components that are oriented perpendicular to each other being disposed between the first and the second objective lens for light transmission.
摘要翻译：一种具有用于调节焦距范围的装置的显微镜，包括用于在检测器的方向上传送被照射物体的物体的第一物镜，其中第二物镜沿检测器上游的光的方向设置，第二物镜之后是可以在光轴方向上调节的第一反射镜，具有至少一个第二反射镜，用于在第二物镜的方向上从第一物镜透射光并从第二物镜传播光所述检测器设置在所述光路中，所述第二反射镜是完全反射镜，或具有用于调节所述焦距的装置的显微镜，所述显微镜包括用于沿检测器的方向透射被照射物体的物体的第一物镜，其中第二物镜沿着检测器上游的光的方向设置，该第二物镜后面是第一镜像 r可以在光轴的方向上调整，其中偏振分束器用于将物体光分成两个彼此垂直取向的分量，这两个分量被布置在第一和第二物镜之间用于透光。

4. 发明授权

US07605976B1 Method and device for changing light in an adjustable manner 有权
标题翻译：用于以可调节的方式改变光的方法和装置
公开(公告)号：US07605976B1
公开(公告)日：2009-10-20
申请号：US11416455
申请日：2006-05-03
申请人： Ralf Wolleschensky , Michael Kempe , Peter Klopfleisch
发明人： Ralf Wolleschensky , Michael Kempe , Peter Klopfleisch
IPC分类号： G02B21/06
CPC分类号： G01J3/4406 , G01J3/02 , G01J3/021 , G01J3/0224 , G01J3/0229 , G01J3/14 , G01N21/21 , G01N21/6445 , G01N21/6458 , G01N2021/6417 , G02B21/0068 , G02B21/0076 , G02B26/0816 , G02B27/143 , G02B27/283
摘要： Method and device for changing the illumination light and/or specimen light with respect to its spectral composition and/or intensity in an adjustable manner, wherein a spatial separation into the radiation components of different polarization is carried out with the first polarization means (Pol 1), a spectral spatial splitting of at least one radiation component is carried out with the first dispersion means (Disp1), and the polarization state of at least one part of the spectrally spatially split radiation component is changed, wherein a reflection of the illumination light and/or the detection light is carried out.
摘要翻译：用于以可调节的方式改变照明光和/或样本光的方法和装置，其中利用第一偏振装置（Pol 1）执行不同偏振的辐射分量的空间分离），利用第一色散装置（Disp1）执行至少一个辐射分量的光谱空间分裂，并且改变光谱空间分裂的辐射分量的至少一部分的偏振状态，其中照明光的反射和/或检测光。

5. 发明申请

US20090250632A1 Method and Arrangement for Collimated Microscopic Imaging 审中-公开
标题翻译：准直显微镜成像的方法和布置
公开(公告)号：US20090250632A1
公开(公告)日：2009-10-08
申请号：US12444290
申请日：2007-10-02
申请人： Michael Kempe , Gerhard Krampert , Matthias Wald , Ralf Wolleschensky
发明人： Michael Kempe , Gerhard Krampert , Matthias Wald , Ralf Wolleschensky
IPC分类号： G01N21/64
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/0032 , G02B21/0072 , G02B21/0076
摘要： A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions.
摘要翻译：一种用于准直显微镜成像的方法和装置，包括用于激发荧光的至少一个区域中的样品的第一照明，以及由检测器元件对样品光进行空间分辨检测，所述检测与所述区域相关联，其中通过发生与检测器元件相关联的区域的分割成分离的荧光部分区域的第二照明。部分区域的分离是通过荧光区域通过具有减少的荧光或无荧光的中间区域和/或通过来自部分区域的荧光的不同光谱性质的空间分离来进行的。

6. 发明授权

US07333213B2 Confocal microscopy 失效
标题翻译：共焦显微镜
公开(公告)号：US07333213B2
公开(公告)日：2008-02-19
申请号：US10103927
申请日：2002-03-22
申请人： Michael Kempe
发明人： Michael Kempe
IPC分类号： G01B9/02
CPC分类号： G02B21/0064 , G02B21/0056 , G02B21/008
摘要： An improved confocal microscope system is provided which images sections of tissue utilizing heterodyne detection. The system has a synthesized light source for producing a single beam of light of multiple, different wavelengths using multiple laser sources. The beam from the synthesized light source is split into an imaging beam and a reference beam. The phase of the reference beam is then modulated, while confocal optics scan and focus the imaging beam below the surface of the tissue and collect from the tissue returned light of the imaging beam. The returned light of the imaging beam and the modulated reference beam are combined into a return beam, such that they spatially overlap and interact to produce heterodyne components. The return beam is detected by a photodetector which converts the amplitude of the return beam into electrical signals in accordance with the heterodyne components. The signals are demodulated and processed to produce an image of the tissue section on a display. The system enables the numerical aperture of the confocal optics to be reduced without degrading the performance of the system.
摘要翻译：提供了一种改进的共焦显微镜系统，其利用外差检测对组织的部分进行成像。该系统具有使用多个激光源产生多个不同波长的单光束的合成光源。来自合成光源的光束被分成成像光束和参考光束。然后对参考光束的相位进行调制，而共焦光学器件扫描并将成像光束聚焦在组织表面下方并从成像光束的组织返回光中收集。成像光束和调制参考光束的返回光被组合成返回光束，使得它们在空间上重叠并相互作用以产生外差分量。返回光束由光电检测器检测，光电检测器根据外差分量将返回光束的幅度转换成电信号。信号被解调和处理以在显示器上产生组织部分的图像。该系统可以减少共焦光学元件的数值孔径，而不会降低系统的性能。

7. 发明申请

US20080007730A1 Microscope with higher resolution and method for increasing same 有权
标题翻译：显微镜具有更高的分辨率和增加方法
公开(公告)号：US20080007730A1
公开(公告)日：2008-01-10
申请号：US11806459
申请日：2007-05-31
申请人： Michael Kempe
发明人： Michael Kempe
IPC分类号： G01J3/30
CPC分类号： G02B21/0056 , G02B21/0076
摘要： Microscope with higher resolution with partial spatial superposition in the illumination by an excitation beam and a de-excitation beam and/or a switching beam in a fluorescing sample, whereby the light from the sample is deflected, whereby, in the excitation beam and/or in the de-excitation and/or the switching beam, at least one combination of devices exercising circular and radial influence on the spatial phase is provided.
摘要翻译：具有较高分辨率的显微镜，其中通过荧光样品中的激发光束和去激发光束和/或切换光束在照明中具有部分空间叠加，由此来自样品的光被偏转，由此在激发光束和/或在去激励和/或切换光束中，提供对空间相位进行圆周和径向影响的装置的至少一个组合。

8. 发明申请

US20050244589A1 POLYMERS FOR ORIENTATION AND STABILITY OF LIQUID CRYSTALS 失效
标题翻译：聚合物用于液晶的定向和稳定性
公开(公告)号：US20050244589A1
公开(公告)日：2005-11-03
申请号：US10993575
申请日：2004-11-19
申请人： Julia Kornfield , Michael Kempe
发明人： Julia Kornfield , Michael Kempe
IPC分类号： G02F1/1334 , C09K19/02 , C09K19/38 , C09K19/54 , C09K19/56 , G02F1/1337 , G02F1/137 , C09K19/52 , G02F1/1333
CPC分类号： C09K19/542 , G02F1/133703 , G02F2001/13775 , Y10T428/10 , Y10T428/1036
摘要： An electro-optically active polymer gel material comprising a high molecular weight alignment polymer adapted to be homogeneously dispersed throughout a liquid crystal to control the alignment of the liquid crystal molecules and/or confer mechanical stability is provided. The electro-optically active polymer gel comprises a homogenous gel in which the polymer strands of the gel are provided in low concentration and are well solvated by the small molecule liquid crystal without producing unacceptable slowing of its electrooptic response. During formation of the gel, a desired orientation is locked into the gel by physical or chemical cross-linking of the polymer chains. The electro-optically active polymer is then utilized to direct the orientation in the liquid crystal gel in the “field off” state of a liquid crystal display. The electro-optically active polymer also provides a memory of the mesostructural arrangement of the liquid crystal and acts to suppress the formation of large scale deviations, such as, for example, fan-type defects in a FLC when subjected to a mechanical shock. A method of making an electro-optically active polymer gel material and an electrooptic device utilizing the electro-optically active polymer gel of the present invention is also provided.
摘要翻译：提供一种电光活性聚合物凝胶材料，其包含适于均匀分散在液晶中以控制液晶分子取向和/或赋予机械稳定性的高分子量对准聚合物。电光活性聚合物凝胶包含均匀的凝胶，其中凝胶的聚合物链以低浓度提供并且被小分子液晶很好地溶剂化，而不会导致其电光响应的不可接受的减慢。在形成凝胶期间，通过聚合物链的物理或化学交联将期望的取向锁定在凝胶中。然后使用电光活性聚合物将液晶凝胶中的取向引导到液晶显示器的“截止”状态。电光活性聚合物还提供液晶的介观结构布置的记忆，并且用于抑制大尺度偏差的形成，例如当受到机械冲击时FLC中的扇形缺陷。还提供了制造电光活性聚合物凝胶材料的方法和利用本发明的电光活性聚合物凝胶的电光装置。

9. 发明申请

US20050006597A1 Arrangement for the optical detection of light radiation which is excited and/or backscattered in a specimen with a double-objective arrangement 失效
标题翻译：光学检测用于双目标布置的样品中被激发和/或反向散射的光辐射的布置
公开(公告)号：US20050006597A1
公开(公告)日：2005-01-13
申请号：US10888896
申请日：2004-07-09
申请人： Ralf Wolleschensky , Michael Kempe
发明人： Ralf Wolleschensky , Michael Kempe
IPC分类号： G01N21/64 , G02B21/00 , G02B21/06 , G02B21/18 , G02B26/10
CPC分类号： G02B21/18 , G02B21/002
摘要： Arrangement and method for the optical detection of light radiation which is excited and/or backscattered in a specimen, wherein the illumination of the specimen and/or the detection of the specimen light is carried out by at least two objectives arranged on different sides of the specimen. The specimen illumination is focused in or in the vicinity of a pupil plane of the beam path between the specimen plane and the detection plane at least on one axis and an element for the spatial separation of the illumination light from the detection light are provided in this plane.
摘要翻译：在样本中被激发和/或反向散射的光辐射的光学检测的布置和方法，其中样本的照明和/或样本光的检测通过布置在样品的不同侧面上的至少两个物体进行标本。样本照明至少在一个轴上聚焦在样本平面和检测平面之间的光束路径的光瞳平面附近或附近，并且在该位置处提供用于照明光与检测光的空间分离的元件飞机

10. 发明授权

US6151127A Confocal microscopy 失效
公开(公告)号：US6151127A
公开(公告)日：2000-11-21
申请号：US86117
申请日：1998-05-28
申请人： Michael Kempe
发明人： Michael Kempe
IPC分类号： G01B9/02 , G02B21/00
CPC分类号： G02B21/0064 , G02B21/0056 , G02B21/008
摘要： An improved confocal microscope system is provided which images sections of tissue utilizing heterodyne detection. The system has a synthesized light source for producing a single beam of light of multiple, different wavelengths using multiple laser sources. The beam from the synthesized light source is split into an imaging beam and a reference beam. The phase of the reference beam is then modulated, while confocal optics scan and focus the imaging beam below the surface of the tissue and collect from the tissue returned light of the imaging beam. The returned light of the imaging beam and the modulated reference beam are combined into a return beam, such that they spatially overlap and interact to produce heterodyne components. The return beam is detected by a photodetector which converts the amplitude of the return beam into electrical signals in accordance with the heterodyne components. The signals are demodulated and processed to produce an image of the tissue section on a display. The system enables the numerical aperture of the confocal optics to be reduced without degrading the performance of the system.

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