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1. 发明申请

US20090214453A1 Use of Transmission Dyes for Protecting Human Skin From Browning and Ageing 有权
标题翻译：使用透射染料保护人体皮肤免于褐变和老化
公开(公告)号：US20090214453A1
公开(公告)日：2009-08-27
申请号：US12086648
申请日：2006-12-11
申请人： Stefan Müller , Jurg Haase , Thomas Ehlis , Gilbert Kreyer , Jochen Giesinger , Martin Vogt
发明人： Stefan Müller , Jurg Haase , Thomas Ehlis , Gilbert Kreyer , Jochen Giesinger , Martin Vogt
IPC分类号： A61Q17/04 , C07D241/04
CPC分类号： C07D295/192 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/494 , A61K2800/43 , A61Q17/04
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.
摘要翻译：公开了包含（a）微波化的微溶有机化合物的水分散体的使用，其具有最大值为380至420nm的UV-Vis光谱; 和（b）用于保护人体皮肤免于褐变和皮肤老化的阴离子分散剂。

2. 发明授权

US08097240B2 Use of transmission dyes for protecting human skin from browning and ageing 有权
标题翻译：使用透射染料保护人体皮肤免受褐变和老化
公开(公告)号：US08097240B2
公开(公告)日：2012-01-17
申请号：US12086648
申请日：2006-12-11
申请人： Stefan Müller , Jürg Haase , Thomas Ehlis , Gilbert Kreyer , Jochen Giesinger , Martin Vogt
发明人： Stefan Müller , Jürg Haase , Thomas Ehlis , Gilbert Kreyer , Jochen Giesinger , Martin Vogt
IPC分类号： A61Q17/04 , C07D241/04
CPC分类号： C07D295/192 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/494 , A61K2800/43 , A61Q17/04
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.
摘要翻译：公开了包含（a）微波化的微溶有机化合物的水分散体的使用，其具有最大值为380至420nm的UV-Vis光谱; 和（b）用于保护人体皮肤免于褐变和皮肤老化的阴离子分散剂。

3. 发明申请

US20100144753A1 CRYSTAL MODIFICATIONS OF TRANSMISSION DYES 有权
标题翻译：传染性染色体的晶体修饰
公开(公告)号：US20100144753A1
公开(公告)日：2010-06-10
申请号：US12597930
申请日：2008-04-28
申请人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
发明人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
IPC分类号： A61K31/4965
CPC分类号： C07D295/192 , A61K8/04 , A61K8/494 , A61K31/495 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.
摘要翻译：公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

4. 发明授权

US08557820B2 Crystal modifications of transmission dyes 有权
标题翻译：透射染料的水晶修饰
公开(公告)号：US08557820B2
公开(公告)日：2013-10-15
申请号：US12597930
申请日：2008-04-28
申请人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
发明人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
IPC分类号： A61K31/497 , A61K8/00 , C07D241/04 , C07D295/00 , A61Q17/04
CPC分类号： C07D295/192 , A61K8/04 , A61K8/494 , A61K31/495 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.
摘要翻译：公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

5. 发明授权

US09176079B2 Device for controlling pharmaceutical products 有权
标题翻译：用于控制药品的装置
公开(公告)号：US09176079B2
公开(公告)日：2015-11-03
申请号：US14111660
申请日：2012-03-01
申请人： Werner Runft , Iulian Maga , Jens Schlipf , Martin Vogt
发明人： Werner Runft , Iulian Maga , Jens Schlipf , Martin Vogt
IPC分类号： B07C5/346 , G01N23/18 , G01N33/15 , G01N23/08 , G01N21/95 , A61J3/07
CPC分类号： G01N23/18 , A61J3/074 , B07C5/346 , G01N21/9508 , G01N23/06 , G01N33/15
摘要： The invention relates to a device (10; 10a) for controlling pharmaceutical products (1) in particular, hard gelatin capsules, by means of a radiation source (11) preferably designed as an X-ray source, comprising a storage device (13) which receives the products (1) in an uncontrolled manner, and from which the products (1) are transferred to a transport element (15) in which the products (1) are arranged such that they form at least one row. The products (1) are transported in a clocked manner in the radiation area (25) of the radiation source (11) which exposes the products (1) to radiation, preferably perpendicular to the longitudinal direction thereof. A first stopping device (20) for separating the products (1) in the row is arranged upstream of the radiation source (11) in the direction of transportation (18) of the products (1), and at least one sensor element (28, 28a) coupled to an evaluation device (30) captures the radiation which passed through the products (1). According to the invention, at least two products (1) are separated from the row by means of the first stopping device (20) and are simultaneously positioned in the radiation area (25) and the image of the product (1) is captured by means of the at least one sensor element (28; 28a).
摘要翻译：本发明涉及一种用于通过优选设计为X射线源的辐射源（11）来控制药物产品（1），特别是硬明胶胶囊的装置（10; 10a），其包括存储装置（13）其以不受控制的方式接收产品（1），并且将产品（1）从该产品（1）转移到其中产品（1）布置成使得它们形成至少一排的运输元件（15）。产品（1）以时钟方式传送到辐射源（11）的辐射区域（25）中，其将产品（1）暴露于放射线，优选垂直于其纵向方向。用于分离行中的产品（1）的第一停止装置（20）在产品（1）的运输方向（18）上布置在辐射源（11）的上游，并且至少一个传感器元件（28）（28a），其耦合到评估装置（30）捕获通过所述产品（1）的辐射。根据本发明，通过第一停止装置（20）将至少两个产品（1）与该行分离，同时位于辐射区域（25）中，并且产品（1）的图像被所述至少一个传感器元件（28; 28a）的装置。

6. 发明授权

US09042515B2 Device for checking pharmaceutical products, in particular hard gelatin capsules 有权
标题翻译：用于检查药品，特别是硬明胶胶囊的装置
公开(公告)号：US09042515B2
公开(公告)日：2015-05-26
申请号：US14111742
申请日：2012-03-01
申请人： Werner Runft , Iulian Maga , Jens Schlipf , Martin Vogt
发明人： Werner Runft , Iulian Maga , Jens Schlipf , Martin Vogt
IPC分类号： G01N23/083 , G01N23/10 , G01N33/15 , H05G1/02 , G01N23/02 , G01T7/08 , G01T7/10 , G01N23/04 , A61J3/07 , G01N15/00 , G01N35/00 , G01N15/14
CPC分类号： G01N23/02 , A61J3/074 , G01N15/1459 , G01N23/043 , G01N33/15 , G01N2015/0019 , G01N2035/00564 , G01N2223/633 , G01N2223/652 , G01T7/08 , G01T7/10
摘要： The invention relates to a device (10; 10a;10b; 10c; 50) for checking pharmaceutical products (1), in particular hard gelatin capsules, by means of at least one radiation source (30; 60) preferably embodied as an X-ray source, and a conveying device which conveys the products (1) in a clocked manner in a radiation area (31) of the radiation source (30; 60). The radiation emitted by the radiation source (30; 60) penetrating the products (1) preferably perpendicular to the longitudinal axes thereof (2), and the radiation is captured on the side of the products (1) opposite the radiation source (30) by means of at least one sensor element (35) which is coupled to an evaluation device (36). The invention is characterized in that the conveyor device is embodied as a conveyor wheel (15; 15a; 51) which can rotate in a stepped manner about an axis (12; 52), and the products (1) are arranged, while being conveyed in the radiation area (31), in receiving areas (28; 37; 56) of the conveyor wheel (15; 5a; 51).
摘要翻译：本发明涉及一种用于通过至少一个辐射源（30; 60）检查药物产品（1），特别是硬明胶胶囊的装置（10; 10a; 10b; 10c; 50）以及输送装置，其以时钟方式在辐射源（30; 60）的辐射区域（31）中传送产品（1）。由辐射源（30; 60）发射的辐射穿透产品（1），优选地垂直于其纵向轴线（2），并且辐射被捕获在与辐射源（30）相对的产品（1）侧上，借助于耦合到评估装置（36）的至少一个传感器元件（35）。本发明的特征在于，输送装置被实施为可以围绕轴线（12; 52）以阶梯式方式旋转的输送轮（15; 15a; 51），并且产品（1）被布置成被输送在所述辐射区域（31）中，在所述输送轮（15; 5a; 51）的接收区域（28; 37; 56）中。

7. 发明申请

US20140050299A1 DEVICE FOR CHECKING PHARMACEUTICAL PRODUCTS, IN PARTICULAR HARD GELATIN CAPSULES 有权
标题翻译：用于检查药用产品，特别是硬胶囊的装置
公开(公告)号：US20140050299A1
公开(公告)日：2014-02-20
申请号：US14111742
申请日：2012-03-01
申请人： Werner Runft , Lulian Maga , Jens Schlipf , Martin Vogt
发明人： Werner Runft , Lulian Maga , Jens Schlipf , Martin Vogt
IPC分类号： G01N23/02
CPC分类号： G01N23/02 , A61J3/074 , G01N15/1459 , G01N23/043 , G01N33/15 , G01N2015/0019 , G01N2035/00564 , G01N2223/633 , G01N2223/652 , G01T7/08 , G01T7/10
摘要： The invention relates to a device (10; 10a;10b; 10c; 50) for checking pharmaceutical products (1), in particular hard gelatin capsules, by means of at least one radiation source (30; 60) preferably embodied as an X-ray source, and a conveying device which conveys the products (1) in a clocked manner in a radiation area (31) of the radiation source (30; 60). The radiation emitted by the radiation source (30; 60) penetrating the products (1) preferably perpendicular to the longitudinal axes thereof (2), and the radiation is captured on the side of the products (1) opposite the radiation source (30) by means of at least one sensor element (35) which is coupled to an evaluation device (36). The invention is characterised in that the conveyor device is embodied as a conveyor wheel (15; 15a; 51) which can rotate in a stepped manner about an axis (12; 52), and the products (1) are arranged, whilst being conveyed in the radiation area (31), in receiving areas (28; 37; 56) of the conveyor wheel (15; 5a; 51).
摘要翻译：本发明涉及一种用于通过至少一个辐射源（30; 60）检查药物产品（1），特别是硬明胶胶囊的装置（10; 10a; 10b; 10c; 50）以及输送装置，其以时钟方式在辐射源（30; 60）的辐射区域（31）中传送产品（1）。由辐射源（30; 60）发射的辐射穿透产品（1），优选地垂直于其纵向轴线（2），并且辐射被捕获在与辐射源（30）相对的产品（1）侧上，借助于耦合到评估装置（36）的至少一个传感器元件（35）。本发明的特征在于，传送装置被实施为可以围绕轴线（12; 52）以阶梯式方式旋转的传送轮（15; 15a; 51），并且产品（1）被布置成被传送在所述辐射区域（31）中，在所述输送轮（15; 5a; 51）的接收区域（28; 37; 56）中。

8. 发明授权

US07118915B2 Muteins of apolipoprotein D 有权
标题翻译：载脂蛋白D的突变蛋白
公开(公告)号：US07118915B2
公开(公告)日：2006-10-10
申请号：US10491001
申请日：2001-09-27
申请人： Martin Vogt , Arne Skerra
发明人： Martin Vogt , Arne Skerra
IPC分类号： C12N15/00
CPC分类号： C07K14/775 , A61K38/00 , C07K2319/00
摘要： A method for generating a mutein of human apolipoprotein D having detectable affinity to a given non-natural ligand of apolipoprotein D is disclosed, which comprises the steps of: (a) subjecting the apolipoprotein D to mutagenesis at the sequence positions 34 to 38, 60, 62 to 66, 68, 89 to 93, 115, 117 to 121, and 123 resulting in a plurality of muteins of apolipoprotein D; and (b) enriching resulting muteins having binding affinity for a given ligand from the plurality of muteins by selection, and/or isolating said mutein. Muteins of apolipoprotein D obtainable by this method are also disclosed.
摘要翻译：公开了一种产生具有对载脂蛋白D的给定非天然配体具有可检测亲和力的人载脂蛋白D的突变蛋白的方法，其包括以下步骤：（a）使载脂蛋白D在序列位置34至38,60进行诱变，62至66,68,89至93,115,117至121和123，导致多个载脂蛋白D的突变蛋白; 和（b）通过选择和/或分离所述突变蛋白，从所述多个突变蛋白中富集对给定配体具有结合亲和力的所得突变蛋白。还公开了通过该方法获得的载脂蛋白D的突变蛋白。

9. 发明授权

US08814135B2 Device for controlling the flow of a liquid or gaseous medium 有权
标题翻译：用于控制液体或气体介质流动的装置
公开(公告)号：US08814135B2
公开(公告)日：2014-08-26
申请号：US12868941
申请日：2010-08-26
申请人： Felix Ams , Martin Vogt
发明人： Felix Ams , Martin Vogt
IPC分类号： F16K31/02 , F16K25/00 , F16F9/30 , H01F7/08 , F16K31/06
CPC分类号： F16K31/0655 , F16K31/0686
摘要： A device for controlling the flow of a liquid or gaseous medium, has at least one flow opening for the medium, and a movable valve element for controlling the flow opening. At least one damping body, which is preferably viscoelastic and acts on the valve element, is provided for obtaining a large dynamic range of the device in order to control flow in a fine, precise, and oscillation-free manner across a broad range of flow volume.
摘要翻译：用于控制液体或气体介质的流动的装置具有用于介质的至少一个流动开口和用于控制流动开口的可移动阀元件。提供至少一个阻尼体，其优选地是粘弹性的并且作用在阀元件上，用于获得该装置的大的动态范围，以便在很宽的流动范围内以精细，精确和无振动的方式控制流动卷。

10. 发明申请

US20110315907A1 DEVICE FOR CONTROLLING THE FLOW OF A LIQUID OR GASEOUS MEDIUM 有权
标题翻译：用于控制液体或气体介质的流动的装置
公开(公告)号：US20110315907A1
公开(公告)日：2011-12-29
申请号：US12868941
申请日：2010-08-26
申请人： Felix Ams , Martin Vogt
发明人： Felix Ams , Martin Vogt
IPC分类号： F16K31/02
CPC分类号： F16K31/0655 , F16K31/0686
摘要： A device for controlling the flow of a liquid or gaseous medium, has at least one flow opening for the medium, and a movable valve element for controlling the flow opening. At least one damping body, which is preferably viscoelastic and acts on the valve element, is provided for obtaining a large dynamic range of the device in order to control flow in a fine, precise, and oscillation-free manner across a broad range of flow volume.
摘要翻译：用于控制液体或气体介质的流动的装置具有用于介质的至少一个流动开口和用于控制流动开口的可移动阀元件。提供至少一个阻尼体，其优选地是粘弹性的并且作用在阀元件上，用于获得该装置的大的动态范围，以便在很宽的流动范围内以精细，精确和无振动的方式控制流动卷。

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