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1. 发明授权

US07373198B2 Method and apparatus for the estimation of anesthetic depth using wavelet analysis of the electroencephalogram 有权
标题翻译：用脑电图小波分析估算麻醉深度的方法和装置
公开(公告)号：US07373198B2
公开(公告)日：2008-05-13
申请号：US10616997
申请日：2003-07-11
申请人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hossain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell Macleod
发明人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hossain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell Macleod
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/4035 , A61B5/7217 , A61B5/726 , A61B5/7267
摘要： A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patient's true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.
摘要翻译：提供了一种监测患有全身麻醉的患者的神经状态的方法和装置。以前用于监测患有全身麻醉的患者的神经状态的自动化系统涉及患者真实催眠状态与计算出的指数之间的显着时间延迟。本发明通过使用应用于自发性EEG的不同分析技术来减少该时间延迟。进行观察脑电图的小波分解和统计分析，并与参考数据进行比较以提供数值指标。此外，该指标与以前系统的计数事件丢失所表示的患者意识丧失更为一致。

2. 发明授权

US08798735B1 Method and apparatus for the estimation of anesthetic depth using wavelet analysis of the electroencephalogram 有权
标题翻译：用脑电图小波分析估算麻醉深度的方法和装置
公开(公告)号：US08798735B1
公开(公告)日：2014-08-05
申请号：US12584083
申请日：2009-08-31
申请人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hossain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell Macleod
发明人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hossain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell Macleod
IPC分类号： A61B5/00
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/4035 , A61B5/7217 , A61B5/726 , A61B5/7267
摘要： A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patient's true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.
摘要翻译：提供了一种监测患有全身麻醉的患者的神经状态的方法和装置。以前用于监测患有全身麻醉的患者的神经状态的自动化系统涉及患者真实催眠状态与计算出的指数之间的显着时间延迟。本发明通过使用应用于自发性EEG的不同分析技术来减少该时间延迟。进行观察脑电图的小波分解和统计分析，并与参考数据进行比较以提供数值指标。此外，该指标与以前系统的计数事件丢失所表示的患者意识丧失更为一致。

3. 发明授权

US07603168B2 Method and apparatus for the estimation of anesthesia depth 有权
标题翻译：估计麻醉深度的方法和装置
公开(公告)号：US07603168B2
公开(公告)日：2009-10-13
申请号：US12148151
申请日：2008-04-17
申请人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hosaain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell MacLeod
发明人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hosaain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell MacLeod
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/4035 , A61B5/7217 , A61B5/726 , A61B5/7267
摘要： A method and apparatus to monitor and control the anesthesia state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the anesthesia state of a patient undergoing general anesthesia involve a significant time delay between the patient's true anesthesia state and the computed indices. The present invention reduces this time delay by using a novel analysis technique applied to spontaneous electrophysiological activity. A transformation and statistical analysis of the observed electrophysiological activity is conducted and compared to reference data to provide numerical indicators. In addition, these indicators are consistent with the levels of depression of patients CNS and ANS states. This method is illustrated in detail by CNS monitoring of electroencephalogram signals.
摘要翻译：提供了一种用于监测和控制进行全身麻醉的患者的麻醉状态的方法和装置。以前的自动系统监测患者进行全身麻醉的麻醉状态涉及患者真实麻醉状态与计算出的指数之间的显着时间延迟。本发明通过使用应用于自发电生理活动的新型分析技术来减少该时间延迟。对观察到的电生理活动进行转化和统计分析，并与参考数据进行比较以提供数值指标。此外，这些指标与患者CNS和ANS状态的抑郁水平一致。 CNS对脑电图信号的监测详细说明了该方法。

4. 发明申请

US20080294063A1 Method and apparatus for the estimation of anesthetic depth using wavelet analysis of the electroencephalogram 有权
标题翻译：用脑电图小波分析估算麻醉深度的方法和装置
公开(公告)号：US20080294063A1
公开(公告)日：2008-11-27
申请号：US12148151
申请日：2008-04-17
申请人： Stephane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hosaain Cyrus Ahimadi , Mihai Huzmezan , Bernard Ansell MacLeod
发明人： Stephane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hosaain Cyrus Ahimadi , Mihai Huzmezan , Bernard Ansell MacLeod
IPC分类号： A61B5/0476
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/4035 , A61B5/7217 , A61B5/726 , A61B5/7267
摘要： A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patients true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.
摘要翻译：提供了一种监测患有全身麻醉的患者的神经状态的方法和装置。以前的自动化系统来监测经历全身麻醉的患者的神经系统状态，包括患者真正催眠状态和计算出的指数之间的显着时间延迟。本发明通过使用应用于自发性EEG的不同分析技术来减少该时间延迟。进行观察脑电图的小波分解和统计分析，并与参考数据进行比较以提供数值指标。此外，该指标与以前系统的计数事件丢失所表示的患者意识丧失更为一致。

5. 发明授权

US07672717B1 Method and system for the denoising of large-amplitude artifacts in electrograms using time-frequency transforms 有权
标题翻译：使用时频变换去除电磁图中大幅度伪影的方法和系统
公开(公告)号：US07672717B1
公开(公告)日：2010-03-02
申请号：US10968348
申请日：2004-10-19
申请人： Tatjana Zikov , Stephane Bibian , Guy Albert Dumont , Mihai Huzmezan , Craig Robert Ries
发明人： Tatjana Zikov , Stephane Bibian , Guy Albert Dumont , Mihai Huzmezan , Craig Robert Ries
IPC分类号： A61B5/04 , A61B5/05
CPC分类号： A61B5/0476 , A61B5/0496 , A61B5/726
摘要： The present invention relates to a method of signal processing of electrograms for use in medical devices, preferably by time-frequency transforms. The present invention additionally relates to a system for receiving and analyzing such signals. The present invention preferably is a method utilizing the time-frequency transforms, such as wavelet transforms, for the purpose of artifact removal from EGs. These transforms decompose a signal in both time and frequency domains, and therefore, are well suited for non-stationary signal analysis. As a result, dissimilar signal features are well localized both in time and frequency, which potentially provides a good separation between the signal of interest and artifacts. This particularly applies to large-amplitude artifacts corrupting EGs.
摘要翻译：本发明涉及一种信号处理方法，用于医疗装置中使用的电描记图，优选地通过时频变换。本发明还涉及一种用于接收和分析这些信号的系统。本发明优选地是利用诸如小波变换的时间 - 频率变换来从EG去除人造物的目的的方法。这些变换在时域和频域都分解信号，因此非常适合于非平稳信号分析。因此，不同的信号特征在时间和频率上都很好地定位，这可能在感兴趣的信号和伪像之间提供良好的分离。这特别适用于破坏EGs的大幅度伪影。

6. 发明授权

US11109789B1 Field deployable brain monitor and method 有权
公开(公告)号：US11109789B1
公开(公告)日：2021-09-07
申请号：US13962533
申请日：2013-08-08
申请人： Stéphane Bibian , Tatjana Zikov , Sankar Barua
发明人： Stéphane Bibian , Tatjana Zikov , Sankar Barua
IPC分类号： A61B5/372 , A61B5/291
摘要： A system and method for using electroencephalographic (EEG) signals to monitor brain function, preferably detect occurrence of traumatic brain injury (TBI) to screen, assess, and potentially provide mitigating treatment to improve short and long term adverse outcomes of mild TBI (mTBI) and TBI. The system and method provides a readily available tool to assist in accurate and objective assessment of subjects with TBI, immediately at the point of injury (POI), during transportation, or upon arrival at a care facility, that preferably is applicable without advanced training or expertise.

7. 发明授权

US09554721B1 Seizure detector, brain dysfunction monitor and method 有权
标题翻译：癫痫检测仪，脑功能障碍监测仪及方法
公开(公告)号：US09554721B1
公开(公告)日：2017-01-31
申请号：US12148815
申请日：2008-04-23
申请人： Tatjana Zikov , Stéphane Bibian , Mohammad Modarres
发明人： Tatjana Zikov , Stéphane Bibian , Mohammad Modarres
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/048
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/04001 , A61B5/04012 , A61B5/048 , A61B5/1128 , A61B5/4094 , A61B5/4839 , A61B5/721 , A61B5/7235 , A61B5/743 , A61N1/36064
摘要： The present invention relates to a brain dysfunction and seizure detector monitor and system, and a method of detecting brain dysfunction and/or seizure of a subject. The various embodiments of the system of the present invention were developed for the brain activity and preferably EEG monitoring of a single patient or multiple patients. Preferably, the system or monitor of the present invention also includes one or more seizure detection algorithms. The analysis method is specifically optimized to amplify abnormal brain activity and minimize normal background activity. This analysis yields a seizure index whose value is directly related to the current presence of ictal activity in the signal. In addition, a seizure probability index based on historical values of the aforementioned seizure index, is derived for diagnostic purposes. The seizure probability index quantifies the probability that the patient has exhibited abnormal brain activity since the beginning of the recording. The real-time seizure index, and the historical seizure probability index, can be used in the context of an emergency and/or clinical situation to assess the status and well being of a patient's brain, or can be used to automatically administer treatment to stop the seizure before clinical signs appear.
摘要翻译：本发明涉及脑功能障碍和癫痫发作检测器监测和系统，以及检测受试者脑功能障碍和/或发作的方法。本发明的系统的各种实施方案是针对脑活动而开发的，优选地对单个患者或多个患者进行EEG监测。优选地，本发明的系统或监视器还包括一个或多个发作检测算法。分析方法被特别优化，以扩大异常大脑活动并最小化正常的背景活动。该分析产生一个缉获指数，其价值与信号中当前存在的动作直接相关。此外，基于上述扣押指数的历史值的缉获概率指数被推导出用于诊断目的。癫痫发作概率指数量化自记录开始以来患者表现出异常脑活动的可能性。可以在紧急情况和/或临床情况的情况下使用实时癫痫发作指数和历史发作概率指数来评估患者的大脑的状态和健康状况，或者可以用于自动管理治疗停止临床前出现癫痫发作。

8. 发明授权

US10194823B1 Physiological recording device with novel and proprietary connector 有权
公开(公告)号：US10194823B1
公开(公告)日：2019-02-05
申请号：US14874725
申请日：2015-10-05
申请人： Stéphane Bibian , Tatjana Zikov
发明人： Stéphane Bibian , Tatjana Zikov
IPC分类号： A61B5/0478 , A61B5/0416
摘要： Electrodes for use in electroencephalographic recording, including consciousness and seizure monitoring applications, have novel features that speed, facilitate or enforce proper placement of the electrodes, including aligning tabs and arrowed aligning juts, color coding, and an insulating bridge between reference and ground electrodes which ensures a safe application distance between the conductive regions of the two electrodes in the event of cardiac defibrillation or to prevent shorting between the adjacent electrodes by preventing the conductive path to be shared. A method of using a set of four such electrodes is also disclosed.

9. 发明授权

US09980662B2 Method and system for electrode impedance measurement 有权
公开(公告)号：US09980662B2
公开(公告)日：2018-05-29
申请号：US13110455
申请日：2011-05-18
申请人： Stéphane Bibian , Tatjana Zikov
发明人： Stéphane Bibian , Tatjana Zikov
IPC分类号： A61B5/0478 , A61B5/053 , A61B5/00
CPC分类号： A61B5/0478 , A61B5/053 , A61B5/4094 , A61B5/4806 , A61B5/4821 , A61B5/7203 , A61B5/7221
摘要： The present invention relates to measuring electrical impedance, and particularly to measuring impedance of electrodes used to acquire physiological signals. The measurement of electrode impedance is typically performed to ensure proper electrode-to-skin contact, and thus verify the quality of the acquired signals. Electrode-to-skin contact impedance has also clinical utility for monitoring, diagnosis, prognosis or treatment, as it can be used to measure skin conductivity, which is function of physiological processes. The present invention relates in particular to a substantially continuous method for performing such measurement. The measurement is performed in such a way that it does not affect the bioband, the range (or ranges) of frequencies that contains components used for diagnostic, prognostic, triage, and/or treatment purposes. The present invention therefore performs this impedance measurement without affecting the physiological signal while allowing for uninterrupted monitoring of said signal.

10. 发明授权

US09050015B2 Physiological electrode assembly for fast application 有权
标题翻译：生理电极组件快速应用
公开(公告)号：US09050015B2
公开(公告)日：2015-06-09
申请号：US14324719
申请日：2014-07-07
申请人： Stéphane Bibian , Tatjana Zikov
发明人： Stéphane Bibian , Tatjana Zikov
IPC分类号： A61B5/0478 , A61B5/0492 , A61B5/0496 , A61B5/042 , A61B5/00 , A61B5/0408
CPC分类号： A61B5/0478 , A61B5/0408 , A61B5/042 , A61B5/0492 , A61B5/0496 , A61B5/6833 , A61B5/6839 , A61B2562/0209 , A61B2562/14 , A61B2562/242
摘要： The present invention relates to a physiological recording electrode, and, more particularly, to an EEG (electroencephalography) recording electrode that can be used without the need for numerous steps in preparing the subject's skin and the electrode itself. The invention further relates to a surface feature or penetrator with a size and shape which that will not bend or break, which limits the depth of application, and/or anchors the electrode or other device during normal application; and a packaging system comprising a well and electrolytic fluid for maintaining a coating of said electrolytic fluid on the surface feature or penetrator.
摘要翻译：本发明涉及一种生理记录电极，更具体地说，涉及一种EEG（脑电图）记录电极，其可以在制备受试者的皮肤和电极本身时不需要许多步骤而使用。本发明还涉及具有不会弯曲或断裂的尺寸和形状的表面特征或穿透器，这限制了施加深度，和/或在正常应用期间锚定电极或其它装置; 以及包括井和电解液的包装系统，用于将所述电解液的涂层保持在表面特征或穿透器上。

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