会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 6. 发明授权
    • N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof
    • N-芳基氮杂螺烯和氮杂环烷烃化合物及其制备方法和用途
    • US07754708B2
    • 2010-07-13
    • US12117946
    • 2008-05-09
    • Balwinder BhattiScott R. BreiningPhilip S. HammondJozef KlucikYun-De Xiao
    • Balwinder BhattiScott R. BreiningPhilip S. HammondJozef KlucikYun-De Xiao
    • A61K31/4406A61K31/4418A61K31/397A61P25/22A61P25/24
    • C07D413/04C07D401/04
    • Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds, prodrugs or metabolites of these compounds, or pharmaceutically acceptable salts thereof. The aryl group can be a phenyl ring or a five- or six-membered heterocyclic ring (heteroaryl). The compounds and compositions can be used to treat and/or prevent a wide variety of conditions or disorders, particularly those disorders characterized by dysfunction of nicotinic cholinergic neurotransmission, including disorders involving neuromodulation of neurotransmitter release, such as dopamine release. CNS disorders, which are characterized by an alteration in normal neurotransmitter release, are another example of disorders that can be treated and/or prevented. The compounds and compositions can also be used to alleviate pain. The compounds can: (i) alter the number of nicotinic cholinergic receptors of the brain of the patient, (ii) exhibit neuroprotective effects and (iii) when employed in effective amounts, not result in appreciable adverse side effects (e.g., side effects such as significant increases in blood pressure and heart rate, significant negative effects upon the gastro-intestinal tract, and significant effects upon skeletal muscle).
    • 公开了化合物,包括该化合物的药物组合物,及其制备和使用方法。 化合物是N-芳基或杂芳基氮杂螺烯/烷烃化合物,这些化合物的前药或代谢物,或其药学上可接受的盐。 芳基可以是苯环或五元或六元杂环(杂芳基)。 化合物和组合物可用于治疗和/或预防各种各样的病症或病症,特别是以烟碱型胆碱能神经传递功能障碍为特征的疾病,包括涉及神经递质释放神经调节的疾病,如多巴胺释放。 其特征在于正常神经递质释放的改变的CNS疾病是可以治疗和/或预防的疾病的另一个例子。 化合物和组合物也可用于缓解疼痛。 化合物可以:(i)改变患者脑部烟碱性胆碱能受体的数量,(ii)表现出神经保护作用,和(iii)当以有效量使用时,不会产生明显的不利副作用(例如副作用 因为血压和心率的显着增加,对胃肠道的显着的负面影响以及对骨骼肌的显着影响)。
    • 9. 发明申请
    • N-ARYL AZASPIROALKENE AND AZASPIROALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF
    • N-ARYL AZASPIROALKENE和AZASPIROALKANE化合物及其制备和使用方法
    • US20080242689A1
    • 2008-10-02
    • US12117946
    • 2008-05-09
    • Balwinder BhattiScott R. BreiningPhilip S. HammondJozef KlucikYun-De Xiao
    • Balwinder BhattiScott R. BreiningPhilip S. HammondJozef KlucikYun-De Xiao
    • A61K31/4427A61P25/00A61K31/4439
    • C07D413/04C07D401/04
    • Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds, prodrugs or metabolites of these compounds, or pharmaceutically acceptable salts thereof. The aryl group can be a phenyl ring or a five- or six-membered heterocyclic ring (heteroaryl). The compounds and compositions can be used to treat and/or prevent a wide variety of conditions or disorders, particularly those disorders characterized by dysfunction of nicotinic cholinergic neurotransmission, including disorders involving neuromodulation of neurotransmitter release, such as dopamine release. CNS disorders, which are characterized by an alteration in normal neurotransmitter release, are another example of disorders that can be treated and/or prevented. The compounds and compositions can also be used to alleviate pain. The compounds can: (i) alter the number of nicotinic cholinergic receptors of the brain of the patient, (ii) exhibit neuroprotective effects and (iii) when employed in effective amounts, not result in appreciable adverse side effects (e.g., side effects such as significant increases in blood pressure and heart rate, significant negative effects upon the gastro-intestinal tract, and significant effects upon skeletal muscle).
    • 公开了化合物,包括该化合物的药物组合物,及其制备和使用方法。 化合物是N-芳基或杂芳基氮杂螺烯/烷烃化合物,这些化合物的前药或代谢物,或其药学上可接受的盐。 芳基可以是苯环或五元或六元杂环(杂芳基)。 化合物和组合物可用于治疗和/或预防各种各样的病症或病症,特别是以烟碱型胆碱能神经传递功能障碍为特征的疾病,包括涉及神经递质释放神经调节的疾病,如多巴胺释放。 其特征在于正常神经递质释放的改变的CNS疾病是可以治疗和/或预防的疾病的另一个例子。 化合物和组合物也可用于缓解疼痛。 化合物可以:(i)改变患者脑部烟碱性胆碱能受体的数量,(ii)表现出神经保护作用,和(iii)当以有效量使用时,不会产生明显的不利副作用(例如副作用 因为血压和心率的显着增加,对胃肠道的显着的负面影响以及对骨骼肌的显着影响)。