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1. 发明授权

US09107606B2 Measuring lung function and lung disease progression at a lobar/segmental level 有权
标题翻译：测量肺功能和肺部疾病进展在肺叶/节段水平
公开(公告)号：US09107606B2
公开(公告)日：2015-08-18
申请号：US12964515
申请日：2010-12-09
申请人： Srikanth Radhakrishnan , Surag Mantri , Ryan Olivera
发明人： Srikanth Radhakrishnan , Surag Mantri , Ryan Olivera
IPC分类号： A61B5/08 , A61B5/085 , A61B5/087 , A61B5/00
CPC分类号： A61B5/085 , A61B5/087 , A61B5/097 , A61B5/6853 , A61B5/7278 , A61B2562/0247
摘要： A method for determining lung function in a patient is disclosed, in which a multi-lumen catheter with an expandable occluding element at its end is used to isolate a targeted lung compartment, and respiratory characteristics at the targeted lung compartment are measured over multiple respiratory cycles. The relation between various characteristics of the respiratory cycle is used to determine compliance of lung tissue within the targeted lung compartment.
摘要翻译：公开了一种用于确定患者的肺功能的方法，其中使用其末端具有可扩张闭塞元件的多腔导管来分离靶向的肺隔室，并且在多个呼吸循环中测量目标肺隔室处的呼吸特征。呼吸周期的各种特征之间的关系用于确定目标肺隔室内肺组织的依从性。

2. 发明申请

US20110313307A1 MEASURING LUNG FUNCTION AND LUNG DISEASE PROGRESSION AT A LOBAR/SEGMENTAL LEVEL 有权
标题翻译：测量肺功能和肺功能障碍进展
公开(公告)号：US20110313307A1
公开(公告)日：2011-12-22
申请号：US12964515
申请日：2010-12-09
申请人： Srikanth Radhakrishnan , Surag Mantri , Ryan Olivera
发明人： Srikanth Radhakrishnan , Surag Mantri , Ryan Olivera
IPC分类号： A61B5/085
CPC分类号： A61B5/085 , A61B5/087 , A61B5/097 , A61B5/6853 , A61B5/7278 , A61B2562/0247
摘要： A method for determining lung function in a patient is disclosed, in which a multi-lumen catheter with an expandable occluding element at its end is used to isolate a targeted lung compartment, and respiratory characteristics at the targeted lung compartment are measured over multiple respiratory cycles. The relation between various characteristics of the respiratory cycle is used to determine compliance of lung tissue within the targeted lung compartment.
摘要翻译：公开了一种用于确定患者的肺功能的方法，其中使用其末端具有可扩张闭塞元件的多腔导管来分离靶向的肺隔室，并且在多个呼吸循环中测量目标肺隔室处的呼吸特征。呼吸周期的各种特征之间的关系用于确定目标肺隔室内肺组织的依从性。

3. 发明申请

US20110295141A1 METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS 审中-公开
标题翻译：内分泌诊断的方法与系统
公开(公告)号：US20110295141A1
公开(公告)日：2011-12-01
申请号：US12954499
申请日：2010-11-24
申请人： Srikanth Radhakrishnan , Ryan Olivera , Niyazi Beyhan , Surag Mantri , Lutz Freitag
发明人： Srikanth Radhakrishnan , Ryan Olivera , Niyazi Beyhan , Surag Mantri , Lutz Freitag
IPC分类号： A61B5/08
CPC分类号： A61B5/082
摘要： A method for assessing lung function in a patient is disclosed. The method comprises isolating a lung compartment. Thereafter, in one embodiment, an inhaled gas of known composition is introduced into the lung and compared to the composition of the exhaled gas. Alternatively, accumulated CO2 content is measured within the isolated lung compartment over time, and compared to a baseline CO2 content. Alternatively, a change in pressure of an isolated lung compartment may be monitored. Alternatively, the magnitude of the range of CO2 values in an isolated lung compartment can be compared to a predetermined threshold. Any of the results obtained via these alternative embodiments may be used to determine lung function.
摘要翻译：公开了一种用于评估患者的肺功能的方法。该方法包括分离肺隔室。此后，在一个实施方案中，将已知组合物的吸入气体引入肺中并与呼出气体的组成进行比较。或者，随着时间的推移在隔离的肺隔室内测量累积的CO 2含量，并与基线CO 2含量进行比较。或者，可以监测隔离的肺隔室的压力变化。或者，可以将隔离的肺隔室中的CO 2值的范围的大小与预定阈值进行比较。通过这些替代实施方案获得的任何结果可用于确定肺功能。

4. 发明申请

US20120149995A1 METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS 有权
标题翻译：内分泌诊断的方法与系统
公开(公告)号：US20120149995A1
公开(公告)日：2012-06-14
申请号：US13174633
申请日：2011-06-30
申请人： Surag Mantri , Srikanth Radhakrishnan
发明人： Surag Mantri , Srikanth Radhakrishnan
IPC分类号： A61B5/08 , A61B5/145 , A61B5/091 , A61M16/06 , A61B5/087 , A61B5/085
CPC分类号： A61B5/14552 , A61B1/00082 , A61B1/2676 , A61B5/08 , A61B5/085 , A61B5/087 , A61B5/091 , A61B5/14542 , A61B5/6853 , A61M16/0003 , A61M16/0404 , A61M2016/0036 , A61M2016/102 , A61M2230/205 , A61M2230/43
摘要： Methods and systems for targeting, accessing and diagnosing diseased lung compartments are disclosed. The method comprises introducing a diagnostic catheter with an occluding member at its distal end into a lung segment via an assisted ventilation device; inflating the occluding member to isolate the lung segment; and performing a diagnostic procedure with the catheter while the patient is ventilated. The proximal end of the diagnostic catheter is configured to be attached to a console. The method may also comprise introducing the diagnostic catheter into the lung segment; inflating the occluding member to isolate the lung segment; and monitoring blood oxygen saturation. The method may further comprise introducing the diagnostic catheter into the lung segment; determining tidal flow volume in the lung segment; determining total lung capacity of the patient; and determining a flow rank value based on the tidal flow volume of the lung segment and the total lung capacity.
摘要翻译：公开了用于靶向，访问和诊断患病肺隔室的方法和系统。该方法包括通过辅助通气装置将具有阻塞构件的诊断导管在其远端引入肺段; 使闭塞部件膨胀以分离肺段; 并且在患者通气时用导管执行诊断程序。诊断导管的近端被配置为附接到控制台。该方法还可以包括将诊断导管引入肺段中; 使闭塞部件膨胀以分离肺段; 并监测血氧饱和度。该方法还可以包括将诊断导管引入肺部段中; 确定肺段的潮汐流量; 确定患者的总肺容量; 并且基于肺段的潮汐流量和总肺容量来确定流量值。

5. 发明授权

US08808194B2 Methods and systems for endobronchial diagnostics 有权
标题翻译：支气管内诊断的方法和系统
公开(公告)号：US08808194B2
公开(公告)日：2014-08-19
申请号：US13174633
申请日：2011-06-30
申请人： Surag Mantri , Srikanth Radhakrishnan
发明人： Surag Mantri , Srikanth Radhakrishnan
IPC分类号： A61B5/08
CPC分类号： A61B5/14552 , A61B1/00082 , A61B1/2676 , A61B5/08 , A61B5/085 , A61B5/087 , A61B5/091 , A61B5/14542 , A61B5/6853 , A61M16/0003 , A61M16/0404 , A61M2016/0036 , A61M2016/102 , A61M2230/205 , A61M2230/43
摘要： Methods and systems for targeting, accessing and diagnosing diseased lung compartments are disclosed. The method comprises introducing a diagnostic catheter with an occluding member at its distal end into a lung segment via an assisted ventilation device; inflating the occluding member to isolate the lung segment; and performing a diagnostic procedure with the catheter while the patient is ventilated. The proximal end of the diagnostic catheter is configured to be attached to a console. The method may also comprise introducing the diagnostic catheter into the lung segment; inflating the occluding member to isolate the lung segment; and monitoring blood oxygen saturation. The method may further comprise introducing the diagnostic catheter into the lung segment; determining tidal flow volume in the lung segment; determining total lung capacity of the patient; and determining a flow rank value based on the tidal flow volume of the lung segment and the total lung capacity.
摘要翻译：公开了用于靶向，访问和诊断患病肺隔室的方法和系统。该方法包括通过辅助通气装置将具有阻塞构件的诊断导管在其远端引入肺段; 使闭塞部件膨胀以分离肺段; 并且在患者通气时用导管执行诊断程序。诊断导管的近端被配置为附接到控制台。该方法还可以包括将诊断导管引入肺段中; 使闭塞部件膨胀以分离肺段; 并监测血氧饱和度。该方法还可以包括将诊断导管引入肺部段中; 确定肺段的潮汐流量; 确定患者的总肺容量; 并且基于肺段的潮汐流量和总肺容量来确定流量值。

6. 发明申请

US20120150027A1 METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSIS AND TREATMENT 审中-公开
标题翻译：内分泌诊断和治疗的方法和系统
公开(公告)号：US20120150027A1
公开(公告)日：2012-06-14
申请号：US13174649
申请日：2011-06-30
申请人： Surag Mantri , Srikanth Radhakrishnan
发明人： Surag Mantri , Srikanth Radhakrishnan
IPC分类号： A61B5/08 , A61B6/03 , A61M16/00 , A61B6/00
CPC分类号： A61B5/097 , A61B5/0813 , A61B5/0816 , A61B5/082 , A61B5/486 , A61B5/6853 , A61B5/7246 , A61B5/7278 , A61B5/742 , A61M16/0404 , A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： A method of assessing a lung compartment of a patient may involve: advancing a diagnostic catheter into a lung airway leading to a first sub-compartment of the lung compartment; inflating an occluding member disposed on the diagnostic catheter to form a seal with a wall of the airway and thus isolate the first sub-compartment; introducing a diagnostic gas into the first sub-compartment; and recording a perfusion value of the diagnostic gas within the first sub-compartment.
摘要翻译：评估患者的肺隔室的方法可以包括：将诊断导管推进到通向肺隔室的第一子隔室的肺气道中; 使设置在诊断导管上的闭塞构件膨胀以与气道的壁形成密封，从而隔离第一子隔室; 将诊断气体引入所述第一子室; 以及将所述诊断气体的灌注值记录在所述第一子室内。

7. 发明申请

US20140315175A1 SYSTEM FOR SIMULATING LUNG FUNCTION 审中-公开
标题翻译：模拟肺功能的系统
公开(公告)号：US20140315175A1
公开(公告)日：2014-10-23
申请号：US13748346
申请日：2013-01-23
申请人： Hoang Nguyen , Ryan Olivera , Alex Yang , Sri Radhakrishnan , Steve Wallace , Surag Mantri , Greg Pulido , Ramon Estrada
发明人： Hoang Nguyen , Ryan Olivera , Alex Yang , Sri Radhakrishnan , Steve Wallace , Surag Mantri , Greg Pulido , Ramon Estrada
IPC分类号： G09B23/32
CPC分类号： G09B23/32 , G09B23/30
摘要： A system for simulating a breathing lung is disclosed. The system comprises a lung model contained within an enclosure, wherein a main bronchus of the lung model is open to ambient air. In one embodiment, the system also comprises a vacuum pump connected to the enclosure, a first normally closed 2-way valve connected to the enclosure, a flow controller connected to both the vacuum pump and the enclosure, and a timer connected to the first normally closed 2-way valve. In alternative embodiments, the system comprises a first pump connected to the enclosure and a second pump connected to the enclosure, wherein the first and second pumps work independently of each other, and wherein the first pump is a vacuum pump, and the second pump is either a peristaltic pump or a piston pump.
摘要翻译：公开了一种用于模拟呼吸肺的系统。该系统包括包含在外壳内的肺模型，其中肺模型的主支气管对环境空气开放。在一个实施例中，系统还包括连接到外壳的真空泵，连接到外壳的第一常闭二通阀，连接到真空泵和外壳的流量控制器以及连接到第一正常的定时器关闭二通阀。在替代实施例中，系统包括连接到外壳的第一泵和连接到外壳的第二泵，其中第一和第二泵彼此独立地工作，并且其中第一泵是真空泵，第二泵是蠕动泵或活塞泵。

8. 发明申请

US20100100104A1 SYSTEMS FOR REDUCING PRESSURE IN AN ORGAN 有权
标题翻译：降低有机体压力的系统
公开(公告)号：US20100100104A1
公开(公告)日：2010-04-22
申请号：US12620564
申请日：2009-11-17
申请人： Dao-Yi Yu , Cory Anderson , Roelof Trip , Ying Yang , Hoang Van Nguyen , Surag Mantri , Er-Ning Su , Stephen Cringle , James McCrea , Daniel Mufson , Colin Tan
发明人： Dao-Yi Yu , Cory Anderson , Roelof Trip , Ying Yang , Hoang Van Nguyen , Surag Mantri , Er-Ning Su , Stephen Cringle , James McCrea , Daniel Mufson , Colin Tan
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F9/0008 , A61L31/045 , A61M27/008
摘要： Methods, system and apparatus for relieving pressure in an organ such as, but not limited to, the eye are disclosed. The method includes implanting a bioabsorbable channel into the selected area of the organ using a delivery apparatus.
摘要翻译：公开了用于减轻诸如但不限于眼睛的器官中的压力的方法，系统和装置。该方法包括使用递送装置将生物可吸收通道植入器官的选定区域。

9. 发明申请

US20120065651A1 GASTRO-INTESTINLAL COMPRESSION DEVICE 有权
标题翻译： GASTRO-INTESTINLAL压缩装置
公开(公告)号：US20120065651A1
公开(公告)日：2012-03-15
申请号：US13186429
申请日：2011-07-19
申请人： Surag Mantri , Hoang Nguyen , Niyazi Beyhan
发明人： Surag Mantri , Hoang Nguyen , Niyazi Beyhan
IPC分类号： A61B17/11
CPC分类号： A61B17/1114 , A61B2017/00818 , A61B2017/1132 , A61F5/0076 , A61F2002/044 , A61F2002/045
摘要： Devices, methods, and systems for treating Type-2 Diabetes and/or obesity by facilitating the delivery of under-digested nutrients within the gastro-intestinal tract without substantial tissue removal are disclosed. In one aspect, the gastro-intestinal tract of a patient is modified by a gastro-intestinal treatment device comprising an elongate element configured to extend within the gastro-intestinal tract, a first attachment element and a second attachment element disposed on the elongate element, wherein the first attachment element and the second attachment element are configured to attach to the gastro-intestinal tract such that a portion of the gastro-intestinal tract is compressed between the first and the second attachment elements. The length of the gastro-intestinal tract modified by the device is effectively shortened, and its surface area is reduced.
摘要翻译：公开了通过促进胃肠道内消化不良的营养物质的递送而不需要大量去除组织来治疗2型糖尿病和/或肥胖症的装置，方法和系统。在一个方面，患者的胃肠道由胃肠治疗装置改变，所述胃肠治疗装置包括构造成在胃肠道内延伸的细长元件，设置在细长元件上的第一附接元件和第二附接元件，其中所述第一附接元件和所述第二附接元件构造成附接到胃肠道，使得胃肠道的一部分在第一和第二附接元件之间被压缩。通过该装置修改的胃肠道的长度被有效地缩短，并且其表面积减小。

10. 发明授权

US07439848B2 Handheld aid for the visually impaired 失效
标题翻译：为视障者提供手持式援助
公开(公告)号：US07439848B2
公开(公告)日：2008-10-21
申请号：US11248796
申请日：2005-10-11
申请人： Surag Mantri
发明人： Surag Mantri
IPC分类号： G08B3/10
CPC分类号： G08B1/08
摘要： The system of the preferred embodiments includes a housing, an input element to detect the characteristics of an area, a processor to convert the detected characteristics of an area to an output signal, and an aiming device to adjust the orientation of the input element with respect to the housing. The system has been designed to detect the characteristics of an area and convert the detected characteristics to an output signal to a visually impaired user.
摘要翻译：优选实施例的系统包括壳体，用于检测区域的特性的输入元件，将检测到的区域的特性转换为输出信号的处理器，以及瞄准装置，以相对于到房屋该系统被设计为检测区域的特性，并将检测到的特性转换为视觉受损用户的输出信号。

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