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1. 发明授权

US07273586B2 Apparatus and process for conditioning mammalian blood 失效
公开(公告)号：US07273586B2
公开(公告)日：2007-09-25
申请号：US11294443
申请日：2005-12-06
申请人： Sonya Mongomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Sen Liao , Duncan Newman
发明人： Sonya Mongomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Sen Liao , Duncan Newman
IPC分类号： A61M1/36 , A61M37/00 , C02F1/44 , A61M5/00
CPC分类号： A61M1/3626 , A61J3/002 , A61M1/0281 , A61M1/3681 , A61M1/3687 , A61M1/369 , A61M2202/0216 , A61M2205/052 , A61M2205/053 , A61M2205/123 , A61M2205/368 , A61M2205/75
摘要： An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.

2. 发明授权

US06736788B1 Apparatus and process for conditioning mammalian blood 失效
标题翻译：用于调节哺乳动物血液的装置和方法
公开(公告)号：US06736788B1
公开(公告)日：2004-05-18
申请号：US09662706
申请日：2000-09-15
申请人： Sonya Mongomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Sen Liao , Duncan Newman
发明人： Sonya Mongomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Sen Liao , Duncan Newman
IPC分类号： A61M3700
CPC分类号： A61M1/3626 , A61J3/002 , A61M1/0281 , A61M1/3681 , A61M1/3687 , A61M1/369 , A61M2202/0216 , A61M2205/052 , A61M2205/053 , A61M2205/123 , A61M2205/368 , A61M2205/75
摘要： The invention provides apparatus for conditioning mammalian blood for subsequent use in a medical procedure. The apparatus includes a cabinet having a secure environment and a door providing the only access to the environment. An input system is provided for transporting a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver. As a result, a charge from the input system is conditioned and delivered to the receiver, the door is then unlocked and the conditioned charge is ready to be removed and used to complete the medical procedure. A flask assembly is also provided for use in the apparatus and a process is also described.
摘要翻译：本发明提供了用于调节哺乳动物血液以便随后在医疗过程中使用的装置。该装置包括具有安全环境的机柜和仅提供对环境的访问的门。提供一种输入系统，用于将血液从源输送到机柜，并且烧瓶可移除地容纳在安全环境中并且耦合到电荷输入系统以接收电荷。应力器连接到机柜并定位成操作以在烧瓶中产生调节的电荷。输出系统耦合到烧瓶并且包括用于调节电荷的接收器。该装置包括一个自动控制系统，其可以在关闭门以锁定门并且然后调节充电时操作，然后使电荷从烧瓶移动到接收器。结果，来自输入系统的电荷被调节并被传送到接收器，然后门解锁并且调节的电荷准备被移除并用于完成医疗程序。还提供了一种用于装置中的烧瓶组件，并且还描述了一种方法。

3. 发明授权

US07250137B2 Apparatus and process for conditioning mammalian blood 失效
标题翻译：用于调节哺乳动物血液的装置和方法
公开(公告)号：US07250137B2
公开(公告)日：2007-07-31
申请号：US11294384
申请日：2005-12-06
申请人： Sonya Mongomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Sen Liao , Duncan Newman
发明人： Sonya Mongomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Sen Liao , Duncan Newman
IPC分类号： A61M1/00 , A61M37/00 , C02F1/44
CPC分类号： A61M1/3626 , A61J3/002 , A61M1/0281 , A61M1/3681 , A61M1/3687 , A61M1/369 , A61M2202/0216 , A61M2205/052 , A61M2205/053 , A61M2205/123 , A61M2205/368 , A61M2205/75
摘要： An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.
摘要翻译：用于调节哺乳动物血液以便随后在医疗过程中使用的装置包括具有安全环境的柜体和仅提供对环境的通路的门。输入系统将血液从源传送到机柜，并且烧瓶可移除地包含在安全环境中并且耦合到电荷输入系统以接收电荷。应力器连接到机柜并定位成操作以在烧瓶中产生调节的电荷。输出系统耦合到烧瓶并且包括用于调节电荷的接收器。该装置包括一个自动控制系统，其可以在关闭门以锁定门并且然后调节充电时操作，然后使电荷从烧瓶移动到接收器。

4. 发明授权

US07128873B2 Apparatus and process for conditioning mammalian blood 失效
公开(公告)号：US07128873B2
公开(公告)日：2006-10-31
申请号：US10827329
申请日：2004-04-20
申请人： Sonya Mongomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Sen Liao , Duncan Newman
发明人： Sonya Mongomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Sen Liao , Duncan Newman
IPC分类号： A61M1/36 , A61M37/00
CPC分类号： A61M1/3626 , A61J3/002 , A61M1/0281 , A61M1/3681 , A61M1/3687 , A61M1/369 , A61M2202/0216 , A61M2205/052 , A61M2205/053 , A61M2205/123 , A61M2205/368 , A61M2205/75
摘要： An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.

5. 发明申请

US20060073069A1 Apparatus and process for conditioning mammalian blood 失效
标题翻译：用于调节哺乳动物血液的装置和方法
公开(公告)号：US20060073069A1
公开(公告)日：2006-04-06
申请号：US11294384
申请日：2005-12-06
申请人： Sonya Montgomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Liao , Duncan Newman
发明人： Sonya Montgomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Liao , Duncan Newman
IPC分类号： A61M1/36 , A61M37/00 , A61M1/34
CPC分类号： A61M1/3626 , A61J3/002 , A61M1/0281 , A61M1/3681 , A61M1/3687 , A61M1/369 , A61M2202/0216 , A61M2205/052 , A61M2205/053 , A61M2205/123 , A61M2205/368 , A61M2205/75
摘要： An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.
摘要翻译：用于调节哺乳动物血液以便随后在医疗过程中使用的装置包括具有安全环境的柜体和仅提供对环境的通路的门。输入系统将血液从源传送到机柜，并且烧瓶可移除地包含在安全环境中并且耦合到电荷输入系统以接收电荷。应力器连接到机柜并定位成操作以在烧瓶中产生调节的电荷。输出系统耦合到烧瓶并且包括用于调节电荷的接收器。该装置包括一个自动控制系统，其可以在关闭门以锁定门并且然后调节充电时操作，然后使电荷从烧瓶移动到接收器。

6. 发明申请

US20060084905A1 Apparatus and process for conditioning mammalian blood 失效
公开(公告)号：US20060084905A1
公开(公告)日：2006-04-20
申请号：US11294443
申请日：2005-12-06
申请人： Sonya Montgomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Liao , Duncan Newman
发明人： Sonya Montgomery , Jeff Dayman , Allen Muirhead , Paul Moore , Taras Worona , Simon Treadwell , Murray Voakes , Thomas Porter , Carlton Chong , Liung Liao , Duncan Newman
IPC分类号： A61M37/00
CPC分类号： A61M1/3626 , A61J3/002 , A61M1/0281 , A61M1/3681 , A61M1/3687 , A61M1/369 , A61M2202/0216 , A61M2205/052 , A61M2205/053 , A61M2205/123 , A61M2205/368 , A61M2205/75
摘要： An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.

7. 发明申请

US20220142738A1 Dental Device 有权
公开(公告)号：US20220142738A1
公开(公告)日：2022-05-12
申请号：US17433510
申请日：2020-02-25
申请人： Paul Moore , Hazel Hendy
发明人： Paul Moore , Hazel Hendy
IPC分类号： A61C5/90 , A61C5/82
摘要： Aspects of the present invention relate to a dental retractor for controlling the position of soft tissue within a mouth, the dental retractor comprising: a lip retractor for controlling the position of a lip; and a cheek retractor comprising a pair of arms for controlling the position of a cheek; and wherein the dental retractor comprises a tongue retractor removably coupled to the dental retractor for controlling the position of a tongue.

8. 发明申请

US20160332486A1 TYRE APPARATUS 审中-公开
标题翻译：轮胎装置
公开(公告)号：US20160332486A1
公开(公告)日：2016-11-17
申请号：US15110441
申请日：2014-11-17
申请人： Igor STRASHNY , Paul MOORE , CATERPILLAR INC.
发明人： Igor Strashny , Paul Moore
IPC分类号： B60C5/22 , B60C23/00 , B60C17/01
CPC分类号： B60C5/22 , B60C17/01 , B60C23/004 , B60C2200/06
摘要： A tyre apparatus is provided, the apparatus including a tyre body for attachment to a wheel rim to define a first inflatable volume. An inner chamber defines a second inflatable volume which is located within the first inflatable volume of the tyre body. A first fluid communication path is provided between the first and second inflatable volumes and a second fluid communication path is provided between the first inflatable volume and the atmosphere. A first valve opens and closes the first fluid communication path, and a second valve opens and closes the second fluid communication path. The tensile strength and pressure-containing capacity of the material structure of the second inflatable volume is greater than that of the tyre first inflatable volume. A first fluid pressure within the first inflatable volume of the tyre body is optimisable by opening the first valve to allow pressure transfer from the second inflatable volume into the tyre body, and/or opening the second valve to allow pressure to vent from the tyre body to atmosphere. A vehicle wheel and active tyre pressure control system incorporating the tyre apparatus are also provided.
摘要翻译：提供了一种轮胎装置，该装置包括用于附接到轮缘的轮胎主体，以限定第一可充气体积。内室限定位于轮胎主体的第一可充气体积内的第二可充气体积。在第一和第二可膨胀体积之间提供第一流体连通路径，并且在第一可充气体积和大气之间设置第二流体连通路径。第一阀打开和关闭第一流体连通路径，第二阀打开和关闭第二流体连通路径。第二可膨胀体积的材料结构的拉伸强度和耐压容量大于轮胎第一可充气体积的拉伸强度和压力容纳能力。轮胎主体的第一可膨胀体积内的第一流体压力通过打开第一阀来允许压力从第二可膨胀容积传递到轮胎主体中并且/或打开第二阀以允许压力从轮胎本体排出而是最佳的到大气。还提供了一种结合轮胎装置的车轮和主动轮胎压力控制系统。

9. 发明授权

US08876176B2 Latch assembly 有权
标题翻译：锁定装配
公开(公告)号：US08876176B2
公开(公告)日：2014-11-04
申请号：US11816445
申请日：2006-02-17
申请人： Nigel V. Spurr , Gurbinder Singh Kalsi , Chris Rhodes , Robert Frank Tolley , David Peatey , Robert James Clawley , Paul Moore , Jean-Vincent Olivier , Sylvain Remi Chonavel , Denis Cavallucci
发明人： Nigel V. Spurr , Gurbinder Singh Kalsi , Chris Rhodes , Robert Frank Tolley , David Peatey , Robert James Clawley , Paul Moore , Jean-Vincent Olivier , Sylvain Remi Chonavel , Denis Cavallucci
IPC分类号： E05C3/06 , E05B81/20 , E05B81/14 , E05C3/16 , E05B77/28 , E05B85/26
CPC分类号： E05C3/12 , E05B77/28 , E05B81/14 , E05B81/20 , E05B85/26 , E05C3/006 , Y10S292/23 , Y10T70/5903 , Y10T70/70 , Y10T292/1047 , Y10T292/1082
摘要： A latch assembly includes a chassis, a latch bolt moveably mounted on the chassis and having a closed position for retaining a striker and an open position for releasing the striker, a pawl having an engaged position at which the pawl is engaged with the latch bolt to hold the latch bolt in the closed position and a disengaged position at which the pawl is disengaged from the latch bolt, thereby allowing the latch bolt to move to the open position, an eccentric arrangement defining an eccentric axis and a pawl axis remote from the eccentric axis. The eccentric arrangement is rotatable about the eccentric axis, and the pawl is rotatable about the pawl axis. When the pawl moves from the engaged position to the disengaged position, the eccentric arrangement rotates in one of a clockwise and a counter-clockwise direction about the eccentric axis. With the pawl in the engaged position, a force applied to the pawl by the latch bolt creates a turning moment on the eccentric arrangement in the one of the clockwise and counter-clockwise direction, and the eccentric arrangement is prevented from rotating in said one of the clockwise and counter-clockwise direction by a moveable abutment.
摘要翻译：闩锁组件包括底盘，可移动地安装在底盘上并具有用于保持撞针的关闭位置和用于释放撞针的打开位置的闩锁;棘爪，其具有接合位置，棘爪与闩锁螺栓接合将闩锁螺栓保持在关闭位置和棘爪从闩锁螺栓脱离的分离位置，从而允许闩锁闩锁移动到打开位置，限定偏心轴线的偏心装置和远离偏心轮的爪轴线轴。偏心装置可围绕偏心轴线旋转，并且棘爪可围绕棘爪轴线转动。当棘爪从接合位置移动到脱离位置时，偏心装置围绕偏心轴线以顺时针和逆时针方向中的一个旋转。在棘爪处于接合位置时，通过闩锁螺栓施加到棘爪的力在顺时针和逆时针方向上的偏心装置上产生转动力矩，并且防止偏心装置在所述一个顺时针方向和逆时针方向可移动的支座。

10. 发明授权

US08524238B2 Cancer targets and uses thereof 有权
标题翻译：癌症目标及其用途
公开(公告)号：US08524238B2
公开(公告)日：2013-09-03
申请号：US13436411
申请日：2012-03-30
申请人： Dong Fang , Paul Moore , Steve Ruben , Sudeepta Aggarwal
发明人： Dong Fang , Paul Moore , Steve Ruben , Sudeepta Aggarwal
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/249 , A61K39/39533 , A61K2039/505 , C07K14/47 , C07K14/57 , C07K16/18 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5011 , G01N33/574 , G01N33/57484 , G01N2500/10
摘要： Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
摘要翻译：提供了使用癌症相关靶标（“CAT”）评估，治疗和预防疾病，特别是癌症的方法和组合物。还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。还提供了使用CAT调节细胞功能的方法和组合物。还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。

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