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1. 发明授权

US07658721B2 Sublingual drug delivery device 失效
标题翻译：舌下给药装置
公开(公告)号：US07658721B2
公开(公告)日：2010-02-09
申请号：US11037737
申请日：2005-01-18
申请人： Solomon S. Steiner , Craig Brown , Roderike Pohl , Trent Poole , Erik Steiner
发明人： Solomon S. Steiner , Craig Brown , Roderike Pohl , Trent Poole , Erik Steiner
IPC分类号： A61M37/00 , A61M15/00 , A61M16/10 , A61M16/00 , A61M11/00
CPC分类号： A61M11/00 , A61M15/0028 , A61M15/0048 , A61M15/0051 , A61M2202/064 , A61M2205/073 , A61M2205/8225
摘要： A drug delivery device that aerosolizes a dry powder formulation so that it forms a fine coating in the oral cavity and, more specifically in the sublingual region of the oral cavity is described herein. In the preferred embodiment, the device contains five main parts: (i) a compressed gas canister, (ii) a dispenser body (also referred to herein as the main housing ), (iii) a means for storing one or more doses of a drug formulation, (iv) a means for releasing a dose of the drug formulation such as a gas canister or spring piston and (v) a mouthpiece. Preferred configurations include circular, tubular, and rectangular. The means for storing the drug formulation may be configured to separately store one or more materials. In one embodiment, the means for storing the active agent is in the form of one or more drug discs, where the drug discs contain a plurality of blister packs, each storing one dose of the drug formulation. In another embodiment, the means for storing the active agent is a dosage cartridge containing a single dose of the drug formulation. In yet another embodiment, the drug formulation is stored on a ribbon containing a plurality of blister packs, each storing one dose of the drug formulation.
摘要翻译：本文描述了使干燥粉末制剂雾化以使其在口腔中形成细小涂层并且更具体地在口腔的舌下区域中的药物递送装置。在优选实施例中，该装置包含五个主要部分：（i）压缩气体罐，（ii）分配器主体（在本文中也称为主壳体），（iii）用于存储一个或多个剂量的药物制剂，（iv）用于释放剂量的药物制剂如气体罐或弹簧活塞的装置，（v）口器。优选的构造包括圆形，管状和矩形。用于储存药物制剂的方法可以被配置成分开存储一种或多种材料。在一个实施方案中，用于储存活性剂的装置是一种或多种药物盘的形式，其中药物盘包含多个泡罩包装，每个存储一剂药物制剂。在另一个实施方案中，用于储存活性剂的装置是含有单剂量药物制剂的剂量筒。在另一个实施方案中，药物制剂储存在含有多个泡罩包装的条带上，每个存在一剂药物制剂。

2. 发明申请

US20050155601A1 Sublingual drug delivery device 失效
标题翻译：舌下给药装置
公开(公告)号：US20050155601A1
公开(公告)日：2005-07-21
申请号：US11037737
申请日：2005-01-18
申请人： Solomon Steiner , Craig Brown , Roderike Pohl , Trent Poole , Erik Steiner
发明人： Solomon Steiner , Craig Brown , Roderike Pohl , Trent Poole , Erik Steiner
IPC分类号： A61K9/14 , A61L9/04 , A61M11/00 , A61M15/00
CPC分类号： A61M11/00 , A61M15/0028 , A61M15/0048 , A61M15/0051 , A61M2202/064 , A61M2205/073 , A61M2205/8225
摘要： A drug delivery device that aerosolizes a dry powder formulation so that it forms a fine coating in the oral cavity and, more specifically, in the sublingual region of the oral cavity is described herein. In the preferred embodiment, the device contains five main parts: (i) a compressed gas canister, (ii) a dispenser body (also referred to herein as the main housing), (iii) a means for storing one or more doses of a drug formulation, (iv) a means for releasing a dose of the drug formulation such as a gas canister or spring piston and (v) a mouthpiece. Preferred configurations include circular, tubular, and rectangular. The means for storing the drug formulation may be configured to separately store one or more materials. In one embodiment, the means for storing the active agent is in the form of one or more drug discs, where the drug discs contain a plurality of blister packs, each storing one dose of the drug formulation. In another embodiment, the means for storing the active agent is a dosage cartridge containing a single dose of the drug formulation. In yet another embodiment, the drug formulation is stored on a ribbon containing a plurality of blister packs, each storing one dose of the drug formulation.
摘要翻译：本文描述了使干燥粉末制剂气雾化以使其在口腔中，更具体地在口腔舌下区域中形成细小涂层的药物递送装置。在优选实施例中，该装置包含五个主要部分：（i）压缩气体罐，（ii）分配器主体（在本文中也称为主壳体），（iii）用于存储一个或多个剂量的药物制剂，（iv）用于释放剂量的药物制剂如气体罐或弹簧活塞的装置，（v）口器。优选的构造包括圆形，管状和矩形。用于储存药物制剂的方法可以被配置成分开存储一种或多种材料。在一个实施方案中，用于储存活性剂的装置是一种或多种药物盘的形式，其中药物盘包含多个泡罩包装，每个存储一剂药物制剂。在另一个实施方案中，用于储存活性剂的装置是含有单剂量药物制剂的剂量筒。在另一个实施方案中，药物制剂储存在含有多个泡罩包装的条带上，每个存在一剂药物制剂。

3. 发明申请

US20080047550A2 SUBLINGUAL DRUG DELIVERY DEVICE 失效
标题翻译：次级药物递送装置
公开(公告)号：US20080047550A2
公开(公告)日：2008-02-28
申请号：US11037737
申请日：2005-01-18
申请人： Solomon Steiner , Craig Brown , Roderike Pohl , Trent Poole , Erik Steiner
发明人： Solomon Steiner , Craig Brown , Roderike Pohl , Trent Poole , Erik Steiner
IPC分类号： A61L9/04 , A61K9/14
CPC分类号： A61M11/00 , A61M15/0028 , A61M15/0048 , A61M15/0051 , A61M2202/064 , A61M2205/073 , A61M2205/8225
摘要： A drug delivery device that aerosolizes a dry powder formulation so that it forms a fine coating in the oral cavity and, more specifically in the sublingual region of the oral cavity is described herein. In the preferred embodiment, the device contains five main parts: (i) a compressed gas canister, (ii) a dispenser body (also referred to herein as the main housing ), (iii) a means for storing one or more doses of a drug formulation, (iv) a means for releasing a dose of the drug formulation such as a gas canister or spring piston and (v) a mouthpiece. Preferred configurations include circular, tubular, and rectangular. The means for storing the drug formulation may be configured to separately store one or more materials. In one embodiment, the means for storing the active agent is in the form of one or more drug discs, where the drug discs contain a plurality of blister packs, each storing one dose of the drug formulation. In another embodiment, the means for storing the active agent is a dosage cartridge containing a single dose of the drug formulation. In yet another embodiment, the drug formulation is stored on a ribbon containing a plurality of blister packs, each storing one dose of the drug formulation.
摘要翻译：本文描述了使干燥粉末制剂雾化以使其在口腔中形成细小涂层并且更具体地在口腔的舌下区域中的药物递送装置。在优选实施例中，该装置包含五个主要部分：（i）压缩气体罐，（ii）分配器主体（在本文中也称为主壳体），（iii）用于存储一个或多个剂量的药物制剂，（iv）用于释放剂量的药物制剂如气体罐或弹簧活塞的装置，（v）口器。优选的构造包括圆形，管状和矩形。用于储存药物制剂的方法可以被配置成分开存储一种或多种材料。在一个实施方案中，用于储存活性剂的装置是一种或多种药物盘的形式，其中药物盘包含多个泡罩包装，每个存储一剂药物制剂。在另一个实施方案中，用于储存活性剂的装置是含有单剂量药物制剂的剂量筒。在另一个实施方案中，药物制剂储存在含有多个泡罩包装的条带上，每个存在一剂药物制剂。

4. 发明申请

US20120247464A1 Inhalation Apparatus 有权
标题翻译：吸入装置
公开(公告)号：US20120247464A1
公开(公告)日：2012-10-04
申请号：US13437840
申请日：2012-04-02
申请人： Trent Poole , Solomon S. Steiner
发明人： Trent Poole , Solomon S. Steiner
IPC分类号： A61M15/00
CPC分类号： A61M15/0093 , A61K9/14 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/06 , A61M2202/064 , A61M2205/12 , A61M2206/16
摘要： An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.
摘要翻译：吸入器在从盖或盖单元移除时立即被激活，并且通过相对于接口部旋转吸入器的盒部件，以便为环境空气和颗粒产生流动通道。墨盒组件包括一个室，其内容物通常包括干粉或类似物。在产生流动路径时，腔室的内容物立即可以通过使用者通过接口部分立即吸入。

5. 发明申请

US20120174923A1 Unit Dose Capsules and Dry Powder Inhaler 有权
公开(公告)号：US20120174923A1
公开(公告)日：2012-07-12
申请号：US13421529
申请日：2012-03-15
申请人： Solomon S. Steiner , Robert Feldstein , Per B. Fog , Trent Poole
发明人： Solomon S. Steiner , Robert Feldstein , Per B. Fog , Trent Poole
IPC分类号： A61M15/00
CPC分类号： A61M15/003 , A61M13/00 , A61M15/002 , A61M15/0021 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43 , F16L37/252
摘要： Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece.

6. 发明授权

US08166970B2 Inhalation apparatus 有权
标题翻译：吸入装置
公开(公告)号：US08166970B2
公开(公告)日：2012-05-01
申请号：US11539082
申请日：2006-10-05
申请人： Trent Poole , Solomon S. Steiner
发明人： Trent Poole , Solomon S. Steiner
IPC分类号： A61M15/00
CPC分类号： A61M15/0093 , A61K9/14 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/06 , A61M2202/064 , A61M2205/12 , A61M2206/16
摘要： An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.
摘要翻译：吸入器在从盖或盖单元移除时立即被激活，并且通过相对于接口部旋转吸入器的盒部件，以便为环境空气和颗粒产生流动通道。墨盒组件包括一个室，其内容物通常包括干粉或类似物。在产生流动路径时，腔室的内容物立即可以通过使用者通过接口部分立即吸入。

7. 发明授权

US08671937B2 Unit dose capsules and dry powder inhaler 有权
标题翻译：单位剂量胶囊和干粉吸入器
公开(公告)号：US08671937B2
公开(公告)日：2014-03-18
申请号：US13421529
申请日：2012-03-15
申请人： Solomon S. Steiner , Per B. Fog , Trent Poole , Robert Feldstein
发明人： Solomon S. Steiner , Per B. Fog , Trent Poole , Robert Feldstein
IPC分类号： A61M11/00
CPC分类号： A61M15/003 , A61M13/00 , A61M15/002 , A61M15/0021 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43 , F16L37/252
摘要： Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece.
摘要翻译：描述了一种干粉吸入器，其包括进气段; 混合部分和喉舌。

8. 发明授权

US08156936B2 Unit dose capsules and dry powder inhaler 有权
标题翻译：单位剂量胶囊和干粉吸入器
公开(公告)号：US08156936B2
公开(公告)日：2012-04-17
申请号：US11934643
申请日：2007-11-02
申请人： Solomon S. Steiner , Per B. Fog , Trent Poole , Robert Feldstein
发明人： Solomon S. Steiner , Per B. Fog , Trent Poole , Robert Feldstein
IPC分类号： A61M15/00
CPC分类号： A61M15/003 , A61M13/00 , A61M15/002 , A61M15/0021 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43 , F16L37/252
摘要： Described are dry powder inhalers comprising an intake section, a mixing section and a mouthpiece. The mixing section can accommodate a capsule having a top keying portion and containing a dry powder medicament. The top keying portion of the capsules may fit within complementary keying structures in inhaler mixing sections.
摘要翻译：描述了包括进气段，混合段和接口管的干粉吸入器。混合部分可以容纳具有顶部键合部分并且含有干粉末药物的胶囊。胶囊的顶部键合部分可以配合在吸入器混合部分中的互补键控结构内。

9. 发明授权

US07140365B2 Inhalation apparatus 有权
公开(公告)号：US07140365B2
公开(公告)日：2006-11-28
申请号：US11118853
申请日：2005-04-29
申请人： Trent Poole , Solomon S. Steiner
发明人： Trent Poole , Solomon S. Steiner
IPC分类号： A61M11/00 , B67D5/60
CPC分类号： A61M15/0093 , A61K9/14 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/06 , A61M2202/064 , A61M2205/12 , A61M2206/16
摘要： An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

10. 发明授权

US06923175B2 Inhalation apparatus 有权
公开(公告)号：US06923175B2
公开(公告)日：2005-08-02
申请号：US10384909
申请日：2003-03-07
申请人： Trent Poole , Solomon S. Steiner
发明人： Trent Poole , Solomon S. Steiner
IPC分类号： A61M15/00 , A61M15/06 , B67D7/78 , A61M11/00
CPC分类号： A61M15/0093 , A61K9/14 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/06 , A61M2202/064 , A61M2205/12 , A61M2206/16
摘要： An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

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