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1. 发明申请

US20120276095A1 B7-H4 FUSION PROTEINS AND METHODS OF USE THEREOF 有权
标题翻译： B7-H4融合蛋白及其使用方法
公开(公告)号：US20120276095A1
公开(公告)日：2012-11-01
申请号：US13392811
申请日：2010-08-31
申请人： Solomon Langermann , Linda Liu , Joseph R. Podojil , Stephen D. Miller , Shannon Marshall
发明人： Solomon Langermann , Linda Liu , Joseph R. Podojil , Stephen D. Miller , Shannon Marshall
IPC分类号： A61K39/395 , A61P29/00 , C07K19/00
CPC分类号： C07K14/70532 , A61K9/0019 , A61K38/00 , A61K38/1709 , A61K39/44 , C07K16/2827 , C07K2317/50 , C07K2317/56 , C07K2317/72 , C07K2319/30 , C07K2319/32 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N2800/52
摘要： Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.
摘要翻译：公开了含有B7-H4多肽的融合蛋白。 B7-H4融合蛋白可以包括全长B7-H4多肽，或者可以含有全长B7-H4多肽的片段，包括B7-H4多肽的一些或全部细胞外结构域。还公开了使用融合蛋白来下调T细胞活化和治疗炎性和自身免疫性疾病和病症的方法。 B7-H4融合蛋白可用于通过抑制或减少Th1，Th17，Th22和/或分泌或引起其他细胞的其他细胞的分化，增殖，活性和/或细胞因子产生和/或分泌来治疗炎症包括但不限于IL-1和bgr; TNF-α，TGF-β，IFN-γ，IL-17，IL-6，IL-23，IL-22，IL-21，和MMPs; 或增强Treg的IL-10分泌，增加Treg的分化，增加Treg的数量或其组合。

2. 发明授权

US09011853B2 B7-H4 fusion proteins and methods of use thereof 有权
标题翻译： B7-H4融合蛋白及其使用方法
公开(公告)号：US09011853B2
公开(公告)日：2015-04-21
申请号：US13392811
申请日：2010-08-31
申请人： Solomon Langermann , Linda Liu , Joseph R. Podojil , Stephen D. Miller , Shannon Marshall
发明人： Solomon Langermann , Linda Liu , Joseph R. Podojil , Stephen D. Miller , Shannon Marshall
IPC分类号： A61K38/16 , C07K14/705 , C07K16/46 , G01N33/68 , A61K38/17 , C07K16/28
CPC分类号： C07K14/70532 , A61K9/0019 , A61K38/00 , A61K38/1709 , A61K39/44 , C07K16/2827 , C07K2317/50 , C07K2317/56 , C07K2317/72 , C07K2319/30 , C07K2319/32 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N2800/52
摘要： Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.
摘要翻译：公开了含有B7-H4多肽的融合蛋白。 B7-H4融合蛋白可以包括全长B7-H4多肽，或可以含有全长B7-H4多肽的片段，包括B7-H4多肽的一些或全部细胞外结构域。还公开了使用融合蛋白来下调T细胞活化和治疗炎性和自身免疫性疾病和病症的方法。 B7-H4融合蛋白可用于通过抑制或减少Th1，Th17，Th22和/或分泌或引起其他细胞的其他细胞的分化，增殖，活性和/或细胞因子产生和/或分泌来治疗炎症包括但不限于IL-1和bgr; TNF-α，TGF-β，IFN-γ，IL-17，IL-6，IL-23，IL-22，IL-21，和MMPs; 或增强Treg的IL-10分泌，增加Treg的分化，增加Treg的数量或其组合。

3. 发明申请

US20130209463A1 POLYPEPTIDES AND USES THEREOF AS A DRUG FOR TREATMENT OF MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISORDERS 审中-公开
标题翻译：多肽及其作为治疗多发性硬化症，恶病质和其他自身免疫性疾病的药物的用途
公开(公告)号：US20130209463A1
公开(公告)日：2013-08-15
申请号：US13806841
申请日：2011-06-30
申请人： Galit Rotman , Iris Hecht , Zurit Levine , Joseph R. Podojil , Stephen D. Miller
发明人： Galit Rotman , Iris Hecht , Zurit Levine , Joseph R. Podojil , Stephen D. Miller
IPC分类号： C07K14/47
CPC分类号： A61K38/1709 , C07K14/4713 , Y02A50/40 , Y02A50/401
摘要： This invention relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.
摘要翻译：本发明涉及蛋白质C1ORF32及其变体及其片段和融合蛋白，以及其用于免疫治疗和药物开发的方法，包括但不限于免疫调节剂和免疫治疗，包括用于自身免疫疾病。

4. 发明授权

US08734786B2 Use of ECDI-fixed cell tolerance as a method for preventing allograft rejection 失效
标题翻译：使用ECDI固定细胞耐受性作为预防同种异体移植排斥的方法
公开(公告)号：US08734786B2
公开(公告)日：2014-05-27
申请号：US12883763
申请日：2010-09-16
申请人： Stephen D. Miller , Xunrong Luo
发明人： Stephen D. Miller , Xunrong Luo
IPC分类号： A01N63/00 , A01N65/00 , C12N5/00 , C12N5/02
CPC分类号： A61K35/15 , A61K35/18 , A61K35/22 , A61K35/26 , A61K35/34 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/42
摘要： The present invention provides methods, systems, and compositions for inducing donor-specific tolerance. In particular, the present invention provides methods of administering ECDI-treated cells before, during, and/or after administration of donor transplant cells or a donor allograft in order to induce tolerance for the cells and/or allograft in a recipient.
摘要翻译：本发明提供用于诱导供体特异性耐受的方法，系统和组合物。特别地，本发明提供在施用供体移植细胞或供体同种异体移植之前，期间和/或之后施用ECDI处理的细胞以诱导受体中细胞和/或同种异体移植物的耐受性的方法。

5. 发明申请

US20080233132A1 MULTIPLE SCLEROSIS THERAPY 审中-公开
标题翻译：多发性硬化症治疗
公开(公告)号：US20080233132A1
公开(公告)日：2008-09-25
申请号：US11934641
申请日：2007-11-02
申请人： Stephen D. Miller , Terra J. Frederick
发明人： Stephen D. Miller , Terra J. Frederick
IPC分类号： A61K39/395 , A61K36/00 , C12N5/06 , A61K38/02 , A61P37/00 , A61K31/55 , A61K31/7088
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K2039/507 , C07K16/2809 , C07K16/2827 , C07K2317/55 , A61K2300/00
摘要： The present invention relates to methods for treating multiple sclerosis by combining immunotherapy with myelin repair.
摘要翻译：本发明涉及通过将免疫治疗与髓磷脂修复组合来治疗多发性硬化的方法。

6. 发明授权

US06429434B1 Transmission attenuation correction method for PET and SPECT 失效
标题翻译： PET和SPECT传输衰减校正方法
公开(公告)号：US06429434B1
公开(公告)日：2002-08-06
申请号：US09398497
申请日：1999-09-17
申请人： Charles C. Watson , Stephen D. Miller , Ronald Nutt , Michael E. Casey , James J. Hamill
发明人： Charles C. Watson , Stephen D. Miller , Ronald Nutt , Michael E. Casey , James J. Hamill
IPC分类号： G01T1166
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1648 , G21K1/02
摘要： A transmission source serves to detect activity from a radiation source for correcting attenuation in either PET mode or SPECT mode. The transmission source includes a detector dedicated to collecting attenuation data in PET mode. A collimated radiation source and a detector are positioned with respect to a tomography device such that only a selected strip of the imaging detector of the tomograph is illuminated such that events unrelated to the attenuation are eliminated. The transmission source can either be a coincidence transmission source or a singles transmission source and includes a collimator in which is disposed a radiation source. An opening is defined by the collimator for exposing a selected portion of the imaging detectors of the tomograph device. Positioned behind the radiation source, relative to the imaging detectors, is the dedicated attenuation detector. In a dual head tomograph device, one transmission source of the present invention is disposed opposite each bank of imaging detectors. The sources and the associated collimators are positioned to the side of each head at a slight angle relative to the respective head. The sources and detectors are fixed relative to the imaging heads. In order to obtain full coverage of the field of view (FOV) in the same manner as for an emission scan, the heads and sources are rotated about the center of the camera. In SPECT mode, the point source is selected to have sufficiently high energy to shine through the patient and the collimators associated with the imaging detector.
摘要翻译：传输源用于检测来自辐射源的活动以校正PET模式或SPECT模式中的衰减。传输源包括专用于在PET模式下收集衰减数据的检测器。准直辐射源和检测器相对于断层摄影装置定位，使得只有层析成像仪的成像检测器的选定条带被照亮，从而消除与衰减无关的事件。传输源可以是重合传输源或单个传输源，并且包括准直仪，其中设置有辐射源。由准直器限定开口以暴露层析成像装置的成像检测器的选定部分。相对于成像检测器定位在辐射源之后，是专用的衰减检测器。在双头断层摄影装置中，本发明的一个发射源与每一组成像检测器相对设置。源和相关联的准直仪相对于相应的头部以相当小的角度定位在每个头部的侧面。源和检测器相对于成像头是固定的。为了以与发射扫描相同的方式获得视场（FOV）的全面覆盖，头部和源围绕照相机的中心旋转。在SPECT模式中，点源被选择为具有足够高的能量以照射通过患者和与成像检测器相关联的准直仪。

7. 发明授权

US4550046A Insulating material 失效
标题翻译：绝缘材料
公开(公告)号：US4550046A
公开(公告)日：1985-10-29
申请号：US638427
申请日：1984-08-07
申请人： Stephen D. Miller
发明人： Stephen D. Miller
IPC分类号： B29D24/00 , B29D99/00 , B32B3/12 , E04B1/78
CPC分类号： B29D99/0089 , B29D24/005 , B32B3/12 , E04B1/78 , Y10S428/92 , Y10T428/24149 , Y10T428/24174 , Y10T428/24322
摘要： A composite insulating material which is comprised of one or more layers of open ended cells formed from flexible thin plastic sheet, and may be fastened to one or more cover sheets. The material is flexible enough to be worn as clothing and derives its insulating properties by reducing thermal conducting paths and areas, by introducing numerous controlled geometry air cells between the heat source and inner layer to further lower conductivity and inhibit convection currents and, by absorbing radiant thermal energy within the cell walls thereby reducing heat transmission by radiation. Metallized reflecting layers are not required to achieve high insulating efficiency.
摘要翻译：复合绝缘材料，其由柔性薄塑料片形成的一层或多层开口单元组成，并且可以被紧固到一个或多个覆盖片。通过在热源和内层之间引入许多受控制的几何空气单元，该材料具有足够的柔韧性，能够作为服装穿着，并通过减少导热路径和面积来获得其绝缘性能，以进一步降低导电性并抑制对流，并通过吸收辐射细胞壁内的热能由此减少辐射的热传递。金属化反射层不需要达到高绝缘效率。

8. 发明授权

US4119220A Sheet feeding apparatus 失效
标题翻译：送纸装置
公开(公告)号：US4119220A
公开(公告)日：1978-10-10
申请号：US771456
申请日：1977-02-24
申请人： Louis J. Frederick , Kenneth E. Hoke , Jerrold W. Greene , Stephen D. Miller
发明人： Louis J. Frederick , Kenneth E. Hoke , Jerrold W. Greene , Stephen D. Miller
IPC分类号： B65H15/02 , B65H1/22
CPC分类号： B65H15/02 , B65H2301/33214
摘要： Disclosed is a sheet feeding apparatus in which the stack of sheets forming the load are fed onto a pivoting cradle whose pivot axis is at a height permitting substantially horizontal delivery of the sheets to the receiving conveyor. After each loading of the cradle, it is moved horizontally toward the receiving conveyor an amount sufficient to cover any feeding gap on the conveyor caused by the excursion of the cradle through its load position.
摘要翻译：公开了一种片材进给装置，其中形成载荷的片材堆叠被馈送到枢转轴支架的枢转轴线的高度允许片材基本上水平地传送到接收输送机。在每个装载托架之后，水平地朝向接收输送机移动足以覆盖由托架通过其加载位置的偏移引起的输送机上的任何进给间隙的量。

9. 发明授权

US5633500A Split window scatter correction 失效
标题翻译：拆分窗口散射校正
公开(公告)号：US5633500A
公开(公告)日：1997-05-27
申请号：US561936
申请日：1995-11-22
申请人： Hugh T. Morgan , Gary G. Jarkewicz , Piotr J. Maniawski , Stephen D. Miller
发明人： Hugh T. Morgan , Gary G. Jarkewicz , Piotr J. Maniawski , Stephen D. Miller
IPC分类号： G01T1/164 , G01T1/161
CPC分类号： G01T1/1647 , G01T1/1642
摘要： A method of scatter correction for use with gamma cameras includes the steps of detecting and producing a first count value indicative of gamma radiation falling within a first energy range generally associated with a radionuclide photopeak. Gamma radiation falling within second and third energy ranges is also detected and a corresponding count produced. The second and third ranges are above and below the photopeak, respectively. The location of the second and third energy ranges is determined based on the energy resolution of the gamma camera such that a predetermined percentage of the radiation falling within the second and third ranges results from primary radiation. The second and third energy ranges may be located such that they are non-contiguous with the first energy range. Based on the count of radiation falling within the second and third ranges, the scatter radiation falling within the first energy range can be estimated, and the first count value corrected. The method is suitable for use with radionuclides having multiple closely spaced photopeaks as well as with multiple widely spaced photopeaks.
摘要翻译：用于伽马照相机的散射校正方法包括以下步骤：检测并产生指示伽马辐射落在通常与放射性核素光峰相关联的第一能量范围内的第一计数值。也检测到落在第二和第三能量范围内的伽马辐射，并产生相应的计数。第二和第三范围分别在光峰之上和之下。基于γ相机的能量分辨率来确定第二和第三能量范围的位置，使得落入第二和第三范围内的预定百分比的辐射源自初级辐射。第二和第三能量范围可以被定位成使得它们与第一能量范围不连续。基于落在第二和第三范围内的辐射计数，可以估计落在第一能量范围内的散射辐射，并且校正第一计数值。该方法适用于具有多个紧密间隔的光峰的放射性核素以及多个宽间隔的光峰。

10. 发明申请

US20110064709A1 USE OF ECDI-FIXED CELL TOLERANCE AS A METHOD FOR PREVENTING ALLOGRAFT REJECTION 失效
标题翻译： ECDI固定细胞耐受性的使用作为预防ALLOGRAFT抑制的方法
公开(公告)号：US20110064709A1
公开(公告)日：2011-03-17
申请号：US12883763
申请日：2010-09-16
申请人： Stephen D. Miller , Xunrong Luo
发明人： Stephen D. Miller , Xunrong Luo
IPC分类号： A61K35/12 , A61K35/14 , A61K35/28 , A61K35/34 , A61K35/39 , A61K35/23 , A61K35/407 , A61K35/38 , A61K35/42 , A61P43/00
CPC分类号： A61K35/15 , A61K35/18 , A61K35/22 , A61K35/26 , A61K35/34 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/42
摘要： The present invention provides methods, systems, and compositions for inducing donor-specific tolerance. In particular, the present invention provides methods of administering ECDI-treated cells before, during, and/or after administration of donor transplant cells or a donor allograft in order to induce tolerance for the cells and/or allograft in a recipient.
摘要翻译：本发明提供用于诱导供体特异性耐受的方法，系统和组合物。特别地，本发明提供在施用供体移植细胞或供体同种异体移植之前，期间和/或之后施用ECDI处理的细胞以诱导受体中细胞和/或同种异体移植的耐受性的方法。

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