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1. 发明申请

US20120019316A1 APPARATUS FOR DRIVING A RESONANT CIRCUIT 审中-公开
标题翻译：用于驱动谐振电路的装置
公开(公告)号：US20120019316A1
公开(公告)日：2012-01-26
申请号：US13145437
申请日：2010-01-20
申请人： Simon Richard Hattersley , Paul Southern , Quentin Andrew Pankhurst , Mathew Kallumadil
发明人： Simon Richard Hattersley , Paul Southern , Quentin Andrew Pankhurst , Mathew Kallumadil
IPC分类号： H03H11/00
CPC分类号： H05B6/06 , A61N1/406 , H05B2214/04
摘要： An apparatus for driving a resonant circuit is disclosed. The apparatus comprises: a first drive circuit, the first drive circuit arranged to provide a drive current to said resonant circuit; and a controller coupled to said first drive circuit, the first drive circuit further comprising: a first input adapted to receive a current from a power supply; a switch; a second input adapted to receive from said controller a signal to control said switch; an output coupled to said resonant circuit; a first inductor, which acts to set the drive current through said resonant circuit when the switch is closed; and a first diode coupled across said first inductor, said first diode arranged to enable current to continue to flow in the first inductor when the switch is open, wherein the controller is adapted to receive from a sensor a signal derived from the current flowing in said resonant circuit, wherein said sensor is coupled to said controller, and said controller is configured to close said switch to enable the drive current to flow through said resonant circuit when said signal derived from said sensor satisfies a first condition and said controller is further configured to open said switch to cause the drive current to stop flowing through the resonant circuit when said signal derived from said sensor satisfies a second condition. In a preferred embodiment, the apparatus also comprises a forward diode in series with the switch, so as to allow the resonance to be driven to a greater amplitude than otherwise possible.
摘要翻译：公开了一种用于驱动谐振电路的装置。该装置包括：第一驱动电路，第一驱动电路被布置成向所述谐振电路提供驱动电流; 以及耦合到所述第一驱动电路的控制器，所述第一驱动电路还包括：适于从电源接收电流的第一输入; 开关第二输入，适于从所述控制器接收控制所述开关的信号; 耦合到所述谐振电路的输出; 第一电感器，其用于在开关闭合时将驱动电流设定通过所述谐振电路; 以及耦合在所述第一电感器上的第一二极管，所述第一二极管被布置成当所述开关断开时使电流继续流过所述第一电感器，其中所述控制器适于从传感器接收从在所述第一电感器谐振电路，其中所述传感器耦合到所述控制器，并且所述控制器被配置为关闭所述开关，以便当从所述传感器得到的所述信号满足第一条件时，驱动电流流过所述谐振电路，并且所述控制器还被配置为当从所述传感器得到的信号满足第二条件时，打开所述开关以使驱动电流停止流过谐振电路。在优选实施例中，该装置还包括与开关串联的正二极管，以便允许谐振被驱动到比其它可能的更大幅度。

2. 发明申请

US20120229130A1 Apparatus and Method for Determining Magnetic Properties of Materials 审中-公开
标题翻译：用于确定材料磁性的装置和方法
公开(公告)号：US20120229130A1
公开(公告)日：2012-09-13
申请号：US13441378
申请日：2012-04-06
申请人： Simon Richard Hattersley , Quentin Andrew Pankhurst , Audrius Brazdeikis
发明人： Simon Richard Hattersley , Quentin Andrew Pankhurst , Audrius Brazdeikis
IPC分类号： G01R33/02
CPC分类号： G01R33/1215
摘要： Apparatus for determining magnetic properties of materials comprises a portable probe, an equipment trolley holding cryogenics and electronics and connecting cables. The probe comprises a drive coil and a correction coil, the drive coil being disposed symmetrically with respect to an inner second-order gradiometer sensor coil. Electrical connectors in the form of 2-metre long Belden (1192A) microphone cables are used to connect the apparatus on the equipment trolley to the drive coil, the correction coil and the sensor coil. The drive coil is driven so as to generate a sinusoidally varying magnetic field. The electronics comprise a flux-locked loop, a SQUID controller, a data acquisition module, which captures and processes the signals and computer. A liquid-nitrogen dewar is supported on the equipment trolley and houses a sensitive SQUID detector and a transfer coil made from copper. Possible applications of the apparatus include an intra-operative tool for sentinel lymph node detection in the treatment of breast cancer, and a non-destructive evaluation tool for detecting voids and defects in aluminum and applications in the aeronautics industry.
摘要翻译：用于确定材料的磁特性的装置包括便携式探针，装有低温物质的设备手推车和电子设备以及连接电缆。探头包括驱动线圈和校正线圈，驱动线圈相对于内二级梯度传感器线圈对称设置。使用2米长Belden（1192A）麦克风电缆形式的电气连接器将设备手推车上的设备连接到驱动线圈，校正线圈和传感器线圈。驱动线圈被驱动以产生正弦变化的磁场。电子装置包括磁通锁定环，SQUID控制器，数据采集模块，其捕获并处理信号和计算机。液氮杜瓦瓶支撑在设备手推车上，并容纳敏感的SQUID检测器和由铜制成的传输线圈。该装置的可能应用包括用于乳腺癌治疗中的前哨淋巴结检测的手术工具，以及用于检测铝中的空隙和缺陷以及在航空工业中的应用的非破坏性评估工具。

3. 发明授权

US08174259B2 Apparatus and method for determining magnetic properties of materials 有权
标题翻译：用于确定材料磁性能的装置和方法
公开(公告)号：US08174259B2
公开(公告)日：2012-05-08
申请号：US11912930
申请日：2006-04-28
申请人： Simon Richard Hattersley , Quentin Andrew Pankhurst , Audrius Brazdeikis
发明人： Simon Richard Hattersley , Quentin Andrew Pankhurst , Audrius Brazdeikis
IPC分类号： G01R33/02 , G01R33/12
CPC分类号： G01R33/1215
摘要： Apparatus for determining magnetic properties of materials comprises a portable probe (1), an equipment trolley (2) holding cryogenics and electronics and connecting cables (3). The probe (1) comprises a drive coil (4) and a correction coil (5), the drive coil (4) being disposed symmetrically with respect to an inner second-order gradiometer sensor coil (8). Electrical connectors in the form of 2-meter long Belden (1192A) microphone cables (3) are used to connect the apparatus on the equipment trolley (2) to the drive coil (4), the correction coil (5) and the sensor coil (8). The drive coil (4) is driven so as to generate a sinusoidally varying magnetic field. The electronics comprise a flux-locked loop (9), a SQUID controller (10), a data acquisition module (11), which captures and processes the signals and a computer (12). A liquid-nitrogen dewar (13) is supported on the equipment trolley (2) and houses a sensitive SQUID detector (14) and a transfer coil (15) made from copper. Possible applications of the apparatus include an intra-operative tool for sentinel lymph node detection in the treatment of breast cancer, and a non-destructive evaluation tool for detecting voids and defects in aluminum and applications in the aeronautics industry.
摘要翻译：用于确定材料的磁特性的装置包括便携式探头（1），容纳低温物质的电子设备和连接电缆（3）的设备手推车（2）。探针（1）包括驱动线圈（4）和校正线圈（5），驱动线圈（4）相对于内二级梯度传感器线圈（8）对称设置。使用2米长Belden（1192A）麦克风电缆（3）形式的电连接器将设备手推车（2）上的设备连接到驱动线圈（4），校正线圈（5）和传感器线圈（8）。驱动线圈（4）被驱动以产生正弦变化的磁场。电子装置包括一个磁通锁定环（9），一个SQUID控制器（10），一个捕获和处理这些信号的数据采集模块（11）和一个计算机（12）。液氮杜瓦瓶（13）被支撑在设备手推车（2）上，并容纳灵敏的SQUID检测器（14）和由铜制成的传送线圈（15）。该装置的可能应用包括用于乳腺癌治疗中的前哨淋巴结检测的手术工具，以及用于检测铝中的空隙和缺陷以及在航空工业中的应用的非破坏性评估工具。

4. 发明申请

US20090201016A1 Apparatus and method for determining magnetic properties of materials 有权
标题翻译：用于确定材料磁性能的装置和方法
公开(公告)号：US20090201016A1
公开(公告)日：2009-08-13
申请号：US11912930
申请日：2006-04-28
申请人： Simon Richard Hattersley , Quentin Andrew Pankhurst , Audrius Brazdeikis
发明人： Simon Richard Hattersley , Quentin Andrew Pankhurst , Audrius Brazdeikis
IPC分类号： G01R33/12 , G01R33/035
CPC分类号： G01R33/1215
摘要： Apparatus for determining magnetic properties of materials comprises a portable probe (1), an equipment trolley (2) holding cryogenics and electronics and connecting cables (3). The probe (1) comprises a drive coil (4) and a correction coil (5), the drive coil (4) being disposed symmetrically with respect to an inner second-order gradiometer sensor coil (8). Electrical connectors in the form of 2-metre long Belden (1192A) microphone cables (3) are used to connect the apparatus on the equipment trolley (2) to the drive coil (4), the correction coil (5) and the sensor coil (8). The drive coil (4) is driven so as to generate a sinusoidally varying magnetic field. The electronics comprise a flux-locked loop (9), a SQUID controller (10), a data acquisition module (11), which captures and processes the signals and a computer (12). A liquid-nitrogen dewar (13) is supported on the equipment trolley (2) and houses a sensitive SQUID detector (14) and a transfer coil (15) made from copper. Possible applications of the apparatus include an intra-operative tool for sentinel lymph node detection in the treatment of breast cancer, and a non-destructive evaluation tool for detecting voids and defects in aluminium and applications in the aeronautics industry.
摘要翻译：用于确定材料的磁特性的装置包括便携式探头（1），容纳低温物质的电子设备和连接电缆（3）的设备手推车（2）。探针（1）包括驱动线圈（4）和校正线圈（5），驱动线圈（4）相对于内二级梯度传感器线圈（8）对称设置。使用2米长Belden（1192A）麦克风电缆（3）形式的电连接器将设备手推车（2）上的设备连接到驱动线圈（4），校正线圈（5）和传感器线圈（8）。驱动线圈（4）被驱动以产生正弦变化的磁场。电子装置包括一个磁通锁定环（9），一个SQUID控制器（10），一个捕获和处理这些信号的数据采集模块（11）和一个计算机（12）。液氮杜瓦瓶（13）被支撑在设备手推车（2）上，并容纳灵敏的SQUID检测器（14）和由铜制成的传送线圈（15）。该装置的可能应用包括用于乳腺癌治疗中的前哨淋巴结检测的手术工具，以及用于检测铝中的空隙和缺陷以及在航空工业中的应用的非破坏性评估工具。

5. 发明授权

US09427186B2 Magnetic probe apparatus 有权
标题翻译：磁探头装置
公开(公告)号：US09427186B2
公开(公告)日：2016-08-30
申请号：US12960746
申请日：2010-12-06
申请人： Simon Richard Hattersley , Quentin Andrew Pankhurst
发明人： Simon Richard Hattersley , Quentin Andrew Pankhurst
IPC分类号： A61B5/00 , A61B5/05 , A61B5/06 , A61B10/00 , A61K49/18 , B82Y5/00
CPC分类号： A61B5/418 , A61B5/05 , A61B5/065 , A61B5/415 , A61B5/4312 , A61B10/0041 , A61K49/1863 , B82Y5/00
摘要： A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a processing module in electrical communication with the power module and the sense module. The processing module generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles collect in the lymph nodes. In one embodiment the particles have a mean hydrodynamic diameter of between 5-200 nm.
摘要翻译：一种用于定位磁性材料的系统和方法。在一个实施例中，系统包括磁探针; 电源模块，与所述磁探头电连通以向所述磁探头供电; 感测模块，与所述磁探头电连通以接收来自所述磁性探头的信号; 以及与电源模块和感测模块电连通的处理模块。处理模块产生一个波形，该波形控制来自功率模块的电流供应，并接收来自感测模块的指示磁性材料的存在的信号。磁性探针由热膨胀系数大致为10 -6 /℃以下，杨氏模量为50GPa以上的材料构成。在一个实施方案中，磁性纳米颗粒收集在淋巴结中。在一个实施方案中，颗粒的平均流体动力学直径在5-200nm之间。

6. 发明申请

US20110137154A1 MAGNETIC PROBE APPARATUS 有权
标题翻译：磁性探针装置
公开(公告)号：US20110137154A1
公开(公告)日：2011-06-09
申请号：US12960746
申请日：2010-12-06
申请人： Simon Richard Hattersley , Quentin Andrew Pankhurst
发明人： Simon Richard Hattersley , Quentin Andrew Pankhurst
IPC分类号： A61B5/05 , A61B17/34
CPC分类号： A61B5/418 , A61B5/05 , A61B5/065 , A61B5/415 , A61B5/4312 , A61B10/0041 , A61K49/1863 , B82Y5/00
摘要： A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a processing module in electrical communication with the power module and the sense module. The processing module generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles collect in the lymph nodes. In one embodiment the particles have a mean hydrodynamic diameter of between 5-200 nm.
摘要翻译：一种用于定位磁性材料的系统和方法。在一个实施例中，系统包括磁探针; 电源模块，与所述磁探头电连通以向所述磁探头供电; 感测模块，与所述磁探头电连通以接收来自所述磁性探头的信号; 以及与电源模块和感测模块电连通的处理模块。处理模块产生一个波形，该波形控制来自功率模块的电流供应，并接收来自感测模块的指示磁性材料的存在的信号。磁性探针由热膨胀系数大致为10 -6 /℃以下，杨氏模量为50GPa以上的材料构成。在一个实施方案中，磁性纳米颗粒收集在淋巴结中。在一个实施方案中，颗粒的平均流体动力学直径在5-200nm之间。

7. 发明授权

US09427396B2 Magnetic microbubbles, methods of preparing them and their uses 有权
标题翻译：磁性微泡，其制备方法及其用途
公开(公告)号：US09427396B2
公开(公告)日：2016-08-30
申请号：US13000841
申请日：2009-06-26
申请人： Quentin Andrew Pankhurst , Eleanor Phoebe Jane Stride , Colin David Porter , Ana García Prieto
发明人： Quentin Andrew Pankhurst , Eleanor Phoebe Jane Stride , Colin David Porter , Ana García Prieto
IPC分类号： A61K9/50 , A61K9/00 , A61K49/22
CPC分类号： A61K9/0009 , A61K9/5094 , A61K49/223
摘要： The invention provides a method of preparing a suspension of microbubbles for use in a carrier liquid, wherein the microbubbles have a gas core and a liquid shell, said liquid shell comprising magnetic nanoparticles, and wherein the microbubbles satisfy the following conditions: (i) the force due to buoyancy (FBW) of the microbubble in the carrier liquid is greater than the weight (W) of the microbubble; (ii) the magnetic force (FM) on the microbubble due to a magnetic field applied to the carrier liquid is greater than the combined weight (W) and force due to buoyancy (FBW) of the microbubble; (iii) said magnetic force (FM) on the microbubble is greater than the force due to viscous drag (FD) on the microbubble due to flow of the carrier liquid; and (iv) the scattering cross section (σscat) of the microbubble to ultrasound allows the microbubble to be detectable and rupturable on exposure to ultrasound.
摘要翻译：本发明提供一种制备用于载体液体的微泡悬浮液的方法，其中微泡具有气芯和液体壳，所述液体壳包含磁性纳米颗粒，并且其中微泡满足以下条件：（i）载液中的微泡的浮力（FBW）的力大于微泡的重量（W）; （ii）由施加于载液的磁场引起的微泡上的磁力（FM）大于由微泡的浮力（FBW）引起的组合重量（W）和力; （iii）微泡上的所述磁力（FM）大于由于载液的流动导致的微泡上的粘滞阻力（FD）的力; 和（iv）微泡对超声波的散射截面（σscat）允许微泡在暴露于超声波时是可检测的和可破裂的。

8. 发明申请

US20110172486A1 MAGNETIC MICROBUBBLES, METHODS OF PREPARING THEM AND THEIR USES 有权
标题翻译：磁性微粒，其制备方法及其用途
公开(公告)号：US20110172486A1
公开(公告)日：2011-07-14
申请号：US13000841
申请日：2009-06-26
申请人： Quentin Andrew Pankhurst , Eleanor Phoebe Jane Stride , Colin David Porter , Ana García Prieto
发明人： Quentin Andrew Pankhurst , Eleanor Phoebe Jane Stride , Colin David Porter , Ana García Prieto
IPC分类号： A61M37/00 , A61K9/00 , G01N29/02 , G06F19/00 , B82Y5/00
CPC分类号： A61K9/0009 , A61K9/5094 , A61K49/223
摘要： The invention provides a method of preparing a suspension of microbubbles for use in a carrier liquid, wherein the microbubbles have a gas core and a liquid shell, said liquid shell comprising magnetic nanoparticles, and wherein the microbubbles satisfy the following conditions: (i) the force due to buoyancy (FBW) of the microbubble in the carrier liquid is greater than the weight (W) of the microbubble; (ii) the magnetic force (FM) on the microbubble due to a magnetic field applied to the carrier liquid is greater than the combined weight (W) and force due to buoyancy (FBW) of the microbubble; (iii) said magnetic force (FM) on the microbubble is greater than the force due to viscous drag (FD) on the microbubble due to flow of the carrier liquid; and (iv) the scattering cross section (σscat) of the microbubble to ultrasound allows the microbubble to be detectable and rupturable on exposure to ultrasound.
摘要翻译：本发明提供一种制备用于载体液体的微泡悬浮液的方法，其中微泡具有气芯和液体壳，所述液体壳包含磁性纳米颗粒，并且其中微泡满足以下条件：（i）载液中的微泡的浮力（FBW）的力大于微泡的重量（W）; （ii）由施加于载液的磁场引起的微泡上的磁力（FM）大于由微泡的浮力（FBW）引起的组合重量（W）和力; （iii）微泡上的所述磁力（FM）大于由于载液的流动导致的微泡上的粘滞阻力（FD）的力; 和（iv）微泡对超声波的散射截面（＆amp; sgr。scat）允许微泡在暴露于超声波时是可检测的和可破裂的。

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