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    • 4. 发明授权
    • (Pyrrolidin-2-yl)phenyl derivatives
    • (吡咯烷-2-基)苯基衍生物
    • US08188123B2
    • 2012-05-29
    • US12611468
    • 2009-11-03
    • Simon James Anthony GroveRonald PalinAshvinkumar Dhirubhai MistryJohn Kinnaird Ferguson MacLean
    • Simon James Anthony GroveRonald PalinAshvinkumar Dhirubhai MistryJohn Kinnaird Ferguson MacLean
    • A61K31/4439C07D401/10
    • C07D401/10
    • The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy; R2 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; R3 is H, (C1-4)alkyl or halo(C1-4)alkyl; R4 is H, (C1-4)alkyl or halo(C1-4)alkyl; R5 is H, (C1-4)alkyl or halo-(C1-4)-alkyl; or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C3-6)cycloalkyl group, optionally substituted with halogen; R6 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.
    • 本发明涉及具有通式I的(吡咯烷-2-基)苯基衍生物,其中R 1是(C 1-4)烷基,卤代(C 1-4)烷基,(C 1-4)烷氧基或卤代(C 1-4) 烷氧基 R 2是H,(C 1-4)烷基,卤代(C 1-4)烷基,(C 1-4)烷氧基,卤代(C 1-4)烷氧基或卤素; R3是H,(C1-4)烷基或卤代(C1-4)烷基; R4是H,(C1-4)烷基或卤代(C1-4)烷基; R5是H,(C1-4)烷基或卤代(C1-4) - 烷基; 或R 4和R 5在与相同碳原子键合时可与碳原子一起形成任选被卤素取代的螺(C 3-6)环烷基; R 6为H,(C 1-4)烷基,卤代(C 1-4)烷基,(C 1-4)烷氧基,卤代(C 1-4)烷氧基或卤素; 或其药学上可接受的盐,包含其的药物组合物,以及这些(吡咯烷-2-基)苯基衍生物用于治疗疼痛如神经性疼痛或炎性疼痛的用途。
    • 5. 发明申请
    • (PYRROLIDIN-2-YL)PHENYL DERIVATIVES
    • (吡咯烷-2-基)苯基衍生物
    • US20100113493A1
    • 2010-05-06
    • US12611468
    • 2009-11-03
    • Simon James Anthony GroveRonald PalinAshvinkumar Dhirubhai MistryJohn Kinnaird Ferguson MacLean
    • Simon James Anthony GroveRonald PalinAshvinkumar Dhirubhai MistryJohn Kinnaird Ferguson MacLean
    • A61K31/4439C07D401/10A61P29/00A61P25/00
    • C07D401/10
    • The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy; R2 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; R3 is H, (C1-4)alkyl or halo(C1-4)alkyl; R4 is H, (C1-4)alkyl or halo(C1-4)alkyl; R5 is H, (C1-4)alkyl or halo-(C1-4)-alkyl; or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C3-6)cycloalkyl group, optionally substituted with halogen; R6 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.
    • 本发明涉及具有通式I的(吡咯烷-2-基)苯基衍生物,其中R 1是(C 1-4)烷基,卤代(C 1-4)烷基,(C 1-4)烷氧基或卤代(C 1-4) 烷氧基 R 2是H,(C 1-4)烷基,卤代(C 1-4)烷基,(C 1-4)烷氧基,卤代(C 1-4)烷氧基或卤素; R3是H,(C1-4)烷基或卤代(C1-4)烷基; R4是H,(C1-4)烷基或卤代(C1-4)烷基; R5是H,(C1-4)烷基或卤代(C1-4) - 烷基; 或R 4和R 5在与相同碳原子键合时可与碳原子一起形成任选被卤素取代的螺(C 3-6)环烷基; R 6为H,(C 1-4)烷基,卤代(C 1-4)烷基,(C 1-4)烷氧基,卤代(C 1-4)烷氧基或卤素; 或其药学上可接受的盐,包含其的药物组合物,以及这些(吡咯烷-2-基)苯基衍生物用于治疗疼痛如神经性疼痛或炎性疼痛的用途。