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1. 发明授权

US07907994B2 Automated pace-mapping for identification of cardiac arrhythmic conductive pathways and foci 有权
标题翻译：用于识别心律失常导电通路和灶的自动步速图
公开(公告)号：US07907994B2
公开(公告)日：2011-03-15
申请号：US11970803
申请日：2008-01-08
申请人： Silvia Stolarski , Aharon Turgeman , Meir Bar-Tal , Ronnie Abbo , Assaf Govari , Yaron Ephrath , Andres Claudio Altmann , Dror Levy
发明人： Silvia Stolarski , Aharon Turgeman , Meir Bar-Tal , Ronnie Abbo , Assaf Govari , Yaron Ephrath , Andres Claudio Altmann , Dror Levy
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/06 , A61B5/062 , G06F19/00 , Y02A90/26
摘要： Ventricular tachycardia signals are induced in a living subject. Pace-mapped signals are then obtained from multiple points within the ventricle, and automatically compared numerically with the induced signals. Recognition of a high degree of cross correlation between the induced signals and one or more of the pace-mapped signals identifies arrhythmogenic foci or pathways, which may then be ablated, so that the arrhythmia becomes non-inducible.
摘要翻译：室性心动过速信号在活体中诱发。然后从心室内的多个点获得步态映射的信号，并自动与感应信号进行数值比较。识别感应信号与一个或多个步速映射信号之间的高度相互关系，可以识别致命的致病灶或通路，然后可能被消融，以致心律失常变得不可诱导。

2. 发明申请

US20080188765A1 AUTOMATED PACE-MAPPING FOR IDENTIFICATION OF CARDIAC ARRHYTHMIC CONDUCTIVE PATHWAYS AND FOCI 有权
标题翻译：用于鉴定心脏导管途径和FOCI的自动拍摄
公开(公告)号：US20080188765A1
公开(公告)日：2008-08-07
申请号：US11970803
申请日：2008-01-08
申请人： Silvia Stolarski , Aharon Turgeman , Meir Bar-Tal , Ronnie Abbo , Assaf Govari , Yaron Ephrath , Andres Claudio Altmann , Dror Levy
发明人： Silvia Stolarski , Aharon Turgeman , Meir Bar-Tal , Ronnie Abbo , Assaf Govari , Yaron Ephrath , Andres Claudio Altmann , Dror Levy
IPC分类号： A61B5/0402
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/06 , A61B5/062 , G06F19/00 , Y02A90/26
摘要： Ventricular tachycardia signals are induced in a living subject. Pace-mapped signals are then obtained from multiple points within the ventricle, and automatically compared numerically with the induced signals. Recognition of a high degree of cross correlation between the induced signals and one or more of the pace-mapped signals identifies arrhythmogenic foci or pathways, which may then be ablated, so that the arrhythmia becomes non-inducible.
摘要翻译：室性心动过速信号在活体中诱发。然后从心室内的多个点获得步态映射的信号，并自动与感应信号进行数值比较。识别感应信号与一个或多个步速映射信号之间的高度相互关系，可以识别致命的致病灶或通路，然后可能被消融，以致心律失常变得不可诱导。

3. 发明申请

US20080306380A1 SHIELDING OF CATHETER HANDLE 有权
标题翻译：电缆手柄的屏蔽
公开(公告)号：US20080306380A1
公开(公告)日：2008-12-11
申请号：US12169693
申请日：2008-07-09
申请人： Yochai Parchak , Meir Bar-Tal , Meiron Atias , Andres Claudio Altmann , Assaf Govari , Yaron Ephrath
发明人： Yochai Parchak , Meir Bar-Tal , Meiron Atias , Andres Claudio Altmann , Assaf Govari , Yaron Ephrath
IPC分类号： A61B5/06 , G01B7/14
CPC分类号： A61B5/061 , A61B5/042 , A61B5/06 , A61B8/12 , A61B8/4254 , A61B8/4411 , A61B34/20 , A61B2017/00243 , A61B2017/00482 , A61B2017/00725 , A61B2034/2051 , A61B2090/3784 , A61B2562/08 , A61B2562/085 , A61B2562/182 , A61B2562/226 , A61B2562/227
摘要： Electrical apparatus includes a probe, having a proximal end and a distal end. The probe includes a sensor, which outputs a sensor signal, and a first connector at the proximal end of the probe, electrically coupled at least to the sensor. A probe adapter includes a second connector, which is arranged to mate with the first connector, and a third connector, for coupling to a console. A shield includes a material of high magnetic permeability, which is configured to enclose an internal volume containing the first and second connectors when the probe is connected to the probe adapter
摘要翻译：电气设备包括具有近端和远端的探针。探头包括输出传感器信号的传感器和在探针的近端处的第一连接器，至少电耦合到传感器。探针适配器包括布置成与第一连接器配合的第二连接器和用于耦合到控制台的第三连接器。屏蔽件包括高导磁率的材料，其被配置为当探头连接到探头适配器时包围包含第一和第二连接器的内部容积

4. 发明授权

US08798711B2 Shielding of catheter handle 有权
标题翻译：导管手柄屏蔽
公开(公告)号：US08798711B2
公开(公告)日：2014-08-05
申请号：US12169693
申请日：2008-07-09
申请人： Yochai Parchak , Meir Bar-Tal , Meiron Atias , Andres Claudio Altmann , Assaf Govari , Yaron Ephrath
发明人： Yochai Parchak , Meir Bar-Tal , Meiron Atias , Andres Claudio Altmann , Assaf Govari , Yaron Ephrath
IPC分类号： A61B5/05
CPC分类号： A61B5/061 , A61B5/042 , A61B5/06 , A61B8/12 , A61B8/4254 , A61B8/4411 , A61B34/20 , A61B2017/00243 , A61B2017/00482 , A61B2017/00725 , A61B2034/2051 , A61B2090/3784 , A61B2562/08 , A61B2562/085 , A61B2562/182 , A61B2562/226 , A61B2562/227
摘要： Electrical apparatus includes a probe, having a proximal end and a distal end. The probe includes a sensor, which outputs a sensor signal, and a first connector at the proximal end of the probe, electrically coupled at least to the sensor. A probe adapter includes a second connector, which is arranged to mate with the first connector, and a third connector, for coupling to a console. A shield includes a material of high magnetic permeability, which is configured to enclose an internal volume containing the first and second connectors when the probe is connected to the probe adapter.
摘要翻译：电气设备包括具有近端和远端的探针。探头包括输出传感器信号的传感器和在探针的近端处的第一连接器，至少电耦合到传感器。探针适配器包括布置成与第一连接器配合的第二连接器和用于耦合到控制台的第三连接器。屏蔽件包括高导磁率的材料，其被配置为当探针连接到探针适配器时，包围包含第一和第二连接器的内部容积。

5. 发明申请

US20080183075A1 ULTRASOUND CATHETER CALIBRATION WITH ENHANCED ACCURACY 有权
标题翻译：超声波导管校准与增强精度
公开(公告)号：US20080183075A1
公开(公告)日：2008-07-31
申请号：US11969541
申请日：2008-01-04
申请人： Assaf Govari , Andres Claudio Altmann , Meir Bar-Tal , Dror Trumer
发明人： Assaf Govari , Andres Claudio Altmann , Meir Bar-Tal , Dror Trumer
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B8/4254 , A61B8/587
摘要： An apparatus for calibration of a probe that includes a magnetic position sensor and an acoustic imaging device has a rigid mechanical framework. One or more field generators, fixed to the framework, generate a magnetic field of known spatial characteristics. An acoustic target assembly includes a phantom coupled to a motion mechanism, which is arranged to move the phantom in a known orbit relative to the framework. A jig, fixed to the framework, holds the probe within the magnetic field of the one or more field generators, in an orientation suitable for the imaging device to image the phantom. A processor processes position and image signals from the probe in order to calibrate coordinates of the imaging device relative to the position sensor.
摘要翻译：用于校准包括磁性位置传感器和声学成像装置的探针的装置具有刚性机械框架。固定到框架的一个或多个场发生器产生已知空间特性的磁场。声学目标组件包括耦合到运动机构的幻影，其被设置成相对于框架在已知轨道中移动体模。固定到框架上的夹具将探针保持在一个或多个场发生器的磁场内，以适于成像装置对成像装置成像的取向。处理器处理来自探针的位置和图像信号，以便校准成像装置相对于位置传感器的坐标。

6. 发明授权

US07996057B2 Ultrasound catheter calibration with enhanced accuracy 有权
标题翻译：超声导管校准精度提高
公开(公告)号：US07996057B2
公开(公告)日：2011-08-09
申请号：US11969541
申请日：2008-01-04
申请人： Assaf Govari , Andres Claudio Altmann , Meir Bar-Tal , Dror Trumer
发明人： Assaf Govari , Andres Claudio Altmann , Meir Bar-Tal , Dror Trumer
IPC分类号： A61B5/05
CPC分类号： A61B8/12 , A61B8/4254 , A61B8/587
摘要： An apparatus for calibration of a probe that includes a magnetic position sensor and an acoustic imaging device has a rigid mechanical framework. One or more field generators, fixed to the framework, generate a magnetic field of known spatial characteristics. An acoustic target assembly includes a phantom coupled to a motion mechanism, which is arranged to move the phantom in a known orbit relative to the framework. A jig, fixed to the framework, holds the probe within the magnetic field of the one or more field generators, in an orientation suitable for the imaging device to image the phantom. A processor processes position and image signals from the probe in order to calibrate coordinates of the imaging device relative to the position sensor.
摘要翻译：用于校准包括磁性位置传感器和声学成像装置的探针的装置具有刚性机械框架。固定到框架的一个或多个场发生器产生已知空间特性的磁场。声学目标组件包括耦合到运动机构的幻影，其被设置成相对于框架在已知轨道中移动体模。固定到框架上的夹具将探针保持在一个或多个场发生器的磁场内，以适于成像装置对成像装置成像的取向。处理器处理来自探针的位置和图像信号，以便校准成像装置相对于位置传感器的坐标。

7. 发明授权

US08827993B2 Gated sampling of electrocardiogram signals during ablation waveform zero-crossing 有权
标题翻译：消融波形零交叉期间心电图信号的门控取样
公开(公告)号：US08827993B2
公开(公告)日：2014-09-09
申请号：US13495084
申请日：2012-06-13
申请人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
发明人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
IPC分类号： A61B18/04
CPC分类号： A61B18/1492 , A61B5/04288 , A61B5/7217 , A61B2018/00357 , A61B2018/00577 , A61B2018/00839
摘要： An apparatus includes detection circuitry and gating circuitry. The detection circuitry is configured to sense a radio frequency (RF) ablation signal that is applied to a heart by an intra-body probe, and to identify time intervals during which an amplitude of an ablation signal is within a predefined window. The gating circuitry is configured to gate an electrocardiogram (ECG) signal acquired in the heart, such that the ECG signal is sampled only within the identified time intervals.
摘要翻译：一种装置包括检测电路和门控电路。检测电路被配置为感测通过体内探针施加到心脏的射频（RF）消融信号，并且识别消融信号的振幅在预定窗口内的时间间隔。门控电路被配置为门控在心脏中获取的心电图（ECG）信号，使得仅在所识别的时间间隔内对ECG信号进行采样。

8. 发明授权

US08615288B2 Robotically guided catheter 有权
标题翻译：机器人引导导管
公开(公告)号：US08615288B2
公开(公告)日：2013-12-24
申请号：US13494273
申请日：2012-06-12
申请人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
发明人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
IPC分类号： A61B5/05
CPC分类号： A61M25/0147 , A61B34/20 , A61B34/30 , A61B34/71 , A61B2017/003 , A61B2034/2051 , A61B2034/2072 , A61B2034/301 , A61M25/0158 , A61M2025/0058
摘要： A system is used for robotically controlling movement of a human-controllable catheter, wherein the catheter has at least one position sensor for generating or receiving signals used for determining six dimensions of location and orientation information. The system uses a robotic control mechanism and a computer for driving the robotic control mechanism to (i) translationally move the catheter distal end in a vicinity of a target, (ii) deflect the distal end of the catheter, and (iii) rotate the catheter. The computer determines roll of the catheter using six dimensions of location and orientation information based on signals generated or received from the at least one position sensor.
摘要翻译：一种系统用于机器人控制人类可控导管的移动，其中导管具有至少一个位置传感器，用于产生或接收用于确定位置和方向信息的六个维度的信号。该系统使用机器人控制机构和用于驱动机器人控制机构的计算机，以（i）在靶附近平移移动导管远端，（ii）使导管的远端偏转，以及（iii）导管。基于从至少一个位置传感器产生或接收的信号，计算机使用位置和方向信息的六个维度来确定导管的滚动。

9. 发明申请

US20130338520A1 GATED SAMPLING OF ELECTROCARDIOGRAM SIGNALS DURING ABLATION WAVEFORM ZERO-CROSSING 有权
标题翻译：消除波浪期间电磁信号的采集ZERO-CROSSING
公开(公告)号：US20130338520A1
公开(公告)日：2013-12-19
申请号：US13495084
申请日：2012-06-13
申请人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
发明人： Assaf Govari , Andres Claudio Altmann , Yaron Ephrath
IPC分类号： A61B5/0402
CPC分类号： A61B18/1492 , A61B5/04288 , A61B5/7217 , A61B2018/00357 , A61B2018/00577 , A61B2018/00839
摘要： An apparatus includes detection circuitry and gating circuitry. The detection circuitry is configured to sense a radio frequency (RF) ablation signal that is applied to a heart by an intra-body probe, and to identify time intervals during which an amplitude of an ablation signal is within a predefined window. The gating circuitry is configured to gate an electrocardiogram (ECG) signal acquired in the heart, such that the ECG signal is sampled only within the identified time intervals.
摘要翻译：一种装置包括检测电路和门控电路。检测电路被配置为感测通过体内探针施加到心脏的射频（RF）消融信号，并且识别消融信号的振幅在预定窗口内的时间间隔。门控电路被配置为门控在心脏中获取的心电图（ECG）信号，使得仅在所识别的时间间隔内对ECG信号进行采样。

10. 发明授权

US08521462B2 Calibration system for a pressure-sensitive catheter 有权
公开(公告)号：US08521462B2
公开(公告)日：2013-08-27
申请号：US12646242
申请日：2009-12-23
申请人： Assaf Govari , Yaron Ephrath , Andres Claudio Altmann
发明人： Assaf Govari , Yaron Ephrath , Andres Claudio Altmann
IPC分类号： G01L1/04
CPC分类号： G01D5/24452 , A61B5/1495 , A61B5/6885 , A61B2560/0223
摘要： A calibration apparatus includes a fixture, which is coupled to accept a probe so that a distal tip of the probe presses against a point in the fixture and produces first measurements indicative of a deformation of the distal tip relative to a distal end of the probe, in response to pressure exerted on the distal tip. A sensing device is coupled to the fixture and is configured to produce second measurements of a mechanical force exerted by the distal tip against the point. A calibration processor is configured to receive the first measurements from the probe, to receive the second measurements from the sensing device and to compute, based on the first and second measurements, one or more calibration coefficients for assessing the pressure as a function of the first measurements.

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